Cited by 221Adipokines, Inflammation, and Metabolic DiseasesGestational Diabetes Research and ManagementPregnancy and preeclampsia studies

Obesity, pregnancy, inflammation, and vascular function

Open access
Denison, F C, Roberts, K A, Barr, S M, Norman, J E·2010·Reproduction

Abstract

Maternal obesity is associated with increased morbidity and mortality for both mother and offspring. The mechanisms underlying the increased risk associated with maternal obesity are not well understood. In non-pregnant populations, many of the complications of obesity are thought to be mediated in part by inflammation and its sequelae. Recent studies suggest that a heightened inflammatory response may also be involved in mediating adverse clinical outcomes during pregnancy. This review summarizes our current knowledge about adipose tissue biology, and its role as an endocrine and inflammatory organ. The evidence for inflammation as a key mediator of adverse pregnancy outcome is also presented, focusing on the role of inflammation in adipose tissue, systemic inflammation, the placenta, and vascular endothelium.

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  • Gestational diabetes is associated with high aerobic fetal metabolism and hypoxia, stimulating the placenta to increase angiogenesis, resulting in increased number of capillaries; placentas also show abnormal endocrine function, increased inflammation, and changes in placental transporters.

    “Gestational diabetes is associated with high aerobic fetal metabolism and hypoxia, stimulating the placenta to in­ crease angiogenesis, resulting in increased number of capillaries. The placentas also show abnormal endocrine function, increased inflam­ mation, and changes in placental transporters (Bedell et al., 2021; Denison et al., 2010; Gaither et al., 1999; Segura et al., 2017”

    From Pregnancy-related maternal physiological adaptations and fetal chemical exposure (2023) · cites this paper as Denison et al., 2010

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Research works printed but not linked: 2

  1. Dorup I, Skajaa K & Sorensen KE 1999 Normal pregnancy is associated with enhanced endothelium-dependent flow-mediated vasodilation. American Journal of Physiology 276 H821-H825.
  2. Gunderson EP, Abrams B & Selvin S 2001 Does the pattern of postpartum weight change differ according to pregravid body size? International Journal of Obesity and Related Metabolic Disorders 25 853-862.

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Authors
Denison, F. C., Roberts, K. A., Barr, S. M., & Norman, J. E.
Affiliations
The Queen's Medical Research Institute (GB)
Venue
Reproduction
Published
2010-09-01
Volume
140
Issue
3
Pages
373-385
ISSN
  • 1470-1626 (ISSN-L)
  • 1741-7899
OpenAlex
W2116489286
Cited by
221
References
125
Citations by year
2026: 8 · 2025: 9 · 2024: 8 · 2023: 15 · 2022: 12 · 2021: 9 · 2020: 20 · 2019: 16 · 2018: 16 · 2017: 21 · 2016: 12 · 2015: 15 · 2014: 18 · 2013: 18 · 2012: 13
FWCI
9.70
Type
journal article
Language
en
Open access
Locations
  • Reproduction (publishedVersion)
  • PubMed (publishedVersion)
  • Bristol Research (University of Bristol) (submittedVersion)
  • Explore Bristol Research (submittedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
Keywords
maternal obesity, pregnancy complications, inflammation, vascular function, adipose tissue, adipokines, systemic inflammation, placenta, vascular endothelium, adverse pregnancy outcomes, maternal morbidity and mortality
MeSH terms
Adipose Tissue, Endothelium, Vascular, Female, Fibrinolysis, Humans, Inflammation, Obesity, Pregnancy, Pregnancy Complications, Pregnancy Complications, Cardiovascular, Pregnancy Outcome, Risk Factors, Inflammation Mediators

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