The DOI matches its Crossref record; 138 of the 138 references it cites were found in a registry or an index.
Resting Heart Rate: Risk Indicator and Emerging Risk Factor in Cardiovascular Disease
Abstract
Resting heart rate is central to cardiac output and is influenced by changes occurring in numerous diseases. It predicts longevity and cardiovascular diseases, and current evidence suggests that it is also an important marker of outcome in cardiovascular disease, including heart failure. Beta-blockers improve outcomes in heart failure; however, they have effects outside reducing heart rate. Ivabradine has demonstrated efficacy in reducing rehospitalizations and mortality in heart failure and in improving exercise tolerance and reducing angina attacks in patients with coronary artery disease, whereas selective heart rate reduction may also prove to be beneficial in therapeutic areas outside those in which ivabradine has already demonstrated clinical efficacy. This review provides an update on the associations between heart rate and cardiovascular outcomes in various conditions, the experimental effects of heart rate reduction with ivabradine, and the potential new indications in cardiovascular disease.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Increased heart rate is generally considered an adverse effect, associated with lower survival. 35”
From Healthy Weight Loss Maintenance with Exercise, Liraglutide, or Both Combined (2021) · cites this paper as [35]
Citations
Cites
McDonagh, T. A., Metra, M., Adamo, M., Gardner, R. S., Baumbach, A., Böhm, M., Burri, H., Butler, J., Čelutkienė, J., Chioncel, O. D., et al. (2021) · PubMed · doi:10.1093/eurheartj/ehab670 · Cited by 20,604
Self-citationEuropean Guidelines on cardiovascular disease prevention in clinical practice (version 2012)
Authors/Task Force Members:, Perk, J., De Backer, G., Gohlke, H., Graham, I., Reiner, Ž., Verschuren, M., Albus, C., Benlian, P., Boysen, G., et al. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehs092 · Cited by 8,490
ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012
Authors/Task Force Members, McMurray, J. J. V., Adamopoulos, S., Anker, S. D., Auricchio, A., Böhm, M., Dickstein, K., Falk, V., Filippatos, G., Fonseca, C., et al. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehs104 · Cited by 6,879
Self-citationImpotence and Its Medical and Psychosocial Correlates: Results of the Massachusetts Male Aging Study
Feldman, H. A., Goldstein, I., Hatzichristou, D. G., Krane, R. J., & McKinlay, J. B. (1994) · Journal of Urology · doi:10.1016/s0022-5347(17)34871-1 · Cited by 5,074
2013 ESC guidelines on the management of stable coronary artery disease
Task Force Members, Montalescot, G., Sechtem, U., Achenbach, S., Andreotti, F., Arden, C., Budaj, A., Bugiardini, R., Crea, F., Cuisset, T., et al. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht296 · Cited by 4,510
European guidelines on cardiovascular disease prevention in clinical practice: executive summary
Graham, I., Atar, D., Borch‐Johnsen, K., Boysen, G., Burell, G. K., Cífková, R., Dallongeville, J., Backer, G. D., Ebrahim, S. B. J., Gjelsvik, B., et al. (2007) · European Heart Journal · doi:10.1093/eurheartj/ehm316 · Cited by 3,865
Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled study
Swedberg, K., Komajda, M., Böhm, M., Borer, J. S., Ford, I., Dubost-Brama, A., Lerebours, G., & Tavazzi, L. (2010) · The Lancet · doi:10.1016/s0140-6736(10)61198-1 · Cited by 2,563
Self-citationGibbons, R. J., Abrams, J., Chatterjee, K., Daley, J., DEEDWANIA, P. C., Douglas, J. S., Ferguson, T. B., Fihn, S. D., Fraker, T. D., Gardin, J. M., et al. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)02848-6 · Cited by 1,685
