The DOI matches its Crossref record; 141 of the 142 references it cites were found in a registry or an index.
Exposure-dependent effects of ethanol on the innate immune system
Open accessAbstract
Extensive evidence indicates that ethanol (alcohol) has immunomodulatory properties. Many of its effects on innate immune response are dose dependent, with acute or moderate use associated with attenuated inflammatory responses, and heavy ethanol consumption linked with augmentation of inflammation. Ethanol may modify innate immunity via functional alterations of the cells of the innate immune system. Mounting evidence indicates that ethanol can diversely affect antigen recognition and intracellular signaling events, which include activation of mitogen activated protein kinases, and NFkappaB, mediated by Toll-like receptors, leading to altered inflammatory responses. The mechanism(s) underlying these changes may involve dose-dependent effects of ethanol on the fluidity of cell membrane, resulting in interference with the timely assembly or disassembly of lipid rafts. Ethanol could also modify cell activation by specific interactions with cell membrane molecules.
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“The effects of chronic alcohol use on the immune response are probably also to increase the risk of infectious disease 82, 83.”
From The relationship between different dimensions of alcohol use and the burden of disease—an update (2017) · cites this paper as [83]
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Coussens, L. M., & Werb, Z. (2002) · Nature · doi:10.1038/nature01322 · Cited by 15,111
Janeway, C. A., & Medzhitov, R. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.083001.084359 · Cited by 8,394
Inflammation in atherosclerosis
Libby, P. (2002) · Nature · doi:10.1038/nature01323 · Cited by 8,315
Takeda, K., Kaisho, T., & Akira, S. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141126 · Cited by 6,143
ROLE OF CYTOKINES IN RHEUMATOID ARTHRITIS
Feldmann, M., Brennan, F. M., & Maini, R. N. (1996) · Annual Review of Immunology · doi:10.1146/annurev.immunol.14.1.397 · Cited by 2,507
NF-κB functions as a tumour promoter in inflammation-associated cancer
Pikarsky, E., Porat, R. M., Stein, I., Abramovitch, R., Amit, S., Kasem, S., Gutkovich-Pyest, E., Urieli-Shoval, S., Galun, E., & Ben‐Neriah, Y. (2004) · Nature · doi:10.1038/nature02924 · Cited by 2,423
Kawai, T., & Akira, S. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401850 · Cited by 1,894
Rimm, E. B., Williams, P., Fosher, K., Criqui, M., & Stampfer, M. J. (1999) · BMJ · doi:10.1136/bmj.319.7224.1523 · Cited by 1,360
Lipid rafts: bringing order to chaos
PIKE, L. J. (2003) · Journal of Lipid Research · doi:10.1194/jlr.r200021-jlr200 · Cited by 1,139
Systemic infections and inflammation affect chronic neurodegeneration
Perry, V. H., Cunningham, C., & Holmes, C. (2007) · Nature Reviews Immunology · doi:10.1038/nri2015 · Cited by 1,027
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The relationship between different dimensions of alcohol use and the burden of disease—an update
Rehm, J., Gmel, G. E., Gmel, G., Hasan, O. S. M., Imtiaz, S., Popova, S., Probst, C., Roerecke, M., Room, R., Samokhvalov, A. V., et al. (2017) · Addiction · doi:10.1111/add.13757 · Cited by 1,204
Drexhage, R. C., Knijff, E. M., Padmos, R. C., Heul-Nieuwenhuijzen, L. V. D., Beumer, W., Versnel, M. A., & Drexhage, H. A. (2010) · Expert Review of Neurotherapeutics · doi:10.1586/ern.09.144 · Cited by 263
Grahl, N., Puttikamonkul, S., Macdonald, J. M., Gamcsik, M. P., Ngo, L. Y., Hohl, T. M., & Cramer, R. A. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1002145 · Cited by 217
Community-acquiredAcinetobacter baumannii: clinical characteristics, epidemiology and pathogenesis
Dexter, C., Murray, G. L., Paulsen, I. T., & Peleg, A. Y. (2015) · Expert Review of Anti-infective Therapy · doi:10.1586/14787210.2015.1025055 · Cited by 198
Chen, A. I., Dolben, E. F., Okegbe, C., Harty, C. E., Golub, Y., Thao, S., Ha, D. G., Willger, S. D., O’Toole, G. A., Harwood, C. S., et al. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004480 · Cited by 181
Metadata
- Authors
- Goral, J., Karavitis, J., & Kovacs, E. J.
- Affiliations
- Loyola University Medical Center (US)
- Corresponding author
- Kovacs, Elizabeth J.
- ORCID
- Kovacs, Elizabeth J.
- Venue
- Alcohol
- Publisher
- Elsevier BV
- Published
- 2008-06
- Volume
- 42
- Issue
- 4
- Pages
- 237-247
- ISSN
- 0741-8329 (ISSN-L)
- PMC
- PMC2453223
- OpenAlex
- W2076165862
- Cited by
- 152
- References
- 142
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 5 · 2022: 5 · 2021: 4 · 2020: 12 · 2019: 4 · 2018: 10 · 2017: 15 · 2016: 8 · 2015: 12 · 2014: 9 · 2013: 18 · 2012: 18
- FWCI
- 1.09
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Alcohol (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (F31AA017027, T32AA013527, R01AA012034)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
- Keywords
- ethanol, innate immunity, immunomodulation, inflammation, Toll-like receptors, NF-κB, MAPK signaling, lipid rafts, membrane fluidity, dose-dependent effects, heavy alcohol consumption, antigen recognition
- MeSH terms
- Alcohol Drinking, Ethanol, Animals, Dose-Response Relationship, Drug, Humans, Immunity, Innate, Immunologic Factors, Inflammation, Membrane Fluidity, Phagocytes, Phagocytosis, Signal Transduction, Inflammation Mediators, Membrane Microdomains, Toll-Like Receptors
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