Galectin-3 Modulates Th17 Responses by Regulating Dendritic Cell Cytokines
Open accessAbstract
Galectin-3 is a β-galactoside-binding animal lectin with diverse functions, including regulation of T helper (Th) 1 and Th2 responses. Current data indicate that galectin-3 expressed in dendritic cells (DCs) may be contributory. Th17 cells have emerged as critical inducers of tissue inflammation in autoimmune disease and important mediators of host defense against fungal pathogens, although little is known about galectin-3 involvement in Th17 development. We investigated the role of galectin-3 in the induction of Th17 immunity in galectin-3-deficient (gal3(-/-)) and gal3(+/+) mouse bone marrow-derived DCs. We demonstrate that intracellular galectin-3 negatively regulates Th17 polarization in response to the dectin-1 agonist curdlan (a β-glucan present on the cell wall of fungal species) and lipopolysaccharide, agents that prime DCs for Th17 differentiation. On activation of dectin-1, gal3(-/-) DCs secreted higher levels of the Th17-axis cytokine IL-23 compared with gal3(+/+) DCs and contained higher levels of activated c-Rel, an NF-κB subunit that promotes IL-23 expression. Levels of active Raf-1, a kinase that participates in downstream inhibition of c-Rel binding to the IL23A promoter, were impaired in gal3(-/-) DCs. Modulation of Th17 by galectin-3 in DCs also occurred in vivo because adoptive transfer of gal3(-/-) DCs exposed to Candida albicans conferred higher Th17 responses and protection against fungal infection. We conclude that galectin-3 suppresses Th17 responses by regulating DC cytokine production.
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The expression of Rel, a nuclear factor κB subunit, in DC cluster 3 promoted Il-23 expression to regulate the Th17 response.
“The expression of Rel , a nuclear factorκ B subunit, in DC cluster 3 promoted Il-23 expression to regulate the Th17 response. 25”
From Single-Cell RNA Sequencing to Dissect the Immunological Network of Autoimmune Myocarditis. (2020) · cites this paper as [25]
The section “Galectin-3 Negatively Regulates Activation of c-Rel in DCs after Curdlan Stimulation” identifies c-Rel as an NF-κB subunit that promotes IL-23 p19 transcription. “Differential IL-23 Production Accounts for Enhanced Th17 Induction by gal3−/− DCs” shows that blocking IL-23 p19 decreased DC-induced Th17 differentiation. The paper does not identify a “DC cluster 3” or establish that this mechanism occurs specifically in that cluster; page numbers were unavailable in our copy. (LLM, conf=0.88)
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Bettelli, E., Carrier, Y., Gao, W., Korn, T., Strom, T. B., Oukka, M., Weiner, H. L., & Kuchroo, V. K. (2006) · Nature · doi:10.1038/nature04753 · Cited by 6,992 · see citing works
IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
Langrish, C. L., Chen, Y., Blumenschein, W. M., Mattson, J., Basham, B., Sedgwick, J. D., McClanahan, T., Kastelein, R. A., & Cua, D. J. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041257 · Cited by 4,099 · see citing works
Hayden, M. S., & Ghosh, S. (2004) · Genes & Development · doi:10.1101/gad.1228704 · Cited by 3,842 · see citing works
Inaba, K., Inaba, M., Romani, N., Aya, H., Deguchi, M., Ikehara, S., Muramatsu, S., & Steinman, R. M. (1992) · The Journal of Experimental Medicine · doi:10.1084/jem.176.6.1693 · Cited by 3,741 · see citing works
Veldhoen, M., Hocking, R. J., Atkins, C. J., Locksley, R. M., & Stockinger, B. (2006) · Immunity · doi:10.1016/j.immuni.2006.01.001 · Cited by 3,605 · cited 3× · see citing works
“Tregs have been reported to act as a source of TGF-b to drive Th17 differentiation.(6) To determine whether galectin-3 in DCs indirectly affected Th17 responses by altering Treg development, we compared the number of CD4þCD25þ Foxp3þ cells induced by curdlan-primed gal3 / and gal3þ/þ DCs.”
