The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.
Death during Intensive Glycemic Therapy of Diabetes: Mechanisms and Implications
Open accessAbstract
Despite its documented microvascular1–3 and potential macrovascular4,5 benefits in both type 1 and type 2 diabetes mellitus, intensive glycemic therapy was not found to produce macrovascular benefits, let alone survival benefits, in three recent randomized clinical trials: Action to Control Cardiovascular Risk in Diabetes (ACCORD),6 Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation (ADVANCE),7 and Veterans Affairs Diabetes Trial (VADT).8 Similarly, it was not found to produce a survival benefit in hyperglycemic intensive care unit patients.9–11 Indeed, intensive glycemic therapy resulted in increased mortality in one large trial involving patients with type 2 diabetes6 and in another large trial involving critically ill individuals (Normoglycemia in Intensive Care—Survival Using Glucose Algorithm Regulation (NICE-SUGAR)).9 Regardless of the specific causative mechanisms, the latter findings are of concern. It appears that some aspect of intensive therapy increased the risk of death.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The primary cause of hypoglycemia is intensification of antihyperglycemic therapy (almost always using SUs [or to a lesser extent glinides] and/or insulin) aimed at achieving lower A1C targets, as demonstrated by intensive therapy trials.1202,1203”
From American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan-2022 Update. (2022) · cites this paper as [1203]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“On the other hand, HAAF is clearly maladaptive since defective glucose counterregulation and hypoglycemia unawareness substantially increase the risk of severe hypoglycemia with its morbidity and potential mortality (26).”
From Hypoglycemia and Diabetes: A Report of a Workgroup of the American Diabetes Association and The Endocrine Society (2013) · cites this paper as [26]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Hypoglycemia puts patients at risk for injury and death.”
From Hypoglycemia and Diabetes: A Report of a Workgroup of the American Diabetes Association and The Endocrine Society (2013) · cites this paper as [26]
The cited source says what the claim attributes to it.
In the citing paper
“Although profound and prolonged hypoglycemia can cause brain death, most episodes of fatal hypoglycemia are probably the result of other mechanisms, such as ventricular arrhythmias (26).”
From Hypoglycemia and Diabetes: A Report of a Workgroup of the American Diabetes Association and The Endocrine Society (2013) · cites this paper as [26]
The cited source says what the claim attributes to it.
In the citing paper
“Although profound and prolonged hypoglycemia can cause brain death, most episodes of fatal hypoglycemia are probably the result of other mechanisms, such as ventricular arrhythmias (26).”
From Hypoglycemia and Diabetes: A Report of a Workgroup of the American Diabetes Association and The Endocrine Society (2013) · cites this paper as [26]
In the citing paper
“There is no doubt that hypoglycemia can be fatal (26).”
From Hypoglycemia and Diabetes: A Report of a Workgroup of the American Diabetes Association and The Endocrine Society (2013) · cites this paper as [26]
In the citing paper
“On the other hand, HAAF is clearly maladaptive since defective glucose counterregulation and hypoglycemia unawareness substantially increase the risk of severe hypoglycemia with its morbidity and potential mortality (26).”
From Hypoglycemia and Diabetes: A Report of a Workgroup of the American Diabetes Association and The Endocrine Society (2013) · cites this paper as [26]
In the citing paper
“Although profound and prolonged hypoglycemia can cause brain death, most episodes of fatal hypoglycemia are probably the result of other mechanisms, such as ventricular arrhythmias (26).”
