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Cited by 350Fibromyalgia and Chronic Fatigue Syndrome ResearchPain Mechanisms and TreatmentsMyofascial pain diagnosis and treatment

The DOI matches its Crossref record; 144 of the 147 references it cites were found in a registry or an index.

Fibromyalgia: An Overview

Clauw, Daniel J.·2009·The American Journal of Medicine
DOI 10.1016/j.amjmed.2009.09.006
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Abstract

Fibromyalgia is the diagnosis given to individuals with chronic widespread musculoskeletal pain for which no alternative cause, such as tissue inflammation or damage, can be identified. Fibromyalgia is now believed to be, at least in part, a disorder of central pain processing that produces heightened responses to painful stimuli (hyperalgesia) and painful responses to nonpainful stimuli (allodynia). Aberrations in central pain processing may also be partly responsible for symptoms experienced in several chronic pain disorders that coaggregate with fibromyalgia, which is itself a product of genetic and environmental factors. Thus, aberrational central pain processing is implicated in irritable bowel syndrome, temporomandibular disorder, chronic low back pain, and certain other chronic pain disorders. Fibromyalgia and related disorders appear to reflect deficiencies in serotonergic and noradrenergic, but not opioidergic, transmission in the central nervous system. The heightened state of pain transmission may also be owing to increases in pronociceptive neurotransmitters such as glutamate and substance P. In some cases, psychological and behavioral factors are also in play. Although the overlapping symptomatology between fibromyalgia and related disorders may present diagnostic challenges, proper examination and observation can help clinicians make an accurate diagnosis. In recent years, the vastly improved understanding of the mechanism underlying fibromyalgia and the related spectrum of diseases has fostered rapid advances in the therapy of these chronic pain disorders by both pharmacologic and nonpharmacologic interventions.

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Crossref · 10.1016/j.amjmed.2009.09.006

Cites

144 of 144 references verified0 citation errors · 0 not checkable

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Citations

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3 retracted

Show all 147 references

Research works printed but not linked: 6

  1. Petzke, 2003, What do tender points measure?, J Rheumatol, 30, 567
  2. Petzke, 1999, Pain sensitivity in patients with fibromyalgia (FM): expectancy effects on pain measurements [abstract], Arthritis Rheum, 42, S342
  3. Welin, 1995, Elevated substance P levels are contrasted by a decrease in met-enkephalin-arg-phe levels in CSF from fibromyalgia patients [abstract], J Musculoskel Pain, 3, 4
  4. Bradley, 1996, Abnormal brain regional cerebral blood flow (rCBF) and cerebrospinal fluid (CSF) levels of substance P (SP) in patients and non-patients with fibromyalgia (FM) [abstract], Arthritis Rheum, 39, S212
  5. Russell, 2002, Therapy with a central alpha 2-adrenergic agonist (tizanidine) decreases cerebrospinal fluid substance P, and may reduce serum hyaluronic acid as it improves the clinical symptoms of the fibromyalgia syndrome [abstract], Arthritis Rheum, 46, S614
  6. Williams, 2000, Randomized controlled trial of CBT to improve functional status in fibromyalgia [abstract], Arthritis Rheum, 43, S210

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Metadata

Authors
Clauw, D. J.
Affiliations
University of Michigan (US)
Corresponding author
Clauw, Daniel J.
ORCID
Clauw, Daniel J.
Venue
The American Journal of Medicine
Publisher
Elsevier BV
Published
2009-12
Volume
122
Issue
12
Pages
S3-S13
ISSN
0002-9343 (ISSN-L)
DOI
10.1016/j.amjmed.2009.09.006
OpenAlex
W2024269125
Cited by
350
References
147
Citations by year
2026: 13 · 2025: 14 · 2024: 13 · 2023: 12 · 2022: 22 · 2021: 29 · 2020: 17 · 2019: 15 · 2018: 13 · 2017: 17 · 2016: 16 · 2015: 18 · 2014: 38 · 2013: 34 · 2012: 39
FWCI
3.16
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • The American Journal of Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
  • Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
  • Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Myofascial pain diagnosis and treatment
Keywords
fibromyalgia, central sensitization, hyperalgesia, allodynia, chronic widespread pain, irritable bowel syndrome, temporomandibular disorders, chronic low back pain, serotonergic neurotransmission, noradrenergic neurotransmission, glutamate, substance P, psychosocial factors, fibromyalgia diagnosis, fibromyalgia treatment
MeSH terms
Analgesics, Antidepressive Agents, Brain, Fibromyalgia, Humans, Magnetic Resonance Imaging, Neurosecretory Systems, Pain, Sleep Wake Disorders, Stress, Physiological, Tomography, Emission-Computed, Single-Photon

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