BackgroundCua, D. J., Sherlock, J., Chen, Y., Murphy, C. A., Joyce, B., Seymour, B., Lucian, L., To, W., Kwan, S., Churakova, T., et al. (2003) · Nature · doi:10.1038/nature01355 · Cited by 2,906 · see citing works
Phenotypic and functional features of human Th17 cells
Annunziato, F., Cosmi, L., Santarlasci, V., Maggi, L., Liotta, F., Mazzinghi, B., Parente, E., Filì, L., Ferri, S., Frosali, F., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070663 · Cited by 1,861 · see citing works
Acosta-Rodriguez, E. V., Napolitani, G., Lanzavecchia, A., & Sallusto, F. (2007) · Nature Immunology · doi:10.1038/ni1496 · Cited by 1,857 · see citing works
Romani, L. (2011) · Nature Reviews Immunology · doi:10.1038/nri2939 · Cited by 1,793 · see citing works
Brown, G. D., & Gordon, S. (2001) · Nature · doi:10.1038/35092620 · Cited by 1,579 · see citing works
The RAF proteins take centre stage
Wellbrock, C., Karasarides, M., & Marais, R. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1498 · Cited by 1,223 · see citing works
LeibundGut-Landmann, S., Groß, O., Robinson, M. J., Osorio, F., Slack, E. C., Tsoni, S. V., Schweighoffer, E., Tybulewicz, V., Brown, G. D., Ruland, J., et al. (2007) · Nature Immunology · doi:10.1038/ni1460 · Cited by 1,191 · see citing works
Galectin-3: An open-ended story
Dumić, J., Dabelić, S., & Flögel, M. (2006) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2005.12.020 · Cited by 1,171 · see citing works
McGeachy, M. J., Chen, Y., Tato, C. M., Laurence, A., Joyce-Shaikh, B., Blumenschein, W. M., McClanahan, T. K., O'Shea, J. J., & Cua, D. J. (2009) · Nature Immunology · doi:10.1038/ni.1698 · Cited by 1,074 · see citing works
Conti, H. R., Shen, F., Nayyar, N., Stocum, E., Sun, J. N., Lindemann, M. J., Ho, A. W., Hai, J. H., Yu, J. J., Jung, J. W., et al. (2009) · Journal of Experimental Medicine · doi:10.1084/jem.20081463 · Cited by 1,024 · see citing works
Self-citationComplexes of Ras⋅GTP with Raf-1 and Mitogen-Activated Protein Kinase Kinase
Moodie, S. A., Willumsen, B. M., Weber, M. J., & Wolfman, A. (1993) · Science · doi:10.1126/science.8503013 · Cited by 968 · see citing works
An integrated model of the recognition of Candida albicans by the innate immune system
Netea, M. G., Brown, G. D., Kullberg, B. J., & Gow, N. A. R. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1815 · Cited by 946 · see citing works
Neutrophil Recruitment by Human IL-17 Via C-X-C Chemokine Release in the Airways
Laan, M., Cui, Z.-H., Hoshino, H., Lötvall, J. O., Sjöstrand, M., Gruenert, D. C., Skoogh, B., & Lindén, A. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.4.2347 · Cited by 880 · see citing works
Requirement of Interleukin‐17A for Systemic Anti– <i>Candida albicans</i> Host Defense in Mice
Huang, W., Na, L., Fidel, P. L., & Schwarzenberger, P. (2004) · The Journal of Infectious Diseases · doi:10.1086/422329 · Cited by 859 · see citing works
Expression of galectin-3 modulates T-cell growth and apoptosis.
Yang, R., Hsu, D. K., & Liu, F. T. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.13.6737 · Cited by 790 · see citing works
Self-citationRomani, L. R. (2003) · Nature reviews. Immunology · doi:10.1038/nri1255 · Cited by 759 · see citing works
Intracellular functions of galectins
Liu, F. T. (2002) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(02)00313-6 · Cited by 676 · see citing works
Self-citationRas recruits Raf‐1 to the plasma membrane for activation by tyrosine phosphorylation.