From Hypoglycemia and Diabetes: A Report of a Workgroup of the American Diabetes Association and The Endocrine Society (2013) · cites this paper as [26]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
(1993) · New England Journal of Medicine · doi:10.1056/nejm199309303291401 · Cited by 24,667
Standards of Medical Care in Diabetes
Power, D. V. (2006) · Diabetes Care · doi:10.2337/diacare.29.02.06.dc05-1593 · Cited by 8,676
Turner, R. C., Fox, C., Matthews, McElroy, H. H., Cull, C. A., Holman, R. R., Neil, P., Hadden, D. R., Wright, D., Manley, E., et al. (1998) · The Lancet · Cited by 8,419
Effects of Intensive Glucose Lowering in Type 2 Diabetes
(2008) · New England Journal of Medicine · doi:10.1056/nejmoa0802743 · Cited by 7,888
10-year follow-up of intensive glucose control in type 2 diabetes
Holman, R. R., Paul, S. K., Bethel, M. A., Matthews, D. R., & Neil, H. A. W. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0806470 · Cited by 7,751
Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes
(2008) · New England Journal of Medicine · doi:10.1056/nejmoa0802987 · Cited by 7,397
Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes
(2005) · New England Journal of Medicine · doi:10.1056/nejmoa052187 · Cited by 5,138
Intensive versus Conventional Glucose Control in Critically Ill Patients
(2009) · New England Journal of Medicine · doi:10.1056/nejmoa0810625 · Cited by 5,119
Cited by
Sorted by citations
Seaquist, E. R., Anderson, J., Childs, B., Cryer, P., Dagogo-Jack, S., Fish, L., Heller, S. R., Rodriguez, H., Rosenzweig, J., & Vigersky, R. (2013) · Diabetes Care · doi:10.2337/dc12-2480 · Cited by 1,389
“Although profound and prolonged hypoglycemia can cause brain death, most episodes of fatal hypoglycemia are probably the result of other mechanisms, such as ventricular arrhythmias (26).”
BackgroundInfluentialSelf-citationGarber, A. J., Abrahamson, M. J., Barzilay, J. I., Blonde, L., Bloomgarden, Z. T., Bush, M. A., Dagogo-Jack, S. E., DeFronzo, R. A., EINHORN, D. F., Fonseca, V. A., et al. (2016) · Endocrine Practice · doi:10.4158/ep151126.cs · Cited by 879
Handelsman, Y., Bloomgarden, Z. T., Grunberger, G., Umpierrez, G. E., Zimmerman, R. S., Bailey, T. S., Blonde, L., Bray, G. A., Cohen, A. J., Dagogo-Jack, S. E., et al. (2015) · Endocrine Practice · doi:10.4158/ep15672.gl · Cited by 646
Garber, A. J., Handelsman, Y., Grunberger, G., Einhorn, D., Abrahamson, M. J., Barzilay, J. I., Blonde, L., Bush, M. A., DeFronzo, R. A., Garber, J. R., et al. (2020) · Endocrine Practice · doi:10.4158/cs-2019-0472 · Cited by 598
Handelsman, Y., Bloomgarden, Z. T., Grunberger, G., Umpierrez, G., Zimmerman, R. S., Bailey, T. S., Blonde, L., Bray, G. A., Cohen, A. J., Dagogo-Jack, S., et al. (2015) · Endocrine Practice · doi:10.4158/ep15672.glsuppl · Cited by 559
Increased mortality of patients with diabetes reporting severe hypoglycemia
McCoy, R. G., Van Houten, H. K., Ziegenfuss, J. Y., Shah, N. D., Wermers, R. A., & Smith, S. A. (2012) · Diabetes Care · doi:10.2337/dc11-2054 · Cited by 539
Blonde, L., Umpierrez, G. E., Reddy, S. S., McGill, J. B., Berga, S. L., Bush, M., Chandrasekaran, S., DeFronzo, R. A., Einhorn, D., Galindo, R. J., et al. (2022) · Endocrine Practice · doi:10.1016/j.eprac.2022.08.002 · Cited by 507
