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Cited by 102Gestational Diabetes Research and ManagementPregnancy and preeclampsia studiesBirth, Development, and Health

The DOI matches its Crossref record; 34 of the 36 references it cites were found in a registry or an index.

Increased glucose and placental GLUT-1 in large infants of obese nondiabetic mothers

Acosta, Ometeotl, Ramirez, Vanessa I., Lager, Susanne, Gaccioli, Francesca, Dudley, Donald J., Powell, Theresa L., Jansson, Thomas·2015·American Journal of Obstetrics and Gynecology
DOI 10.1016/j.ajog.2014.08.009
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Abstract

Objective Obese women are at increased risk to deliver a large infant, however, the underlying mechanisms are poorly understood. Fetal glucose availability is critically dependent on placental transfer and is linked to fetal growth by regulating the release of fetal growth hormones such as insulin. We hypothesized that (1) umbilical vein glucose and insulin levels and (2) placental glucose transporter (GLUT) expression and activity are positively correlated with early pregnancy maternal body mass index and infant birthweight.Study design Subjects in this prospective observational cohort study were nondiabetic predominantly Hispanic women delivered at term. Fasting maternal and umbilical vein glucose and insulin concentrations were determined in 29 women with varying early pregnancy body mass index (range, 18.0-54.3) who delivered infants with birthweights ranging from 2800-4402 g. We isolated syncytiotrophoblast microvillous and basal plasma membranes from 33 placentas and determined the expression of GLUT-1 and -9 (Western blot) and glucose uptake (radiolabeled glucose).Results Birthweight was positively correlated with umbilical vein glucose and insulin and maternal body mass index. Umbilical vein glucose levels were positively correlated with placental weight and maternal body mass index, but not with maternal fasting glucose. Basal plasma membranes GLUT-1 expression was positively correlated with birthweight. In contrast, syncytiotrophoblast microvillous GLUT-1 and -9, basal plasma membranes GLUT-9 expression and syncytiotrophoblast microvillous and basal plasma membranes glucose transport activity were not correlated with birthweight.Conclusion Because maternal fasting glucose levels and placental glucose transport capacity were not increased in obese women delivering larger infants, we speculate that increased placental size promotes glucose delivery to these fetuses.

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  1. Day, 2013, What factors determine placental glucose transfer, Placenta, 40, 391

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Metadata

Authors
Acosta, O., Ramirez, V. I., Lager, S., Gaccioli, F., Dudley, D. J., Powell, T. L., & Jansson, T.
Affiliations
The University of Texas at San Antonio Health Science Center (US)
Corresponding author
Acosta, Ometeotl
ORCID
Venue
American Journal of Obstetrics and Gynecology
Publisher
Elsevier BV
Published
2015-02
Volume
212
Issue
2
Pages
227.e1-227.e7
ISSN
0002-9378 (ISSN-L)
DOI
10.1016/j.ajog.2014.08.009
OpenAlex
W2062280233
Cited by
102
References
36
Citations by year
2026: 2 · 2025: 5 · 2024: 9 · 2023: 9 · 2022: 5 · 2021: 11 · 2020: 17 · 2019: 13 · 2018: 5 · 2017: 5 · 2016: 12 · 2015: 9
FWCI
9.20
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • American Journal of Obstetrics and Gynecology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK089989, DK089989)
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Keywords
maternal obesity, large for gestational age, birth weight, maternal body mass index, syncytiotrophoblast, placental size
MeSH terms
Adult, Birth Weight, Blood Glucose, Female, Fetal Macrosomia, Humans, Infant, Newborn, Insulin, Male, Maternal-Fetal Exchange, Obesity, Organ Size, Placenta, Placentation, Pregnancy, Pregnancy Complications, Prospective Studies, Trophoblasts, Umbilical Veins, Cohort Studies, Body Mass Index, Case-Control Studies, Glucose Transport Proteins, Facilitative, Glucose Transporter Type 1

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