Cited by 102Gestational Diabetes Research and ManagementPregnancy and preeclampsia studiesBirth, Development, and Health

The DOI matches its Crossref record; 34 of the 36 references it cites were found in a registry or an index.

Increased glucose and placental GLUT-1 in large infants of obese nondiabetic mothers

Acosta, Ometeotl, Ramirez, Vanessa I., Lager, Susanne, Gaccioli, Francesca, Dudley, Donald J., Powell, Theresa L., Jansson, Thomas·2015·American Journal of Obstetrics and Gynecology

DOI 10.1016/j.ajog.2014.08.009

Open this paper in CoChat — free account

Abstract

Objective Obese women are at increased risk to deliver a large infant, however, the underlying mechanisms are poorly understood. Fetal glucose availability is critically dependent on placental transfer and is linked to fetal growth by regulating the release of fetal growth hormones such as insulin. We hypothesized that (1) umbilical vein glucose and insulin levels and (2) placental glucose transporter (GLUT) expression and activity are positively correlated with early pregnancy maternal body mass index and infant birthweight.Study design Subjects in this prospective observational cohort study were nondiabetic predominantly Hispanic women delivered at term. Fasting maternal and umbilical vein glucose and insulin concentrations were determined in 29 women with varying early pregnancy body mass index (range, 18.0-54.3) who delivered infants with birthweights ranging from 2800-4402 g. We isolated syncytiotrophoblast microvillous and basal plasma membranes from 33 placentas and determined the expression of GLUT-1 and -9 (Western blot) and glucose uptake (radiolabeled glucose).Results Birthweight was positively correlated with umbilical vein glucose and insulin and maternal body mass index. Umbilical vein glucose levels were positively correlated with placental weight and maternal body mass index, but not with maternal fasting glucose. Basal plasma membranes GLUT-1 expression was positively correlated with birthweight. In contrast, syncytiotrophoblast microvillous GLUT-1 and -9, basal plasma membranes GLUT-9 expression and syncytiotrophoblast microvillous and basal plasma membranes glucose transport activity were not correlated with birthweight.Conclusion Because maternal fasting glucose levels and placental glucose transport capacity were not increased in obese women delivering larger infants, we speculate that increased placental size promotes glucose delivery to these fetuses.

Integrity signals

Registry

Crossref · 10.1016/j.ajog.2014.08.009

Cites

34 of 34 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Hyperglycemia and adverse pregnancy outcomes
(2008) · New England Journal of Medicine · doi:10.1056/nejmoa0707943 · Cited by 5,563
Metabolic Syndrome in Childhood: Association With Birth Weight, Maternal Obesity, and Gestational Diabetes Mellitus
Boney, C. M., Verma, A., Tucker, R., & Vohr, B. R. (2005) · Pediatrics · doi:10.1542/peds.2004-1808 · Cited by 2,303
Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter
Donovan, A., Brownlie, A., Zhou, Y., Shepard, J., Pratt, S. J., Moynihan, J., Paw, B. H., Drejer, A., Barut, B., Zapata, A., et al. (2000) · Nature · doi:10.1038/35001596 · Cited by 1,667
Review article: The short‐ and long‐term implications of maternal obesity on the mother and her offspring
Catalano, P., & Ehrenberg, H. M. (2006) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2006.00989.x · Cited by 828
Obesity in Pregnancy Stimulates Macrophage Accumulation and Inflammation in the Placenta
Challier, J. C., Basu, S., Bintein, T., Minium, J., Hotmire, K., Catalano, P. M., & Hauguel-de Mouzon, S. (2008) · Placenta · doi:10.1016/j.placenta.2007.12.010 · Cited by 712
Fetuses of obese mothers develop insulin resistance in utero
Catalano, P. M., Presley, L., Minium, J., & Hauguel-de Mouzon, S. (2009) · Diabetes Care · doi:10.2337/dc08-2077 · Cited by 655
WEIGHT AND LENGTH AT BIRTH OF INFANTS OF DIABETIC MOTHERS
Pedersen, J. (1954) · European Journal of Endocrinology · doi:10.1530/acta.0.0160330 · Cited by 496
Management of Obesity in Pregnancy
Catalano, P. M. (2007) · Obstetrics and Gynecology · doi:10.1097/01.aog.0000253311.44696.85 · Cited by 373
Glucose transporter protein expression in human placenta throughout gestation and in intrauterine growth retardation.
Jansson, T., Wennergren, M., & Illsley, N. P. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.77.6.8263141 · Cited by 320
Self-citation
Identification and Characterization of Human Glucose Transporter-like Protein-9 (GLUT9)
Augustin, R., Carayannopoulos, M. O., Dowd, L. O., Phay, J. E., Moley, J. F., & Moley, K. H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312226200 · Cited by 284

