Antiviral Potential of Lactic Acid Bacteria and Their Bacteriocins
Abstract
Emerging resistance to antiviral agents is a growing public health concern worldwide as it was reported for respiratory, sexually transmitted and enteric viruses. Therefore, there is a growing demand for new, unconventional antiviral agents which may serve as an alternative to the currently used drugs. Meanwhile, published literature continues shedding the light on the potency of lactic acid bacteria (LAB) and their bacteriocins as antiviral agents. Health-promoting LAB probiotics may exert their antiviral activity by (1) direct probiotic-virus interaction; (2) production of antiviral inhibitory metabolites; and/or (3) via stimulation of the immune system. The aim of this review was to highlight the antiviral activity of LAB and substances they produce with antiviral activity.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
These metabolites create an acidic pH that is known to inactivate some common enteric viruses while the infant immune system matures.
“These metabolites create an acidic pH which is known to inactivate some common enteric viruses (Al Kassaa et al., 2014), while the infant immune system matures.”
From Viral Infections, the Microbiome, and Probiotics (2021) · cites this paper as Al Kassaa et al., 2014
Cites
Abdool Karim, Q., Abdool Karim, S. S., Frohlich, J. A., Grobler, A. C., Baxter, C., Mansoor, L. E., Kharsany, A. B. M., Sibeko, S., Mlisana, K. P., Omar, Z., et al. (2010) · Science · doi:10.1126/science.1193748 · Cited by 2,435 · see citing works
Bacteriocins: Developing innate immunity for food
Cotter, P. D., Hill, C., & Ross, R. P. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1273 · Cited by 2,380 · see citing works
Genetics of bacteriocins produced by lactic acid bacteria
Klaenhammer, T. R. (1993) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.1993.tb00012.x · Cited by 1,835 · see citing works
Fong, T.-T., & Lipp, E. K. (2005) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.69.2.357-371.2005 · Cited by 795 · see citing works
Guarner, F. (1998) · International Journal of Food Microbiology · doi:10.1016/s0168-1605(97)00136-0 · Cited by 638 · see citing works
Class IIa bacteriocins: biosynthesis, structure and activity
Ennahar, S., Sashihara, T., Sonomoto, K., & Ishizaki, A. (2000) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2000.tb00534.x · Cited by 637 · see citing works
The Role of Functional Foods, Nutraceuticals, and Food Supplements in Intestinal Health
Čenčič, A., & Chingwaru, W. (2010) · Nutrients · doi:10.3390/nu2060611 · Cited by 591 · see citing works
Szajewska, H., & Mrukowicz, J. Z. (2001) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200110002-00004 · Cited by 509 · see citing works
Bacteriocins: modes of action and potentials in food preservation and control of food poisoning
Abee, T., Kröckel, L., & Hill, C. (1995) · International Journal of Food Microbiology · doi:10.1016/0168-1605(95)00055-0 · Cited by 443 · see citing works
Weiss, L., Donkova-Petrini, V., Caccavelli, L., Balbo, M., Carbonneil, C., & Lévy, Y. (2004) · Blood · doi:10.1182/blood-2004-01-0365 · Cited by 384 · see citing works
Martin, L. S., McDougal, J. S., & Loskoski, S. L. (1985) · The Journal of Infectious Diseases · doi:10.1093/infdis/152.2.400 · Cited by 366 · see citing works
Probiotics as Biotherapeutic Agents: Present Knowledge and Future Prospects
Mercenier, A., Pavan, S., & Pot, B. (2003) · Current Pharmaceutical Design · doi:10.2174/1381612033392224 · Cited by 342 · see citing works
Probiotic Effects on Cold and Influenza-Like Symptom Incidence and Duration in Children
Leyer, G. J., Li, S., Mubasher, M., Reifer, C. J., & Ouwehand, A. C. (2009) · PEDIATRICS · doi:10.1542/peds.2008-2666 · Cited by 305 · see citing works
Liu, S. (2003) · International Journal of Food Microbiology · doi:10.1016/s0168-1605(02)00366-5 · Cited by 293 · see citing works
Bacteriocins: mechanism of membrane insertion and pore formation
Moll, G. N., Konings, W. N., & Driessen, A. J. M. (1999) · Antonie van Leeuwenhoek · doi:10.1023/a:1002002718501 · Cited by 276 · see citing works
Klebanoff, S. J., & Coombs, R. W. (1991) · The Journal of Experimental Medicine · doi:10.1084/jem.174.1.289 · Cited by 273 · see citing works
Pathogenesis of type 1 diabetes mellitus: interplay between enterovirus and host
Hober, D., & Sauter, P. (2010) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2010.27 · Cited by 271 · see citing works