Garber, A. J., Abrahamson, M. J., Barzilay, J. I., Blonde, L., Bloomgarden, Z. T., Bush, M. A., Dagogo-Jack, S. E., DeFronzo, R. A., EINHORN, D. F., Fonseca, V. A., et al. (2018) · Endocrine Practice · doi:10.4158/cs-2017-0153 · Cited by 503
Mechanisms of hypoglycemia-associated autonomic failure in diabetes
Cryer, P. E. (2013) · New England Journal of Medicine · doi:10.1056/nejmra1215228 · Cited by 433
Self-citationSeaquist, E. R., Anderson, J., Childs, B., Cryer, P., Dagogo-Jack, S., Fish, L., Heller, S. R., Rodriguez, H., Rosenzweig, J., & Vigersky, R. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-4127 · Cited by 412
Self-citationMeloni, A. R., DeYoung, M. B., Lowe, C., & Parkes, D. G. (2013) · Diabetes, Obesity and Metabolism · doi:10.1111/j.1463-1326.2012.01663.x · Cited by 407
Garber, A. J., Abrahamson, M. J., Barzilay, J. I., Blonde, L., Bloomgarden, Z. T., Bush, M. A., Dagogo-Jack, S., DeFronzo, R. A., Einhorn, D., Fonseca, V. A., et al. (2019) · Endocrine Practice · doi:10.4158/cs-2018-0535 · Cited by 297
Glycemic Goals in Diabetes: Trade-off Between Glycemic Control and Iatrogenic Hypoglycemia
Cryer, P. E. (2014) · Diabetes · doi:10.2337/db14-0059 · Cited by 241
Self-citationSilbert, R., Salcido-Montenegro, A., Rodriguez-Gutierrez, R., Katabi, A., & McCoy, R. G. (2018) · Current Diabetes Reports · doi:10.1007/s11892-018-1018-0 · Cited by 229
Papademetriou, V., Lovato, L., Doumas, M., Nylen, E., Mottl, A., Cohen, R. M., Applegate, W. B., Puntakee, Z., Yale, J. F., & Cushman, W. C. (2015) · Kidney International · doi:10.1038/ki.2014.296 · Cited by 210
Mechanisms of hypoglycemia unawareness and implications in diabetic patients
Martín-Timón, I. (2015) · World Journal of Diabetes · doi:10.4239/wjd.v6.i7.912 · Cited by 204
Severe Hypoglycemia Predicts Mortality in Diabetes
Cryer, P. E. (2012) · Diabetes Care · doi:10.2337/dc12-0749 · Cited by 163
Self-citationFreeman, R. L. (2014) · Handbook of clinical neurology · doi:10.1016/b978-0-444-53480-4.00006-0 · Cited by 137
Bosi, E., Scavini, M., Ceriello, A., Cucinotta, D., Tiengo, A., Marino, R., Bonizzoni, E., Giorgino, F., & on behalf of the PRISMA Study Group (2013) · Diabetes Care · doi:10.2337/dc13-0092 · Cited by 105
Tramadol Use and the Risk of Hospitalization for Hypoglycemia in Patients With Noncancer Pain
Fournier, J., Azoulay, L., Yin, H., Montastruc, J., & Suissa, S. (2014) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2014.6512 · Cited by 108
Haynes, A., Hermann, J. M., Miller, K. M., Hofer, S. E., Jones, T. W., Beck, R. W., Maahs, D. M., Davis, E. A., Holl, R. W., & for the T1D Exchange, W. A. D. R. (2017) · Pediatric Diabetes · doi:10.1111/pedi.12477 · Cited by 88
Understanding hypoglycemia in hospitalized patients
Hulkower, R., Pollack, R. M., & Zonszein, J. (2014) · Diabetes Management · doi:10.2217/dmt.13.73 · Cited by 90
Standl, E., Stevens, S. R., Armstrong, P. W., Buse, J. B., Chan, J. C. N., Green, J. B., Lachin, J. M., Scheen, A., Travert, F., Van de Werf, F., et al. (2018) · Diabetes Care · doi:10.2337/dc17-1778 · Cited by 76
The clinical impact of inpatient hypoglycemia
Brutsaert, E. F., Carey, M., & Zonszein, J. (2014) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2014.03.002 · Cited by 76
