Cited by 96Estrogen and related hormone effectsLiver physiology and pathologyLiver Disease Diagnosis and Treatment

Critical role of estrogen in the progression of chronic liver diseases

Ezhilarasan, Devaraj·2020·Hepatobiliary & Pancreatic Diseases International

Abstract

Background Estrogens regulate sexual function and also have a significant role in various pathophysiological processes. Estrogens have a non-reproductive role as the modulators of the immune system, growth, neuronal function, and metabolism. Estrogen receptors are expressed in the liver and their impaired expression and function are implicated with obesity and liver associated metabolic dysfunctions. The purpose of the current review is to discuss the disparity role of estrogens on several forms of liver diseases. Data sources A comprehensive search in PubMed and EMBASE was conducted using the keywords "estrogens and liver diseases", "estradiol and liver diseases", "hormones and liver diseases", "endocrine function in liver diseases", and "female hormones in liver diseases". Relevant papers published before September 30, 2019 were included. Results The present review confirms the imperative role of estrogen in various forms of chronic liver diseases. Estrogens play a key role in maintaining homeostasis and make the liver less susceptible to several forms of chronic liver diseases in healthy premenopausal individuals. In contrast, clinical studies also showed increased estrogen levels with chronic liver diseases. Conclusions Several studies reported the protective role of estrogens in chronic liver diseases and this has been widely accepted and confirmed in experimental studies using ovariectomized rat models. However, in a few clinical studies, increased estrogen levels are also implicated in chronic liver diseases. Therefore, further studies are warranted at molecular level to explore the role of estrogen in various forms of chronic liver diseases.

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Crossref · 10.1016/j.hbpd.2020.03.011

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Authors
Ezhilarasan, D.
Affiliations
Saveetha University (IN)
Corresponding author
Ezhilarasan, Devaraj
Venue
Hepatobiliary & Pancreatic Diseases International
Publisher
Elsevier BV
Published
2020-10
Volume
19
Issue
5
Pages
429-434
ISSN
  • 2352-9377 (ISSN-L)
  • 1499-3872
OpenAlex
W3015240719
Cited by
96
References
68
Citations by year
2026: 12 · 2025: 15 · 2024: 9 · 2023: 15 · 2022: 17 · 2021: 28
FWCI
2.14
Type
journal article
Language
en
Open access
closed
Locations
  • Hepatobiliary & pancreatic diseases international (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
  • Health Sciences › Medicine › Hepatology › Liver physiology and pathology
  • Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
Keywords
estrogen, chronic liver disease, estrogen receptor, estradiol, liver disease progression, liver homeostasis, premenopausal women, ovariectomy, hepatoprotection, female sex hormones
MeSH terms
Animals, Chronic Disease, Disease Models, Animal, Estrogens, Female, Humans, Liver, Liver Diseases, Male, Ovariectomy, Receptors, Estrogen, Signal Transduction, Hepatic Stellate Cells

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