The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Frailty and Chronic Kidney Disease: The Third National Health and Nutrition Evaluation Survey
Open accessAbstract
BACKGROUND Frailty is common in the elderly and in persons with chronic diseases. Few studies have examined the association of frailty with chronic kidney disease. METHODS We used data from the Third National Health and Nutrition Examination Survey to estimate the prevalence of frailty among persons with chronic kidney disease. We created a definition of frailty based on established validated criteria, modified to accommodate available data. We used logistic regression to determine whether and to what degree stages of chronic kidney disease were associated with frailty. We also examined factors that might mediate the association between frailty and chronic kidney disease. RESULTS The overall prevalence of frailty was 2.8%. However, among persons with moderate to severe chronic kidney disease (estimated glomerular filtration rate <45 mL/min/1.73 m2), 20.9% were frail. The odds of frailty were significantly increased among all stages of chronic kidney disease, even after adjustment for the residual effects of age, sex, race, and prevalent chronic diseases. The odds of frailty associated with chronic kidney disease were only marginally attenuated with additional adjustment for sarcopenia, anemia, acidosis, inflammation, vitamin D deficiency, hypertension, and cardiovascular disease. Frailty and chronic kidney disease were independently associated with mortality. CONCLUSION Frailty is significantly associated with all stages of chronic kidney disease and particularly with moderate to severe chronic kidney disease. Potential mechanisms underlying the chronic kidney disease and frailty connection remain elusive.
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Frailty in Older Adults: Evidence for a Phenotype
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Significance of Frailty among Dialysis Patients
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Self-citationOperationalizing a frailty index from a standardized comprehensive geriatric assessment
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Levey, A. S., & Coresh, J. (2012) · The Lancet · doi:10.1016/s0140-6736(11)60178-5 · Cited by 1,841
Chapter 1: Definition and classification of CKD
(2013) · Kidney International Supplements · doi:10.1038/kisup.2012.64 · Cited by 1,110
Early recognition and prevention of chronic kidney disease
James, M. T., Hemmelgarn, B. R., & Tonelli, M. (2010) · The Lancet · doi:10.1016/s0140-6736(09)62004-3 · Cited by 606
Measures of frailty in population-based studies: an overview
Bouillon, K., Kivimaki, M., Hamer, M., Sabia, S., Fransson, E. I., Singh-Manoux, A., Gale, C. R., & Batty, G. D. (2013) · BMC Geriatrics · doi:10.1186/1471-2318-13-64 · Cited by 469
Schnell, K., Weiss, C. O., Lee, T., Krishnan, J. A., Leff, B., Wolff, J. L., & Boyd, C. (2012) · BMC Pulmonary Medicine · doi:10.1186/1471-2466-12-26 · Cited by 274
Metadata
- Authors
- Wilhelm-Leen, E. R., Hall, Y. N., Tamura, M. K., & Chertow, G. M.
- Venue
- The American Journal of Medicine
- Publisher
- Elsevier BV
- Published
- 2009-07
- Volume
- 122
- Issue
- 7
- Pages
- 664-671.e2
- ISSN
- 0002-9343 (ISSN-L)
- OpenAlex
- W2087839380
- Cited by
- 351
- References
- 21
- FWCI
- 7.56
- Type
- journal article
- Language
- en
- Open access
- green
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