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Mindfulness Meditation Modulates Pain Through Endogenous Opioids
Open accessAbstract
Background Recent evidence supports the beneficial effects of mindfulness meditation on pain. However, the neural mechanisms underlying this effect remain poorly understood. We used an opioid blocker to examine whether mindfulness meditation-induced analgesia involves endogenous opioids. Methods Fifteen healthy experienced mindfulness meditation practitioners participated in a double-blind, randomized, placebo-controlled, crossover study. Participants rated the pain and unpleasantness of a cold stimulus prior to and after a mindfulness meditation session. Participants were then randomized to receive either intravenous naloxone or saline, after which they meditated again, and rated the same stimulus. Results A (3) × (2) repeated-measurements analysis of variance revealed a significant time effect for pain and unpleasantness scores (both P <.001) as well as a significant condition effect for pain and unpleasantness (both P <.2). Post hoc comparisons revealed that pain and unpleasantness scores were significantly reduced after natural mindfulness meditation and after placebo, but not after naloxone. Furthermore, there was a positive correlation between the pain scores following naloxone vs placebo and participants' mindfulness meditation experience. Conclusions These findings show, for the first time, that meditation involves endogenous opioid pathways, mediating its analgesic effect and growing resilient with increasing practice to external suggestion. This finding could hold promising therapeutic implications and further elucidate the fine mechanisms involved in human pain modulation.
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Mindfulness-based pain relief was reversed by naloxone in response to a brief (10 seconds) noxious cold stimulus in a randomized crossover design.
“By contrast, another group used a randomized, crossover design and reported that mindfulness-based pain relief was reversed by naloxone105 in response to a brief (10 seconds) noxious cold stimulus.”
From The neural mechanisms of mindfulness-based pain relief: a functional magnetic resonance imaging-based review and primer (2019) · cites this paper as [105]
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Metadata
- Authors
- Sharon, H., Maron-Katz, A., Ben Simon, E., Flusser, Y., Hendler, T., Tarrasch, R., & Brill, S.
- Affiliations
- Tel Aviv Sourasky Medical Center (IL)
- Tel Aviv University (IL)
- Corresponding author
- Sharon, Haggai
- Venue
- The American Journal of Medicine
- Publisher
- Elsevier BV
- Published
- 2016-07
- Volume
- 129
- Issue
- 7
- Pages
- 755-758
- ISSN
- 0002-9343 (ISSN-L)
- OpenAlex
- W2316497012
- Cited by
- 44
- References
- 10
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 4 · 2023: 6 · 2022: 2 · 2021: 4 · 2020: 4 · 2019: 7 · 2018: 4 · 2017: 5 · 2016: 3
- FWCI
- 7.42
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The American Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Israel Science Foundation
- Planning and Budgeting Committee of the Council for Higher Education of Israel
- Topics
- Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
- Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Keywords
- mindfulness meditation, pain modulation, endogenous opioids, naloxone, analgesia, pain unpleasantness, cold pressor pain, meditation experience, opioid blockade
- MeSH terms
- Cold Temperature, Double-Blind Method, Humans, Naloxone, Narcotic Antagonists, Pain Measurement, Cross-Over Studies, Opioid Peptides, Meditation, Pain Management, Mindfulness
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