Hermanns, N., Heinemann, L., Freckmann, G., Waldenmaier, D., & Ehrmann, D. (2019) · Journal of Diabetes Science and Technology · doi:10.1177/1932296819831695 · Cited by 66
Standl, E., Stevens, S. R., Lokhnygina, Y., Bethel, M. A., Buse, J. B., Gustavson, S. M., Maggioni, A. P., Mentz, R. J., Hernandez, A. F., & Holman, R. R. (2020) · Diabetes Care · doi:10.2337/dc19-1079 · Cited by 65
Hypoglycemia Associated With Hospitalization and Adverse Events in Older People
Majumdar, S. R., Hemmelgarn, B. R., Lin, M., McBrien, K., Manns, B., & Tonelli, M. A. (2013) · Diabetes Care · doi:10.2337/dc13-0523 · Cited by 66
Tschöpe, D., Bramlage, P., Binz, C., Krekler, M., Deeg, E., & Gitt, A. K. (2012) · BMC Endocrine Disorders · doi:10.1186/1472-6823-12-23 · Cited by 64
Prediction and Prevention of Treatment-Related Inpatient Hypoglycemia
Elliott, M., Schafers, S. J., McGill, J. B., & Tobin, G. S. (2012) · Journal of Diabetes Science and Technology · doi:10.1177/193229681200600213 · Cited by 63
The proarrhythmic effect of hypoglycemia: evidence for increased risk from ischemia and bradycardia
Nordin, C. (2013) · Acta Diabetologica · doi:10.1007/s00592-013-0528-0 · Cited by 58
Arbeláez, A. M., Xing, D., Cryer, P. E., Kollman, C., Beck, R. W., Sherr, J. L., Ruedy, K. J., Tamborlane, W. V., Mauras, N., Tsalikian, E., et al. (2013) · Pediatric Diabetes · doi:10.1111/pedi.12070 · Cited by 56
Self-citationBode, B. W., & Garg, S. K. (2015) · Endocrine Practice · doi:10.4158/ep15869.ra · Cited by 55
Jensen, M. H., Dethlefsen, C., Vestergaard, P., & Hejlesen, O. K. (2019) · Journal of Diabetes Science and Technology · doi:10.1177/1932296819868727 · Cited by 56
Individualizing Targets and Tactics for High-Risk Patients With Type 2 Diabetes
Riddle, M. C., & Karl, D. M. (2012) · Diabetes Care · doi:10.2337/dc12-0650 · Cited by 51
Chhasatia, R., Sweetman, M. J., Harding, F. J., Waibel, M., Kay, T., Thomas, H. E., Loudovaris, T., & Voelcker, N. H. (2017) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2017.01.004 · Cited by 50
Kalantar‐Zadeh, K., Uppot, R. N., & Lewandrowski, K. B. (2013) · New England Journal of Medicine · doi:10.1056/nejmcpc1208154 · Cited by 48
McNicholas, B., Pham, M. H., Carli, K., Chen, C. H., Smith, N. C., Anderson, A. E., & Pham, H. (2017) · Kidney International Reports · doi:10.1016/j.ekir.2017.10.009 · Cited by 46
Vinci, M. C., Costantino, S., Damiano, G., Rurali, E., Rinaldi, R., Vigorelli, V., Sforza, A., Carulli, E., Pirola, S., Mastroiacovo, G., et al. (2024) · Cardiovascular Diabetology · doi:10.1186/s12933-024-02195-1 · Cited by 45
Avoiding or coping with severe hypoglycemia in patients with type 2 diabetes
Yun, J., & Ko, S. (2015) · The Korean Journal of Internal Medicine · doi:10.3904/kjim.2015.30.1.6 · Cited by 41
Munshi, M. N., Kahkoska, A. R., Neumiller, J. J., Alexopoulos, A., Allen, N. A., Cukierman‐Yaffe, T., Huang, E. S., Lee, S. J., Lipska, K. J., McCarthy, L. M., et al. (2025) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(24)00372-3 · Cited by 42
Hambling, C. E., Khunti, K., Cos, X., Wens, J., Martinez, L., Topsever, P., Prato, S. D., Sinclair, A. J., Schernthaner, G., Rutten, G. E. H. M., et al. (2019) · Primary care diabetes · doi:10.1016/j.pcd.2018.12.005 · Cited by 38
