Cited by 770Nitric Oxide and Endothelin EffectsAntioxidant Activity and Oxidative StressRedox biology and oxidative stress

Reactive oxygen species in cardiovascular disease

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Sugamura, Koichi, Keaney,, John F.·2011·Free Radical Biology and Medicine

Abstract

Based on the "free radical theory" of disease, researchers have been trying to elucidate the role of oxidative stress from free radicals in cardiovascular disease. Considerable data indicate that reactive oxygen species and oxidative stress are important features of cardiovascular diseases including atherosclerosis, hypertension, and congestive heart failure. However, blanket strategies with antioxidants to ameliorate cardiovascular disease have not generally yielded favorable results. However, our understanding of reactive oxygen species has evolved to the point at which we now realize these species have important roles in physiology as well as pathophysiology. Thus, it is overly simplistic to assume a general antioxidant strategy will yield specific effects on cardiovascular disease. Indeed, there are several sources of reactive oxygen species that are known to be active in the cardiovascular system. This review addresses our understanding of reactive oxygen species sources in cardiovascular disease and both animal and human data defining how reactive oxygen species contribute to physiology and pathology.

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Crossref · 10.1016/j.freeradbiomed.2011.05.004

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Authors
Sugamura, K., & Keaney
Affiliations
University of Massachusetts Chan Medical School (US)
Corresponding author
Keaney,, John F.
Venue
Free Radical Biology and Medicine
Publisher
Elsevier BV
Published
2011-09
Volume
51
Issue
5
Pages
978-992
ISSN
0891-5849 (ISSN-L)
OpenAlex
W2037586146
Cited by
769
References
304
Citations by year
2026: 12 · 2025: 31 · 2024: 40 · 2023: 48 · 2022: 56 · 2021: 48 · 2020: 51 · 2019: 56 · 2018: 58 · 2017: 67 · 2016: 45 · 2015: 69 · 2014: 72 · 2013: 49 · 2012: 58
FWCI
6.50
Type
journal article
Language
en
Open access
Locations
  • Free Radical Biology and Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Uehara Memorial Foundation
  • Japan Heart Foundation
  • National Institutes of Health
  • Bayer Yakuhin
  • National Heart, Lung, and Blood Institute (HL081587, R01HL098407, P01HL081587, HL098407, HL092122, R01HL092122)
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK 32520, P30DK032520)
Topics
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords
reactive oxygen species, oxidative stress, free radicals, cardiovascular disease, atherosclerosis, hypertension, congestive heart failure, antioxidants, antioxidant therapy, redox signaling
MeSH terms
Animals, Antioxidants, Cardiovascular Diseases, Clinical Trials as Topic, Heart, Humans, Biomarkers, Reactive Oxygen Species, Oxidative Stress, Molecular Targeted Therapy

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