Show all 36 references

Research works printed but not linked: 1

Day, 2013, What factors determine placental glucose transfer, Placenta, 40, 391

Sorted by citations

Influence of Maternal Obesity on the Long-Term Health of Offspring
Godfrey, K. M., Reynolds, R. M., Prescott, S. L., Nyirenda, M., Jaddoe, V. W. V., Eriksson, J. G., & Broekman, B. F. P. (2017) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(16)30107-3 · Cited by 1,059
Placental Origins of Chronic Disease
Burton, G. J., Fowden, A. L., & Thornburg, K. L. (2016) · Physiological Reviews · doi:10.1152/physrev.00029.2015 · Cited by 717
Developmental origins of metabolic diseases
Hoffman, D. J., Powell, T. L., Barrett, E. S., & Hardy, D. B. (2020) · Physiological Reviews · doi:10.1152/physrev.00002.2020 · Cited by 504
Self-citation
Effects of maternal obesity on placental function and fetal development
Howell, K. R., & Powell, T. L. (2016) · Reproduction · doi:10.1530/rep-16-0495 · Cited by 370
Self-citation
Placental Function in Maternal Obesity
Kelly, A. C., Powell, T. L., & Jansson, T. (2020) · Clinical Science · doi:10.1042/cs20190266 · Cited by 227
Self-citation
Metabolic landscape in cardiac aging: insights into molecular biology and therapeutic implications
Xie, S., Xu, S., Deng, W., & Tang, Q. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01378-8 · Cited by 197
Adiponectin supplementation in pregnant mice prevents the adverse effects of maternal obesity on placental function and fetal growth
Aye, I. L. M. H., Rosario, F. J., Powell, T. L., & Jansson, T. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1515484112 · Cited by 165
Self-citation
Maternal Obesity and Diabetes Mellitus as Risk Factors for Congenital Heart Disease in the Offspring
Helle, E., & Priest, J. R. (2020) · Journal of the American Heart Association · doi:10.1161/jaha.119.011541 · Cited by 151
Δ9-tetrahydrocannabinol exposure during rat pregnancy leads to symmetrical fetal growth restriction and labyrinth-specific vascular defects in the placenta
Natale, B. V., Gustin, K., Lee, K., Holloway, A. C., Laviolette, S. R., Natale, D. R. C., & Hardy, D. B. (2020) · Scientific Reports · doi:10.1038/s41598-019-57318-6 · Cited by 125
Large for gestational age and macrosomia in singletons born after frozen/thawed embryo transfer (FET) in assisted reproductive technology (ART)
Berntsen, S., & Pinborg, A. B. (2018) · Birth Defects Research · doi:10.1002/bdr2.1219 · Cited by 116
Placental Function and the Development of Fetal Overgrowth and Fetal Growth Restriction
Dumolt, J. H., Powell, T. L., & Jansson, T. (2021) · Obstetrics and Gynecology Clinics of North America · doi:10.1016/j.ogc.2021.02.001 · Cited by 111
Self-citation
Maternal-fetal cross-talk via the placenta: influence on offspring development and metabolism
Kramer, A. C., Jansson, T., Bale, T. L., & Powell, T. L. (2023) · Development · doi:10.1242/dev.202088 · Cited by 119
Self-citation
Review: Placental transport and metabolism of energy substrates in maternal obesity and diabetes
Gallo, L. A., Barrett, H. L., & Nitert, M. D. (2016) · Placenta · doi:10.1016/j.placenta.2016.12.006 · Cited by 88
Exercise prevents the adverse effects of maternal obesity on placental vascularization and fetal growth
Son, J. S., Liu, X., Tian, Q., Zhao, L., Chen, Y., Hu, Y., Chae, S. A., de Avila, J. M., Zhu, M. J., & Du, ‬. (2019) · The Journal of Physiology · doi:10.1113/jp277698 · Cited by 86
Expression and functional characterisation of System L amino acid transporters in the human term placenta
Gaccioli, F., Aye, I. L. M. H., Roos, S., Lager, S., Ramirez, V. I., Kanai, Y., Powell, T. L., & Jansson, T. (2015) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-015-0054-8 · Cited by 85
Self-citation
Let-7a-5p inhibits triple-negative breast tumor growth and metastasis through GLUT12-mediated warburg effect
Shi, Y., Zhang, Y., Ran, F., Liu, J., Lin, J., Hao, X., Ding, L., & Ye, Q. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.09.012 · Cited by 83
Expression of epigenetic machinery genes is sensitive to maternal obesity and weight loss in relation to fetal growth in mice
Panchenko, P. E., Voisin, S. A. C., Jouin, M., Jouneau, L., Prézelin, A., Lecoutre, S., Breton, C., Jammes, H., Junien, C., & Gabory, A. (2016) · Clinical Epigenetics · doi:10.1186/s13148-016-0188-3 · Cited by 83
Protein expression of fatty acid transporter 2 is polarized to the trophoblast basal plasma membrane and increased in placentas from overweight/obese women
Lager, S., Ramirez, V. I., Gaccioli, F., Jang, B., Jansson, T., & Powell, T. L. (2016) · Placenta · doi:10.1016/j.placenta.2016.02.010 · Cited by 78
