Cited by 152Alcohol Consumption and Health EffectsImmune Response and InflammationImmunotoxicology and immune responses

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Exposure-dependent effects of ethanol on the innate immune system

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Goral, Joanna, Karavitis, John, Kovacs, Elizabeth J.·2008·Alcohol

DOI 10.1016/j.alcohol.2008.02.003PMC PMC2453223

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Abstract

Extensive evidence indicates that ethanol (alcohol) has immunomodulatory properties. Many of its effects on innate immune response are dose dependent, with acute or moderate use associated with attenuated inflammatory responses, and heavy ethanol consumption linked with augmentation of inflammation. Ethanol may modify innate immunity via functional alterations of the cells of the innate immune system. Mounting evidence indicates that ethanol can diversely affect antigen recognition and intracellular signaling events, which include activation of mitogen activated protein kinases, and NFkappaB, mediated by Toll-like receptors, leading to altered inflammatory responses. The mechanism(s) underlying these changes may involve dose-dependent effects of ethanol on the fluidity of cell membrane, resulting in interference with the timely assembly or disassembly of lipid rafts. Ethanol could also modify cell activation by specific interactions with cell membrane molecules.

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Authors: Goral, J., Karavitis, J., & Kovacs, E. J.
Affiliations: Loyola University Medical Center (US)
Corresponding author: Kovacs, Elizabeth J.
ORCID: Kovacs, Elizabeth J.
Venue: Alcohol
Publisher: Elsevier BV
Published: 2008-06
Volume: 42
Issue: 4
Pages: 237-247
ISSN: 0741-8329 (ISSN-L)
DOI: 10.1016/j.alcohol.2008.02.003
PMC: PMC2453223
OpenAlex: W2076165862
Cited by: 152
References: 142
Citations by year: 2026: 2 · 2025: 1 · 2024: 1 · 2023: 5 · 2022: 5 · 2021: 4 · 2020: 12 · 2019: 4 · 2018: 10 · 2017: 15 · 2016: 8 · 2015: 12 · 2014: 9 · 2013: 18 · 2012: 18
FWCI: 1.09
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Alcohol (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Alcohol Abuse and Alcoholism (F31AA017027, T32AA013527, R01AA012034)
Topics: Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
Keywords: ethanol, innate immunity, immunomodulation, inflammation, Toll-like receptors, NF-κB, MAPK signaling, lipid rafts, membrane fluidity, dose-dependent effects, heavy alcohol consumption, antigen recognition
MeSH terms: Alcohol Drinking, Ethanol, Animals, Dose-Response Relationship, Drug, Humans, Immunity, Innate, Immunologic Factors, Inflammation, Membrane Fluidity, Phagocytes, Phagocytosis, Signal Transduction, Inflammation Mediators, Membrane Microdomains, Toll-Like Receptors

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Exposure-dependent effects of ethanol on the innate immune system

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