Critical role of estrogen in the progression of chronic liver diseases
Abstract
Background Estrogens regulate sexual function and also have a significant role in various pathophysiological processes. Estrogens have a non-reproductive role as the modulators of the immune system, growth, neuronal function, and metabolism. Estrogen receptors are expressed in the liver and their impaired expression and function are implicated with obesity and liver associated metabolic dysfunctions. The purpose of the current review is to discuss the disparity role of estrogens on several forms of liver diseases. Data sources A comprehensive search in PubMed and EMBASE was conducted using the keywords "estrogens and liver diseases", "estradiol and liver diseases", "hormones and liver diseases", "endocrine function in liver diseases", and "female hormones in liver diseases". Relevant papers published before September 30, 2019 were included. Results The present review confirms the imperative role of estrogen in various forms of chronic liver diseases. Estrogens play a key role in maintaining homeostasis and make the liver less susceptible to several forms of chronic liver diseases in healthy premenopausal individuals. In contrast, clinical studies also showed increased estrogen levels with chronic liver diseases. Conclusions Several studies reported the protective role of estrogens in chronic liver diseases and this has been widely accepted and confirmed in experimental studies using ovariectomized rat models. However, in a few clinical studies, increased estrogen levels are also implicated in chronic liver diseases. Therefore, further studies are warranted at molecular level to explore the role of estrogen in various forms of chronic liver diseases.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The male mice were used to preclude effects of sex hormone since liver metabolism and inflammatory responses are highly influenced by estrogen levels and activity of estrogen receptor.
“The male mice were used to preclude the effects of sex hormone since liver metabolism and inflammatory responses are highly influenced by estrogen levels and activity of estrogen receptor67,68.”
From Bioengineered liver crosslinked with nano-graphene oxide enables efficient liver regeneration via MMP suppression and immunomodulation (2023) · cites this paper as [67]
Cites
Singh, S., Allen, A. M., Wang, Z., Prokop, L. J., Murad, M. H., & Loomba, R. (2015) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2014.04.014 · Cited by 1,748 · see citing works
Hepatic stellate cells as key target in liver fibrosis
Higashi, T., Friedman, S. L., & Hoshida, Y. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.05.007 · Cited by 1,485 · see citing works
ACG Clinical Guideline: Alcoholic Liver Disease
Singal, A. K., Bataller, R. A., Ahn, J. C., Kamath, P. S., & Shah, V. H. (2018) · The American Journal of Gastroenterology · doi:10.1038/ajg.2017.469 · Cited by 834 · see citing works
Estrogen synthesis and signaling pathways during aging: from periphery to brain
Cui, J., Shen, Y., & Li, R. (2013) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2012.12.007 · Cited by 785 · see citing works
Role of Estrogens in the Regulation of Liver Lipid Metabolism
Palmisano, B. T., Zhu, L., & Stafford, J. M. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-70178-3_12 · Cited by 550 · see citing works
Marcellin, P., & Kutala, B. K. (2018) · Liver International · doi:10.1111/liv.13682 · Cited by 513 · see citing works
Obesity, inflammation, and liver cancer
Sun, B., & Karin, M. (2011) · Journal of Hepatology · doi:10.1016/j.jhep.2011.09.020 · Cited by 496 · see citing works
Estrogen Receptors and the Metabolic Network
Barros, R. P. A., & Gustafsson, J.-Å. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.08.005 · Cited by 458 · see citing works
Liver fibrosis: Direct antifibrotic agents and targeted therapies
Schuppan, D., Ashfaq–Khan, M., Yang, A. T., & Kim, Y. O. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.04.006 · Cited by 440 · see citing works
Berasain, C., Castillo, J., Perugorria, M. J., Latasa, M. U., Prìeto, J., & Avila, M. A. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.03704.x · Cited by 391 · see citing works
Molecular mechanisms underlying chemical liver injury
Gu, X., & Manautou, J. E. (2012) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399411002110 · Cited by 389 · see citing works
Syringic acid triggers reactive oxygen species–mediated cytotoxicity in HepG2 cells
Gheena, S., & Ezhilarasan, D. (2019) · Human & Experimental Toxicology · doi:10.1177/0960327119839173 · Cited by 323 · see citing works
Self-citationThe global burden of liver disease: a challenge for methods and for public health
Byass, P. (2014) · BMC Medicine · doi:10.1186/s12916-014-0159-5 · Cited by 321 · see citing works