Self-citation
Impact of pre-gestational and gestational diabetes mellitus on the expression of glucose transporters GLUT-1, GLUT-4 and GLUT-9 in human term placenta
Stanirowski, P. J., Szukiewicz, D., Pyźlak, M., Abdalla, N., Sawicki, W., & Cendrowski, K. (2016) · Endocrine · doi:10.1007/s12020-016-1202-4 · Cited by 75
Curcumin ameliorates high glucose-induced neural tube defects by suppressing cellular stress and apoptosis
Wu, Y., Wang, F., Reece, E. A., & Yang, P. (2015) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2015.01.017 · Cited by 74
Uteroplacental Glucose Uptake and Fetal Glucose Consumption: A Quantitative Study in Human Pregnancies
Michelsen, T. M., Holme, A. M., Holm, M. B., Roland, M. C. P., Haugen, G. N., Powell, T. L., Jansson, T., & Henriksen, T. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-01154 · Cited by 76
Self-citation
Complex, coordinated and highly regulated changes in placental signaling and nutrient transport capacity in IUGR
Chassen, S. S., & Jansson, T. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.12.024 · Cited by 72
Self-citation
Adipokines underlie the early origins of obesity and associated metabolic comorbidities in the offspring of women with pregestational obesity
Arroyo‐Jousse, V., Jaramillo, A., Castaño‐Moreno, E., Lépez, M., Carrasco‐Negüe, K., & Casanello, P. C. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2019.165558 · Cited by 68
Effects of Maternal Obesity and Gestational Diabetes Mellitus on the Placenta: Current Knowledge and Targets for Therapeutic Interventions
Bedell, S., Hutson, J. R., de Vrijer, B., & Eastabrook, G. D. M. (2020) · Current Vascular Pharmacology · doi:10.2174/1570161118666200616144512 · Cited by 94
Lower risk of adverse perinatal outcomes in natural versus artificial frozen–thawed embryo transfer cycles: a systematic review and meta-analysis
Moreno-Sepulveda, J. A., Espinós, J. J., & Checa, M. Á. (2021) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2021.03.002 · Cited by 61
Milk consumption during pregnancy increases birth weight, a risk factor for the development of diseases of civilization
Melnik, B. C., John, S. M., & Schmitz, G. (2015) · Journal of Translational Medicine · doi:10.1186/s12967-014-0377-9 · Cited by 59
Insulin Stimulates GLUT4 Trafficking to the Syncytiotrophoblast Basal Plasma Membrane in the Human Placenta
James‐Allan, L. B., Arbet, J., Teal, S. B., Powell, T. L., & Jansson, T. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2018-02778 · Cited by 55
Self-citation
RETRACTED: Punicalagin exerts protective effect against high glucose-induced cellular stress and neural tube defects
Zhong, J., Reece, E. A., & Yang, P. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.10.024 · Cited by 52
Retracted
Persistent influence of maternal obesity on offspring health: Mechanisms from animal models and clinical studies
Wankhade, U. D., Thakali, K. M., & Shankar, K. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.07.001 · Cited by 51
Maternal Obesity Influences Placental Nutrient Transport, Inflammatory Status, and Morphology in Human Term Placenta
Nogues, P., Santos, E. D., Couturier‐Tarrade, A., Berveiller, P., Arnould, L., Lamy, E., Grassin‐Delyle, S., Vialard, F., & Dieudonné, M. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaa660 · Cited by 47
Placental Expression of Glucose Transporter Proteins in Pregnancies Complicated by Gestational and Pregestational Diabetes Mellitus
Stanirowski, P. J., Szukiewicz, D., Pazura, M., Sawicki, W., & Cendrowski, K. (2017) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2017.04.008 · Cited by 47
Maternal obesity causes fetal cardiac hypertrophy and alters adult offspring myocardial metabolism in mice
Vaughan, O. R., Rosario, F. J., Chan, J., Cox, L. A., Ferchaud‐Roucher, V., Berry, K. A. Z., Reusch, J. E. B., Keller, A. C., Powell, T. L., & Jansson, T. (2022) · The Journal of Physiology · doi:10.1113/jp282462 · Cited by 44
Self-citation
Pre-pregnancy underweight and obesity are positively associated with small-for-gestational-age infants in a Chinese population
Chen, Y. H., Li, L., Chen, W., Liu, Z. B., Ma, L., Gao, X., He, J. L., Wang, H., Zhao, M., Yang, Y., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-52018-7 · Cited by 43
Impact of pregravid obesity on maternal and fetal immunity: Fertile grounds for reprogramming
Sureshchandra, S., Marshall, N., & Messaoudi, I. (2019) · Journal of Leukocyte Biology · doi:10.1002/jlb.3ri0619-181r · Cited by 38
Docosahexaenoic Acid Supplementation in Pregnancy Modulates Placental Cellular Signaling and Nutrient Transport Capacity in Obese Women
