Cited by 127Atrial Fibrillation Management and OutcomesAcute Ischemic Stroke ManagementInflammatory Biomarkers in Disease Prognosis

Body mass index and adverse events in patients with incident atrial fibrillation

Overvad, Thure Filskov, Rasmussen, Lars Hvilsted, Skjøth, Flemming, Overvad, Kim, Lip, Gregory Y.H., Larsen, Torben Bjerregaard·2013·The American Journal of Medicine

Abstract

Background Obesity is associated with the development of atrial fibrillation and may impact atrial fibrillation-related outcomes. To date, no anthropometric measure is included in any risk stratification scheme for stroke and death in atrial fibrillation patients.Methods The prospective Danish Diet, Cancer and Health study is a cohort including 57,053 participants (27,178 men and 29,875 women) aged between 50 and 64 years. The study population for this study included the 3135 patients (2025 men and 1110 women) who developed incident atrial fibrillation during follow-up.Results Of the subjects with atrial fibrillation, 1414 (45%) had a body mass index (BMI) in the overweight category (BMI 25 to <30 kg/m(2)) and 767 (24%) were categorized as obese (BMI ≥30 kg/m(2)). During a median follow-up of 4.9 years, 609 deaths and 216 thromboembolic events (98% ischemic strokes) occurred. Using normal-weight patients as reference, the risk of a composite end point of "ischemic stroke, thromboembolism, or death" was significantly higher in overweight (crude hazard ratio [HR] 1.31; 95% confidence interval [CI], 1.09-1.56) and obese patients (crude HR 1.55; 95% CI 1.27-1.90). After adjustment for CHADS2 and CHA2DS2-VASc scores, the HRs for the composite end point were 1.21 (95% CI 1.02-1.45) and 1.31 (95% CI 1.10-1.56), respectively, for overweight and 1.25 (95% CI 1.03-1.53) and 1.36 (95% CI 1.11-1.65), respectively, for obese. Continuous analyses of BMI stratified by sex identified obese men and normal-weight women as the sex-specific "high-risk" categories.Conclusion Overweight and obesity are risk factors for "ischemic stroke, thromboembolism or death" in patients with atrial fibrillation, even after adjustment for CHADS2 and CHA2DS2-VASc scores. The association between BMI and outcomes among atrial fibrillation patients may be modified by sex.

Integrity signals

Registry

Crossref · 10.1016/j.amjmed.2012.11.024

Cites

42 of 42 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Overvad, T. F., Rasmussen, L. H., Skjøth, F., Overvad, K., Lip, G. Y. H., & Larsen, T. B.
Affiliations
  • Birmingham City Hospital (GB)
  • Aalborg University Hospital (DK)
  • Aarhus University (DK)
Corresponding author
Larsen, Torben Bjerregaard
Venue
The American Journal of Medicine
Publisher
Elsevier BV
Published
2013-07
Volume
126
Issue
7
Pages
640.e9-640.e17
ISSN
0002-9343 (ISSN-L)
OpenAlex
W2096795943
Cited by
127
References
42
Citations by year
2026: 5 · 2025: 10 · 2024: 6 · 2023: 14 · 2022: 11 · 2021: 19 · 2020: 8 · 2019: 10 · 2018: 12 · 2017: 4 · 2016: 13 · 2015: 9 · 2014: 5 · 2013: 1
FWCI
6.34
Type
journal article
Language
en
Open access
closed
Locations
  • The American Journal of Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • VBN Forskningsportal (Aalborg Universitet) (submittedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
  • Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
  • Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
Keywords
body mass index, obesity, overweight, atrial fibrillation, incident atrial fibrillation, ischemic stroke, thromboembolism, mortality, risk stratification, CHA2DS2-VASc score, CHADS2 score, sex differences, stroke risk factors, anthropometric measures
MeSH terms
Aged, Atrial Fibrillation, Denmark, Female, Humans, Male, Middle Aged, Obesity, Prospective Studies, Sex Factors, Thromboembolism, Cohort Studies, Body Mass Index, Incidence, Proportional Hazards Models, Stroke, Overweight

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review