The DOI matches its Crossref record; 141 of the 142 references it cites were found in a registry or an index.
Exposure-dependent effects of ethanol on the innate immune system
Open accessAbstract
Extensive evidence indicates that ethanol (alcohol) has immunomodulatory properties. Many of its effects on innate immune response are dose dependent, with acute or moderate use associated with attenuated inflammatory responses, and heavy ethanol consumption linked with augmentation of inflammation. Ethanol may modify innate immunity via functional alterations of the cells of the innate immune system. Mounting evidence indicates that ethanol can diversely affect antigen recognition and intracellular signaling events, which include activation of mitogen activated protein kinases, and NFkappaB, mediated by Toll-like receptors, leading to altered inflammatory responses. The mechanism(s) underlying these changes may involve dose-dependent effects of ethanol on the fluidity of cell membrane, resulting in interference with the timely assembly or disassembly of lipid rafts. Ethanol could also modify cell activation by specific interactions with cell membrane molecules.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The effects of chronic alcohol use on the immune response are probably also to increase the risk of infectious disease 82, 83.”
From The relationship between different dimensions of alcohol use and the burden of disease—an update (2017) · cites this paper as [83]
Citations
Cites
Coussens, L. M., & Werb, Z. (2002) · Nature · doi:10.1038/nature01322 · Cited by 15,111
Janeway, C. A., & Medzhitov, R. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.083001.084359 · Cited by 8,394
Inflammation in atherosclerosis
Libby, P. (2002) · Nature · doi:10.1038/nature01323 · Cited by 8,315
Takeda, K., Kaisho, T., & Akira, S. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141126 · Cited by 6,143
ROLE OF CYTOKINES IN RHEUMATOID ARTHRITIS
Feldmann, M., Brennan, F. M., & Maini, R. N. (1996) · Annual Review of Immunology · doi:10.1146/annurev.immunol.14.1.397 · Cited by 2,507
NF-κB functions as a tumour promoter in inflammation-associated cancer
Pikarsky, E., Porat, R. M., Stein, I., Abramovitch, R., Amit, S., Kasem, S., Gutkovich-Pyest, E., Urieli-Shoval, S., Galun, E., & Ben‐Neriah, Y. (2004) · Nature · doi:10.1038/nature02924 · Cited by 2,423
Kawai, T., & Akira, S. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401850 · Cited by 1,894
Rimm, E. B., Williams, P., Fosher, K., Criqui, M., & Stampfer, M. J. (1999) · BMJ · doi:10.1136/bmj.319.7224.1523 · Cited by 1,360
Lipid rafts: bringing order to chaos
PIKE, L. J. (2003) · Journal of Lipid Research · doi:10.1194/jlr.r200021-jlr200 · Cited by 1,139
Systemic infections and inflammation affect chronic neurodegeneration
Perry, V. H., Cunningham, C., & Holmes, C. (2007) · Nature Reviews Immunology · doi:10.1038/nri2015 · Cited by 1,027
Flagged first, then by citations
1 of the 142 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 101–150 of 150
Characteristic Analysis of Peripheral Blood Mononuclear Cell Apoptosis in Coke Oven Workers
Zhang, H., Nie, J. S., Li, X., & Niu, Q. L. (2011) · Journal of Occupational Health · doi:10.1539/joh.11-0155-oa · Cited by 6