Self-citationOral intake of Lactobacillus fermentum CECT5716 enhances the effects of influenza vaccination
Olivares, M. M., Díaz-Ropero, M. P., Sierra, S., Lara‐Villoslada, F., Fonollá, J., Navas, M., Rodríguez, J. M., & Xaus, J. (2007) · Nutrition · doi:10.1016/j.nut.2007.01.004 · Cited by 264 · see citing works
Guillemard, E., Tondu, F., Lacoin, F., & Schrezenmeir, J. (2009) · British Journal Of Nutrition · doi:10.1017/s0007114509991395 · Cited by 257 · see citing works
Rautava, S., Salminen, S., & Isolauri, E. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114508116282 · Cited by 244 · see citing works
Boge, T., Remigy, M., Vaudaine, S., Tanguy, J., Bourdet‐Sicard, R., & van der Werf, S. (2009) · Vaccine · doi:10.1016/j.vaccine.2009.06.094 · Cited by 221 · see citing works
de Vrese, M., Winkler, P., Rautenberg, P., Harder, T., Noah, C., Laue, C., Ott, S., Hampe, J., Schreiber, S., Heller, K., et al. (2006) · Vaccine · doi:10.1016/j.vaccine.2006.05.048 · Cited by 201 · see citing works
Characterisation of an antiviral pediocin-like bacteriocin produced by Enterococcus faecium
Todorov, S. D., Wachsman, M. B., Tomè, E., Dousset, X., Destro, M. T., Dicks, L. M. T., Franco, B. D. G. D. M., Vaz‐Velho, M., & Drider, D. (2010) · Food Microbiology · doi:10.1016/j.fm.2010.05.001 · Cited by 189 · see citing works
Self-citationProbiotics as Antiviral Agents in Shrimp Aquaculture
Lakshmi, B., Viswanath, B., & Gopal, D. V. R. S. (2013) · Journal of Pathogens · doi:10.1155/2013/424123 · Cited by 181 · see citing works
Maeda, N., Nakamura, R., Hirose, Y., Murosaki, S., Yamamoto, Y., Kase, T., & Yoshikai, Y. (2009) · International Immunopharmacology · doi:10.1016/j.intimp.2009.04.015 · Cited by 179 · see citing works
Immunobiotics and the probiotic evolution
Clancy, R. (2003) · FEMS Immunology & Medical Microbiology · doi:10.1016/s0928-8244(03)00147-0 · Cited by 176 · see citing works
Probiotics in respiratory virus infections
Lehtoranta, L., Pitkäranta, A., & Korpela, R. (2014) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-014-2086-y · Cited by 174 · see citing works
Férir, G., Petrova, M., Andreï, G., Huskens, D., Hoorelbeke, B., Snoeck, R., Vanderleyden, J., Balzarini, J. M., Bartoschek, S., Brönstrup, M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064010 · Cited by 167 · see citing works
A novel eukaryotic cell culture model to study antiviral activity of potential probiotic bacteria
Botić, T., Klingberg, T. D., Weingartl, H., & Cencič, A. (2007) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2006.10.044 · Cited by 163 · see citing works
Enterocin CRL35 inhibits late stages of HSV-1 and HSV-2 replication in vitro
Wachsman, M. B., Castilla, V., Holgado, A. P. D. R., Torres, R. A. D., Sesma, F., & Coto, C. E. (2003) · Antiviral Research · doi:10.1016/s0166-3542(02)00099-2 · Cited by 161 · see citing works
Abee, T. (1995) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1995.tb07548.x · Cited by 158 · see citing works
Yasui, H., Kiyoshima‐Shibata, J., & Hori, T. (2004) · Clinical and Vaccine Immunology · doi:10.1128/cdli.11.4.675-679.2004 · Cited by 157 · see citing works
Abee, T. (1995) · FEMS Microbiology Letters · doi:10.1016/0378-1097(95)00137-t · Cited by 155 · see citing works
Prokaryotic Antimicrobial Peptides
(2011) · Springer eBooks · doi:10.1007/978-1-4419-7692-5 · Cited by 153 · see citing works
Maragkoudakis, P. A., Chingwaru, W., Gradišnik, L., Tsakalidou, E., & Čenčič, A. (2010) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2009.12.024 · Cited by 146 · see citing works
Sarker, S. A., Sultana, S., Fuchs, G. J., Alam, N. H., Azim, T., Brüssow, H., & Hammarström, L. L. G. (2005) · PEDIATRICS · doi:10.1542/peds.2004-2334 · Cited by 146 · see citing works
Todorov, S. D., Wachsman, M. B., Knoetze, H., Meincken, M., & Dicks, L. M. T. (2005) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2005.02.005 · Cited by 144 · see citing works
Torres, N. I., Noll, K. S., Xu, S., Li, J., Huang, Q., Sinko, P. J., Wachsman, M. B., & Chikindas, M. L. (2013) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-012-9123-x · Cited by 122 · see citing works
Lactobacillus plantarum strain YU from fermented foods activates Th1 and protective immune responses
Kawashima, T., Hayashi, K., Kosaka, A., Kawashima, M., Igarashi, T., Tsutsui, H., Tsuji, N. M., Nishimura, I., Hayashi, T., & Obata, A. (2011) · International Immunopharmacology · doi:10.1016/j.intimp.2011.08.013 · Cited by 119 · see citing works
Inhibition of herpes simplex virus type 2 by vaginal lactobacilli.