Metabolic Actions of Estrogen Receptor Beta (ERβ) are Mediated by a Negative Cross-Talk with PPARγ
Foryst‐Ludwig, A., Clemenz, M., Hohmann, S., Hartge, M., Sprang, C., Frost, N., Krikov, M., Bhanot, S., Barros, R. P. A., Morani, A., et al. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000108 · Cited by 288 · see citing works
Suppressive effects of estradiol on dimethylnitrosamine-induced fibrosis of the liver in rats
Yasuda, M., Shimizu, I., Shiba, M., & Ito, S. (1999) · Hepatology · doi:10.1002/hep.510290307 · Cited by 283 · see citing works
Radiotherapy-Related Lung Fibrosis Enhanced by Tamoxifen
Bentzen, S. M., Skoczylas, J., Overgaard, M., & Overgaard, J. (1996) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/88.13.918 · Cited by 281 · see citing works
Oxidative stress is bane in chronic liver diseases: Clinical and experimental perspective
Ezhilarasan, D. (2018) · Arab Journal of Gastroenterology · doi:10.1016/j.ajg.2018.03.002 · Cited by 239 · see citing works
Self-citationSex hormones and their receptors regulate liver energy homeostasis
Shen, M., & Shi, H. (2015) · International Journal of Endocrinology · doi:10.1155/2015/294278 · Cited by 239 · see citing works
Global Epidemiology, Prevention, and Management of Hepatocellular Carcinoma
Mak, L., Cruz-Ramón, V., Chinchilla-López, P., Torres, H. A., LoConte, N. K., Rice, J. P., Foxhall, L. E., Sturgis, E. M., Merrill, J. K., Bailey, H. H., et al. (2018) · American Society of Clinical Oncology Educational Book · doi:10.1200/edbk_200939 · Cited by 237 · see citing works
The diversity of sex steroid action: regulation of metabolism by estrogen signaling
Faulds, M. H., Zhao, C., Dahlman-Wright, K., & Gustafsson, J.-Å. (2012) · Journal of Endocrinology · doi:10.1530/joe-11-0044 · Cited by 230 · see citing works
Hepatic fibrosis: It is time to go with hepatic stellate cell-specific therapeutic targets
Ezhilarasan, D., Sokal, E., & Najimi, M. (2018) · Hepatobiliary & Pancreatic Diseases International · doi:10.1016/j.hbpd.2018.04.003 · Cited by 204 · see citing works
Self-citationBesse‐Patin, A., Léveillé, M., Oropeza, D., Nguyen, B., Prat, A., & Estall, J. L. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.09.017 · Cited by 178 · see citing works
Estrogen deficiency worsens steatohepatitis in mice fed high-fat and high-cholesterol diet
Kamada, Y., Kiso, S., Yoshida, Y., Chatani, N., Kizu, T., Hamano, M., Tsubakio, M., Takemura, T., Ezaki, H., Hayashi, N., et al. (2011) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00211.2011 · Cited by 154 · see citing works
Qiu, S., Vazquez, J. T., Boulger, E., Liu, H., Xue, P., Hussain, M. A., & Wolfe, A. (2017) · Scientific Reports · doi:10.1038/s41598-017-01937-4 · Cited by 135 · see citing works
Estrogen signaling prevents diet-induced hepatic insulin resistance in male mice with obesity
Zhu, L., Martinez, M. N., Emfinger, C. H., Palmisano, B. T., & Stafford, J. M. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00579.2013 · Cited by 130 · see citing works
Mohamed, M., & Abdel-Rahman, A. (2000) · European Journal of Endocrinology · doi:10.1530/eje.0.1420307 · Cited by 127 · see citing works
Estrogen reduces CCL4- induced liver fibrosis in rats
Xu, J.-W. (2002) · World Journal of Gastroenterology · doi:10.3748/wjg.v8.i5.883 · Cited by 121 · see citing works
Inhibitory effect of oestradiol on activation of rat hepatic stellate cells in vivo and in vitro
Shimizu, I., Mizobuchi, Y., Yasuda, M., Shiba, M., Ma, Y.-R., HORIE, T., Liu, F., & Ito, S. (1999) · Gut · doi:10.1136/gut.44.1.127 · Cited by 120 · see citing works
Bissell, M. D. (1999) · Hepatology · doi:10.1002/hep.510290351 · Cited by 114 · see citing works
ESTROGEN: PHYSIOLOGY, PHARMACOLOGY, AND FORMULATIONS FOR REPLACEMENT THERAPY
Ruggiero, R. J., & Likis, F. E. (2002) · Journal of Midwifery & Women s Health · doi:10.1016/s1526-9523(02)00233-7 · Cited by 108 · see citing works
The roles of microRNA families in hepatic fibrosis
Jiang, X.-P., Ai, W., Wan, L., Zhang, Y., & Wu, J. (2017) · Cell & Bioscience · doi:10.1186/s13578-017-0161-7 · Cited by 108 · see citing works
Zhang, Y., Wu, L., Wang, Y., Zhang, M., Li, L., Zhu, D., Li, X., Gu, H., Zhang, C., & Zen, K. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.314922 · Cited by 107 · see citing works
Review of nonalcoholic fatty liver disease in women with polycystic ovary syndrome
Kelley, C. E. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i39.14172 · Cited by 101 · see citing works
Estrogen, estrogen receptors, and hepatocellular carcinoma: Are we there yet?
Sukocheva, O. A. (2018) · World Journal of Gastroenterology · doi:10.3748/wjg.v24.i1.1 · Cited by 94 · see citing works
Emerging and Disease-Specific Mechanisms of Hepatic Stellate Cell Activation
Wallace, M., Mann, D. A., & Friedman, S. L. (2015) · Seminars in Liver Disease · doi:10.1055/s-0035-1550060 · Cited by 93 · see citing works
Antifibrotic Therapies: Where Are We Now?