Lager, S., Ramirez, V. I., Acosta, O. M., Meireles, C. L., Miller, E., Gaccioli, F., Rosario, F. J., Gelfond, J. A. L., Hakala, K. W., Weintraub, S. T., et al. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-01384 · Cited by 39
Self-citation
The impact of maternal obesity in pregnancy on placental glucocorticoid and macronutrient transport and metabolism
Johns, E. C., Denison, F. C., & Reynolds, R. M. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.12.025 · Cited by 42
Fetomaternal Expression of Glucose Transporters (GLUTs)—Biochemical, Cellular and Clinical Aspects
Sibiak, R., Ożegowska, K., Wender-Ożegowska, E., Gutaj, P., Mozdziak, P. E., & Kempisty, B. (2022) · Nutrients · doi:10.3390/nu14102025 · Cited by 47
Modulation of fetoplacental growth, development and reproductive function by endocrine disrupters
Basak, S., Varma, S., & Duttaroy, A. K. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1215353 · Cited by 39
Role of Placental Glucose Transporters in Determining Fetal Growth
Joshi, N. P., Mane, A. R., Sahay, A. S., Sundrani, D. P., Joshi, S., & Yajnik, C. S. (2021) · Reproductive Sciences · doi:10.1007/s43032-021-00699-9 · Cited by 38
Independent factors influencing large-for-gestation birth weight in singletons born after in vitro fertilization
Korošec, S., Frangež, H. B., Steblovnik, L., Verdenik, I., & Bokal, E. V. (2015) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-015-0601-4 · Cited by 37
Normalizing adiponectin levels in obese pregnant mice prevents adverse metabolic outcomes in offspring
Paulsen, M. E., Rosario, F. J., Wesolowski, S. R., Powell, T. L., & Jansson, T. (2018) · The FASEB Journal · doi:10.1096/fj.201801015r · Cited by 38
Self-citation
Normalisation of circulating adiponectin levels in obese pregnant mice prevents cardiac dysfunction in adult offspring
Vaughan, O. R., Rosario, F. J., Powell, T. L., & Jansson, T. (2019) · International Journal of Obesity · doi:10.1038/s41366-019-0374-4 · Cited by 32
Self-citation
Analysis of correlations between the placental expression of glucose transporters GLUT-1, GLUT-4 and GLUT-9 and selected maternal and fetal parameters in pregnancies complicated by diabetes mellitus
Stanirowski, P. J., Szukiewicz, D., Pyźlak, M., Abdalla, N., Sawicki, W., & Cendrowski, K. (2017) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767058.2017.1387897 · Cited by 33
HTLV-1 targets human placental trophoblasts in seropositive pregnant women
Tezuka, K., Fuchi, N., Okuma, K., Tsukiyama, T., Miura, S., Hasegawa, Y., Nagata, A., Komatsu, N., Hasegawa, H., Sasaki, D., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci135525 · Cited by 32
Changes in Placental Nutrient Transporter Protein Expression and Activity Across Gestation in Normal and Obese Women
James‐Allan, L. B., Teal, S. B., Powell, T. L., & Jansson, T. (2020) · Reproductive Sciences · doi:10.1007/s43032-020-00173-y · Cited by 30
Self-citation
Elevated body mass index during pregnancy and gestational weight gain in HIV‐infected and HIV‐uninfected women in Cape Town, South Africa: association with adverse birth outcomes
Madlala, H. P., Malaba, T. R., Newell, M., & Myer, L. (2020) · Tropical Medicine & International Health · doi:10.1111/tmi.13387 · Cited by 29
Maternal High Linoleic Acid Alters Placental Fatty Acid Composition
Shrestha, N., Holland, O. J., Kent, N. L., Perkins, A. V., McAinch, A. J., Cuffe, J. S. M., & Hryciw, D. H. (2020) · Nutrients · doi:10.3390/nu12082183 · Cited by 28
Maternal body mass index impacts fetal-placental size at birth and umbilical cord oxygen values with implications for regulatory mechanisms
Richardson, B. S., Ruttinger, S., Brown, H. K., Regnault, T. R. H., & de Vrijer, B. (2017) · Early Human Development · doi:10.1016/j.earlhumdev.2017.06.009 · Cited by 27
Placenta nutrient transport-related gene expression: the impact of maternal obesity and excessive gestational weight gain
Brett, K., Ferraro, Z. M., Holčı́k, M., & Adamo, K. B. (2015) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767058.2015.1049522 · Cited by 26
First trimester mechanisms of gestational sac placental and foetal teratogenicity: a framework for birth cohort studies
Adibi, J. J., Layden, A. J., Birru, R. L., Miragaia, A. S., Xun, X., Smith, M. C., Yin, Q., Millenson, M. E., O’Connor, T. G., Barrett, E. S., et al. (2020) · Human Reproduction Update · doi:10.1093/humupd/dmaa063 · Cited by 26
No evidence of attenuation of placental insulin-stimulated Akt phosphorylation and amino acid transport in maternal obesity and gestational diabetes mellitus
