Five-year glycemic trajectories among healthy African-American and European-American offspring of parents with type 2 diabetes
Open accessAbstract
Background Cross-sectional surveys report a higher prevalence of diagnosed type 2 diabetes mellitus (T2DM) in African Americans (AA) than European Americans (EA). We studied 5-year glycemic excursions among AA and EA in the Pathobiology of Prediabetes in A Biracial Cohort study, to assess ethnic disparities.Materials and methods Pathobiology of Prediabetes in A Biracial Cohort followed normoglycemic offspring of parents with T2DM for 5 years, with serial assessments of oral glucose tolerance test , anthropometry, body fat, insulin sensitivity and beta-cell function. The primary outcome was progression to prediabetes (impaired fasting glucose and/or impaired glucose tolerance). We further analyzed 5-year changes in fasting (FPG) and 2-hour plasma glucose (2hrPG).Results One hundred and one (52 AA, 49 EA) out of 343 subjects developed prediabetes during follow-up. The change in FPG ranged from -24 mg/dl to +38 mg/dl. The FPG remained stable (± 5 mg/dl from baseline) in 50% of EA and 46.8% of AA and the 2hrPG remained stable (± 25 mg/dl from baseline) in 73.7% of EA and 71.0 % of AA during follow-up. The proportions with change in FPG of 5mg/dl to >25 mg/dl and 2hrPG of 25 mg/dl to >50 mg/dl were similar in EA and AA offspring, as were the 10th - 90th percentiles of the distribution of 5-year changes in FPG and 2hrPG.Conclusions During 5 years of follow-up, black and white offspring of parents with T2DM exhibited remarkable phenotypic concordance of glycemic trajectories. Thus, parental history of T2DM may be a stronger factor than race/ethnicity in the prediction of longitudinal glycemic trends.
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The CDC reports a higher prevalence of diagnosed diabetes in African Americans, Hispanic Americans, and other non-European-origin persons than in European Americans.
“The Centers for Disease Control and Prevention (CDC) has reported a higher prevalence of diagnosed DM in African Americans, Hispanic Americans, and other persons of non-European origin compared with European Americans.36,37”
From American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan-2022 Update. (2022) · cites this paper as [37]
The Discussion (page unavailable) says reports found higher diagnosed type 2 diabetes prevalence in African Americans and other racial/ethnic groups than in European Americans, and cites CDC estimates comparing non-Hispanic Black and white adults. It does not specifically say that the CDC reported higher diagnosed-diabetes prevalence in Hispanic Americans or every other non-European-origin group; the quoted CDC figures also combine diagnosed and undiagnosed diabetes. (LLM, conf=0.84)
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Cites
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“The homeostasis model of insulin resistance (HOMA-IR) and of beta-cell function (HOMA-B) were derived from FPG and insulin levels (10).”
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Self-citationEditorial: The continuum of dysglycemia: Predicting progression from prediabetes to type 2 diabetes
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- Authors
- Razavi, L. N., Ebenibo, S., Edeoga, C., Wan, J., & Dagogo-Jack, S.
- Affiliations
- University of Tennessee Health Science Center (US)
- Corresponding author
- Dagogo-Jack, Samuel
- Venue
- The American Journal of the Medical Sciences
- Publisher
- Elsevier BV
- Published
- 2020-05
- Volume
- 359
- Issue
- 5
- Pages
- 266-270
- ISSN
- 0002-9629 (ISSN-L)
- PMC
- PMC7246091
- OpenAlex
- W3010663769
- Cited by
- 4
- References
- 18
- Citations by year
- 2025: 2 · 2023: 1 · 2022: 1
- FWCI
- 0.38
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The American Journal of the Medical Sciences (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- American Diabetes Association
- National Institutes of Health (7-07-MN-13)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Keywords
- type 2 diabetes, prediabetes, ethnic disparities, fasting blood glucose, 2-hour plasma glucose, oral glucose tolerance test, insulin sensitivity, beta-cell function
- MeSH terms
- Adult, Anthropometry, Black or African American, Blood Glucose, Diabetes Mellitus, Type 2, Family Health, Female, Follow-Up Studies, Glucose Tolerance Test, Glycated Hemoglobin, Humans, Hyperglycemia, Insulin, Insulin Resistance, Male, Middle Aged, Parents, Phenotype, Prediabetic State, United States, Body Mass Index, Prevalence, Treatment Outcome, Glucose Intolerance, White People, Insulin-Secreting Cells, Healthcare Disparities
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