Yoon, Y., Lee, Y., & Friedman, S. L. (2016) · Seminars in Liver Disease · doi:10.1055/s-0036-1571295 · Cited by 88 · see citing works
Hishida, M., Nomoto, S., Inokawa, Y., Hayashi, M., Kanda, M., Okamura, Y., Nishikawa, Y., Tanaka, C., Kobayashi, D., Yamada, S., et al. (2013) · International Journal of Oncology · doi:10.3892/ijo.2013.1951 · Cited by 88 · see citing works
Estrogens and female liver health
Chen, K. L., & Madak‐Erdogan, Z. (2017) · Steroids · doi:10.1016/j.steroids.2017.10.015 · Cited by 81 · see citing works
Carthy, J., Sundqvist, A., Heldin, A., van Dam, H., Kletsas, D., Heldin, C., & Moustakas, A. (2015) · Journal of Cellular Physiology · doi:10.1002/jcp.25049 · Cited by 77 · see citing works
Estrogen receptor expression in chronic hepatitis C and hepatocellular carcinoma pathogenesis
Iyer, J. K., Kalra, M., Kaul, A., Payton, M. E., & Kaul, R. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i37.6802 · Cited by 69 · see citing works
Hepatic Fibrosis: Emerging Therapies
Friedman, S. L. (2015) · Digestive Diseases · doi:10.1159/000374098 · Cited by 68 · see citing works
Weigt, C., Hertrampf, T., Kluxen, F. M., Flenker, U., Hülsemann, F., Fritzemeier, K. H., & Diel, P. R. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.07.007 · Cited by 68 · see citing works
Montella, M., D'Arena, G. F., Crispo, A., Capunzo, M., Nocerino, F., Grimaldi, M., Barbieri, A., D’Ursi, A. M., Tecce, M. F., Amore, A., et al. (2015) · International Journal of Endocrinology · doi:10.1155/2015/854530 · Cited by 66 · see citing works
OESTROGEN METABOLISM IN LIVER DISEASE
Adlercreutz, H. (1970) · Journal of Endocrinology · doi:10.1677/joe.0.0460129 · Cited by 65 · see citing works
Zhang, B., Zhang, C., Ji, L., Zhao, G., & Wu, Z. (2017) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.13976 · Cited by 62 · see citing works
Polyzos, S., Kountouras, J., Tsatsoulis, A., Zafeiriadou, E., Katsiki, E., Patsiaoura, K., Zavos, C., Anastasiadou, V., & Slavakis, A. (2013) · HORMONES · doi:10.1007/bf03401306 · Cited by 59 · see citing works
Jiang, M., Klein, M., Zanger, U. M., Mohammad, M. K., Cave, M. C., Gaikwad, N. W., Dias, N. J., Selcer, K. W., Guo, Y., He, J., et al. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.07.022 · Cited by 51 · see citing works
Recent advances in the molecular mechanism of sex disparity in hepatocellular carcinoma (Review)
Li, Y., Xu, A., Jia, S., & Huang, J. (2019) · Oncology Letters · doi:10.3892/ol.2019.10127 · Cited by 47 · see citing works
Suppressive effects of 17β-estradiol on hepatic fibrosis in CCl4-induced rat model
Liu, Q.-H., Li, D., Huang, X., Zong, C.-H., Xu, Q., & Lu, H.-M. (2004) · World Journal of Gastroenterology · doi:10.3748/wjg.v10.i9.1315 · Cited by 47 · see citing works
Ezhilarasan, D., Evraerts, J., Sid, B., Calderón, P. B., Karthikeyan, S., Sokal, E. M., & Najimi, M. (2017) · Hepatobiliary & pancreatic diseases international · doi:10.1016/s1499-3872(16)60166-2 · Cited by 43 · see citing works
Self-citationEffects of estradiol on liver estrogen receptor- and its mRNA expression in hepatic fibrosis in rats
Xu, J., Gong, J., Chang, X.-M., Luo, J., Dong, L., Jia, A., & Xu, G. (2004) · World Journal of Gastroenterology · doi:10.3748/wjg.v10.i2.250 · Cited by 39 · see citing works
Ge, S., Xie, J., Liu, F., He, J., & He, J. (2015) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25116 · Cited by 30 · see citing works
Plant derived antioxidants and antifibrotic drugs: past, present and future
Ezhilarasan, D., Sokal, E. M., Karthikeyan, S., & Najimi, M. (2014) · Journal of Coastal Life Medicine · doi:10.12980/jclm.2.2014apjtb-2014-0111 · Cited by 30 · see citing works
Self-citationBaldissera, V. D., Alves, A. F., Almeida, S., Porawski, M., & Giovenardi, M. (2015) · Medical Hypotheses · doi:10.1016/j.mehy.2015.11.030 · Cited by 29 · see citing works
Que, R., Shen, Y., Ren, J., Tao, Z., Zhu, X., & Li, Y. (2017) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2017.3349 · Cited by 28 · see citing works
The Prevalence of Viral Hepatitis C in Latvia: A Population-Based Study
Tolmane, I., Rozentāle, B., Keišs, J., Arsa, F., Briģis, Ģ., & Zvaigzne, A. (2011) · Medicina · doi:10.3390/medicina47100076 · Cited by 25 · see citing works
Improvement of portal hypertension and hepatic blood flow in cirrhotic rats by oestrogen
Sakamoto, M., Ueno, T., Nakamura, T., Sakata, R., HASHIMOTO, O., Torimura, T., & Sata, M. (2005) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2005.01476.x · Cited by 23 · see citing works
Efstathiadou, Z. A., Sakka, C., Pοlyzos, S. A., Goutou, M., Stakias, N., Bargiota, Α., & KOUKOULIS, G. N. (2015) · Metabolism · doi:10.1016/j.metabol.2015.01.006 · Cited by 22 · see citing works
Sarkar, M., Lai, J. C., Sawinski, D., Zeigler, T. E., Cedars, M., & Forde, K. A. (2019) · Journal of Viral Hepatitis · doi:10.1111/jvh.13027 · Cited by 22 · see citing works
Kappas, A. (1967) · Gastroenterology · doi:10.1016/s0016-5085(67)80108-2 · Cited by 21 · see citing works
Treatment of chronic hepatitis B.