Marais, R., Light, Y., Paterson, H. F., & Marshall, C. J. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb07316.x · Cited by 613 · see citing works
Gringhuis, S. I., den Dunnen, J., Litjens, M., Hof, B. V. H., van Kooyk, Y., & Geijtenbeek, T. B. H. (2007) · Immunity · doi:10.1016/j.immuni.2007.03.012 · Cited by 588 · see citing works
Dendritic Cells Discriminate between Yeasts and Hyphae of the Fungus Candida albicans
d’Ostiani, C. F., Sero, G. D., Bacci, A., Montagnoli, C., Spreca, A., Mencacci, A., Ricciardi‐Castagnoli, P., & Romani, L. R. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.10.1661 · Cited by 492 · see citing works
Gringhuis, S. I., den Dunnen, J., Litjens, M., van der Vlist, M., Wevers, B. A., Bruijns, S. C. M., & Geijtenbeek, T. B. H. (2009) · Nature Immunology · doi:10.1038/ni.1692 · Cited by 490 · see citing works
Plowman, S. J., Muncke, C., Parton, R. G., & Hancock, J. F. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504114102 · Cited by 468 · see citing works
Identification of a Novel, Dendritic Cell-associated Molecule, Dectin-1, by Subtractive cDNA Cloning
Ariizumi, K., Shen, G.-L., Shikano, S., Xu, S., Ritter, R., Kumamoto, T., Edelbaum, D., Morita, A., Bergstresser, P. R., & Takashima, A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m909512199 · Cited by 468 · see citing works
Critical role of galectin-3 in phagocytosis by macrophages
Sano, H., Hsu, D. K., Apgar, J. R., Yu, L., Sharma, B. B., Kuwabara, I., Izui, S., & Liu, F.-T. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200317592 · Cited by 429 · see citing works
Self-citationTargeted Disruption of the Galectin-3 Gene Results in Attenuated Peritoneal Inflammatory Responses
Hsu, D. K., Yang, R., Pan, Z. K., Yu, L., Salomon, D. R., Fung‐Leung, W., & Liu, F. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64975-9 · Cited by 428 · see citing works
Self-citationIdentification of galectin-3 as a factor in pre-mRNA splicing.
Dagher, S. F., Wang, J. L., & Patterson, R. J. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.4.1213 · Cited by 398 · see citing works
Extracellular functions of galectin-3
Ochieng, J., Furtak, V. A., & Lukyanov, P. A. (2002) · Glycoconjugate Journal · doi:10.1023/b:glyc.0000014082.99675.2f · Cited by 368 · see citing works
Nakahira, K., Kim, H. P., Geng, X. H., Nakao, A., Wang, X., Murase, N., Drain, P. F., Wang, X., Sasidhar, M., Nabel, E. G., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20060845 · Cited by 356 · see citing works
Immune Recognition of <i>Candida albicans</i> β‐glucan by Dectin‐1
Gow, N. A. R., Netea, M. G., Munro, C. A., Ferwerda, G., Bates, S., Mora‐Montes, H. M., Walker, L., Jansen, T., Jacobs, L., Tsoni, V., et al. (2007) · The Journal of Infectious Diseases · doi:10.1086/523110 · Cited by 314 · see citing works
Elad-Sfadia, G., Haklai, R., Balan, E., & Kloog, Y. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312697200 · Cited by 305 · see citing works
Jouault, T., Behi, M. E. A.-E., Martínez-Esparza, M., Breuilh, L., Trinel, P., Chamaillard, M., Trottein, F., & Poulain, D. (2006) · Journal of Immunology · doi:10.4049/jimmunol.177.7.4679 · Cited by 256 · see citing works
Galectin-3 Induces Death of Candida Species Expressing Specific β-1,2-Linked Mannans
Kohatsu, L., Hsu, D. K., Jegalian, A. G., Liu, F., & Baum, L. G. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.7.4718 · Cited by 221 · see citing works
Self-citationGalectin-3 Deficiency Reduces the Severity of Experimental Autoimmune Encephalomyelitis