Castillo‐Castrejón, M., Jansson, T., & Powell, T. L. (2019) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00196.2019 · Cited by 26
Self-citation
Effect of type 2 diabetes mellitus on placental expression and activity of nutrient transporters and their association with birth weight and neonatal adiposity
Castillo‐Castrejón, M., Yamaguchi, K., Rodel, R. L., Erickson, K., Kramer, A. W., Hirsch, N. M., Rolloff, K. P., Jansson, T., Barbour, L. A., & Powell, T. L. (2021) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2021.111319 · Cited by 24
Self-citation
Expression of placental glucose transporter proteins in pregnancies complicated by fetal growth disorders
Stanirowski, P. J., Lipa, M., Bomba-Opon, D. A., & Wielgoś, M. (2020) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2019.12.003 · Cited by 27
Characterization of Visceral and Subcutaneous Adipose Tissue Transcriptome and Biological Pathways in Pregnant and Non-Pregnant Women: Evidence for Pregnancy-Related Regional-Specific Differences in Adipose Tissue
Mazaki‐Tovi, S., Vaisbuch, E., Tarca, A. L., Kusanovic, J. P., Than, N. G., Chaiworapongsa, T., Dong, Z., Hassan, S. S., & Romero, R. J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0143779 · Cited by 24
Associations between maternal body mass index and diet composition with placental DNA methylation at term
Thakali, K. M., Zhong, Y., Cleves, M., Andres, A., & Shankar, K. (2020) · Placenta · doi:10.1016/j.placenta.2020.02.018 · Cited by 26
Maternal health around pregnancy and autism risk: a diagnosis-wide, population-based study
Kodesh, A., Levine, S. Z., Khachadourian, V., Rahman, R., Schlessinger, A., O’Reilly, P. F., Grove, J., Schendel, D., Buxbaum, J. D., Croen, L., et al. (2021) · Psychological Medicine · doi:10.1017/s0033291721001021 · Cited by 25
Placental Nutrient Transporters and Maternal Fatty Acids in SGA, AGA, and LGA Newborns From Mothers With and Without Obesity
García-Santillán, J.-A., Lazo-de-la-Vega-Monroy, M.-L., Rodriguez-Saldaña, G.-C., Solís‐Barbosa, M. A., Corona-Figueroa, M.-A., Gónzalez-Domínguez, M.-I., Gomez-Zapata, H.-M., Malacara, J. M., & Barbosa‐Sabanero, G. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.822527 · Cited by 24
Differential Expression of Glucose Transporter Proteins GLUT-1, GLUT-3, GLUT-8 and GLUT-12 in the Placenta of Macrosomic, Small-for-Gestational-Age and Growth-Restricted Foetuses
Stanirowski, P. J., Szukiewicz, D., Majewska, A., Wątroba, M., Pyźlak, M., Bomba-Opon, D. A., & Wielgoś, M. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10245833 · Cited by 20
The unexplored role of sedentary time and physical activity in glucose and lipid metabolism‐related placental mRNAs in pregnant women who are obese: the DALI lifestyle randomised controlled trial
Acosta‐Manzano, P., Leopold‐Posch, B., Simmons, D. S., Devlieger, R., Galjaard, S., Corcoy, R., Adelantado, J. M., Dunne, F., Harreiter, J., Kautzky‐Willer, A., et al. (2021) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.16945 · Cited by 18
Maternal prepregnancy weight as an independent risk factor for congenital heart defect: systematic review and meta‐analysis stratified by subtype and severity of defect
Salmeri, N., Seidenari, A., Cavoretto, P. I., Papale, M., Candiani, M., & Farina, A. (2024) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.27659 · Cited by 18
Made in the Womb: Maternal Programming of Offspring Cardiovascular Function by an Obesogenic Womb
Diniz, M. S., Grilo, L. F., Tocantins, C., Falcão‐Pires, I., & Pereira, S. P. (2023) · Metabolites · doi:10.3390/metabo13070845 · Cited by 17
Insulin-dependent, glucose transporter 1 mediated glucose uptake and tube formation in the human placental first trimester trophoblast cells
Basak, S., Vilasagaram, S., Naidu, K., & Duttaroy, A. K. (2018) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-018-3396-7 · Cited by 17
FGF15/FGF19 alleviates insulin resistance and upregulates placental IRS1/GLUT expression in pregnant mice fed a high-fat diet
Zhao, S., Wang, D., Li, Z., Xu, S., Chen, H., Ding, W., Yang, J., Zhao, W., Sun, B., & Wang, Z. (2021) · Placenta · doi:10.1016/j.placenta.2021.07.286 · Cited by 16
Differential Effects of Post-Weaning Diet and Maternal Obesity on Mouse Liver and Brain Metabolomes
Safi-Stibler, S., Thévenot, E., Jouneau, L., Jouin, M., Seyer, A., Jammes, H., Rousseau‐Ralliard, D., Baly, C., & Gabory, A. (2020) · Nutrients · doi:10.3390/nu12061572 · Cited by 14
The early life exposome and autism risk: a role for the maternal microbiome?
Gesù, C. M. D., & Buffington, S. A. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2385117 · Cited by 16
Placental Glucose Transporters and Response to Bisphenol A in Pregnancies from of Normal and Overweight Mothers