Cornberg, M., Jaroszewicz, J., Manns, M. P., & Wedemeyer, H. H. (2010) · PubMed · Cited by 20 · see citing works
THE LIVER AND ESTROGEN METABOLISM
Long, R. S. (1951) · A M A Archives of Internal Medicine · doi:10.1001/archinte.1951.03810120063006 · Cited by 16 · see citing works
Treatment of Chronic Hepatitis B
Marcellin, P., Asselah, T., & Boyer, N. (2005) · doi:10.1002/9780470987131.ch20 · Cited by 12 · see citing works
Changes of Some Hormones Levels in Patients With Hepatitis B Virus-Related Chronic Liver Disease
Serin (2013) · Gastroenterology Research · doi:10.4021/gr532w · Cited by 7 · see citing works
Ho, H., Lee, F., Hsu, S., Wang, S.-S., Hsin, I., Huang, H., Lee, J.-Y., Lin, H., & Lee, S. (2015) · Annals of Hepatology · doi:10.1016/s1665-2681(19)31281-5 · Cited by 6 · see citing works
[The liver and estrogen metabolism].
Donnet, V., & Zwirn, P. (1952) · PubMed · Cited by 3 · see citing works
Biochemical effects of estrogens in non-reproductive organs
As, M., Ковзун, О. І., & Tronko, M. D. (2015) · The Ukrainian Biochemical Journal · doi:10.15407/ubj87.05.010 · Cited by 2 · see citing works
[The effect of estrogen level on Budd Chiari syndrome related hepatocellular carcinoma].
Xu, Z., Wang, Y. D., Zhang, X., Deng, D. F., Fu, Z., Huang, J. Z., & Cai, J. (2019) · PubMed · doi:10.3760/cma.j.issn.0376-2491.2019.16.010 · Cited by 1 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Role of estrogen receptors in health and disease
Chen, P., Li, B., & Ou-Yang, L. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.839005 · Cited by 339 · see citing works
Molecular mechanisms in thioacetamide-induced acute and chronic liver injury models
Ezhilarasan, D. (2023) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2023.104093 · Cited by 107 · see citing works
Self-citationKim, D.-H., Kim, M.-J., Kwak, S.-Y., Jeong, J., Choi, D., Choi, S. W., Ryu, J., & Kang, K.-S. (2023) · Nature Communications · doi:10.1038/s41467-023-35941-2 · Cited by 53 · see citing works
Association of serum vitamin C with liver fibrosis in adults with nonalcoholic fatty liver disease
Zhao, Y., & Li, H. (2022) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365521.2022.2041085 · Cited by 39 · see citing works
Danpanichkul, P., Ng, C. H., Muthiah, M. D., Suparan, K., Tan, D. J. H., Duangsonk, K., Sukphutanan, B., Kongarin, S., Harinwan, N., Panpradist, N., et al. (2023) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000002642 · Cited by 36 · see citing works
Nanodrug delivery: Strategies to circumvent nanoparticle trafficking by Kupffer cells in the liver
Ezhilarasan, D., & Harini, K. S. (2023) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2023.104731 · Cited by 35 · see citing works
Self-citationHuang, Q., Liu, X., & Guo, S. (2021) · Reproductive Medicine and Biology · doi:10.1002/rmb2.12423 · Cited by 30 · see citing works
Insights on drug and gene delivery systems in liver fibrosis
Vyas, K., & Patel, M. M. (2023) · Asian Journal of Pharmaceutical Sciences · doi:10.1016/j.ajps.2023.100779 · Cited by 30 · see citing works
Li, B., Zhang, X., Huo, S., Zhang, J., Du, J., Xiao, B., Song, M., Shao, B., & Li, Y. (2022) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2022.110229 · Cited by 23 · see citing works
Advantages and challenges in nanomedicines for chronic liver diseases: A hepatologist's perspectives
Ezhilarasan, D. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173832 · Cited by 22 · see citing works
Self-citationRelaxin in hepatic fibrosis: What is known and where to head?
