Accuracy of the triglyceride to high-density lipoprotein cholesterol ratio for prediction of the low-density lipoprotein phenotype B

Hanak, Viktor; Munoz, Julian; Teague, Joe; Stanley, Alfred; Bittner, Vera

doi:10.1016/j.amjcard.2004.03.069

Cited by 169Lipoproteins and Cardiovascular HealthDiabetes, Cardiovascular Risks, and LipoproteinsLipid metabolism and disorders

Accuracy of the triglyceride to high-density lipoprotein cholesterol ratio for prediction of the low-density lipoprotein phenotype B

Hanak, Viktor, Munoz, Julian, Teague, Joe, Stanley, Alfred, Bittner, Vera·2004·The American Journal of Cardiology

DOI 10.1016/j.amjcard.2004.03.069

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Abstract

This study examined the accuracy of a triglyceride/high-density lipoprotein (HDL) cholesterol ratio of 3.8 for the prediction of low-density lipoprotein (LDL) phenotype B. The ratio of 3.8 was based on Adult Treatment Panel recommendations for normal fasting triglycerides (<150 mg/dl) and HDL cholesterol (>40 mg/dl). Fasting blood samples were obtained from 658 patients. LDL phenotype analysis was performed by nuclear magnetic resonance spectroscopy. A triglyceride/HDL cholesterol ratio of 3.8 divided the distribution of LDL phenotypes with 79% (95% confidence interval [CI] 74 to 83) of phenotype B greater than and 81% (95% CI 77 to 85) of phenotype A less than the ratio of 3.8. The ratio was reliable for identifying LDL phenotype B in men and women.

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The ratio of triglycerides to HDL-C is linked to small, dense LDL particles and higher LDL particle numbers.
“and to small, dense LDL particles and higher LDL particle numbers.”
From Triglycerides and Cardiovascular Disease: A Scientific Statement From the American Heart Association (2011) · cites this paper as [235]

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Authors: Hanak, V., Munoz, J., Teague, J., Stanley, A., & Bittner, V.
Affiliations: Carraway Methodist Medical Center (US)
University of Alabama at Birmingham (US)
Corresponding author: Hanak, Viktor
ORCID: Bittner, Vera
Venue: The American Journal of Cardiology
Publisher: Elsevier BV
Published: 2004-07
Volume: 94
Issue: 2
Pages: 219-222
ISSN: 0002-9149 (ISSN-L)
DOI: 10.1016/j.amjcard.2004.03.069
OpenAlex: W1981002254
Cited by: 167
References: 11
Citations by year: 2026: 1 · 2025: 3 · 2024: 6 · 2023: 3 · 2022: 10 · 2021: 12 · 2020: 9 · 2019: 12 · 2018: 9 · 2017: 7 · 2016: 6 · 2015: 17 · 2014: 9 · 2013: 13 · 2012: 13
FWCI: 3.03
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The American Journal of Cardiology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Keywords: triglyceride to HDL cholesterol ratio, LDL particle size, NMR spectroscopy, dyslipidemia, fasting triglycerides, HDL cholesterol, diagnostic accuracy
MeSH terms: Aged, Female, Humans, Cholesterol, HDL, Cholesterol, LDL, Male, Middle Aged, Magnetic Resonance Spectroscopy, Particle Size, Phenotype, Sensitivity and Specificity, Triglycerides, Logistic Models

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Accuracy of the triglyceride to high-density lipoprotein cholesterol ratio for prediction of the low-density lipoprotein phenotype B

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