Evaluation of Some Immunoregulatory Cytokines in Serum of Rats Exposed to Cadmium and Ethanol
Moniuszko-Jakoniuk, J., Jurczuk, M., & Gałażyn-Sidorczuk, M. (2009) · Polish Journal of Environmental Studies · Cited by 6
Alcohol Effects on TNF-α and IL-10 Production in an Ex-Vivo Model of Whole Blood Stimulated by LPS
Gavala, A., Myrianthefs, P. M., & Venetsanou, K. (2015) · Journal of psychiatry · doi:10.4172/2378-5756.1000339 · Cited by 6
Moreno, M. C., Lewis, J. B., Kovacs, E. J., & Lowery, E. M. (2018) · Alcohol · doi:10.1016/j.alcohol.2018.11.003 · Cited by 6
Self-citationHumoral immune response to phosphatidylethanol
Nissinen, A. E. T. (2011) · Cited by 6
DIABETES MELLITUS, OBESIDADE E MAUS HÁBITOS DE VIDA: SUA RELAÇÃO COM A COVID-19
Monteiro, A. R., Barros, L. A. D. S., Albernaz, P. C. S., Vieira, V. B. D. A., Barroso, V. D. D. M. P., & Rodrigues, M. C. D. C. (2020) · Revista Científica da Faculdade de Medicina de Campos · doi:10.29184/1980-7813.rcfmc.377.vol.15.n2.2020 · Cited by 5
Xu, H., Qiao, L.-J., Fang, S., Ren, Z., Wu, G., Zheng, Y., Yang, B., & Zhao, Y. (2022) · Sao Paulo Medical Journal · doi:10.1590/1516-3180.2021.0075.r1.14092021 · Cited by 5
Hashemi, H., Ghareghani, S., Nasimi, N., Shahbazi, M., Derakhshan, Z., & Sarkodie, S. A. (2022) · Sustainability · doi:10.3390/su142013614 · Cited by 5
Raju, S. V., Painter, R. G., Bagby, G., Nelson, S., & Wang, G. (2013) · Medical Sciences · doi:10.3390/medsci1010002 · Cited by 5
Effects of acute ethanol intoxication in an ovine peritonitis model
Hosokawa, K., Su, F., Taccone, F. S., Post, E. H., Créteur, J., & Vincent, J. (2018) · BMC Anesthesiology · doi:10.1186/s12871-018-0537-1 · Cited by 5
Alcohol & cancer: Evidence to action
Mehrotra, R., Kapahtia, S., Kaur, T., Priyanka, K., & Dhaliwal, R. S. (2022) · International Journal of Microbiology Research · doi:10.4103/ijmr.ijmr_4037_20 · Cited by 4
Khair, S., Walrath, T., Curtis, B. J., Orlicky, D. J., McMahan, R. H., & Kovacs, E. J. (2023) · Burns · doi:10.1016/j.burns.2023.07.008 · Cited by 4
Self-citationÁrnyas, E. M., Pál, L., Kovács, C., Ádány, R., McKee, M., & Szűcs, S. (2012) · Immunopharmacology and Immunotoxicology · doi:10.3109/08923973.2012.663387 · Cited by 4
The effect of the products of ethanol metabolism on the liver – a review
Kołota, A. (2018) · Alcoholism and Drug Addiction · doi:10.5114/ain.2018.81664 · Cited by 4
Reduction of Cell Proliferation by Acute C2H6O Exposure
Baldari, S., Manni, I., Rocco, G. D., Paolini, F., Palermo, B., Piaggio, G., & Toietta, G. (2021) · Cancers · doi:10.3390/cancers13194999 · Cited by 4
Summary of the 2016 Alcohol and Immunology Research Interest Group (AIRIG) meeting
Boulé, L. A., Ju, C., Agudelo, M., Parira, T., Cannon, A. R., Davis, B. T., Eby, J. M., Cresci, G., Samuelson, D. R., Shukla, P. K., et al. (2017) · Alcohol · doi:10.1016/j.alcohol.2017.07.005 · Cited by 3
Self-citationEffect of chronic ethanol consumption in female rats subjected to experimental sepsis
Castro, C. L. C., Nemer, A. S. D. A., Castro-Faria-Neto, H. C., Barros, F. R., da Rocha, E. M. D. S., & Fonseca, V. A. D. S. (2013) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x20133189 · Cited by 3
Is ethanol consumption beneficial for oral lichen planus?
