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Cited by 156Gestational Diabetes Research and ManagementBirth, Development, and HealthLipid metabolism and biosynthesis

Differential regulation of genes for fetoplacental lipid pathways in pregnancy with gestational and type 1 diabetes mellitus

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Radaelli, Tatiana, Lepercq, Jacques, Varastehpour, Ali, Basu, Subhabrata, Catalano, Patrick M., Hauguel-De Mouzon, Sylvie·2009·American Journal of Obstetrics and Gynecology
DOI 10.1016/j.ajog.2009.04.019PMC PMC3613858
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Abstract

Objective Changes in metabolic homeostasis in pregnant diabetic women are potential determinants of increased adiposity of the fetus. The aim of this study was to characterize diabetes mellitus-induced changes in genes for fetoplacental energy metabolism in relation to fetal adiposity. Study design Placentas of women with type 1 diabetes mellitus, gestational diabetes mellitus (GDM), or no complications were analyzed by microarray profiling. The pattern of gene expression was assessed in primary placental cell cultures. Results Diabetes mellitus was associated with 49 alterations in gene expression at key steps in placental energy metabolism, with 67% of the alterations related to lipid pathways and 9% of the alterations related to glucose pathways. Preferential activation of lipid genes was observed in pregnancy with GDM. Type 1 diabetes mellitus induced fewer lipid modifications but an enhancement of glycosylation and acylation pathways. Oleate enhanced expression of genes for fatty acid esterification and the formation of lipid droplets 3 times as much as glucose in cultured placental cells. Conclusion These results point to fatty acids as preferential lipogenic substrates for placental cells and suggest that genes for fetoplacental lipid metabolism are enhanced selectively in GDM. The recruited genes may be instrumental in increasing transplacental lipid fluxes and the delivery of lipid substrates for fetal use.

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  • The majority of placental gene expression alterations in GDM occur in lipid pathways (67%), as compared with glucose pathways (9%).

    “The majority of placental gene expression alterations in GDM occur in lipid pathways (67%), as compared with glucose pathways (9%) [152].”

    From The Pathophysiology of Gestational Diabetes Mellitus (2018) · cites this paper as [152]

    The Results section, under “Clusters for metabolic genes in placenta of gestational and type 1 diabetes,” reports that 67% of the altered genes were implicated in lipid pathways and 9% in glucose metabolism. Those percentages describe genes modified across GDM and type 1 diabetes, not GDM alone, although the paper reports preferential activation of lipid genes in GDM. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • Preferential activation of placental lipid genes is associated with GDM compared with T1DM.

    “Preferential activation of placental lipid genes is also associated with GDM compared with T1DM [152].”

    From The Pathophysiology of Gestational Diabetes Mellitus (2018) · cites this paper as [152]

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Authors
Radaelli, T., Lepercq, J., Varastehpour, A., Basu, S., Catalano, P. M., & Hauguel-De Mouzon, S.
Affiliations
  • Hôpital Cochin (FR)
  • MetroHealth Medical Center (US)
ORCID
Venue
American Journal of Obstetrics and Gynecology
Publisher
Elsevier BV
Published
2009-08
Volume
201
Issue
2
Pages
209.e1-209.e10
ISSN
0002-9378 (ISSN-L)
DOI
10.1016/j.ajog.2009.04.019
PMC
PMC3613858
OpenAlex
W2039524521
Cited by
156
References
46
Citations by year
2026: 4 · 2025: 7 · 2024: 8 · 2023: 10 · 2022: 7 · 2021: 10 · 2020: 10 · 2019: 4 · 2018: 13 · 2017: 14 · 2016: 11 · 2015: 11 · 2014: 10 · 2013: 13 · 2012: 8
FWCI
8.81
Type
journal article
Language
en
Open access
Licence
Locations
  • American Journal of Obstetrics and Gynecology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Case Western Reserve University
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01 HD 22965, R01HD022965)
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Keywords
gestational diabetes mellitus, type 1 diabetes, placental gene expression, fetal adiposity, placental energy metabolism, fatty acid esterification, lipid droplets, oleate, glycosylation, acylation
MeSH terms
Adipose Tissue, Adult, Blood Glucose, Cells, Cultured, Diabetes Mellitus, Type 1, Energy Metabolism, Female, Fetus, Homeostasis, Humans, Obesity, Placenta, Pregnancy, Diabetes, Gestational, Gene Expression Regulation, Developmental, Oligonucleotide Array Sequence Analysis, Gene Expression Profiling, Lipid Metabolism

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