Insights on drug and gene delivery systems in liver fibrosis

Vyas, Kunj; Patel, Mayur M

doi:10.1016/j.ajps.2023.100779

Cited by 30Liver physiology and pathologyNanoparticle-Based Drug DeliveryRNA Interference and Gene Delivery

Insights on drug and gene delivery systems in liver fibrosis

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Vyas, Kunj, Patel, Mayur M·2023·Asian Journal of Pharmaceutical Sciences

DOI 10.1016/j.ajps.2023.100779PMC PMC9950450

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Abstract

Complications of the liver are amongst the world's worst diseases. Liver fibrosis is the first stage of liver problems, while cirrhosis is the last stage, which can lead to death. The creation of effective anti-fibrotic drug delivery methods appears critical due to the liver's metabolic capacity for drugs and the presence of insurmountable physiological impediments in the way of targeting. Recent breakthroughs in anti-fibrotic agents have substantially assisted in fibrosis; nevertheless, the working mechanism of anti-fibrotic medications is not fully understood, and there is a need to design delivery systems that are well-understood and can aid in cirrhosis. Nanotechnology-based delivery systems are regarded to be effective but they have not been adequately researched for liver delivery. As a result, the capability of nanoparticles in hepatic delivery was explored. Another approach is targeted drug delivery, which can considerably improve efficacy if delivery systems are designed to target hepatic stellate cells (HSCs). We have addressed numerous delivery strategies that target HSCs, which can eventually aid in fibrosis. Recently genetics have proved to be useful, and methods for delivering genetic material to the target place have also been investigated where different techniques are depicted. To summarize, this review paper sheds light on the most recent breakthroughs in drug and gene-based nano and targeted delivery systems that have lately shown useful for the treatment of liver fibrosis and cirrhosis.

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Research works printed but not linked: 2

[49]Devaraj E. Rajeshkumar S. Nanomedicine for hepatic fibrosis Shukla A, editor Nanoparticles their biomedical applications 2020 Springer Singapore Singapore 45 64
[141]Aravalli R.N. Chapter60-Gene therapy for liver disease Muriel P, editor Liver pathophysiology 2017 Academic Press Boston 837 851

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Found in translation—Fibrosis in metabolic dysfunction–associated steatohepatitis (MASH)
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Authors: Vyas, K., & Patel, M. M.
Affiliations: Nirma University (IN)
Corresponding author: Patel, Mayur M
ORCID: Vyas, Kunj
Patel, Mayur M
Venue: Asian Journal of Pharmaceutical Sciences
Publisher: Elsevier BV
Published: 2023-03
Volume: 18
Issue: 2
Pages: 100779
ISSN: 1818-0876 (ISSN-L)
DOI: 10.1016/j.ajps.2023.100779
PMC: PMC9950450
OpenAlex: W4318426603
Cited by: 30
References: 156
Citations by year: 2026: 4 · 2025: 11 · 2024: 10 · 2023: 5
FWCI: 1.29
Type: journal article
Language: en
Open access: diamond
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor)
Locations: Asian Journal of Pharmaceutical Sciences (publishedVersion, cc-by-nc-nd)
PubMed Central (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Nirma University
Topics: Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
Keywords: liver fibrosis, liver cirrhosis, gene delivery, nanoparticles, hepatic drug delivery, targeted drug delivery, hepatic stellate cells

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Insights on drug and gene delivery systems in liver fibrosis

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