The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
The Role of Microglia and Peripheral Monocytes in Retinal Damage after Corneal Chemical Injury
Abstract
Eyes that have experienced alkali burn to the surface are excessively susceptible to subsequent severe glaucoma and retinal ganglion cell loss, despite maximal efforts to prevent or slow down the disease. Recently, we have shown, in mice and rabbits, that such retinal damage is neither mediated by the alkali itself reaching the retina nor by intraocular pressure elevation. Rather, it is caused by the up-regulation of tumor necrosis factor-α (TNF-α), which rapidly diffuses posteriorly, causing retinal ganglion cell apoptosis and CD45+ cell activation. Herein, we investigated the involvement of peripheral blood monocytes and microglia in retinal damage. Using CX3CR1+/EGFP::CCR2+/RFP reporter mice and bone marrow chimeras, we show that peripheral CX3CR1+CD45hiCD11b+MHC-II+ monocytes infiltrate into the retina from the optic nerve at 24 hours after the burn and release further TNF-α. A secondary source of peripheral monocyte response originates from a rare population of patrolling myeloid CCR2+ cells of the retina that differentiate into CX3CR1+ macrophages within hours after the injury. As a result, CX3CR1+CD45loCD11b+ microglia become reactive at 7 days, causing further TNF-α release. Prompt TNF-α inhibition after corneal burn suppresses monocyte infiltration and microglia activation, and protects the retina. This study may prove relevant to other injuries of the central nervous system.
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“Given that peripheral monocytes have been shown to participate in CNS disease via both infiltration and repopulation of neuroglia following microglia depletion (4–10), it is important to determine if CSF1R inhibition causes functional changes in peripheral immune cells that can become part of the CNS (3, 4, 10–14).”
From CSF1R inhibition by a small-molecule inhibitor is not microglia specific; affecting hematopoiesis and the function of macrophages (2020) · cites this paper as [9]
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Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages
Ginhoux, F., Greter, M., Leboeuf, M., Nandi, S., See, P., Gokhan, S., Mehler, M. F., Conway, S. J., Ng, L. G., Stanley, E. R., et al. (2010) · Science · doi:10.1126/science.1194637 · Cited by 5,175
Macrophage biology in development, homeostasis and disease
Wynn, T. A., Chawla, A., & Pollard, J. W. (2013) · Nature · doi:10.1038/nature12034 · Cited by 4,684
Microglia-mediated neurotoxicity: uncovering the molecular mechanisms
Block, M. L., Zecca, L., & Hong, J.-S. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2038 · Cited by 4,110
Microglia: Active sensor and versatile effector cells in the normal and pathologic brain
Hanisch, U.-K., & Kettenmann, H. (2007) · Nature Neuroscience · doi:10.1038/nn1997 · Cited by 3,676
Kettenmann, H., Hanisch, U.-K., Noda, M., & Verkhratsky, A. (2011) · Physiological Reviews · doi:10.1152/physrev.00011.2010 · Cited by 3,547
Identification of a unique TGF-β–dependent molecular and functional signature in microglia
Butovsky, O., Jedrychowski, M. P., Moore, C. S., Cialic, R., Lanser, A. J., Gabriely, G., Koeglsperger, T., Dake, B., Wu, P. M., Doykan, C. E., et al. (2014) · Nature Neuroscience · doi:10.1038/nn.3599 · Cited by 2,543
Microglia emerge as central players in brain disease
Salter, M. W., & Stevens, B. (2017) · Nature Medicine · doi:10.1038/nm.4397 · Cited by 1,767
The role of microglia and macrophages in glioma maintenance and progression
Hambardzumyan, D., Gutmann, D. H., & Kettenmann, H. (2016) · Nature Neuroscience · doi:10.1038/nn.4185 · Cited by 1,683
Local self-renewal can sustain CNS microglia maintenance and function throughout adult life
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Cited by
Lei, F., Cui, N., Zhou, C., Chodosh, J., Vavvas, D. G., & Paschalis, E. I. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1922788117 · Cited by 322
Self-citationPlemel, J. R., Stratton, J. A., Michaels, N. J., Rawji, K. S., Zhang, E., Sinha, S., Baaklini, C. S., Dong, Y., Ho, M., Thorburn, K., et al. (2020) · Science Advances · doi:10.1126/sciadv.aay6324 · Cited by 208
Paschalis, E. I., Lei, F., Zhou, C., Kapoulea, V., Dana, R., Chodosh, J., Vavvas, D. G., & Dohlman, C. H. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1807123115 · Cited by 72
Self-citationTarale, P., & Alam, M. M. (2022) · Inflammopharmacology · doi:10.1007/s10787-022-00958-4 · Cited by 26
Metadata
- Authors
- Paschalis, E. I., Lei, F., Zhou, C., Kapoulea, V., Thanos, A., Dana, R., Vavvas, D. G., Chodosh, J., & Dohlman, C. H.
- Venue
- The American Journal of Pathology
- Publisher
- Elsevier BV
- Published
- 2018-07
- Volume
- 188
- Issue
- 7
- Pages
- 1580-1596
- ISSN
- 0002-9440
- Cited by
- 68
- References
- 51
- Language
- en
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 530 d)
- Funders
- Massachusetts Eye and Ear
- National Eye Institute (P30EY003790)
- Massachusetts Lions Eye Research Fund
- Research to Prevent Blindness
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- Paschalis, E. I., Lei, F., Zhou, C., Kapoulea, V., Thanos, A., Dana, R., Vavvas, D. G., Chodosh, J., & Dohlman, C. H. (2018). The Role of Microglia and Peripheral Monocytes in Retinal Damage after Corneal Chemical Injury. The American Journal of Pathology. https://doi.org/10.1016/j.ajpath.2018.03.005
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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