Andrus, L. P., Unruh, R. M., Wisniewski, N. A., & McShane, M. J. (2015) · Biosensors · doi:10.3390/bios5030398 · Cited by 39
Fagher, K., & Löndahl, M. (2013) · Diabetologia · doi:10.1007/s00125-013-2860-x · Cited by 37
QT prolongation caused by insulin-induced hypoglycaemia – An interventional study in 119 individuals
Kacheva, S., Karges, B., Göller, K., Marx, N., Mischke, K., & Karges, W. (2016) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2016.11.021 · Cited by 38
Residual dysglycemia when at target HbA1c of 7% (53mmol/mol) in persons with type 2 diabetes
Monnier, L., Colette, C., Dejager, S., & Owens, D. R. (2014) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2014.03.012 · Cited by 32
The Role of Bromocriptine-Qr in the Management of Type 2 Diabetes Expert Panel Recommendations
Garber, A. J., Blonde, L., Bloomgarden, Z. T., Handelsman, Y., & Dagogo-Jack, S. E. (2013) · Endocrine Practice · doi:10.4158/ep12325.or · Cited by 31
Brown, J. B., Reichert, S. M., Valliere, Y., Webster-Bogaert, S., Ratzki‐Leewing, A. A., Ryan, B. L., & Harris, S. B. (2019) · Diabetes Spectrum · doi:10.2337/ds18-0074 · Cited by 31
Sharif, Κ., Ghadir, S., Jakubowicz, D. J., Amital, H., Bragazzi, N. L., Watad, ., Wainstein, J., & Bar‐Dayan, Y. (2019) · Cardiovascular Diabetology · doi:10.1186/s12933-019-0810-8 · Cited by 31
Hypoglycemia in cystic fibrosis: Prevalence, impact and treatment
Moheet, A. A., Chan, C. L., Granados, A., Ode, K. L., Moran, A., & Battezzati, A. (2019) · Journal of Cystic Fibrosis · doi:10.1016/j.jcf.2019.08.004 · Cited by 29
Hypoglycemia Begets Hypoglycemia: The Order Effect in the ASPIRE In-Clinic Study
Garg, S. K., Brazg, R., Bailey, T. S., Buckingham, B. A., Slover, R. H., Klonoff, D. C., Shin, J., Welsh, J. B., & KAUFMAN, F. R. (2014) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2013.0219 · Cited by 29
Horton, W. B., Barros, A. J., Andris, R. T., Clark, M. T., & Moorman, J. R. (2021) · Critical Care Medicine · doi:10.1097/ccm.0000000000005171 · Cited by 27
Stress, hypoglycemia, and the autonomic nervous system
Haas, A. V., Borsook, D., Adler, G. K., & Freeman, R. L. (2022) · Autonomic Neuroscience · doi:10.1016/j.autneu.2022.102983 · Cited by 30
Moheet, A. A., Kumar, A. F., Eberly, L. E., Kim, J., Roberts, R., & Seaquist, E. R. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-3493 · Cited by 27
Gq signaling in α cells is critical for maintaining euglycemia
Liu, L., Dattaroy, D., Simpson, K. F., Barella, L. F., Cui, Y., Xiong, Y., Jin, J. J., König, G. M., Kostenis, E., ROMAN, J., et al. (2021) · JCI Insight · doi:10.1172/jci.insight.152852 · Cited by 26
Rubin, D. J., & Golden, S. H. (2013) · Hospital Practice · doi:10.3810/hp.2013.02.1016 · Cited by 25
Erejuwa, O. O. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms13032965 · Cited by 26
Baroreflex sensitivity impairment during hypoglycemia: implications for cardiovascular control
Rao, A. D., Bonyhay, I., Dankwa, J., Baimas-George, M., Kneen, L., Ballatori, S., Freeman, R., & Adler, G. K. (2016) · Diabetes · doi:10.2337/db15-0871 · Cited by 25
Divergent Effects of Various Diabetes Drugs on Cardiovascular Prognosis