Ermini, L., Nuzzo, A. M., Ietta, F., Romagnoli, R., Moretti, L., Masturzo, B., Paulesu, L. R., & Rolfo, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126625 · Cited by 14
Hyperglycemia in Pregnancy-Associated Oxidative Stress Augments Altered Placental Glucose Transporter 1 Trafficking via AMPKα/p38MAPK Signaling Cascade
Wang, S., Ning, J., Huai, J., & Yang, H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158572 · Cited by 15
Maternal diet modulates placental nutrient transporter gene expression in a mouse model of diabetic pregnancy
Kappen, C., Krüger, C., Jones, S., Herion, N. J., & Salbaum, J. M. (2019) · PLoS ONE · doi:10.1371/journal.pone.0224754 · Cited by 13
Sex hormone‐binding globulin regulates glucose metabolism in human placental trophoblasts via cAMP/PKA/CREB1
Chi, X., Feng, C., Wang, X., & Jin, Z. (2020) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.14429 · Cited by 13
Mouse models of preeclampsia with preexisting comorbidities
Waker, C. A., Hwang, A. E., Bowman-Gibson, S., Chandiramani, C. H., Linkous, B., Stone, M. L., Keoni, C., Kaufman, M. R., & Brown, T. L. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1137058 · Cited by 12
Chlorpyrifos and Δ9 Tetrahydrocannabinol exposure and effects on parameters associated with the endocannabinoid system and risk factors for obesity
Silva, M. H. (2021) · Current Research in Toxicology · doi:10.1016/j.crtox.2021.08.002 · Cited by 12
Histone modifications as molecular drivers of cardiac aging: Metabolic alterations, epigenetic mechanisms, and emerging therapeutic strategies
Alrumaihi, F., Al-Doaiss, A. A., Ullah, F., Alwanian, W. M., Alharbi, H. O., Alassaf, F. S., Alfifi, S. M., Alshabrmi, F. M., Alkhayl, F. F. A., & Alatawi, E. A. (2025) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2025.103056 · Cited by 10
Isthmin-1 Improves Aging-Related Cardiac Dysfunction in Mice through Enhancing Glycolysis and SIRT1 Deacetylase Activity
Hu, M., Zhang, X., Gao, Y.-P., Hu, Y., Teng, T., Wang, S., & Tang, Q. (2024) · Aging and Disease · doi:10.14336/ad.2024.0113 · Cited by 10
Adiponectin Deficiency Alters Placenta Function but Does Not Affect Fetal Growth in Mice
Shrestha, M. M., Wermelin, S., Stener‐Victorin, E., Asterholm, I. W., & Benrick, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094939 · Cited by 9
Characterization of visceral and subcutaneous adipose tissue transcriptome in pregnant women with and without spontaneous labor at term: implication of alternative splicing in the metabolic adaptations of adipose tissue to parturition
Mazaki‐Tovi, S., Tarca, A. L., Vaisbuch, E., Kusanovic, J. P., Than, N. G., Chaiworapongsa, T., Dong, Z., Hassan, S. S., & Romero, R. J. (2016) · Journal of Perinatal Medicine · doi:10.1515/jpm-2015-0259 · Cited by 7
Synthesis of phospholipids in human placenta
Powell, T. L., Ferchaud‐Roucher, V., Madi, L., Uhlson, C. L., Berry, K. A. Z., Kramer, A. C., Erickson, K., Palmer, C. E., Chassen, S. S., & Castillo‐Castrejón, M. (2024) · Placenta · doi:10.1016/j.placenta.2024.01.007 · Cited by 9
Self-citation
The impact of obesity on placental vascular development and function
Ramanlal, I., James, J. L., & Boss, A. L. (2026) · Molecular Human Reproduction · doi:10.1093/molehr/gaag002 · Cited by 7
Maternal obesity-related placental dysfunction: From peri-conception to late gestation
Amabebe, E., Ikumi, N. M., Pillay, K., Matjila, M. J., & Anumba, D. O. C. (2023) · Placenta and Reproductive Medicine · doi:10.54844/prm.2023.0361 · Cited by 6
AMPK–mTORC1 pathway mediates hepatic IGFBP-1 phosphorylation in glucose deprivation: a potential molecular mechanism of hypoglycemia-induced impaired fetal growth
Kakadia, J. H., Khalid, M. U., Heinemann, I. U., & Han, V. K. M. (2024) · Journal of Molecular Endocrinology · doi:10.1530/jme-23-0137 · Cited by 5
Maternal obesity attenuates PPARγ nuclear migration impairing offspring adipogenesis
de Sousa, É., & Rodrigues, A. C. (2023) · Journal of Molecular Endocrinology · doi:10.1530/jme-23-0050 · Cited by 5
d-Glucose and its derivatives labeled with radioactive carbon and hydrogen: key tools for investigating biological processes and molecular mechanisms
Bayat, F. (2025) · EJNMMI Radiopharmacy and Chemistry · doi:10.1186/s41181-025-00346-7 · Cited by 4
Placental expression of GLUT ‐1, GLUT ‐3, and GLUT ‐4 mRNA and transcriptome profiling in pregnant women with diabetes
Sibiak, R., Gutaj, P., Mantaj, U., Adamczak, Ł., Blatkiewicz, M., Ruciński, M., & Wender-Ożegowska, E. (2024) · Journal of Diabetes Investigation · doi:10.1111/jdi.14369 · Cited by 4