Self-citationGraham (2007) · doi:10.1097/01.hjr.0000277983.23934.c9 · Cited by 1,647
Chatzizisis, Y. S., Coskun, A. U., Jonas, M., Edelman, E. R., Feldman, C. L., & Stone, P. H. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.02.059 · Cited by 1,483
Flagged first, then by citations
Cited by
Sorted by citations
Items 201–237 of 237
Ma, L., Li, Y., Wu, Z., & Mu, Y. (2016) · PubMed Central
Voloshynska, K. O., Kovalchuk, S. М., Kovalchuk, M., & Peresunko, O. M. (2019) · ScienceRise Medical Science · doi:10.15587/2519-4798.2020.193270
PREVALENCE OF ELEVATED RESTING HEART RATE AMONG YOUNG ADULTS
Muhammad, A. (2020) · Pakistan Journal of Rehabilitation · doi:10.36283/pjr.zu.9.2/012
Elevated heart rate across cardiovascular continuum and its management
Punjabi, A., George, S., Khera, P., & Srivastava, S. (2021) · International Journal of Advances in Medicine · doi:10.18203/2349-3933.ijam20214147
Chan, Y., Cheung, B. M. Y., & Tse, H. (2022) · Journal of the Hong Kong College of Cardiology · doi:10.55503/2790-6744.1487
Hao, Z., He, C., Li, J., Yang, H., Fan, S., Hu, L.-X., Liu, X., Zhang, Y., Qiu, H., Xie, Y., et al. (2023) · Atmosphere · doi:10.3390/atmos14020394
Individualized Maternal Sleep Quality Evaluation
-, T. H. G., -, T. H. G., -, G. S., -, B. S., & Afsheen (2023) · International Journal For Multidisciplinary Research · doi:10.36948/ijfmr.2023.v05i04.5859
Chen, L., Xie, W., Hong, X., & Hong, H. (2024) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2024.1366282
Oota, N., Yamauchi, Y., Iwase, G., Abuku, M., & Hiraguri, Y. (2024) · Indoor Environments · doi:10.1016/j.indenv.2024.100050
Chen, S., Yuan, X., & Zhu, W. (2024) · Acta Diabetologica · doi:10.1007/s00592-024-02369-z
Cardiovascular Measures for Social and Behavioral Research
Carey, M. G. (2024) · Cambridge University Press eBooks · doi:10.1017/9781009000796.021
Haboussi, A. E., El‐Mansoury, B., Khiat, A. E., Hilali, M.-K., & Loukid, M. (2025) · Journal of Education and Health Promotion · doi:10.4103/jehp.jehp_2241_24
Du, Z., Zhang, D., Li, J., Li, Q., & Pang, Y. (2022) · Figshare · doi:10.6084/m9.figshare.20508596
Du, Z., Zhang, D., Li, J., Li, Q., & Pang, Y. (2022) · Figshare · doi:10.6084/m9.figshare.20508602
Du, Z., Zhang, D., Li, J., Li, Q., & Pang, Y. (2022) · Figshare · doi:10.6084/m9.figshare.20508605
Du, Z., Zhang, D., Li, J., Li, Q., & Pang, Y. (2022) · Figshare · doi:10.6084/m9.figshare.20508593
Deng, Y.-T., Kuo, K., Wu, B.-S., Ou, Y.-N., Yang, L., Zhang, Y.-R., Huang, S.-Y., Chen, S.-D., Guo, Y., Zhang, R.-Q., et al. (2022) · Figshare · doi:10.6084/m9.figshare.21285758
Luna-Alcala, S., Espejel-Guzman, A., Lerma, C., León, P., Guerra, E. C., Fernández, J. R. E., Martinez‐Dominguez, P., Serrano‐Roman, J., Cabello‐Ganem, A., Aparicio-Ortiz, A. D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.25929204
Du, Z., Zhang, D., Li, J., Li, Q., & Pang, Y. (2022) · Figshare · doi:10.6084/m9.figshare.20508599
Du, Z., Zhang, D., Li, J., Li, Q., & Pang, Y. (2022) · Figshare · doi:10.6084/m9.figshare.20508611
Du, Z., Zhang, D., Li, J., Li, Q., & Pang, Y. (2022) · Figshare · doi:10.6084/m9.figshare.20508608
Ma, X., Yang, H., Qu, J., & Tang, M. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5164050
Du, Z., Zhang, D., Li, J., Li, Q., & Pang, Y. (2022) · Figshare · doi:10.6084/m9.figshare.20508590
Association Between Elevated Resting Heart Rate and Early Atherosclerotic Changes in Young Adults
Mumtaz, A. H., Rahman, A., & Javed, A. R. (2024) · Developmental medico-life-sciences · doi:10.69750/dmls.01.010.039
Resting Heart Rate: a risk marker or factor for outcomes?