Xu, X., Chen, D., Mei, L., & Deng, H. (2009) · Medical Hypotheses · doi:10.1016/j.mehy.2008.10.029 · Cited by 3
Hu, T. M., Subeq, Y. M., Yang, F. L., Hsu, B. G., Lin, N. T., & Lee, R. P. (2013) · Journal of Psychopharmacology · doi:10.1177/0269881113494938 · Cited by 3
Chang, S. L., & Liu, X. (2012) · Springer eBooks · doi:10.1007/978-1-4614-4729-0_15 · Cited by 3
Hu, Y., Patial, S., Saini, Y., & Yoshimura, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252312831 · Cited by 2
Togre, N. S., Bhoj, P. S., Mekala, N. K., Trivedi, J., Winfield, M., Hancock, R. E., Sriram, U., Rom, S., & Persidsky, Y. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27052332 · Cited by 2
Metabolites of Aliphatic Alcohols Detected in Alcoholic Beverages Inhibit Phagocytosis
Árnyas, E. M., Pál, L., Baranyi, G., Bujdosó, O., Rácz, G., Ádány, R., McKee, M., & Szűcs, S. (2015) · Alcohol and Alcoholism · doi:10.1093/alcalc/agv132 · Cited by 2
Systemic immune modulation induced by alcoholic beverage intake in obese-diabetes (db/db) mice
Lee, H.-A., Jang, I., Park, J., Kim, S.-H., Baek, S.-Y., Go, S.-H., & Lee, S. (2012) · Food and Chemical Toxicology · doi:10.1016/j.fct.2012.12.014 · Cited by 2
Effects of Low-level Laser Therapy on Muscle Repair in Rats with Chronic Alcohol Intake
Céspedes, I. C., Assis, L., Thomaz, R. M., Panfílio, C. E., Gonçalves, L. C. O., & Muniz, A. C. R. (2018) · Brazilian Archives of Biology and Technology · doi:10.1590/1678-4324-2018161223 · Cited by 2
Naccache, R., Scemama, U., Ahmadi, A.-A. E., Habert, P., Zieleskiewicz, L., Chaumoître, K., Michelet, P., Varoquaux, A. D., & Biscéglie, M. D. (2023) · European Journal of Radiology · doi:10.1016/j.ejrad.2023.111278 · Cited by 1
Kong, L., Li, G., Yang, P., Wu, W., Jin-he, S., Li, X., & Wang, W. (2014) · Molecular Biology Reports · doi:10.1007/s11033-014-3731-3 · Cited by 1
RetractedJimenez, V. M., Jr., & Monroy, F. P. (2019) · BIO-PROTOCOL · doi:10.21769/bioprotoc.3143 · Cited by 1
Nebulized Ethanol: An Old Treatment for a New Disease
Stogner, S. W. (2023) · IntechOpen eBooks · doi:10.5772/intechopen.111695 · Cited by 1
Hormetic Responses to Ethanol Ingestion
Korthuis, R. J. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-814253-0.00009-7 · Cited by 1
Kong, L., Li, G., Yang, P., Wu, W., Jin-he, S., Li, X., & Wang, W. (2015) · Molecular Biology Reports · doi:10.1007/s11033-015-3873-y · Cited by 1
RetractedAutoimmune Liver Diseases in Canterbury, New Zealand
Ngu, J. H. (2013) · Otago University Research Archive (University of Otago) · Cited by 1
Alcohol and Cancer: Biological Basis
Singletary, K. W. (2010) · Humana Press eBooks · doi:10.1007/978-1-60761-627-6_31
Aiche, S. (2011) · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver · doi:10.17169/refubium-12738
Study of ethanol metabolism in mouse brain
Patel, D. C. (2010) · doi:10.17760/d20000275
Alcoholism as a factor of development and spread of diseases (analytical review)
Курылев, Валентинович, К. В., Успенская, Uspenskaya, O. S., Потемина, Потемина, Т. Е., Шевченко, Shevchenko, E., Рудая, & Рудая, П. О. (2015) · Journal of New Medical Technologies · doi:10.12737/7592