Bell, D. S. H., Patil, H., & O’Keefe, J. H. (2013) · Reviews in Cardiovascular Medicine · doi:10.3909/ricm0671 · Cited by 25
Opioid receptor activation impairs hypoglycemic Counterregulation in humans
Carey, M., Gospin, R., Goyal, A., Tomuta, N., Sandu, O., Mbanya, A., Lontchi-Yimagou, E., Hulkower, R., Shamoon, H., Gabriely, I., et al. (2017) · Diabetes · doi:10.2337/db16-1478 · Cited by 23
Thalamic Activation During Slightly Subphysiological Glycemia in Humans
Arbeláez, A. M., Rutlin, J. R., Hershey, T. G., Powers, W. J., Videen, T. O., & Cryer, P. E. (2012) · Diabetes Care · doi:10.2337/dc12-0297 · Cited by 21
Self-citationThe Role of Hypoglycemia in Cardiovascular Outcomes in Diabetes
Paty, B. W. (2015) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2015.09.009 · Cited by 21
Malik, A. H., Yandrapalli, S., Aronow, W. S., Jain, D., Frishman, W. H., Panza, J. A., & Cooper, H. A. (2019) · Cardiology in Review · doi:10.1097/crd.0000000000000276 · Cited by 21
Insulin Therapy in Type 1 Diabetes
Stephens, E. (2014) · Medical Clinics of North America · doi:10.1016/j.mcna.2014.08.016 · Cited by 21
Griffing, K. L. (2016) · Clinical Diabetes · doi:10.2337/cd15-0055 · Cited by 20
Lontchi-Yimagou, E., Aleksic, S., Hulkower, R., Gospin, R., Goyal, A., Kuo, B., Mitchell, W. G., You, J. Y., Upadhyay, L., Carey, M., et al. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaa539 · Cited by 17
Hypoglycemia and Cardiovascular Outcomes in the CARMELINA and CAROLINA Trials of Linagliptin
Marx, N., Kolkailah, A. A., Rosenstock, J., Johansen, O. E., Cooper, M. E., Alexander, J. H., Toto, R. D., Wanner, C., Espeland, M. A., Mattheus, M., et al. (2024) · JAMA Cardiology · doi:10.1001/jamacardio.2023.4602 · Cited by 15
Wei, X., Chang, A. C. H., Chang, H., Xu, S., Xue, Y., Zhang, Y., Lei, M., Chang, A. C. Y., & Zhang, Q. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.800185 · Cited by 15
Toward clinical islet xenotransplantation – are revisions to the IXA guidelines warranted?
Cooper, D. K. C., Bottino, R., Satyananda, V., Wijkstrom, M. N., & Trucco, M. (2013) · Xenotransplantation · doi:10.1111/xen.12015 · Cited by 14
Dambha-Miller, H., Hounkpatin, H. O., Stuart, B., Farmer, A., & Griffin, S. (2023) · PLOS ONE · doi:10.1371/journal.pone.0290791 · Cited by 13
Matsumoto, S., Abalovich, A., Wynyard, S., Carulla, M. E., & Abalovich, D. (2023) · Xenotransplantation · doi:10.1111/xen.12798 · Cited by 13
Nuzzo, A., Brignoli, A., Ponziani, M. C., Zavattaro, M., Prodam, F., Castello, L. M., Avanzi, G. C., Marzullo, P., & Aimaretti, G. (2021) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2021.09.016 · Cited by 13
Martyn-Nemeth, P. A., Duffecy, J. L., Quinn, L., Park, C., Mihailescu, D. V., & Penckofer, S. M. (2019) · Trials · doi:10.1186/s13063-019-3876-4 · Cited by 13
Kakall, Z. M., Kavurma, M. M., Cohen, E. M., Howe, P. R. C., Nedoboy, P. E., & Pilowsky, P. M. (2019) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00051.2019 · Cited by 13
Potential approaches to prevent hypoglycemia-associated autonomic failure
Lontchi-Yimagou, E., You, J. Y., Carey, M., Gabriely, I., Shamoon, H., & Hawkins, M. (2018) · Journal of Investigative Medicine · doi:10.1136/jim-2017-000582 · Cited by 12
Bedtime Prediction of Nocturnal Hypoglycemia in Insulin-Treated Type 2 Diabetes Patients