Jiang, H., Rasbi, Z. A., Mensah‐Brown, E. P. K., Shahin, A., Xu, D., Goodyear, C. S., Fukada, S. Y., Liu, F., Liew, F. Y., & Lukić, M. L. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.182.2.1167 · Cited by 188 · see citing works
Self-citationZuberi, R. I., Hsu, D. K., Kalaycı, Ö., Chen, H., Sheldon, H. K., Yu, L., Apgar, J. R., Kawakami, T., Lilly, C. M., & Liu, F. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63255-5 · Cited by 183 · see citing works
Self-citationFungal recognition is mediated by the association of dectin-1 and galectin-3 in macrophages
Esteban, A., Popp, M. W., Vyas, V. K., Strijbis, K., Ploegh, H. L., & Fink, G. R. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1111415108 · Cited by 150 · see citing works
K-Ras Nanoclustering Is Subverted by Overexpression of the Scaffold Protein Galectin-3
Shalom‐Feuerstein, R., Plowman, S. J., Rotblat, B., Ariotti, N., Tian, T., Hancock, J. F., & Kloog, Y. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-1117 · Cited by 141 · see citing works
Bernardes, E. S., Silva, N. M., Ruas, L. P., Mineo, J. R., Loyola, A. M., Hsu, D. K., Liu, F., Chammas, R. J., & Roque‐Barreira, M. C. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.050636 · Cited by 137 · see citing works
Self-citationRabinovich, G. A., & Gruppi, A. (2005) · Parasite Immunology · doi:10.1111/j.1365-3024.2005.00749.x · Cited by 134 · see citing works
Essential Roles of c-Rel in TLR-Induced IL-23 p19 Gene Expression in Dendritic Cells
Carmody, R. J., Ruan, Q., Liou, H., & Chen, Y. H. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.1.186 · Cited by 131 · see citing works
The role of dendritic cells in the innate immune system
Clark, G. J., Angel, N. Z., Kato, M., López, J. A., MacDonald, K. P. A., Vučković, S., & Hart, D. N. J. (2000) · Microbes and Infection · doi:10.1016/s1286-4579(00)00302-6 · Cited by 122 · see citing works
Hsu, D. K., Chernyavsky, A. I., Chen, H., Yu, L., Grando, S. A., & Liu, F. (2008) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.276 · Cited by 105 · see citing works
Self-citationSaegusa, J., Hsu, D. K., Chen, H. Y., Yu, L., Fermin, A., Fung, M. A., & Liu, F. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.080500 · Cited by 91 · see citing works
Self-citationXu, S., Huo, J., Gunawan, M., Su, I.-H., & Lam, K. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.009076 · Cited by 75 · see citing works
Radosavljevic, G. D., Jovanović, I., Majstorović, I., Mitrović, M., Lisnić, V. J., Arsenijević, N., Jonjić, S., & Lukić, M. L. (2011) · Clinical & Experimental Metastasis · doi:10.1007/s10585-011-9383-y · Cited by 73 · see citing works
T‐cell polarization depends on concentration of the danger signal used to activate dendritic cells
Peters, M., Dudziak, K., Stiehm, M., & Bufe, A. (2010) · Immunology and Cell Biology · doi:10.1038/icb.2010.3 · Cited by 42 · see citing works
Implications of lipid raft disintegration: Enhanced anti-inflammatory macrophage phenotype
Cuschieri, J. (2004) · Surgery · doi:10.1016/j.surg.2004.04.009 · Cited by 34 · see citing works
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Kouo, T., Huang, L., Pucsek, A. B., Cao, M., Solt, S., Armstrong, T., & Jaffee, E. (2015) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-14-0150 · Cited by 531 · see citing works
The role of galectins in immunity and infection
Liu, F., & Stowell, S. R. (2023) · Nature reviews. Immunology · doi:10.1038/s41577-022-00829-7 · Cited by 329 · see citing works
Self-citationSingle-Cell RNA Sequencing to Dissect the Immunological Network of Autoimmune Myocarditis.
