Cited by 151Gut microbiota and healthAsthma and respiratory diseasesProbiotics and Fermented Foods

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Reduced Akkermansia muciniphila and Faecalibacterium prausnitzii levels in the gut microbiota of children with allergic asthma

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Demirci, M., Tokman, H.B., Uysal, H.K., Demiryas, S., Karakullukcu, A., Saribas, S., Cokugras, H., Kocazeybek, B.S.·2019·Allergologia et Immunopathologia

DOI 10.1016/j.aller.2018.12.009

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Abstract

INTRODUCTION AND OBJECTIVES: The amounts of Akkermansia muciniphila and Faecalibacterium prausnitzii in gut microbiota are reduced in patients with allergic diseases compared to healthy controls. We aimed to quantify levels of A. muciniphila and F. prausnitzii amounts using real-time quantitative PCR (qPCR) in the gut microbiota of children with allergic asthma and in healthy controls. MATERIALS AND METHODS: In total, 92 children between the ages of three and eight who were diagnosed with asthma and 88 healthy children were included in the study and bacterial DNA was isolated from the stool samples using the stool DNA isolation Kit. qPCR assays were studied with the microbial DNA qPCR Kit for A. muciniphila and microbial DNA qPCR Kit for F. prausnitzii. RESULTS: Both bacterial species showed a reduction in the patient group compared to healthy controls. A. muciniphila and F. prausnitzii were found to be 5.45±0.004, 6.74±0.01 and 5.71±0.002, 7.28±0.009 in the stool samples of the asthma and healthy control groups, respectively. CONCLUSIONS: F. prausnitzii and A. muciniphila may have induced anti-inflammatory cytokine IL-10 and prevented the secretion of pro-inflammatory cytokines like IL-12. These findings suggest that A. muciniphila and F. prausnitzii may suppress inflammation through its secreted metabolites.

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Authors: Demirci, M., Tokman, H. B., Uysal, H. K., Demiryas, S., Karakullukcu, A., Saribas, S., Cokugras, H., & Kocazeybek, B. S.
Affiliations: Istanbul University-Cerrahpaşa (TR)
Istanbul University (TR)
Corresponding author: Kocazeybek, B.S.
ORCID: Tokman, H.B.
Uysal, H.K.
Demiryas, S.
Kocazeybek, B.S.
Venue: Allergologia et Immunopathologia
Publisher: Codon Publications
Published: 2019-07
Volume: 47
Issue: 4
Pages: 365-371
ISSN: 0301-0546 (ISSN-L)
DOI: 10.1016/j.aller.2018.12.009
OpenAlex: W2914517759
Cited by: 150
References: 42
Citations by year: 2026: 16 · 2025: 27 · 2024: 30 · 2023: 17 · 2022: 27 · 2021: 15 · 2020: 12 · 2019: 5
FWCI: 4.88
Type: journal article
Language: en
Open access: gold
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Allergologia et Immunopathologia (publishedVersion)
PubMed (publishedVersion)
Beykent University Repository (submittedVersion, cc-by-nc-nd)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Keywords: Akkermansia muciniphila, Faecalibacterium prausnitzii, allergic asthma, gut microbiota, children, stool microbiome, anti-inflammatory cytokines, IL-10, IL-12, inflammation reduction, bacterial metabolites
MeSH terms: Gastrointestinal Microbiome, Faecalibacterium prausnitzii, Asthma, Child, Child, Preschool, DNA, Bacterial, Eosinophils, Feces, Female, Humans, Immunoglobulin E, Male, Probiotics, Real-Time Polymerase Chain Reaction, Verrucomicrobia

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Reduced Akkermansia muciniphila and Faecalibacterium prausnitzii levels in the gut microbiota of children with allergic asthma

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