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Cited by 181Coffee research and impactsPlatelet Disorders and TreatmentsNitric Oxide and Endothelin Effects

The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.

Detrimental Effects of Energy Drink Consumption on Platelet and Endothelial Function

Worthley, Matthew I., Prabhu, Anisha, De Sciscio, Paolo, Schultz, Carlee, Sanders, Prashanthan, Willoughby, Scott R.·2010·The American Journal of Medicine
DOI 10.1016/j.amjmed.2009.09.013
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Abstract

Background Energy drink consumption has been anecdotally linked with sudden cardiac death and, more recently, myocardial infarction. As myocardial infarction is strongly associated with both platelet and endothelial dysfunction, we tested the hypothesis that energy drink consumption alters platelet and endothelial function.Methods Fifty healthy volunteers (34 male, aged 22+/-2 years) participated in the study. Platelet aggregation and endothelial function were tested before, and 1 hour after, the consumption of 250 mL (1 can) of a sugar-free energy drink. Platelet function was assessed by adenosine diphosphate-induced (1 micromol/L) optical aggregometry in platelet-rich plasma. Endothelial function was assessed via changes in peripheral arterial tonometry and expressed as the reactive hyperemia index (RHI).Results Compared with baseline values, there was a significant increase in platelet aggregation following energy drink consumption, while no change was observed with control (13.7+/-3.7% vs 0.3+/-0.8% aggregation, respectively, P <.01). Similarly, RHI decreased following energy drink consumption (-0.33+/-0.13 vs 0.07+/-0.12 RHI [control], P <.05). Mean arterial pressure significantly increased following energy drink consumption, compared with control (P <.05). Heart rate was unaffected by energy drink consumption.Conclusion Energy drink consumption acutely increases platelet aggregation and decreases endothelial function in healthy young adults.

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Crossref · 10.1016/j.amjmed.2009.09.013

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Metadata

Authors
Worthley, M. I., Prabhu, A., De Sciscio, P., Schultz, C., Sanders, P., & Willoughby, S. R.
Affiliations
Royal Adelaide Hospital (AU)
Corresponding author
Willoughby, Scott R.
ORCID
Venue
The American Journal of Medicine
Publisher
Elsevier BV
Published
2010-02
Volume
123
Issue
2
Pages
184-187
ISSN
0002-9343 (ISSN-L)
DOI
10.1016/j.amjmed.2009.09.013
OpenAlex
W2074640646
Cited by
179
References
15
Citations by year
2026: 10 · 2025: 2 · 2024: 7 · 2023: 15 · 2022: 4 · 2021: 8 · 2020: 5 · 2019: 10 · 2018: 14 · 2017: 14 · 2016: 14 · 2015: 16 · 2014: 19 · 2013: 17 · 2012: 16
FWCI
9.62
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • The American Journal of Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology (medical) › Coffee research and impacts
  • Health Sciences › Medicine › Hematology › Platelet Disorders and Treatments
  • Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Keywords
energy drinks, platelet aggregation, endothelial function, reactive hyperemia index, sudden cardiac death, myocardial infarction, mean arterial pressure, cardiovascular risk
MeSH terms
Central Nervous System Stimulants, Beverages, Caffeine, Endothelium, Vascular, Female, Glucuronates, Humans, Male, Platelet Aggregation, Taurine, Cohort Studies, Young Adult

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