Hua, X., Hu, G., Hu, Q., Chang, Y., Hu, Y., Gao, L., Chen, X., Yang, P.-C., Zhang, Y., Li, M., et al. (2020) · Circulation · doi:10.1161/circulationaha.119.043545 · Cited by 201 · see citing works
Galectin-3 in autoimmunity and autoimmune diseases
de Oliveira, F. L., Gatto, M., Bassi, N., Luisetto, R., Ghirardello, A., Punzi, L., & Doria, A. (2015) · Experimental Biology and Medicine · doi:10.1177/1535370215593826 · Cited by 202 · see citing works
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Radovani, B., & Gudelj, I. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.893365 · Cited by 145 · see citing works
Translating the ‘Sugar Code’ into Immune and Vascular Signaling Programs
Cerliani, J. P., Blidner, A. G., Toscano, M. A., Croci, D. O., & Rabinovich, G. A. (2016) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2016.11.003 · Cited by 119 · see citing works
Galectin-3 impacts Cryptococcus neoformans infection through direct antifungal effects
Almeida, F. B. D. R., Wolf, J. M., da Silva, T. A., DeLeon‐Rodriguez, C. M., Rezende, C. P., Pessoni, A. M., Fernandes, F. F., Silva‐Rocha, R., Martínez, R., Rodrigues, M. L., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-02126-7 · Cited by 101 · see citing works
Lazar, M. N., Banerjee, A., Feng, C., Amin, M. N., Frieman, M. B., Chen, W. H., Cross, A. S., Wang, L., & Vasta, G. R. (2015) · Molecular Immunology · doi:10.1016/j.molimm.2014.12.010 · Cited by 93 · see citing works
Saadh, M. J., Mikhailova, M. V., Rasoolzadegan, S., Falaki, M., Akhavanfar, R., Gonzáles, J. L. A., Rigi, A. M., & Kiasari, B. A. (2023) · European journal of medical research · doi:10.1186/s40001-023-01008-7 · Cited by 77 · see citing works
Chen, S.-S., Sun, L., Brickner, H., & Sun, P. (2015) · Cellular Immunology · doi:10.1016/j.cellimm.2015.01.017 · Cited by 68 · see citing works
Re‐wiring regulatory cell networks in immunity by galectin–glycan interactions
Blidner, A. G., Méndez‐Huergo, S. P., Cagnoni, A. J., & Rabinovich, G. A. (2015) · FEBS Letters · doi:10.1016/j.febslet.2015.08.037 · Cited by 57 · see citing works
The role of pattern recognition receptors in the innate recognition ofCandida albicans
Zheng, N.-X., Wang, Y., Hu, D., Yan, L., & Jiang, Y. (2015) · Virulence · doi:10.1080/21505594.2015.1014270 · Cited by 55 · see citing works
Beccaría, C. G., Vesely, M. C. A., Vernengo, F. F., Gehrau, R. C., Ramello, M. C., Tosello, J., Serrán, M. G., Mucci, J., Piaggio, E., Campetella, O., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04063-5 · Cited by 51 · see citing works
Fan, Y., Song, S., Li, Y., Dhar, S. S., Jin, J., Yoshimura, K., Yao, X., Wang, R., Scott, A. W., Pizzi, M. P., et al. (2023) · Cancer Research · doi:10.1158/0008-5472.can-23-0783 · Cited by 50 · see citing works
Volarević, V., Marković, B. S., Gazdic, M., Djokovic, B., Jovicic, N. U., Harrell, C. R., Fellabaum, C., Djonov, V., Arsenijević, N., & Lukić, M. L. (2019) · Theranostics · doi:10.7150/thno.33959 · Cited by 50 · see citing works
