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In situ forming hydrogels based on chitosan for drug delivery and tissue regeneration
Open accessAbstract
In situ forming hydrogels with simple sol–gel transition are more practicable as injectable hydrogels for drug delivery and tissue regeneration. State-of-the-art in situ gelling systems can easily and efficiently be formed by different mechanisms in situ. Chitosan is a kind of natural polysaccharide that is widely exploited for biomedical applications due to its good biocompatibility, low immunogenicity and specific biological activities. Chitosan-based in situ gelling systems have already gained much attention as smart biomaterials in the development of several biomedical applications, such as for drug delivery systems and regeneration medicine. Herein, we review the typical in situ gelling systems based on chitosan and mechanisms involved in hydrogel forming, and report advances of chitosan-based in situ gels for the applications in drug delivery and tissue regeneration. Finally, development prospects of in situ forming hydrogels based on chitosan are also discussed in brief.
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Cited by
Harugade, A., Sherje, A. P., & Pethe, A. (2023) · Reactive and Functional Polymers · doi:10.1016/j.reactfunctpolym.2023.105634 · Cited by 474
Kou, S. (., Peters, L., & Mucalo, M. (2022) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2022.119132 · Cited by 380
The production and application of hydrogels for wound management: A review
Gupta, A., Kowalczuk, M., Heaselgrave, W., Britland, S. T., Martin, C., & Radecka, I. (2019) · European Polymer Journal · doi:10.1016/j.eurpolymj.2018.12.019 · Cited by 336
Chitosan based bioadhesives for biomedical applications: A review
Hamedi, H., Moradi, S., Hudson, S. M., Tonelli, A. E., & King, M. W. (2022) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2022.119100 · Cited by 281
Pita-López, M. L., Fletes-Vargas, G., Espinosa-Andrews, H., & Rodríguez-Rodríguez, R. (2021) · European Polymer Journal · doi:10.1016/j.eurpolymj.2020.110176 · Cited by 256
Metadata
- Authors
- Liu, L., Gao, Q., Lu, X., & Zhou, H.
- Venue
- Asian Journal of Pharmaceutical Sciences
- Publisher
- Elsevier BV
- Published
- 2016-12
- Volume
- 11
- Issue
- 6
- Pages
- 673-683
- ISSN
- 1818-0876 (ISSN-L)
- OpenAlex
- W2469037914
- Cited by
- 232
- References
- 0
- FWCI
- 9.22
- Type
- journal article
- Language
- en
- Open access
- diamond
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- Liu, L., Gao, Q., Lu, X., & Zhou, H. (2016). In situ forming hydrogels based on chitosan for drug delivery and tissue regeneration. Asian Journal of Pharmaceutical Sciences. https://doi.org/10.1016/j.ajps.2016.07.001
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