The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Nutritional, Physical, Cognitive, and Combination Interventions and Frailty Reversal Among Older Adults: A Randomized Controlled Trial
Open accessAbstract
BACKGROUND: It is important to establish whether frailty among older individuals is reversible with nutritional, physical, or cognitive interventions, singly or in combination. We compared the effects of 6-month-duration interventions with nutritional supplementation, physical training, cognitive training, and combination treatment vs control in reducing frailty among community-dwelling prefrail and frail older persons. METHODS: We conducted a parallel group, randomized controlled trial in community-living prefrail and frail old adults in Singapore. The participants' mean age was 70.0 years, and 61.4% (n = 151) were female. Five different 6-month interventions included nutritional supplementation (n = 49), cognitive training (n = 50), physical training (n = 48), combination treatment (n = 49), and usual care control (n = 50). Frailty score, body mass index, knee extension strength, gait speed, energy/vitality, and physical activity levels and secondary outcomes (activities of daily living dependency, hospitalization, and falls) were assessed at 0 months, 3 months, 6 months, and 12 months. RESULTS: Frailty score and status over 12 months were reduced in all groups, including control (15%), but were significantly higher (35.6% to 47.8%) in the nutritional (odds ratio [OR] 2.98), cognition (OR 2.89), and physical (OR 4.05) and combination (OR 5.00) intervention groups. Beneficial effects were observed at 3 months and 6 months, and persisted at 12 months. Improvements in physical frailty domains (associated with interventions) were most evident for knee strength (physical, cognitive, and combination treatment), physical activity (nutritional intervention), gait speed (physical intervention), and energy (combination intervention). There were no major differences with respect to the small numbers of secondary outcomes. CONCLUSIONS: Physical, nutritional, and cognitive interventional approaches were effective in reversing frailty among community-living older persons.
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Frailty in Older Adults: Evidence for a Phenotype
Fried, L. P., Tangen, C. M., Walston, J., Newman, A. B., Hirsch, C., Gottdiener, J., Seeman, T., Tracy, R., Kop, W. J., Burke, G., et al. (2001) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/56.3.m146 · Cited by 24,907
Exercise training and nutritional supplementation for physical frailty in very elderly people
Fiatarone, M. A., O'Neill, E. F., Ryan, N. D., Clements, K. M., Solares, G. R., Nelson, M. E., Roberts, S. B., Kehayias, J. J., Lipsitz, L. A., & Evans, W. J. (1994) · New England Journal of Medicine · doi:10.1056/nejm199406233302501 · Cited by 2,857
Long-term Effects of Cognitive Training on Everyday Functional Outcomes in Older Adults
Willis, S. L., Tennstedt, S. L., Marsiske, M., Ball, K., Elias, J., Koepke, K. M., Morris, J. N., Rebok, G. W., Unverzagt, F. W., Stoddard, A. M., et al. (2006) · JAMA · doi:10.1001/jama.296.23.2805 · Cited by 1,496
Rockwood, K., Mitnitski, A., Song, X., Steen, B., & Skoog, I. (2006) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2006.00738.x · Cited by 481
de Vries, N. M., van Ravensberg, C. D., Hobbelen, J. S. M., Olde Rikkert, M. G. M., Staal, J. B., & Nijhuis-van der Sanden, M. W. G. (2012) · Ageing Research Reviews · doi:10.1016/j.arr.2011.11.002 · Cited by 396
Kim, C.-O., & Lee, K.-R. (2013) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/gls167 · Cited by 184
Cited by
Physical Frailty: ICFSR International Clinical Practice Guidelines for Identification and Management
Dent, E., Morley, J. E., Cruz-Jentoft, A. J., Woodhouse, L., Rodríguez-Mañas, L., Fried, L. P., Woo, J., Aprahamian, I., Sanford, A., Lundy, J., et al. (2019) · The Journal of nutrition, health and aging · doi:10.1007/s12603-019-1273-z · Cited by 1,049
The Asia-Pacific Clinical Practice Guidelines for the Management of Frailty
Dent, E., Lien, C., Lim, W. S., Wong, W. C., Wong, C. H., Ng, T. P., Woo, J., Dong, B., de la Vega, S., Hua Poi, P. J., et al. (2017) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2017.04.018 · Cited by 631
Self-citationCao, L., & Morley, J. E. (2016) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2016.06.001 · Cited by 424
Interventions for Frailty Among Older Adults With Cardiovascular Disease
Ijaz, N., Buta, B., Xue, Q.-L., Mohess, D. T., Bushan, A., Tran, H., Batchelor, W., deFilippi, C. R., Walston, J. D., Bandeen-Roche, K., et al. (2022) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2021.11.029 · Cited by 412
Delaying and reversing frailty: a systematic review of primary care interventions
Travers, J., Romero-Ortuno, R., Bailey, J., & Cooney, M.-T. (2019) · British Journal of General Practice · doi:10.3399/bjgp18x700241 · Cited by 401
Metadata
- Authors
- Ng, T. P., Feng, L., Nyunt, M. S. Z., Feng, L., Niti, M., Tan, B. Y., Chan, G., Khoo, S. A., Chan, S. M., Yap, P., & Yap, K. B.
- Venue
- The American Journal of Medicine
- Publisher
- Elsevier BV
- Published
- 2015-11
- Volume
- 128
- Issue
- 11
- Pages
- 1225-1236.e1
- ISSN
- 0002-9343 (ISSN-L)
- OpenAlex
- W2105061478
- Cited by
- 725
- References
- 7
- FWCI
- 24.32
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Ng, T. P., Feng, L., Nyunt, M. S. Z., Feng, L., Niti, M., Tan, B. Y., Chan, G., Khoo, S. A., Chan, S. M., Yap, P., & Yap, K. B. (2015). Nutritional, Physical, Cognitive, and Combination Interventions and Frailty Reversal Among Older Adults: A Randomized Controlled Trial. The American Journal of Medicine. https://doi.org/10.1016/j.amjmed.2015.06.017
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