Conti, C., Malacrino, C., & Mastromarino, P. (2009) · PubMed · Cited by 115 · see citing works
Agarwal, K., & Bhasin, S. (2002) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601664 · Cited by 108 · see citing works
Role of coxsackievirus B4 in the pathogenesis of type 1 diabetes
Jaïdane, H., & Hober, D. (2008) · Diabetes & Metabolism · doi:10.1016/j.diabet.2008.05.008 · Cited by 107 · see citing works
Self-citationKassaa, I. A., Hamzé, M., Hober, D., Chihib, N., & Drider, D. (2014) · Microbial Ecology · doi:10.1007/s00248-014-0384-7 · Cited by 100 · see citing works
Self-citationAntiviral activity of Bifidobacterium adolescentisSPM1005-A on human papillomavirus type 16
Cha, M.-K., Lee, D., An, H.-M., Lee, S., Shin, S. H., Kwon, J.-H., Kim, K.-J., & Ha, N. (2012) · BMC Medicine · doi:10.1186/1741-7015-10-72 · Cited by 95 · see citing works
Chiba, E., Tomosada, Y., Vizoso-Pinto, M. G., Salva, S., Takahashi, T., Tsukida, K., Kitazawa, H., Alvarez, S., & Villena, J. (2013) · International Immunopharmacology · doi:10.1016/j.intimp.2013.06.024 · Cited by 94 · see citing works
Seo, B. J., Rather, I. A., Rejish Kumar, V. J., et al. (2012) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2012.05326.x · Cited by 84 · see citing works
Salva, S., Nuñez, M. S., Villena, J., Ramón, A. N., Font, G., & Alvarez, S. (2011) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.4467 · Cited by 83 · see citing works
Antiviral activity of enterocin CRL35 against herpesviruses
Wachsman, M. B., Farías, M. E., Takeda, E., Sesma, F. J. M., Holgado, A. P. D. R., de Torres, R. A., & Coto, C. E. (1999) · International Journal of Antimicrobial Agents · doi:10.1016/s0924-8579(99)00078-3 · Cited by 83 · see citing works
Ishibashi, N., Himeno, K., FUJITA, K., Masuda, Y., Pérez, R., Zendo, T., Wilaipun, P., Leelawatcharamas, V., Nakayama, J., & Sonomoto, K. (2012) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.110972 · Cited by 81 · see citing works
Inhibitory Influence of Enterococcus faecium on the Propagation of Swine Influenza A Virus In Vitro
Wang, Z., Chai, W., Burwinkel, M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053043 · Cited by 78 · see citing works
Mastromarino, P., Cacciotti, F., Masci, A., & Mosca, L. (2011) · Anaerobe · doi:10.1016/j.anaerobe.2011.04.022 · Cited by 77 · see citing works
Hill, J. A., & Anderson, D. J. (1992) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(92)91703-d · Cited by 77 · see citing works
Kiso, M., Takano, R., Sakabe, S., Katsura, H., Shinya, K., Uraki, R., Watanabe, S., Saito, H., Toba, M., Kohda, N., et al. (2013) · Scientific Reports · doi:10.1038/srep01563 · Cited by 75 · see citing works
Villena, J., Oliveira, M. L. S., Ferreira, P. C. D., Salva, S., & Alvarez, S. (2011) · International Immunopharmacology · doi:10.1016/j.intimp.2011.06.004 · Cited by 74 · see citing works
Inhibition of human immunodeficiency virus type 1 by lactic acid bacteria from human breastmilk
Martín, V., Maldonado, A., Fernández, L., Rodríguez, J. M., & Connor, R. I. (2010) · Breastfeeding Medicine · doi:10.1089/bfm.2010.0001 · Cited by 64 · see citing works
Antiinfluenza virus activity of a bacteriocin produced by Lactobacillus delbrueckii
Serkedjieva, J., Danova, S., & Ivanova, I. (2000) · Applied Biochemistry and Biotechnology · doi:10.1385/abab:88:1-3:285 · Cited by 64 · see citing works
Waterborne enteroviruses as a hazard for human health
Kocwa‐Haluch, R. (2001) · Polish Journal of Environmental Studies · Cited by 58 · see citing works
Tuyama, A. C., Cheshenko, N., Carlucci, M. J., et al. (2006) · The Journal of Infectious Diseases · doi:10.1086/506948 · Cited by 56 · see citing works
Harzallah, D., & Belhadj, H. (2013) · InTech eBooks · doi:10.5772/50732 · Cited by 47 · see citing works