Ezhilarasan, D. (2021) · Biochimie · doi:10.1016/j.biochi.2021.06.001 · Cited by 21 · see citing works
Self-citationMorris, R., Bu, K., Han, W., Wood, S., Velez, P. M. H., Ward, J., Crescitelli, A., Martin, M., & Cheng, F. (2025) · Genes · doi:10.3390/genes16030248 · Cited by 19 · see citing works
Y-box binding protein 1 promotes chromatin accessibility to aggravate liver fibrosis
Tang, Z., Lin, B., Li, W., Li, X., Liu, F., & Zhu, X. (2023) · Cellular Signalling · doi:10.1016/j.cellsig.2023.110750 · Cited by 16 · see citing works
Padmapriya, A., Preetha, S., Jayaraman, S., & Sridevi, G. (2022) · Research Journal of Pharmacy and Technology · doi:10.52711/0974-360x.2022.00924 · Cited by 15 · see citing works
Kumar, V., Kumar, R. K., Gurusubramanian, G., Rathore, S. S., & Roy, V. K. (2024) · 3 Biotech · doi:10.1007/s13205-024-04012-8 · Cited by 15 · see citing works
Like a Rolling Stone? A Review on Spontaneous Clearance of Hepatitis C Virus Infection
Rzymski, P., Brzdęk, M., Dobrowolska, K., Poniedziałek, B., Murawska-Ochab, A., Zarębska‐Michaluk, D., & Flisiak, R. (2024) · Viruses · doi:10.3390/v16091386 · Cited by 15 · see citing works
Lerdsuwanrut, N., Zamani, R., & Akrami, M. (2025) · Sustainability · doi:10.3390/su17020491 · Cited by 15 · see citing works
Wang, Z., Li, X., Liu, X., Yang, Y., Yan, Y., Cui, D., Meng, C., Ali, M. I., Zhang, J., Yao, Z., et al. (2025) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2025.106701 · Cited by 13 · see citing works
Novel Nano-Based Drug Delivery Systems Targeting Hepatic Stellate Cells in the Fibrotic Liver
Ezhilarasan, D., Thangavelu, L. P., & Raut, B. (2021) · Journal of Nanomaterials · doi:10.1155/2021/4674046 · Cited by 13 · see citing works
Self-citationSrivarsan, R., Sridevi, G., & Preetha, S. (2021) · Journal of Pharmaceutical Research International · doi:10.9734/jpri/2021/v33i47b33150 · Cited by 10 · see citing works
Rifaath, M. (2022) · Bioinformation · doi:10.6026/97320630018289 · Cited by 10 · see citing works
Ku, G. D. L. C., Aizpuru, M., Hackl, H., Ubl, D. S., Habermann, E. B., Pery, R., Driedger, M. R., Assinger, A., Nagorney, D. M., Cleary, S. P., et al. (2022) · HPB · doi:10.1016/j.hpb.2022.02.009 · Cited by 9 · see citing works
Hepatoprotective effect of Artichoke (Cynara scolymus) in laying hens
Ürüşan, H. (2023) · Journal of the Hellenic Veterinary Medical Society · doi:10.12681/jhvms.28954 · Cited by 9 · see citing works
Nataraj, K., Schonfeld, M. P., Rodriguez, A., & Tikhanovich, I. (2024) · Hepatology Communications · doi:10.1097/hc9.0000000000000428 · Cited by 9 · see citing works
Xu, J., Xu, Z.-X., Yang, Q.-F., Zhuang, J., Zhu, X. J., & Yao, J. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2023.1266253 · Cited by 7 · see citing works
Nodeh, H. R. Y., Farshbaf‐Khalili, A., Oskouei, B. S., Jafarilar, N., Kazemi-Zanjani, N., & Pourzeinali, S. (2022) · Health Care For Women International · doi:10.1080/07399332.2022.2117815 · Cited by 7 · see citing works
Liang, M., Ye, S., Jing, R., Zhu, B., Yuan, W., Chu, X., Li, Y., & Zhang, W. (2023) · Environmental Toxicology · doi:10.1002/tox.23906 · Cited by 7 · see citing works
Reddy, C. S. S. (2022) · Bioinformation · doi:10.6026/97320630018337 · Cited by 7 · see citing works
Estrogen receptor-α ablation reverses muscle fibrosis and inguinal hernias
Potluri, T., You, T., Yin, P., Coon, J. S., Stulberg, J. J., Dai, Y. D., Escobar, D., Lieber, R. L., Zhao, H., & Bulun, S. E. (2025) · Journal of Clinical Investigation · doi:10.1172/jci179137 · Cited by 6 · see citing works
Irfan, M., Ahmad, R., Ahmed, M. S., Khan, A. M., Aamir, Z., Imran, R., & Ahmed, R. (2025) · Life · doi:10.3390/life15060852 · Cited by 6 · see citing works
Gao, B., Wang, Y., Li, C., & Lu, S. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1114717 · Cited by 6 · see citing works
Li, K., Qi, Z., Xie, Z., Li, W., Yang, X., Zhai, Y., Zhou, X., Xie, X., & Song, W. (2024) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2024.135379 · Cited by 6 · see citing works
The gut‐immune‐liver axis in patients with alcohol use disorder and clinically low serum zinc levels
Thakurdesai, A., Jha, S. K., Erinkitola, I., Said, A., Joshi, T., Schwandt, M. L., Parajuli, D., Singal, A. K., Kong, M., Cave, M. C., et al. (2024) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.15408 · Cited by 6 · see citing works