Kronborg, T., Hangaard, S., Hejlesen, O. K., Vestergaard, P., & Jensen, M. H. (2022) · Journal of Diabetes Science and Technology · doi:10.1177/19322968221141736 · Cited by 12
Cardiovascular Safety of Antihyperglycemic Agents: “Do Good or Do No Harm”
Manolis, A. S., Manolis, T. A., & Manolis, A. S. (2018) · Drugs · doi:10.1007/s40265-018-0985-4 · Cited by 12
Thomsen, H. B., Jakobsen, M. M., Hecht-Pedersen, N., Jensen, M. H., & Kronborg, T. (2023) · Journal of Diabetes Science and Technology · doi:10.1177/19322968231215324 · Cited by 12
Prevalence of severe hypoglycemia in a cohort of patients with type 1 diabetes
Corrales, P. J. P., Lozano, C. A., Martínez, C. J., Jiménez, L. M. L., Segovia, A. E. S., Blasco, L. G., & Romero, F. B. (2021) · Endocrinología Diabetes y Nutrición (English ed ) · doi:10.1016/j.endien.2020.01.011 · Cited by 11
Myers, L. A., Swanson, K. M., Glasgow, A. E., & McCoy, R. G. (2022) · Diabetes Care · doi:10.2337/dc21-1811 · Cited by 11
Dissanayake, H. A., Keerthisena, G. S. P., Gamage, K. K. K., Liyanage, J. H., Ihalagama, I. R. H. S., Wijetunga, W. M. U. A., Tillekaratne, T. A. D., Katulanda, G. W., & Katulanda, P. (2018) · BMC Endocrine Disorders · doi:10.1186/s12902-018-0264-0 · Cited by 12
Bailey, N. C., Dimsits, J., Hammer, M., Kendall, D. M., & Bailey, T. S. (2021) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2021.0367 · Cited by 12
Lyngsie, P. J., Lopes, S. H. K., & Olsen, J. (2016) · Journal of Comparative Effectiveness Research · doi:10.2217/cer.15.68 · Cited by 10
Exercise Strategies to Prevent Hypoglycemia in Patients with Diabetes
Jung, A. R., Kim, H., Kim, C., Kim, C., & Choi, W.-S. (2020) · Korean Journal of Family Medicine · doi:10.4082/kjfm.19.0043 · Cited by 11
The dead in bed syndrome revisited: a review of the evidence
Weston, P. J. (2012) · Diabetes Management · doi:10.2217/dmt.12.2 · Cited by 11
Pedersen‐Bjergaard, U., Kristensen, P. L., Nørgaard, K., Perrild, H., Jensen, T. J., Thorsteinsson, B., Nikolajsen, A., & Tarnow, L. (2016) · Current Medical Research and Opinion · doi:10.1080/03007995.2016.1205006 · Cited by 10
Prevalencia de hipoglucemia grave en una cohorte de pacientes con diabetes tipo 1
Corrales, P. J. P., Lozano, C. A., Martínez, C. J., Jiménez, L. M. L., Segovia, A. E. S., Blasco, L. G., & Romero, F. B. (2020) · Endocrinología Diabetes y Nutrición · doi:10.1016/j.endinu.2020.01.002 · Cited by 14
Pissarnitski, D. A., Kekec, A., Yan, L. Y., Zhu, Y., Feng, D. D., Huo, P., Madsen-Duggan, C. B., Moyes, C. R., Nargund, R. P., Kelly, T. M., et al. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.1c02073 · Cited by 10
Stefenon, P., da Silveira, A. L. M., Giaretta, L. S., Leitão, C. B., & Bauer, A. C. (2020) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-020-0521-z · Cited by 9
Glibenclamide Prevents Hypoglycemia-Induced Fatal Cardiac Arrhythmias in Rats
Reno, C. M., Bayles, J., Skinner, A., & Fisher, S. J. (2018) · Endocrinology · doi:10.1210/en.2018-00419 · Cited by 9
Jensen, M. H., Hejlesen, O. K., & Vestergaard, P. (2020) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.14263 · Cited by 7
McCoy, R. G., Lipska, K. J., Houten, H. K. V., & Shah, N. D. (2020) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2020-001878 · Cited by 7
