Oophorectomy as a risk factor for coronary heart disease
Open accessAbstract
Objective The objective of the study was to examine the relationship between bilateral oophorectomy (BSO) and risk of coronary heart disease (CHD).Study design We searched PubMed, EMBASE, meeting abstracts, and reference lists for studies that compared women with BSO at the time of hysterectomy with: (1) women with hysterectomy and ovarian conservation, (2) naturally menopausal women, (3) premenopausal women, or (4) women with no history of hysterectomy or BSO but unreported menopausal status. The primary outcome was fatal or nonfatal CHD.Results We reviewed 1956 citations. Seven observational studies met inclusion criteria. Heterogeneity among studies precluded formal metaanalysis. Four studies reported BSO increases risk for CHD but only in some subgroups of women or not in fully adjusted multivariate models. Three studies found no increased risk of CHD following BSO, but these studies had significant limitations.Conclusion The existing evidence is inconclusive to determine the effect of BSO on risk of CHD.
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Hysterectomy, treatment with GnRH agonists, PID, PCOS and adverse pregnancy outcomes are linked to higher CVD risk.
“Hysterectomy, treatment with gonadotropin-releasing hormone (GnRH) agonists, PID, PCOS and adverse pregnancy outcomes are linked to higher CVD risk.”
From Risk of cardiovascular outcomes among women with endometriosis in the United Kingdom: a retrospective matched cohort study (2021) · cites this paper as [16]
The COMMENT section (page unavailable) reports that women who undergo hysterectomy have more cardiovascular risk factors and CHD events than women who do not. Our copy does not link GnRH agonists, PID, PCOS, or adverse pregnancy outcomes to higher CVD risk, so it supports only the hysterectomy portion of the claim. (LLM, conf=0.89)
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- Authors
- Jacoby, V. L., Grady, D., & Sawaya, G. F.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Jacoby, Vanessa L.
- Venue
- American Journal of Obstetrics and Gynecology
- Publisher
- Elsevier BV
- Published
- 2009-02
- Volume
- 200
- Issue
- 2
- Pages
- 140.e1-140.e9
- ISSN
- 0002-9378 (ISSN-L)
- PMC
- PMC2770431
- OpenAlex
- W1978457782
- Cited by
- 31
- References
- 52
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2016: 3 · 2015: 4 · 2014: 2 · 2013: 4 · 2012: 2
- FWCI
- 0.46
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- American Journal of Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (K12HD001262)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Keywords
- bilateral oophorectomy, coronary artery disease, hysterectomy, ovarian preservation, menopause, cardiovascular risk, postmenopausal women, premenopausal women
- MeSH terms
- Coronary Disease, Female, Humans, Menopause, Ovariectomy, Risk Factors
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