The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.
Pathophysiology of Fibromyalgia
Open accessAbstract
This article reviews the biologic, genetic, and environmental factors that may contribute to the pathophysiology of fibromyalgia. As an affective spectrum disorder, fibromyalgia may share these causal factors with a number of related and co-occurring pain conditions such as irritable bowel syndrome or temporomandibular disorder. There is strong evidence that cardinal pain symptoms of fibromyalgia may be due to alterations in central processing of sensory input, along with aberrations in the endogenous inhibition of pain, Genetic research has shown familial aggregation of fibromyalgia and other related disorders such as major depressive disorder. Exposure to physical or psychosocial stressors, as well as abnormal biologic responses in the autonomic nervous system and neuroendocrine responses, may also contribute to dysfunctional pain processing. As fibromyalgia research continues to progress, it is expected that the pathophysiology of this disorder will be further elucidated, leading to more rational and targeted strategies for the treatment of fibromyalgia patients.
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Cited by
Fibromyalgia: Pathogenesis, Mechanisms, Diagnosis and Treatment Options Update
Siracusa, R., Paola, R. D., Cuzzocrea, S., & Impellizzeri, D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22083891 · Cited by 659
Cognitive behavioural therapies for fibromyalgia
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miR-7a alleviates the maintenance of neuropathic pain through regulation of neuronal excitability
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Metadata
- Authors
- Bradley, L. A.
- Venue
- The American Journal of Medicine
- Publisher
- Elsevier BV
- Published
- 2009-12
- Volume
- 122
- Issue
- 12
- Pages
- S22-S30
- ISSN
- 0002-9343 (ISSN-L)
- OpenAlex
- W2003290433
- Cited by
- 360
- References
- 70
- FWCI
- 15.50
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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