Antiviral activity of Lactobacillus brevis towards herpes simplex virus type 2: Role of cell wall associated components
Abstract
The aim of this research was to study the mechanisms of Lactobacillus brevis antiviral activity towards HSV-2 and to identify the bacterial components responsible for the inhibiting effect. Bacterial extract and cell walls were prepared by lysozyme digestion of L. brevis cells untreated or treated with LiCl to remove S-layer proteins. Bacterial extract and cell wall fragments showed a dose dependent inhibitory effect on HSV-2 multiplication. In order to characterize the inhibitory activity of L. brevis, the bacterial extract was subjected to different physical and chemical treatments. The inhibitory activity was resistant to high temperature and proteases digestion and appeared to be associated with compounds with a molecular weight higher than 10 kDa. DNA, RNA and lipids isolated from bacterial cells were devoid of inhibitory effect. The antiviral activity of both bacterial extract and cell wall fragments obtained from L. brevis cells after the S-layer removal was significantly reduced compared to untreated cells suggesting that the inhibitory activity is likely due to a heat-resistant non-protein cell surface bacterial component.
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Other metabolites and bacterial cell fragments may interfere with virus binding, and Levilactobacillus brevis cell wall fragments have been reported to inhibit herpes simplex replication.
“Also other metabolites and bacterial cell fragments may interfere with virus binding (Martín et al., 2010) and Levilactobacillus brevis cell wall fragments have been reported to inhibit herpes simplex replication (Mastromarino et al., 2011).”
From Viral Infections, the Microbiome, and Probiotics (2021) · cites this paper as Mastromarino et al., 2011
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- Authors
- Mastromarino, P., Cacciotti, F., Masci, A., & Mosca, L.
- Affiliations
- Sapienza University of Rome (IT)
- Corresponding author
- Mastromarino, Paola
- Venue
- Anaerobe
- Publisher
- Elsevier BV
- Published
- 2011-12
- Volume
- 17
- Issue
- 6
- Pages
- 334-336
- ISSN
- 1075-9964 (ISSN-L)
- OpenAlex
- W1997391581
- Cited by
- 77
- References
- 13
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 5 · 2023: 7 · 2022: 9 · 2021: 9 · 2020: 10 · 2019: 3 · 2018: 4 · 2017: 5 · 2016: 4 · 2015: 2 · 2014: 4 · 2013: 4 · 2012: 1
- FWCI
- 5.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Anaerobe (publishedVersion)
- PubMed (publishedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
- Physical Sciences › Environmental Science › Ecology › Bacteriophages and microbial interactions
- Keywords
- Lactobacillus brevis, herpes simplex virus type 2, antiviral activity, bacterial cell wall, S-layer proteins, lysozyme digestion, bacterial extracts, viral replication inhibition, lactic acid bacteria
- MeSH terms
- Antibiosis, Antiviral Agents, Cell Wall, Humans, Virus Replication, Herpesvirus 2, Human, Levilactobacillus brevis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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