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Chatterjee, A., Villarreal, G., & Rhee, D. J. (2014) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.2014.0013 · Cited by 48 · see citing works
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Borovčanin, M., Janicijevic, S. M., Jovanović, I., Gajović, N., Arsenijević, N., & Lukić, M. L. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00271 · Cited by 45 · see citing works
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Kremsreiter, S. M., Kroell, A.-S. H., Weinberger, K., & Boehm, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910577 · Cited by 39 · see citing works
Hatanaka, O., Rezende, C. P., Moreno, P., Fernandes, F. F., Brito, P. M. O. O., Martinez, R., Coelho, C., Roque-Barreira, M., Casadevall, A., & Almeida, F. (2019) · Msphere · doi:10.1128/msphere.00209-19 · Cited by 28 · see citing works
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Li, F.-Y., Wang, S., Bernardes, E. S., & Liu, F. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-981-15-1580-4_6 · Cited by 35 · see citing works
Self-citationGalectin-3, Possible Role in Pathogenesis of Periodontal Diseases and Potential Therapeutic Target
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Román, E., Correia, I., Salazin, A., Fradin, C., Jouault, T., Poulain, D., Liu, F., & Plá, J. (2016) · Virulence · doi:10.1080/21505594.2016.1163458 · Cited by 31 · see citing works
Self-citationThe expression and function of galectins in skin physiology and pathology
Wu, N., & Liu, F. (2018) · Experimental Dermatology · doi:10.1111/exd.13512 · Cited by 29 · see citing works
Self-citationLi, F., Wang, H., Li, Y., Gu, Y., & Jia, X. (2023) · Nature Communications · doi:10.1038/s41467-023-42216-3 · Cited by 27 · see citing works
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Sendid, B., Salvetat, N., Sarter, H., Loridant, S., Cunisse, C., François, N., Aijjou, R., Gelé, P., Leroy, J., Deplanque, D., et al. (2021) · Journal of Fungi · doi:10.3390/jof7050324 · Cited by 19 · see citing works
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Coady, A. M., & Sil, A. (2015) · Infection and Immunity · doi:10.1128/iai.02619-14 · Cited by 18 · see citing works
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Gao, N., Yu, W., Nong-jian, G., Wang, X., & Sun, J. (2016) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428194.2016.1243677 · Cited by 15 · see citing works
Zhao, J., Fan, Y., Liu, X., Zhao, Z., Li, F., & Wang, K. (2017) · Digestive and Liver Disease · doi:10.1016/j.dld.2017.01.158 · Cited by 14 · see citing works
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Rabinovich, G. A., Rademacher, C., Schattner, M. A., & Macauley, M. S. (2026) · Annual Review of Immunology · doi:10.1146/annurev-immunol-083024-030822 · Cited by 14 · see citing works
Emerging Roles of Galectin-3 in Pulmonary Diseases
Jia, Q., Yang, Y., Yao, S., Chen, X., & Hu, Z. (2024) · Lung · doi:10.1007/s00408-024-00709-y · Cited by 12 · see citing works
