Prognostic Value of Admission Myeloperoxidase Levels in Patients With ST-Segment Elevation Myocardial Infarction and Cardiogenic Shock
Abstract
Inflammation plays a critical role in acute myocardial infarction. One inflammatory marker is myeloperoxidase (MPO). Its role as a predictor of in-hospital death in patients with ST-segment elevation myocardial infarction (STEMI) presenting with cardiogenic shock (CS) is unclear. Therefore, the aim of this study was to investigate the role of MPO as a predictor of in-hospital death in patients with STEMIs presenting with CS and treated with primary percutaneous coronary intervention. In 38 consecutive patients with CS complicating STEMIs who were treated with primary percutaneous coronary intervention, serum MPO levels were measured at coronary care unit admission using a commercially available enzyme-linked immunosorbent assay. The primary study end point was in-hospital cardiac death. Among the 38 patients included in the study, 20 died during their coronary care unit stays, whereas 18 survived. Compared with patients who survived, patients who died showed, at coronary care unit admission, higher serum MPO levels (81 +/- 28 vs 56 +/- 23 ng/ml, p <0.006). After controlling for different baseline clinical, laboratory, and angiographic variables, baseline serum MPO level was an independent predictor of in-hospital mortality on multivariate analysis (odds ratio 3.9, 95% confidence interval 1.8 to 7.5, p <0.001). In conclusion, admission MPO concentration is an independent predictor of in-hospital mortality in patients with STEMIs presenting with CS.
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Several studies have correlated low circulating MPO levels with better cardiovascular prognosis.
“Several studies have correlated low circulating MPO levels with better cardiovascular prognosis (239, 260, 644, 690, 1059).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [239]
Cites
Treatment of myocardial infarction in a coronary care unit
Killip, T., & Kimball, J. T. (1967) · The American Journal of Cardiology · doi:10.1016/0002-9149(67)90023-9 · Cited by 2,071 · see citing works
Treatment of myocardial infarction in a coronary care unit.
Lf, T., Berman, D. A., Goldfarb, B., Mb, S., & Berman, R. S. (1969) · PubMed · Cited by 1,611 · see citing works
Prognostic Value of Myeloperoxidase in Patients with Chest Pain
Brennan, M., Penn, M. S., Lente, F. V., Nambi, V., Shishehbor, M. H., Aviles, R. J., Goormastic, M., Pepoy, M. L., McErlean, E. S., Topol, E. J., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa035003 · Cited by 1,071 · see citing works
Myeloperoxidase Serum Levels Predict Risk in Patients With Acute Coronary Syndromes
Baldus, S. E., Heeschen, C., Meinertz, T., Zeiher, A. M., Eiserich, J. P., Münzel, T. F., Simoons, M. L., & Hamm, C. W. (2003) · Circulation · doi:10.1161/01.cir.0000090690.67322.51 · Cited by 1,007 · see citing works
Myeloperoxidase and Cardiovascular Disease
Nicholls, S. J., & Hazen, S. L. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000163262.83456.6d · Cited by 803 · see citing works
Zhang, R., Brennan, M.-L., Shen, Z., MacPherson, J. C., Schmitt, D., Molenda, C. E., & Hazen, S. L. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m209124200 · Cited by 432 · see citing works
Baldus, S. E., Rudolph, V., Roiss, M., Ito, W. D., Rudolph, T. K., Eiserich, J. P., Sydow, K., Lau, D., Szöcs, K., Klinke, A., et al. (2006) · Circulation · doi:10.1161/circulationaha.105.590083 · Cited by 200 · see citing works
Plasma Myeloperoxidase Levels in Patients With Chronic Heart Failure
Tang, W. H. W., Brennan, M.-L., Philip, K. J., et al. (2006) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2006.04.018 · Cited by 192 · see citing works
Çavuşoğlu, E., Ruwende, C., Eng, C., Chopra, V., Yanamadala, S., Clark, L. T., Pinsky, D. J., & Marmur, J. D. (2007) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2006.12.060 · Cited by 125 · see citing works
Ng, L. L., Pathik, B., Loke, I. W., Squire, I. B., & Davies, J. E. (2006) · American Heart Journal · doi:10.1016/j.ahj.2005.09.020 · Cited by 95 · see citing works
Cardiogenic shock: a lethal complication of acute myocardial infarction.
Holmes, D. R. (2003) · PubMed · Cited by 41 · see citing works
Çavuşoğlu, E., Chopra, V., Gupta, A. K., et al. (2006) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2006.05.048 · Cited by 37 · see citing works
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Reactive oxygen species in cardiovascular disease
Sugamura, K., & Keaney (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.05.004 · Cited by 769 · see citing works
Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation
Tejero, J., Shiva, S., & Gladwin, M. T. (2019) · Physiological Reviews · doi:10.1152/physrev.00036.2017 · Cited by 541 · see citing works
- Authors
- Dominguez-Rodriguez, A., Samimi-Fard, S., Abreu-Gonzalez, P., Garcia-Gonzalez, M. J., & Kaski, J. C.
- Affiliations
- University of London (GB)
- ORCID
- Kaski, Juan Carlos
- Venue
- The American Journal of Cardiology
- Publisher
- Elsevier BV
- Published
- 2008-06
- Volume
- 101
- Issue
- 11
- Pages
- 1537-1540
- ISSN
- 0002-9149 (ISSN-L)
- OpenAlex
- W2170379045
- Cited by
- 46
- References
- 12
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2020: 2 · 2019: 1 · 2018: 3 · 2016: 1 · 2015: 3 · 2014: 5 · 2013: 3 · 2012: 4
- FWCI
- 4.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
- Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
- Physical Sciences › Engineering › Biomedical Engineering › Mechanical Circulatory Support Devices
- Keywords
- myeloperoxidase, ST-elevation myocardial infarction, cardiogenic shock, in-hospital mortality, prognostic factors, inflammation, primary percutaneous coronary intervention, coronary care unit admission
- MeSH terms
- Aged, Coronary Care Units, Diagnostic Tests, Routine, Electrocardiography, Enzyme-Linked Immunosorbent Assay, Female, Humans, Male, Peroxidase, Myocardial Infarction, Prognosis, Risk Factors, Severity of Illness Index, Shock, Cardiogenic, Biomarkers, Confidence Intervals, Odds Ratio, Hospital Mortality
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