Deciphering the toxicological role of Porphyromonas gingivalis derived endotoxins in liver diseases
Ezhilarasan, D. (2021) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2021.103755 · Cited by 6 · see citing works
Self-citationSelvaraj, K. (2022) · Bioinformation · doi:10.6026/97320630018331 · Cited by 6 · see citing works
Nanoparticle-based systems for liver therapy: Overcoming fibrosis and enhancing drug efficacy
Armillotta, M. G., Lizzi, L., & Massimi, M. (2025) · World Journal of Hepatology · doi:10.4254/wjh.v17.i10.108810 · Cited by 7 · see citing works
Qiu, Q., Xiaohong, C. H. E. N., Pan, S., & Jin, M. (2022) · Chinese Journal of Chromatography · doi:10.3724/sp.j.1123.2022.01017 · Cited by 5 · see citing works
Hui, Q., Du, X., Li, M., Liu, S., Wang, Z., Song, S., Gao, Y., Yang, Y., Zhou, C., & Li, Y. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1552150 · Cited by 5 · see citing works
Hou, X., Mao, Z., Song, X., Li, R., Liao, W., Kang, N., Zhang, C., Liu, X., Chen, R., Huo, W., et al. (2023) · Environmental Science and Pollution Research · doi:10.1007/s11356-023-28337-8 · Cited by 5 · see citing works
de Andrade, D. C., Monteiro, S. A., de Oliveira, T. E., & Merib, J. (2024) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-024-05560-x · Cited by 5 · see citing works
Effects of COVID-19 on the liver: The experience of a single center
Liakina, V., Stundienė, I., Milaknytė, G., Bytautiene, R., Reivytyte, R., Puronaitė, R., Urbanoviciute, G., & Kazėnaitė, E. (2022) · World Journal of Gastroenterology · doi:10.3748/wjg.v28.i39.5735 · Cited by 4 · see citing works
Serum vitamin D is associated with ultrasound-defined hepatic fibrosis
Jiang, R., Zhou, Y., Han, L., & Hong, Z. (2023) · Clinics and Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2023.102228 · Cited by 4 · see citing works
Ji, Y., Wang, Y., Liu, Y., Liu, Y., Qin, J., Yuan, D., & Liu, Q. (2024) · Scientific Reports · doi:10.1038/s41598-024-78752-1 · Cited by 4 · see citing works
Kang, C., Fan, R., Xiao, H., & Wang, X. (2022) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.9345 · Cited by 4 · see citing works
Jayachandran, S. (2022) · Bioinformation · doi:10.6026/97320630018299 · Cited by 4 · see citing works
Benzopyrene Aggravates Nonalcoholic Liver Fatty Diseases in Female Mice Via the AHR/ERα Axis
Wu, Y., Xie, J., Tao, Q., Tan, L., Zhu, X., & Yong, J. (2025) · Current Molecular Medicine · doi:10.2174/0115665240338923241219152329 · Cited by 3 · see citing works
Ma, C., Zhang, X., Zhang, W., Duan, J., & Yang, H. (2025) · Medicine · doi:10.1097/md.0000000000043395 · Cited by 3 · see citing works
Tzoupis, H., Papadourakis, M., Papavasileiou, K. D., Burk, O., Lauschke, V. M., Tsoumanis, A., Melagraki, G., & Afantitis, A. (2025) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.5c01437 · Cited by 3 · see citing works
Estimation of Tactile Sensation by Two Point Discrimination among 18 Years Old People
Maheswari, K. U., Devi, R. G., & Priya, A. J. (2021) · Journal of Pharmaceutical Research International · doi:10.9734/jpri/2021/v33i47b33135 · Cited by 3 · see citing works
Ruhina, A., & Sridevi, G. (2021) · Journal of Pharmaceutical Research International · doi:10.9734/jpri/2021/v33i47b33132 · Cited by 3 · see citing works
Binigha, M., Devi, R. G., Selavaraj, J., & Priya, A. J. (2021) · Journal of Pharmaceutical Research International · doi:10.9734/jpri/2021/v33i47b33161 · Cited by 3 · see citing works
In-vitro Antidiabetic on leaf extracts of Mimosa pudica and Euphorbia hirta - A Comparative Study
Prakasam, N. V., Gayatri Devi., R., Jayaraman, S., & Priya, A. J. (2022) · Research Journal of Pharmacy and Technology · doi:10.52711/0974-360x.2022.00920 · Cited by 3 · see citing works
Reference ranges for liver function tests in pregnancy controlling for maternal characteristics
Judah, H., Rigby, R. A., Stasinopoulos, M. D., Pateras, K., Rahim, M. N., Heneghan, M. A., Nicolaides, K. H., & Kametas, N. A. (2025) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2025.06.056 · Cited by 2 · see citing works
Samudhrasri, S., Sridevi, G., & Preetha, S. (2021) · Journal of Pharmaceutical Research International · doi:10.9734/jpri/2021/v33i47b33216 · Cited by 2 · see citing works