The Role of Galectin-3 in Liver Inflammation and Fibrosis
Lurje, I., Biegel, D. K., Zhang, I., & Tacke, F. (2026) · Journal of Inflammation Research · doi:10.2147/jir.s572637 · Cited by 13 · see citing works
Davis, C. M., Hiremath, G. S., Wiktorowicz, J. E., Soman, K. V., Straub, C., Nance, C. L., Quintanilla, N., Pazdrak, K., Thakkar, K. H., Olivé, A., et al. (2016) · Digestion · doi:10.1159/000444675 · Cited by 11 · see citing works
IL-17 Is a Key Regulator of Mucin-Galectin-3 Interactions in Asthma
Mammen, M. J., Ali, J., Aurora, A., Sharma, U. C., Aalinkeel, R., Mahajan, S. D., Sands, M. F., & Schwartz, S. A. (2021) · International Journal of Cell Biology · doi:10.1155/2021/9997625 · Cited by 11 · see citing works
Tumor-secreted galectin-3 suppresses antitumor response by inducing IL-10 + B cells
Zheng, P., Xiao, Y., Wu, Z., Wang, Q., Lv, Y., Niu, W., Zhang, Y., Xiao, J., Cao, J., Li, M., et al. (2025) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2024-011445 · Cited by 10 · see citing works
The Two Faces of Galectin-3: Roles in Various Pathological Conditions
Radosavljevic, G. D., Pantic, J. M., Jovanović, I., Lukić, M. L., & Arsenijević, N. (2016) · Serbian Journal of Experimental and Clinical Research · doi:10.1515/sjecr-2016-0011 · Cited by 10 · see citing works
Multi-Method Molecular Characterisation of Human Dust-Mite-associated Allergic Asthma
Whittle, E., Leonard, M. O., Gant, T. W., & Tonge, D. P. (2019) · Scientific Reports · doi:10.1038/s41598-019-45257-1 · Cited by 10 · see citing works
Mikhael, N. W., Attya, G. A., EL-FALLAH, A., & Hamed, A. M. (2021) · Journal of Cosmetic Dermatology · doi:10.1111/jocd.14430 · Cited by 9 · see citing works
Chen, C., Li, H.-P., Chao, Y., Tu, M., Yen, C., Lan, Y., Yang, S., Chong, K., Lin, C., & Chen, C. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.721594 · Cited by 9 · see citing works
Serum galectin‐3 levels in patients with psoriasis
Hayran, Y., Allı, N., Akpınar, Ü., Öktem, A., Yücel, Ç., Oğuz, E. F., & Turhan, T. (2021) · International Journal of Clinical Practice · doi:10.1111/ijcp.14545 · Cited by 8 · see citing works
Grujcic, M., Milovanović, M., Nedeljkovic, J., Jovanović, D., Arsenijević, D., Solovjova, N., Stanković, V., Tanasković, I., Arsenijević, A., & Milovanović, J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25158129 · Cited by 7 · see citing works
Shen, X. (2023) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2023.107850 · Cited by 7 · see citing works
Dynamic changes of DC and T cell subsets in mice during Echinococcus multilocularis infection
Wei, X., Xu, Q., Rexiti, F.-L., Zhu, M., Lin, R., & Wen, H. (2014) · Central European Journal of Immunology · doi:10.5114/ceji.2014.42117 · Cited by 5 · see citing works
Expression and Influence of Galectin-3 on Missed Abortion
Gao, L., & Fang, A.-H. (2014) · Chin J Reprod Contracep · doi:10.7669/j.issn.1001-7844.2014.04.0227 · Cited by 4 · see citing works
Could Galectin-3 be a key player in the etiology of neuromyelitis optica spectrum disorder?
