The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
No, Mindfulness Meditation-Based Analgesia Is Not Mediated by Endogenous Opioids
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The authors did not directly statistically compare the differences in pain between the saline and naloxone conditions.
“Importantly, the authors did not directly statistically compare the differences in pain between the saline and naloxone conditions, which begs the question on why they used the elegant crossover-controlled design.”
From The neural mechanisms of mindfulness-based pain relief: a functional magnetic resonance imaging-based review and primer (2019) · cites this paper as [133]
The authors' interpretations that mindfulness-based pain relief was reversed by naloxone were not justified because of the significant decrease in pain (↓19%) during mindfulness and naloxone infusion and comparable reductions during meditation and saline infusion (↓25%).
“In our rebutting commentary of this study, we postulated that the authors' interpretations were not justified because of the significant decrease in pain (ie, ↓19%) during mindfulness and naloxone infusion and the comparable reductions during meditation and saline infusion (ie, ↓25%).133”
From The neural mechanisms of mindfulness-based pain relief: a functional magnetic resonance imaging-based review and primer (2019) · cites this paper as [133]
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Mindfulness-meditation-based pain relief is not mediated by endogenous opioids
Zeidan, F., Adler-Neal, A. L., Wells, R. E., Stagnaro, E., May, L. M., Eisenach, J. C., McHaffie, J. G., & Coghill, R. C. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.4328-15.2016 · Cited by 132
Self-citationMindfulness Meditation Modulates Pain Through Endogenous Opioids
Sharon, H., Maron-Katz, A., Ben Simon, E., Flusser, Y., Hendler, T., Tarrasch, R., & Brill, S. (2016) · The American Journal of Medicine · doi:10.1016/j.amjmed.2016.03.002 · Cited by 44
Naloxone hydrochloride: a review.
Pm, G. (1990) · PubMed · Cited by 18
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Zeidan, F., Baumgartner, J. N., & Coghill, R. C. (2019) · PAIN Reports · doi:10.1097/pr9.0000000000000759 · Cited by 115
Self-citationEnhancement of meditation analgesia by opioid antagonist in experienced meditators
May, L. M., Kosek, P., Zeidan, F., & Berkman, E. T. (2018) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000580 · Cited by 24
Self-citationCase, L. K., Adler-Neal, A. L., Wells, R. E., & Zeidan, F. Z. (2021) · Psychosomatic Medicine · doi:10.1097/psy.0000000000000908 · Cited by 16
Self-citationOpioid Antagonist Enhances Meditation Analgesia in Experienced MeditatorsPreprint
May, L. M., Kosek, P. S., Zeidan, F. Z., & Berkman, E. T. (2017) · doi:10.31231/osf.io/y8nbe
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Metadata
- Authors
- Zeidan, F.
- Affiliations
- Wake Forest University Health Sciences (US)
- Corresponding author
- Zeidan, Fadel
- ORCID
- Zeidan, Fadel
- Venue
- The American Journal of Medicine
- Publisher
- Elsevier BV
- Published
- 2016-11
- Volume
- 129
- Issue
- 11
- Pages
- e297
- ISSN
- 0002-9343 (ISSN-L)
- PMC
- PMC5505568
- OpenAlex
- W2531952913
- Cited by
- 4
- References
- 3
- Citations by year
- 2021: 1 · 2019: 1 · 2018: 1 · 2017: 1
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The American Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Mind and Life Institute
- National Institutes of Health (UL1TR001420)
- National Center for Advancing Translational Sciences
- National Center for Complementary and Integrative Health (L30 AT006838, K99AT008238)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
- Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Keywords
- mindfulness meditation, analgesia, endogenous opioids, naloxone, opioid antagonists, experienced meditators, analgesic mechanism, placebo effect
- MeSH terms
- Analgesia, Analgesics, Opioid, Humans, Meditation, Pain Management, Mindfulness
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