Sanidas, E. A., & Thomopoulos, C. (2026) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2026.106831
Cardioprotection contre les lésions d’ischémie-reperfusion par réduction de la fréquence cardiaque
Betancourt, S. D. (2015) · theses.fr (ABES) · doi:10.70675/8d5deb30zd61dz437czbce5zb5f0416eecb0
Everyday movement through nature linked to nighttime cardiac regulation
Samuelsson, K., Giusti, M., Hallman, D., Koch, S., Touli, E. F., Buekers, J., van den Bosch, M. A., Bornioli, A., Dadvand, P., & Barthel, S. (2026) · npj Urban Sustainability · doi:10.1038/s42949-026-00387-0
Thyroid function tests and resting heart rate in Graves’ disease: a prospective longitudinal study
Egger, B., Riedmann, U., Schmitt, L., Kraus, D. A., Pichler, H., Trummer, C., Theiler‐Schwetz, V., Lindschinger, S., März, W., Tsybrovskyy, O., et al. (2026) · Endocrine Connections · doi:10.1530/ec-26-0129
Shao, W., Li, X., Lin, J., Yao, H., Xue, X., Yang, T., Li, J., Zhang, H., Qiu, Z., Yuan, R., et al. (2026) · Ecological Frontiers · doi:10.1016/j.ecofro.2026.06.003
Resting heart rate and long-term mortality in young adults: a population-based cohort study
Chen, H., Chen, Q., & Wang, Y. (2026) · Open Heart · doi:10.1136/openhrt-2026-004279
Shang, S., Dang, L., Gao, L., Wei, S., Zhao, Y., Hu, N., Peng, W., Yuan, Y., Wang, J., Wang, J., et al. (2026) · BMC Neurology · doi:10.1186/s12883-026-05194-9
Xu, X., Niu, Y., Zhao, X., Liu, S., Shi, Y., Yan, Q., Wang, Y., & Li, J. (2026) · Frontiers in Medicine · doi:10.3389/fmed.2026.1914874
Herencia, J. A. C., Artigao-Rodenas, L. M., Rueda, M. S., Escribano, F. M., Navarro-Blazquez, F., Gil-Guillén, V. F., Banegas, J. R., & Divisón, J. A. (2026) · Journal of Clinical Medicine · doi:10.3390/jcm15187333
Cardiac signal monitoring using femtosecond laser inscribed FBGs in CYTOP optical fiber
Hu, Y. Y., Ioannou, A., Yu, C., & Kalli, K. (2026) · Sensors and Actuators A Physical · doi:10.1016/j.sna.2026.118622
Metadata
- Authors
- Böhm, M., Reil, J.-C., Deedwania, P., Kim, J. B., & Borer, J. S.
- Affiliations
- Universitätsklinikum des Saarlandes (DE)
- University of California, San Francisco (US)
- Amgen (United States) (US)
- Cornell University (US)
- Corresponding author
- Böhm, Michael
- Venue
- The American Journal of Medicine
- Publisher
- Elsevier BV
- Published
- 2015-03
- Volume
- 128
- Issue
- 3
- Pages
- 219-228
- ISSN
- 0002-9343 (ISSN-L)
- OpenAlex
- W2082410000
- Cited by
- 236
- References
- 138
- Citations by year
- 2026: 12 · 2025: 25 · 2024: 22 · 2023: 25 · 2022: 34 · 2021: 24 · 2020: 16 · 2019: 16 · 2018: 14 · 2017: 14 · 2016: 24 · 2015: 9
- FWCI
- 2.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Amgen
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart rate and cardiovascular health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Keywords
- resting heart rate, cardiovascular risk, heart failure, ivabradine, beta-blockers, heart rate reduction, cardiovascular outcomes, coronary artery disease, mortality, hospital readmission, angina pectoris, exercise tolerance
- MeSH terms
- Ivabradine, Benzazepines, Cardiovascular Agents, Cardiovascular Diseases, Heart Rate, Humans, Rest, Risk Factors, Treatment Outcome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