Banton, M. E. (2017) · UCL Discovery (University College London)
Mécanismes d'immunomodulation par les alcanols aliphatiques
Carignan, D. (2013) · Corpus Université Laval (Université Laval)
Pál, L., Bujdosó, O., McKee, M., Sándor, J., & Szűcs, S. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00728
Коротина, О. Л., Zubareva, I. M., Yupatov, Y., Моисеев, Д. В., & Generalov, I. I. (2013) · Immunopathology Allergology Infectology · doi:10.14427/jipai.2013.3.10
Crichton, R. R., & Ward, R. J. (2013) · Wiley eBooks · doi:10.1002/9781118553480.ch12
Higher Alcohol Consumption Is Not Linked To Higher SARS CoVid19 Infection and DeathPreprint
Mohanta, Y. K., Hashem, A., Allah, E. F. A., & Mohanta, T. K. (2020) · doi:10.21203/rs.3.rs-30073/v1
Jin, Y. J., Han, Y. E., & Choi, H. G. (2020) · Figshare · doi:10.6084/m9.figshare.12150957
Wang, X., Bu, H.-F., Zhong, W., Asai, A., Zhou, Z., & Tan, X.-D. (2013) · Figshare · doi:10.6084/m9.figshare.7194260
Jin, Y. J., Han, Y. E., & Choi, H. G. (2020) · Figshare · doi:10.6084/m9.figshare.12150963
Harrop, C., Clark, N., Darby, R., James, D., Quimby, S., Black, B., Tran, V., Ostrom, E. L., Traustadóttir, T., Monroy, F. P., et al. (2026) · Medicines · doi:10.3390/medicines13010008
Alcohol-Derived Changes in Pain-Related Pathways in Crohn’s Disease
Amodeo, G., Franchi, S., Galimberti, G., Riboldi, B., Braganti, C., Ceruti, S., & Sacerdote, P. (2026) · Springer eBooks · doi:10.1007/978-3-031-35658-2_34-1
Oczkowski, M., Kołota, A., Barański, M., & Gromadzka-Ostrowska, J. (2015) · Alcoholism and Drug Addiction · doi:10.1016/j.alkona.2015.06.002
Metadata
- Authors
- Goral, J., Karavitis, J., & Kovacs, E. J.
- Affiliations
- Loyola University Medical Center (US)
- Corresponding author
- Kovacs, Elizabeth J.
- ORCID
- Kovacs, Elizabeth J.
- Venue
- Alcohol
- Publisher
- Elsevier BV
- Published
- 2008-06
- Volume
- 42
- Issue
- 4
- Pages
- 237-247
- ISSN
- 0741-8329 (ISSN-L)
- PMC
- PMC2453223
- OpenAlex
- W2076165862
- Cited by
- 152
- References
- 142
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 5 · 2022: 5 · 2021: 4 · 2020: 12 · 2019: 4 · 2018: 10 · 2017: 15 · 2016: 8 · 2015: 12 · 2014: 9 · 2013: 18 · 2012: 18
- FWCI
- 1.09
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Alcohol (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (F31AA017027, T32AA013527, R01AA012034)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
- Keywords
- ethanol, innate immunity, immunomodulation, inflammation, Toll-like receptors, NF-κB, MAPK signaling, lipid rafts, membrane fluidity, dose-dependent effects, heavy alcohol consumption, antigen recognition
- MeSH terms
- Alcohol Drinking, Ethanol, Animals, Dose-Response Relationship, Drug, Humans, Immunity, Innate, Immunologic Factors, Inflammation, Membrane Fluidity, Phagocytes, Phagocytosis, Signal Transduction, Inflammation Mediators, Membrane Microdomains, Toll-Like Receptors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