A Comparative Study to assess the Stress Buster among Working and Non-Working Women
Hinaz, Z. F., Devi, R. G., & Priya, A. J. (2021) · Journal of Pharmaceutical Research International · doi:10.9734/jpri/2021/v33i47b33165 · Cited by 2 · see citing works
Evaluation of respiratory function among homemakers exposed to indoor air pollution
Raja, D., & Sridevi, G. (2022) · Journal of Advanced Pharmaceutical Technology amp Research · doi:10.4103/japtr.japtr_193_22 · Cited by 2 · see citing works
Biochemical and Histological Effects of Long-Term Administration of Estrogen on Female Mice
Hussen, T. J., AL‐Shaeli, S. J. J., Al-Mahna, B. H. R., & Gharban, H. A. J. (2024) · Advances in Animal and Veterinary Sciences · doi:10.17582/journal.aavs/2024/12.8.1563.1572 · Cited by 2 · see citing works
Knowledge, Attitude and Awareness on Effect of Air Pollution on Children among Parents
Krishna, B. A., Devi, R. G., & Priya, A. J. (2021) · Journal of Pharmaceutical Research International · doi:10.9734/jpri/2021/v33i47b33134 · Cited by 2 · see citing works
Knowledge and Awareness about the Connection between Lifestyle and Dementia among Adolescents
Arora, D., Devi, R. G., & Priya, A. J. (2021) · Journal of Pharmaceutical Research International · doi:10.9734/jpri/2021/v33i47b33130 · Cited by 1 · see citing works
Tousson, E., El‐Atrash, A., Abdelrasol, M. Y., & Ghoneim, A. I. (2026) · Scientific Reports · doi:10.1038/s41598-026-45548-4 · Cited by 1 · see citing works
Harshini, S. S., Sridevi, G., & Preetha, S. (2021) · Journal of Pharmaceutical Research International · doi:10.9734/jpri/2021/v33i47b33204 · Cited by 1 · see citing works
Blessy, S., Devi, R. G., Selvaraj, J., & Priya, A. J. (2021) · Journal of Pharmaceutical Research International · doi:10.9734/jpri/2021/v33i60b34884 · Cited by 1 · see citing works
Mahdi, D. (2022) · International Multi-Disciplinary Conference: Integrated Sciences and Technologies (IMDC-IST) · doi:10.4108/eai.7-9-2021.2315367 · Cited by 1 · see citing works
Letter: Lubiprostone Treatment for MASLD —Gender Imbalance and Blinding Considerations
Li, J., & Shen, Q. (2025) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.70089 · Cited by 1 · see citing works
Dhivya, S., Devi, R. G., Selvaraj, J., & Priya, A. J. (2021) · Journal of Pharmaceutical Research International · doi:10.9734/jpri/2021/v33i47b33158 · Cited by 1 · see citing works
Sujitha, V. S., & Sridevi, G. (2021) · Journal of Pharmaceutical Research International · doi:10.9734/jpri/2021/v33i60b34942 · Cited by 1 · see citing works
Chen, T. (2023) · Applied Ecology and Environmental Research · doi:10.15666/aeer/2105_46054614 · Cited by 1 · see citing works
Abdullah, M. A., Al-Akayshee, R. J., & Lafta, K. B. (2023) · AL-Kindy College Medical Journal · doi:10.47723/kcmj.v19i3.1058 · Cited by 1 · see citing works
Aberrant medial entorhinal cortex dynamics link tau pathology to spatial memory impairmentPreprint
Malone, T. J., Cekada, K., Tyan, J., Chen, L., Wang, G., & Gu, Y. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.30.696887 · Cited by 1 · see citing works
Mukka, S., Sridevi, G., & Preetha, S. (2021) · Journal of Pharmaceutical Research International · doi:10.9734/jpri/2021/v33i47b33215
Bhavesh, S., Sridevi, G., Selvaraj, J., & Preetha, S. (2021) · Journal of Pharmaceutical Research International · doi:10.9734/jpri/2021/v33i47b33159
Revathy, E., Sridevi, G., & Preetha, S. (2021) · Journal of Pharmaceutical Research International · doi:10.9734/jpri/2021/v33i47b33192
Mufeetha, Sridevi, G., & Preetha, S. (2021) · Journal of Pharmaceutical Research International · doi:10.9734/jpri/2021/v33i47b33199
Nisha, M. A., Preetha, S., Selvaraj, J., & Sridevi, G. (2021) · Journal of Pharmaceutical Research International · doi:10.9734/jpri/2021/v33i47b33167
Immanuel, J., Devi, R. G., & Priya, A. J. (2021) · Journal of Pharmaceutical Research International · doi:10.9734/jpri/2021/v33i50b33422
Evaluation of Lung Function Test in Zumba Dancers
Moharana, P., Preetha, S., Sridevi, G., & Prathap, L. (2021) · Journal of Pharmaceutical Research International · doi:10.9734/jpri/2021/v33i60b34578
Prithiksha, Devi, R. G., Selvaraj, J., & Priya, A. J. (2021) · Journal of Pharmaceutical Research International · doi:10.9734/jpri/2021/v33i60b34882