Kim, J. L., Gamma, E. F. L., Estabrook, T., Kudrick, N., & Nankova, B. B. (2017) · PLoS ONE · doi:10.1371/journal.pone.0172789 · Cited by 8
Nishimura, R., Okada, Y., Kuroda, A., Suzuki, J., Hirota, Y., Matsuhisa, M., Ishiguro, M., Ohno, T., Suganuma, Y., Tanaka, K., et al. (2025) · Diabetology International · doi:10.1007/s13340-025-00820-2 · Cited by 7
Aleksić, S., Lontchi‐Yimagou, E., Mitchell, W. G., Boyle, C., Matias, P., Manavalan, A. D., Goyal, A., Carey, M., Gabriely, I., & Hawkins, M. A. (2024) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgae479 · Cited by 6
Антонова, К. В., Лагода, О. В., & Tanashyan, M. М. (2022) · Diabetes Mellitus · doi:10.14341/dm12840 · Cited by 5
Arrhythmogenic effects of hypoglycemia in children and adolescents with type 1 diabetes mellitus
Лаптев, Д. Н., & Ryabykina, G. V. (2013) · Diabetes Mellitus · doi:10.14341/dm2013466-71 · Cited by 7
Gregory, J. M., Rivera, N., Kraft, G., Winnick, J. J., Farmer, B., Allen, E. J., Donahue, E. P., Smith, M. S., Edgerton, D. S., Williams, P. E., et al. (2017) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00099.2017 · Cited by 6
Nya‐Ngatchou, J. J., Corl, D. E., Onstad, S., Yin, T. S., Tylee, T. S., Suhr, L. D., Thompson, R. E., & Wisse, B. E. (2014) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2575 · Cited by 4
Mazzi, S., Ravasio, R., Forlani, G., Veronese, G., Fabbri, A., & Marchesini, G. (2017) · ClinicoEconomics and Outcomes Research · doi:10.2147/ceor.s148368 · Cited by 4
Kumar, A., Shaikh, Z. A., Prithiani, S. L., Shaikh, B. A., Ansari, I. A., & Hyder, I. (2021) · Pakistan Journal of Medical and Health Sciences · doi:10.53350/pjmhs2115112961 · Cited by 3
Metadata
- Authors
- Cryer, P. E.
- Affiliations
- Washington University in St. Louis (US)
- Corresponding author
- Cryer, Philip E.
- Venue
- The American Journal of Medicine
- Publisher
- Elsevier BV
- Published
- 2011-11
- Volume
- 124
- Issue
- 11
- Pages
- 993-996
- ISSN
- 0002-9343 (ISSN-L)
- PMC
- PMC3464092
- OpenAlex
- W2044277864
- Semantic Scholar
- bcc2ac94423ef826cfcd974b1f808d52497258e4
- Cited by
- 137
- References
- 68
- Citations by year
- 2025: 5 · 2024: 7 · 2023: 7 · 2022: 8 · 2021: 8 · 2020: 9 · 2019: 15 · 2018: 8 · 2017: 10 · 2016: 10 · 2015: 10 · 2014: 12 · 2013: 18 · 2012: 10
- FWCI
- 10.48
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The American Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- American Diabetes Association
- Bristol-Myers Squibb
- AstraZeneca
- MannKind Corporation
- Novo Nordisk
- National Institutes of Health (5p60dk020579-35, DK20579, P60-DK-20579, RR‐00036)
- National Institute of Diabetes and Digestive and Kidney Diseases (R37DK027085, P60-DK20579, R37-DK27085, T32 DK07120, P60-DK-020579, T32DK007120)
- National Center for Research Resources (UL1-RR-24992, M01-RR00036, UL1RR024992, M01RR000036)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Keywords
- diabetes mortality, type 1 diabetes, type 2 diabetes, cardiovascular risk, tight glycemic control, cardiovascular complications
- MeSH terms
- Female, Humans, Hypoglycemia, Hypoglycemic Agents, Male, Hospital Mortality
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