Khani, S., Motamedifar, M., Golmoghaddam, H., Hosseini, H. M., & Hashemizadeh, Z. (2012) · The Brazilian Journal of Infectious Diseases · doi:10.1016/s1413-8670(12)70293-3 · Cited by 43 · see citing works
Salvucci, E., Saavedra, L., & Sesma, F. J. M. (2007) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkm096 · Cited by 36 · see citing works
., S. S., Rasool, S. A., Ahmad, S., Zaidi, S., & ., S. R. (2007) · Research Journal of Microbiology · doi:10.3923/jm.2007.796.806 · Cited by 26 · see citing works
Belhadj, H., Harzallah, D., Khennouf, S., et al. (2010) · Acta Horticulturae · doi:10.17660/actahortic.2010.854.5 · Cited by 22 · see citing works
Qureshi, H., Saeed, S., Ahmed, S. A., et al. (2006) · PubMed · Cited by 21 · see citing works
Human papilloma virus--role in precancerous and cancerous oral lesions of tobacco chewers.
Zil-a-Rubab, Baig, S., Siddiqui, A., et al. (2013) · PubMed · Cited by 15 · see citing works
Clinical Study of Experimentally Induced Anaphylactic Shock in Goats
Qureshi, T. A., Mirbahar, K. B., Samo, M. U., et al. (2006) · International Journal of Pharmacology · doi:10.3923/ijp.2006.357.361 · Cited by 11 · see citing works
Lysine-iron-cystine-neutral red (LICNR) broth
(1993) · International Journal of Food Microbiology · doi:10.1016/0168-1605(93)90245-c · Cited by 2 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Exopolysaccharides from Probiotic Bacteria and Their Health Potential
Angelin, J., & Kavitha, M. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.06.190 · Cited by 617 · see citing works
Mitra, A., MacIntyre, D. A., Marchesi, J. R., Lee, Y. S., Bennett, P. R., & Kyrgiou, M. (2016) · Microbiome · doi:10.1186/s40168-016-0203-0 · Cited by 484 · see citing works
Exopolysaccharides as Antimicrobial Agents: Mechanism and Spectrum of Activity
Abdalla, A. K., Ayyash, M. M., Olaimat, A. N., Osaili, T. M., Al-Nabulsi, A. A., Shah, N. P., & Holley, R. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.664395 · Cited by 268 · see citing works
Viral Infections, the Microbiome, and Probiotics
Harper, A., Vijayakumar, V., Ouwehand, A. C., ter Haar, J., Obis, D., Espadaler, J., Binda, S., Desiraju, S., & Day, R. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.596166 · Cited by 177 · see citing works
Biliavska, L., Pankivska, Y., Povnitsa, O., & Zagorodnya, S. (2019) · Medicina · doi:10.3390/medicina55090519 · Cited by 81 · see citing works
- Authors
- Al Kassaa, I., Hober, D., Hamze, M., Chihib, N. E., & Drider, D.
- Affiliations
- Centre Hospitalier Universitaire de Lille (FR)
- Institut Charles Viollette (FR)
- Corresponding author
- Drider, D.
- Venue
- Probiotics and Antimicrobial Proteins
- Published
- 2014-06-01
- Volume
- 6
- Issue
- 3-4
- Pages
- 177-185
- ISSN
- 1867-1306 (ISSN-L)
- 1867-1314
- OpenAlex
- W2041506403
- Cited by
- 217
- References
- 67
- Citations by year
- 2026: 10 · 2025: 11 · 2024: 21 · 2023: 29 · 2022: 28 · 2021: 40 · 2020: 20 · 2019: 13 · 2018: 16 · 2017: 9 · 2016: 11 · 2015: 8
- FWCI
- 1.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Probiotics and Antimicrobial Proteins (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Université Lille 1 - Sciences et Technologies
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Physical Sciences › Environmental Science › Ecology › Bacteriophages and microbial interactions
- Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
- Keywords
- lactic acid bacteria, bacteriocins, antiviral activity, probiotics, antiviral resistance, immunostimulation, respiratory viruses, enteric viruses
- MeSH terms
- Animals, Antiviral Agents, Bacteriocins, Humans, Lactobacillaceae, Virus Diseases, Probiotics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review