Ramakrishnan, P. (2020) · Medical Hypotheses · doi:10.1016/j.mehy.2020.110450 · Cited by 3 · see citing works
Stojanović, B., Zdravković, N., Petrović, M., Jovanovic, I., Stojanović, B., Stojanovic, M. D., Nešić, J., Paunovic, M., Bevc, I. M., Mirković, N., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26157216 · Cited by 3 · see citing works
Song, Y., Wang, S., Hong, Y., Yan, H., Liu, Y., Mi, J., Zeng, Z., Liu, Y., Sun, M., Liu, M., et al. (2025) · Journal of Applied Toxicology · doi:10.1002/jat.4920 · Cited by 2 · see citing works
Self-citationСергеевич, П. В., Kolobovnikova, Y. V., Urazova, O. I., Васильева, О. А., Дмитриева, А. И., Игоревна, Я. К., Novitsky, V. V., Ryabova, L. M., & Grishchenko, M. Y. (2020) · Bulletin of Siberian Medicine · doi:10.20538/1682-0363-2020-3-76-82 · Cited by 2 · see citing works
Furones, A. R., Brands, T., Gameren, G. V., Florencio-Zabaleta, M., Bathini, M., Delgado, S., Wijfjes, Z., Fedorova, K., Classens, R., Kroese, L. J., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2501381122 · Cited by 1 · see citing works
Datta, S., Ghosh, M., Dewan, K., Banerjee, N., Saha, B., & Mukhopadhyay, S. (2019) · American journal of dermatopathology · doi:10.1097/dad.0000000000001412 · Cited by 1 · see citing works
Wang, H., Wen, X., Huang, W., Li, D., Huang, X., Zhou, C., Niu, C., Du, D., Song, J., Song, Y., et al. (2020) · SSRN Electronic Journal · doi:10.2139/ssrn.3741239 · Cited by 1 · see citing works
Utilizing Galectin 3 as a Marker of Ruptured Vesicles In Vivo
London, J. (2015) · Loyola eCommons (Loyola University of Chicago)
Influência de galectina-3 no curso da infecção por Cryptococcus neoformans
Rezende, C. P. (2020) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.17.2020.tde-19092019-125830
The intricate relationship between cytokines and galectins in immune modulation
Gennesse, S. M., Koenen, R. R., & Thijssen, V. L. (2026) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2026.02.002
Galectin-3 restrains T cell-driven inflammation in the testis and epididymis
Hasan, H., Jandel, K., Wahle, E., Michel, G., Kreyling, L., Kumar, V., Procida‐Kowalski, T., Bhushan, S., Frolíková, M., Rosellen, J., et al. (2026) · Cell Death and Disease · doi:10.1038/s41419-026-09304-w
Host receptor-mediated responses to Candida albicans : An update
Zhu, H., Wang, X., & Shao, J. (2026) · Medical Mycology · doi:10.1093/mmy/myag111
- Authors
- Fermin Lee, A., Chen, H.-Y., Wan, L., Wu, S.-Y., Yu, J.-S., Huang, A. C., Miaw, S.-C., Hsu, D. K., Wu-Hsieh, B. A., & Liu, F.-T.
- Affiliations
- Institute of Biomedical Sciences, Academia Sinica (TW)
- China Medical University Hospital (TW)
- National Taiwan University (TW)
- Corresponding author
- Liu, Fu-Tong
- Venue
- The American Journal of Pathology
- Publisher
- Elsevier BV
- Published
- 2013-10
- Volume
- 183
- Issue
- 4
- Pages
- 1209-1222
- ISSN
- 0002-9440 (ISSN-L)
- PMC
- PMC3791687
- OpenAlex
- W2110432110
- Cited by
- 63
- References
- 51
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 3 · 2023: 5 · 2022: 1 · 2021: 9 · 2020: 6 · 2019: 5 · 2018: 4 · 2017: 2 · 2016: 5 · 2015: 11 · 2014: 3
- FWCI
- 3.51
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- American Journal Of Pathology (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Academia Sinica
- Institute of Biomedical Sciences, Academia Sinica
- National Heart, Lung, and Blood Institute (T32-HL-07013, T32HL007013)
- National Cancer Institute (P30CA093373)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR056343, AR056343)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Galectins and Cancer Biology
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- galectin-3, Th17 cells, dendritic cells, IL-23, c-Rel, Raf-1, Dectin-1, curdlan, lipopolysaccharide, Candida albicans, fungal infection, Th17 polarization, cytokine production, beta-galactoside-binding lectin
- MeSH terms
- Dectin-1, Animals, Candida albicans, Candidiasis, Chickens, Dendritic Cells, Enzyme Activation, Immunity, Lipopolysaccharides, Mice, Inbred C57BL, Models, Biological, Signal Transduction, Cytokines, Cell Polarity, Adoptive Transfer, Proto-Oncogene Proteins c-raf, Proto-Oncogene Proteins c-rel, Lectins, C-Type, Galectin 3, beta-Glucans, Extracellular Signal-Regulated MAP Kinases, Mice, Interleukin-23, Th17 Cells
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