A probiotic has differential effects on allergic airway inflammation in A/J and C57BL/6 mice and is correlated with the gut microbiome
Open accessAbstract
The phenotypes of allergic airway diseases are influenced by the interplay between host genetics and the gut microbiota, which may be modulated by probiotics. We investigated the probiotic effects on allergic inflammation in A/J and C57BL/6 mice. C57BL/6 mice had increased gut microbiota diversity compared to A/J mice at baseline. Acetate producer probiotics differentially modulated and altered the genus abundance of specific bacteria, such as Akkermansia and Allistipes, in mouse strains. We induced airway inflammation followed by probiotic treatment and found that only A/J mice exhibited decreased inflammation, and the beneficial effects of probiotics in A/J mice were partially due to acetate production. To understand the relevance of microbial composition colonization in the development of allergic diseases, we implanted female C57BL/6 mice with A/J embryos to naturally modulate the microbial composition of A/J mice, which increased gut microbiota diversity and reduced eosinophilic inflammation in A/J. These data demonstrate the central importance of microbiota to allergic phenotype severity. Video Abstract.
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Probiotic efficacy appears to be strain- and population-specific, with some strains effective in certain patient groups but not in others.
“Accordingly, probiotic efficacy appears to be strain- and population-specific, with some strains being effective in certain patient groups but not in others [92,93], and there is evidence that probiotics may increase the risk of sensitization in individuals predisposed to allergic diseases [94].”
From Current Concepts in Probiotic Safety and Efficacy (2026) · cites this paper as [93]
The Discussion (page unavailable) reports that Bifidobacterium longum 51A reduced allergic airway responses in A/J mice but did not prevent exacerbated inflammation in C57BL/6 mice, supporting host-dependent efficacy. The study tested one probiotic strain in mice; it does not establish differences among probiotic strains or efficacy in particular patient groups. (LLM, conf=0.88)
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Probiotics Mechanism of Action on Immune Cells and Beneficial Effects on Human Health
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“Accordingly, probiotic efficacy appears to be strain-and population-specific, with some strains being effective in certain patient groups but not in others [92,93], and there is evidence that probiotics may increase the risk of sensitization in individuals pre-disposed to allergic diseases [94].”
- Authors
- Casaro, M. B., Thomas, A. M., Mendes, E., Fukumori, C., Ribeiro, W. R., Oliveira, F. A., Crisma, A. R., Murata, G. M., Bizzarro, B., Sá-Nunes, A., Setubal, J. C., Mayer, M. P. A., Martins, F. S., Vieira, A. T., Antiorio, A. T. F. B., Tavares-de-Lima, W., Camara, N. O. S., Curi, R., Dias-Neto, E., & Ferreira, C. M.
- Affiliations
- Universidade Federal de São Paulo (BR)
- Universidade de São Paulo (BR)
- Universidade Federal do ABC (BR)
- Universidade Federal do Paraná (BR)
- Universidade Federal de Minas Gerais (BR)
- Universidade Cruzeiro do Sul (BR)
- Corresponding author
- Ferreira, Caroline M.
- ORCID
- Venue
- Microbiome
- Published
- 2021-06-10
- Volume
- 9
- Issue
- 1
- Pages
- 134-134
- ISSN
- 2049-2618 (ISSN-L)
- PMC
- PMC8194189
- OpenAlex
- W3166611784
- Cited by
- 24
- References
- 83
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 4 · 2023: 3 · 2022: 6 · 2021: 4
- FWCI
- 1.33
- Type
- journal article
- Language
- en
- Update notices
- correction (2021-07-14)
- Open access
- gold
- doi.org
- Locations
- Microbiome (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- FAPESP (2012/50410-8, 2019/12324-1, 2016/13496-2)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Keywords
- probiotics, allergic airway inflammation, gut microbiota, acetate production, Akkermansia, strain differences, A/J mice, C57BL/6 mice, eosinophilic inflammation, microbiota transfer, host genetics, allergic phenotype
- MeSH terms
- Gastrointestinal Microbiome, Animals, Female, Inflammation, Mice, Inbred C57BL, Respiratory System, Probiotics, Mice
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