Awareness of Blood Pressure Changes during Menstrual Cycle
Joshitha, Priya, A. J., & Devi, R. G. (2021) · Journal of Pharmaceutical Research International · doi:10.9734/jpri/2021/v33i60b34826
Raj, M., Priya, A. J., & Devi, R. G. (2021) · Journal of Pharmaceutical Research International · doi:10.9734/jpri/2021/v33i60b34963
Ganesh, M. K. A., Devi, R. G., & Priya, A. J. (2021) · Journal of Pharmaceutical Research International · doi:10.9734/jpri/2021/v33i60b34855
Face Mask - Benefits and Risks during the COVID 19 among Outpatients
Sudev, S. S., Priya, A. J., & Devi, R. G. (2022) · Journal of Pharmaceutical Research International · doi:10.9734/jpri/2022/v34i45a36348
Bahrul, W. I., Murtala, B., Rauf, R., & Bachtiar, N. A. (2023) · E-Jurnal Medika Udayana · doi:10.24843/mu.2023.v12.i05.p11
Di, J., Qi, L., Liu, L., Xing, X., Liu, Y., & Xiang, C. (2024) · Expert Opinion on Drug Safety · doi:10.1080/14740338.2024.2393470
Fatty Liver in Pregnancy: Bridging the Gap Between Diagnosis and Treatment
Ningtyas, M. C., Pratiwi, L., Sutanto, H., & Vidyani, A. (2025) · Current Hepatology Reports · doi:10.1007/s11901-025-00695-6
Léon, C., Odou, M., Roquelaure, B., Lebreton, L., Ruiz, M., Schneider, C. V., Renoux, C., Evrard, A., Balduyck, M., Dechomet, M., et al. (2025) · Orphanet Journal of Rare Diseases · doi:10.1186/s13023-025-04142-z
Li, Y., Gong, J., Tan, G., Luo, H., Hu, X., & Qin, B. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1698786
Estrogens in Liver Regeneration: From Molecular Mechanisms to Clinical Translation
Oliveira, T., & Gonçalves, G. K. N. (2026) · IntechOpen eBooks · doi:10.5772/intechopen.1012571
Chen, Z. Y., Panga, M. J., Wang, X., Chen, S., & Zhao, Y. (2026) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2026.106995
Yuanze, G., Wang, F., Ganesan, K., & Chen, J. (2026) · Science China Life Sciences · doi:10.1007/s11427-025-3176-0
Liver cirrhosis among females with cystic fibrosis using hormonal contraception
Chin, J., Sarkar, M., Magaret, A., Hsu, C. Y., West, N., Walker, P., Langfelder-Schwind, E., Taylor-Cousar, J. L., Ladores, S., Hadijiliadis, D., et al. (2026) · Contraception · doi:10.1016/j.contraception.2026.111454
Xie, R., & Schöttker, B. (2026) · medRxiv · doi:10.64898/2026.04.13.26350754
Rehman, K. A., Javaid, S. S., Pirih, F., Malik, M., Tirmizi, S. U., Amin, E., Faizan, A., Bilal, Z., Khatoon, A., Afzal, E., et al. (2026) · Medicine · doi:10.1097/md.0000000000048363
Rivera, R., Castaneda, R., Sobel, T., & Andrade, M. D. H. (2026) · Springer eBooks · doi:10.1007/978-3-032-18203-6_8
Wang, Y., Zhang, N., Zhao, H., Liu, Y., Hu, M., Wang, X., Ma, P., Shaohua, W., Cao, S., Zhao, Y., et al. (2026) · Discover Oncology · doi:10.1007/s12672-026-05732-4
Delnicki, M. E., Vielee, S. T., Griffin, G., Meaza, I., Ogunsuyi, O. I., Gueye, S. F., Brownell, A., Butzke-Souza, N., Easley, J., Lü, H., et al. (2026) · Livers · doi:10.3390/livers6050090
Steatotic Liver Disease Risk Scores to Predict Cirrhosis and Hepatocellular Carcinoma
Mezzacappa, C., Tate, J. P., Torgersen, J., Skanderson, M., Taddei, T. H., & Justice, A. C. (2026) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2026.4110
- Authors
- Ezhilarasan, D.
- Affiliations
- Saveetha University (IN)
- Corresponding author
- Ezhilarasan, Devaraj
- ORCID
- Ezhilarasan, Devaraj
- Venue
- Hepatobiliary & Pancreatic Diseases International
- Publisher
- Elsevier BV
- Published
- 2020-10
- Volume
- 19
- Issue
- 5
- Pages
- 429-434
- ISSN
- 2352-9377 (ISSN-L)
- 1499-3872
- OpenAlex
- W3015240719
- Cited by
- 96
- References
- 68
- Citations by year
- 2026: 12 · 2025: 15 · 2024: 9 · 2023: 15 · 2022: 17 · 2021: 28
- FWCI
- 2.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hepatobiliary & pancreatic diseases international (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Keywords
- estrogen, chronic liver disease, estrogen receptor, estradiol, liver disease progression, liver homeostasis, premenopausal women, ovariectomy, hepatoprotection, female sex hormones
- MeSH terms
- Animals, Chronic Disease, Disease Models, Animal, Estrogens, Female, Humans, Liver, Liver Diseases, Male, Ovariectomy, Receptors, Estrogen, Signal Transduction, Hepatic Stellate Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review