The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
The cost-effectiveness of universal screening in pregnancy for subclinical hypothyroidism
Abstract
Objective The purpose of this study was to determine whether routine screening for subclinical hypothyroidism during pregnancy would be cost-effective.Study design We developed a decision analysis model to compare the cost-effectiveness of 2 screening strategies during pregnancy for subclinical hypothyroidism: (1) no routine screening of serum thyroid-stimulating hormone (TSH) levels (standard) and (2) routine screening of TSH levels. In the latter, women with subclinical hypothyroidism received thyroid hormone replacement. We assumed that thyroid hormone replacement could reduce the incidence of an offspring IQ < 85 for pregnancies with subclinical hypothyroidism. The main outcome measure was marginal cost per quality-adjusted life year (QALY) gained.Results Our model predicts that universal screening is the dominant strategy. For every 100,000 pregnant women who were screened, $8,356,383 are saved, and 589.3 QALYs are gained. When subclinical hypothyroidism prevalence is reduced to 0.25%, screening remains cost-effective at $21,664/QALY gained.Conclusion Screening for subclinical hypothyroidism in pregnancy will be a cost-effective strategy under a wide range of circumstances.
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“two recent initiatives in the US 98 and Europe 99 have included prevention among the top priorities for mental health research.”
From Preventive strategies for mental health (2018) · cites this paper as [98]
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The Colorado Thyroid Disease Prevalence Study
Canaris, G. J., Manowitz, N. R., Mayor, G., & Ridgway, E. C. (2000) · Archives of Internal Medicine · doi:10.1001/archinte.160.4.526 · Cited by 2,824
Haddow, J. E., Palomaki, G. E., Allan, W. C., Williams, J. R., Knight, G. J., Gagnon, J., O'Heir, C. E., Mitchell, M. L., Hermos, R. J., Waisbren, S. E., et al. (1999) · New England Journal of Medicine · doi:10.1056/nejm199908193410801 · Cited by 2,558
A systematic review of the associations between dose regimens and medication compliance
Claxton, A. J., Cramer, J., & Pierce, C. (2001) · Clinical Therapeutics · doi:10.1016/s0149-2918(01)80109-0 · Cited by 2,388
DeGroot, L. J., Abalovich, M., Alexander, E. K., Amino, N., Barbour, L. A., Cobin, R. H., Eastman, C. J., Lazarus, J. H., Luton, D., Mandel, S. J., et al. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-2803 · Cited by 1,885
Subclinical Thyroid Disease: Scientific Review and Guidelines for Diagnosis and Management
Surks, M. I., Ortiz, E., Daniels, G. H., Sawin, C. T., Col, N. F., Cobin, R. H., Franklyn, J. A., Hershman, J. M., Burman, K. D., Denke, M. A., et al. (2004) · JAMA · doi:10.1001/jama.291.2.228 · Cited by 1,800
Low Serum Thyrotropin Concentrations as a Risk Factor for Atrial Fibrillation in Older Persons
Sawin, C. T., Geller, A., Wolf, P. A., Belanger, A. J., Baker, E., Bacharach, P., Wilson, P., Benjamin, E. J., & D'Agostino, R. B. (1994) · New England Journal of Medicine · doi:10.1056/nejm199411103311901 · Cited by 1,259
Pop, V. J., Kuijpens, J. L. P., van Baar, A. L., Verkerk, G. J. M., van Son, M. J. M., de Vijlder, J. J. M., Vulsma, T., Wiersinga, W. M., Drexhage, H. A., & Vader, H. L. (1999) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1999.00639.x · Cited by 1,006
Abalovich, M., Amino, N., Barbour, L. A., Cobin, R. H., DeGroot, L. J., Glinoer, D., Mandel, S. J., & Stagnaro‐Green, A. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-0141 · Cited by 934
Subclinical hypothyroidism and pregnancy outcomes
Casey, B. M., Dashe, J. S., Wells, C. E., McIntire, D. D., Byrd, W., Leveno, K. J., & Cunningham, F. G. (2005) · Obstetrics & Gynecology · doi:10.1097/01.aog.0000152345.99421.22 · Cited by 903
Pop, V. J., Brouwers, E. P. M., Vader, H. L., Vulsma, T., van Baar, A. L., & de Vijlder, J. J. M. (2003) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2003.01822.x · Cited by 727
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Research works printed but not linked: 1
- 2002, Thyroid disease in pregnancy; practice bulletin no.: 37, Int J Gynaecol Obstet, 79, 171
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Detección precoz de trastornos endocrinológicos
Trincado, M. P., & Letelier, B. (2010) · Revista Médica Clínica Las Condes · doi:10.1016/s0716-8640(10)70594-0 · Cited by 2
The Pre-Eclampsia like Syndrome. A Rare Complication of Pregnancy Associated Hypothyroidism
Russu, M. C., Cantacuzino, I., & Davila, C. (2015)
To screen or not to screen for subclinical hypothyroidism in pregnancy?