Expression of glucose transporters in the human amnion derived mesenchymal stromal cells under normoglycemic and hyperglycemic conditions
Ünek, G., Çetinkaya, B. D., Doğru, S., Dogum, K., Molbay, M., Özmen, A., Yanar, K., Kipmen‐Korgun, D., Köksoy, S., Sakıncı, M., et al. (2019) · Biologia · doi:10.2478/s11756-019-00350-8 · Cited by 3
Insulin like growth factor 1 (IGF-1) and IGF binding proteins in obese pregnant women and their babies: Potential effects on placental function and fetal growth
Soliman, A. T., Hamed, N., Alyafei, F., Alaaraj, N., Ahmad, S., Itani, M., & Soliman, N. A. (2023) · World Journal of Advanced Research and Reviews · doi:10.30574/wjarr.2023.17.2.0222 · Cited by 2
Ferrous–sucrose complex supplementation regulates maternal plasma metabolism and the fecal microbiota composition and improves neonatal immunity and placental glucose transportation by activating the EGF/PI3K/AKT signaling pathways in sows
Dong, Z., Liu, H., Wan, D., Wu, X., & Yin, Y. (2023) · Food & Function · doi:10.1039/d3fo03733a · Cited by 2
Association between changes in glycosylated hemoglobin during the second and third trimesters and adverse pregnancy outcomes among women without hyperglycemia in pregnancy
Hu, M., Liang, S., Wu, Q., Lee, C. S., Lu, J., Bao, S., Wu, C., & Liang, Z. (2024) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2024.111841 · Cited by 2
Gene expression profiles in placenta and their association with anesthesia, delivery mode and maternal diabetes
Aljani, B., Garbe, A. I., Sedlmeier, E., Lickert, R., Rost, F., Ziegler, A., Bonifacio, E. E., & Eugster, A. (2024) · Placenta · doi:10.1016/j.placenta.2024.10.008 · Cited by 3
The Potential Impact of Maternal Milk Consumption During Pregnancy on mTORC1-Driven Fetal Growth
Melnik, B. C. (2016) · Springer eBooks · doi:10.1007/978-3-319-14874-8_18 · Cited by 2
Placental Nutrient Transport
James‐Allan, L. B., Powell, T. L., & Jansson, T. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.64683-4 · Cited by 2
Self-citation
Gestational High-Fat Diet Drives Premature Differentiation of Orexigenic Neurons and Reactivity of Astrocytes in the Fetal Rat Lateral Hypothalamus
Galindo-Solano, N., Trejo-Villarreal, X., Díaz-Olivares, G., Rea-Palomino, G., Montes-Aguirre, D., Villagrán-Santa-Cruz, M., & Gutiérrez‐Ospina, G. (2025) · Brain Sciences · doi:10.3390/brainsci16010052 · Cited by 1
Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions
Connor, K. L., Souza, N. I. S., dos Anjos, B. G., Matthews, S. G., & Bloise, E. (2026) · The Journal of Physiology · doi:10.1113/jp289627 · Cited by 1
Glucose and Amino Acid and Their Roles in Placentation
Duttaroy, A. K., & Basak, S. (2016) · Springer eBooks · doi:10.1007/978-3-319-38804-5_3 · Cited by 1
Carbohydrate Metabolism During Pregnancy
Chu, A., & Devaskar, S. U. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-35214-7.00040-8
Studies of the human placenta in vivo -The role of the placenta in glucose transfer and secretion of anti-angiogenic factors
Holme, A. M. (2018) · NORA - Norwegian Open Research Archives
Obésité et perte de poids maternelle chez la souris : effets métaboliques olfactifs et epigénétiques sur la descendance mâle et femelle
Junien, C., Panchenko, P. E., Lacroix, M. C., Jouin, M., Badonnel, K., Lemaire, M., Meunier, N., Safi-Stibler, S., Jammes, H., Breton, C., et al. (2020) · Bulletin de l Académie Nationale de Médecine · doi:10.1016/j.banm.2020.09.042
Physical activity during pregnancy alters gene expression in neonatal tissue
Reynolds, L. J., Vsevolozhskaya, O. A., Rice, B. B., Chavan, N. R., Dugan, A. J., Maddox, H. F., Preston, J. D., DeHoff, L. B., O’Brien, J., & Pearson, K. J. (2021) · Physiology International · doi:10.1556/2060.2021.00003
Placental Nutrient Transport
James‐Allan, L. B., Powell, T. L., & Jansson, T. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-21477-6.00085-7 · Cited by 1
Self-citation
Placental dysfunction in maternal obesity is a key mechanism of fetal programming of metabolic syndrome
Galagudza, M. M., Uspensky, Y. P., Fominykh, Y. A., Butko, D. Y., & Komar, V. V. (2025) · Translational Medicine · doi:10.18705/2311-4495-2025-12-3-268-282
ДИСФУНКЦИЯ ПЛАЦЕНТЫ ПРИ МАТЕРИНСКОМ ОЖИРЕНИИ — КЛЮЧЕВОЙ МЕХАНИЗМ ФЕТАЛЬНОГО ПРОГРАММИРОВАНИЯ МЕТАБОЛИЧЕСКОГО СИНДРОМА У ПЛОДА
Komar, V. V., Galagudza, M. M., Успенский, Ю. П., & Насыров, Р. А. (2025) · University therapeutic journal · doi:10.56871/utj.2025.49.25.002
Mémoire épigénétique des trajectoires pondérales maternelles préconceptionnelles au cours du développement et à long terme
Panchenko, P. E. (2015) · theses.fr (ABES) · doi:10.70675/1c8455acza5c1z427fzb7c6z5b17ad36641e

