Transfer of metformin across the dually perfused human placental lobule
Abstract
Objective The purpose of this study was to determine the transfer characteristics of metformin across placentas that were obtained from uncomplicated pregnancies and from patients with gestational diabetes mellitus.Study design The technique of dual perfusion of placental lobule was used. Metformin, 5 microg/mL and its [14C]-isotope were co-transfused with the marker compound antipyrine, 20 microg/mL and its [3H]-isotope from the maternal to fetal circuit. The drug content in both circulations and placental tissue was determined by liquid scintillation spectrometry.Results The transfer of metformin across term human placentas that were obtained from uncomplicated pregnancies was rapid and was not different from that in placentas that were obtained from patients with gestational diabetes mellitus. Metformin is distributed between the maternal and fetal circuits, with reliable amounts retained by the tissue.Conclusion In an ex vivo model system, metformin was transferred readily from the maternal to fetal circuit across placentas that were obtained from uncomplicated pregnancies and pregnancies with gestational diabetes mellitus.
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Metformin has a molecular weight of 129 dalton, and it crosses the placenta in direct diffusion without affecting the facilitated transfer of glucose.
“Metformin has a molecular weight of 129 dalton, and it crosses the placenta in direct diffusion without affecting the facilitated transfer of glucose(242).”
From Metformin, the Aspirin of the 21st Century: Its Role in Gestational Diabetes Mellitus, Prevention of Preeclampsia and Cancer, and the Promotion of Longevity (2017) · cites this paper as [242]
An ex vivo dually perfused human placental lobule demonstrated the rapid transfer of metformin from maternal to fetal circulation with a lag time of 1.7±0.28 minutes similarly observed in women with normal pregnancies and those diagnosed with gestational diabetes mellitus.
“Indeed, an ex vivo dually perfused human placental lobule demonstrated the rapid transfer of metformin from maternal to fetal circulation with a lag time of 1.7±0.28 minutes similarly observed in women with normal pregnancies and those diagnosed with gestational diabetes mellitus(242).”
From Metformin, the Aspirin of the 21st Century: Its Role in Gestational Diabetes Mellitus, Prevention of Preeclampsia and Cancer, and the Promotion of Longevity (2017) · cites this paper as [242]
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- Authors
- Nanovskaya, T. N., Nekhayeva, I. A., Patrikeeva, S. L., Hankins, G. D. V., & Ahmed, M. S.
- Affiliations
- The University of Texas Medical Branch at Galveston (US)
- Belarusian State Medical University (BY)
- Corresponding author
- Ahmed, Mahmoud S.
- Venue
- American Journal of Obstetrics and Gynecology
- Publisher
- Elsevier BV
- Published
- 2006-10
- Volume
- 195
- Issue
- 4
- Pages
- 1081-1085
- ISSN
- 0002-9378 (ISSN-L)
- OpenAlex
- W2069428016
- Cited by
- 98
- References
- 14
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 3 · 2020: 5 · 2019: 3 · 2018: 8 · 2017: 8 · 2016: 3 · 2015: 6 · 2014: 11 · 2013: 6 · 2012: 5
- FWCI
- 5.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (U10HD047891)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy and Medication Impact
- Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Keywords
- metformin, maternal-fetal drug transfer, dual perfusion, gestational diabetes mellitus, antipyrine, maternal-fetal exchange
- MeSH terms
- Female, Humans, Hypoglycemic Agents, Maternal-Fetal Exchange, Metformin, Perfusion, Placenta, Pregnancy, Diabetes, Gestational
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