Freyne, A., & Byrne, B. (2013) · PubMed
Mansourian, A. R. (2013) · Journal of Biological Sciences · doi:10.3923/jbs.2013.649.664
Milewicz, T., Żuk, M., Stochmal, E., Hubalewska–Dydejczyk, A., Galicka-Latała, D., Juszczyk, L., & Krzysiek, J. (2011) · PubMed
Hypothyroidism: To Screen or not to Screen, that is the Question?
Bhargava, A. (2016) · Journal of Thyroid Disorders & Therapy · doi:10.4172/2167-7948.1000e126
Fetomaternal Effects of TSH Values in the Initial Stage of Pregnancy
Anğın, A. D. (2019) · Haydarpasa Numune Training and Research Hospital Medical Journal · doi:10.14744/hnhj.2019.06641
Screening for Thyroid Dysfunction in 1st Trimester of Pregnancy
Ramji, B., Karthikeyan, K., Swaminathan, P., Nalini, A. P., & Thatheus, A. (2016) · Journal of South Asian Federation of Obstetrics and Gynaecology · doi:10.5005/jp-journals-10006-1407
Evidence Based Review: Thyroid Dysfunction Universal Screening During Prenatal Care and Pregnancy
Santos, N., & Santos, M. I. (1999) · Revista Portuguesa de Endocrinologia Diabetes e Metabolismo · doi:10.26497/ao180022
Subclinical hypothyroidism worth screening for in pregnancy
(2009) · PharmacoEconomics & Outcomes News · doi:10.2165/00151234-200905760-00026
A STUDY OF PREVALENCE AND INCIDENCE OF THYROID DISORDER DURING PREGNANCY AT MUZAFFARPUR, BIHAR
Saroj, K. S., & Yadawa, V. K. (2022) · Indian Journal Of Applied Research · doi:10.36106/ijar/5101758
(2013) · Klinická biochemie a metabolismus · doi:10.61568/kbm.2013.008
Dong, Z., Lin, J., Han, M., & Meng, Y. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1700641
Metadata
- Authors
- Thung, S. F., Funai, E. F., & Grobman, W. A.
- Affiliations
- Yale University (US)
- Northwestern University (US)
- Venue
- American Journal of Obstetrics and Gynecology
- Publisher
- Elsevier BV
- Published
- 2009-03
- Volume
- 200
- Issue
- 3
- Pages
- 267.e1-267.e7
- ISSN
- 0002-9378 (ISSN-L)
- OpenAlex
- W2006626665
- Cited by
- 115
- References
- 39
- Citations by year
- 2025: 3 · 2024: 1 · 2023: 4 · 2022: 3 · 2021: 3 · 2020: 3 · 2019: 7 · 2018: 5 · 2017: 10 · 2016: 4 · 2015: 7 · 2014: 9 · 2013: 15 · 2012: 18
- FWCI
- 5.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- American Journal of Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Keywords
- subclinical hypothyroidism, pregnancy, universal screening, cost-effectiveness, thyroid-stimulating hormone, thyroid hormone replacement, quality-adjusted life years, decision-analytic model
- MeSH terms
- Cost-Benefit Analysis, Decision Trees, Female, Humans, Hypothyroidism, Infant, Newborn, Mass Screening, Pregnancy, Pregnancy Complications, Thyrotropin, Incidence, Prevalence, Quality-Adjusted Life Years
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