Authors: Acosta, O., Ramirez, V. I., Lager, S., Gaccioli, F., Dudley, D. J., Powell, T. L., & Jansson, T.
Affiliations: The University of Texas at San Antonio Health Science Center (US)
Corresponding author: Acosta, Ometeotl
ORCID: Lager, Susanne
Gaccioli, Francesca
Dudley, Donald J.
Powell, Theresa L.
Jansson, Thomas
Venue: American Journal of Obstetrics and Gynecology
Publisher: Elsevier BV
Published: 2015-02
Volume: 212
Issue: 2
Pages: 227.e1-227.e7
ISSN: 0002-9378 (ISSN-L)
DOI: 10.1016/j.ajog.2014.08.009
OpenAlex: W2062280233
Cited by: 102
References: 36
Citations by year: 2026: 2 · 2025: 5 · 2024: 9 · 2023: 9 · 2022: 5 · 2021: 11 · 2020: 17 · 2019: 13 · 2018: 5 · 2017: 5 · 2016: 12 · 2015: 9
FWCI: 9.20
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: American Journal of Obstetrics and Gynecology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (R01DK089989, DK089989)
Topics: Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Keywords: maternal obesity, large for gestational age, birth weight, maternal body mass index, syncytiotrophoblast, placental size
MeSH terms: Adult, Birth Weight, Blood Glucose, Female, Fetal Macrosomia, Humans, Infant, Newborn, Insulin, Male, Maternal-Fetal Exchange, Obesity, Organ Size, Placenta, Placentation, Pregnancy, Pregnancy Complications, Prospective Studies, Trophoblasts, Umbilical Veins, Cohort Studies, Body Mass Index, Case-Control Studies, Glucose Transport Proteins, Facilitative, Glucose Transporter Type 1

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Increased glucose and placental GLUT-1 in large infants of obese nondiabetic mothers

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks