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Pollen food allergy syndrome (PFAS): A review of current available literature
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In the citing paper
“Pollen-food allergy syndrome (PFAS), also known as oral allergy syndrome, is a common condition affecting individuals sensitized to pollens such as birch, ragweed, and grass.”
From Pollen–Food Allergy Syndrome: Allergens, Clinical Insights, Diagnostic and Therapeutic Challenges (2024) · cites this paper as [33]
In the citing paper
“Although typically presenting with mild oral and pharyngeal symptoms, PFAS can occasionally result in severe allergic reactions, underscoring its clinical significance.”
From Pollen–Food Allergy Syndrome: Allergens, Clinical Insights, Diagnostic and Therapeutic Challenges (2024) · cites this paper as [33]
In the citing paper
“Class II allergens are proteins that typically do not cause primary sensitization through the gastrointestinal tract but instead trigger allergic reactions due to cross-reactivity with aeroallergens (such as pollen) that have already sensitized the immune system.”
From Pollen–Food Allergy Syndrome: Allergens, Clinical Insights, Diagnostic and Therapeutic Challenges (2024) · cites this paper as [33]
In the citing paper
“While precise global prevalence rates for PFAS are difficult to determine due to geographical variability, it is estimated to affect 5-8% of the general population and up to 50-70% of individuals with pollen sensitization [33,44,45].”
From Pollen–Food Allergy Syndrome: Allergens, Clinical Insights, Diagnostic and Therapeutic Challenges (2024) · cites this paper as [33]
In the citing paper
“As mentioned before, PFAS is a result of immunological cross-reactivity between airborne pollen allergens and structurally similar proteins present in various plant-based foods.”
From Pollen–Food Allergy Syndrome: Allergens, Clinical Insights, Diagnostic and Therapeutic Challenges (2024) · cites this paper as [33]
In the citing paper
“In contrast, heat-stable proteins, such as those found in nuts, peanuts, and LTPs, are more likely to cause severe or systemic reactions, even after the food has been cooked [33].”
From Pollen–Food Allergy Syndrome: Allergens, Clinical Insights, Diagnostic and Therapeutic Challenges (2024) · cites this paper as [33]
In the citing paper
“Their stability and ubiquitous presence make them central to the pathophysiology of PFAS, as they form the molecular link between pollinosis (pollen allergy) and food allergy [33].”
From Pollen–Food Allergy Syndrome: Allergens, Clinical Insights, Diagnostic and Therapeutic Challenges (2024) · cites this paper as [33]
In the citing paper
“Laryngospasm and dysphonia are less common but can occur when swelling affects the laryngeal structures [33].”
From Pollen–Food Allergy Syndrome: Allergens, Clinical Insights, Diagnostic and Therapeutic Challenges (2024) · cites this paper as [33]
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Citations
Cites
Asero (1998) · Clinical & Experimental Allergy · doi:10.1046/j.1365-2222.1998.00399.x · Cited by 195
How long does the effect of birch pollen injection SIT on apple allergy last?
Asero, R. (2003) · Allergy · doi:10.1034/j.1398-9995.2003.00139.x · Cited by 94
Birch-Apple Syndrome Treated with Birch Pollen Immunotherapy
Mauro, M., Russello, M., Incorvaia, C., Gazzola, G., Frati, F., Moingeon, P., & Passalacqua, G. (2011) · International Archives of Allergy and Immunology · doi:10.1159/000323909 · Cited by 90
Westwood, M., Ramaekers, B., Lang, S., Armstrong, N., Noake, C., de Kock, S., Joore, M., Severens, J., & Kleijnen, J. (2016) · Health Technology Assessment · doi:10.3310/hta20670 · Cited by 49
Research works printed but not linked: 79
- Tuft, 1942, Studies in food allergy: II. Sensitization to fresh fruits: clinical and experimental observations, J Allergy, 13, 574
- Amlot, 1987, Oral allergy syndrome (OAS): symptoms of IgE-mediated hypersensitivity to foods, Clin Allergy, 17, 33, 10.1111/j.1365-2222.1987.tb02317.x · DOI
- Ortolani, 1988, The oral allergy syndrome, Ann Allergy, 61, 47
- Valenta, 1996, Type 1 allergic reactions to plant derived food: a consequence of primary sensitization to pollen allergens, J Allergy Clin Immunol, 97, 893, 10.1016/S0091-6749(96)80062-5 · DOI
- Boyce, 2010, Guidelines for the diagnosis and management of food allergy in the United States: report of the NIAID-sponsored expert panel, J Allergy Clin Immunol, 126, S1, 10.1016/j.jaci.2010.10.008 · DOI
- Webber, 2010, Oral allergy syndrome: a clinical, diagnostic, and therapeutic challenge, Ann Allergy Asthma Immunol, 104, 101, 10.1016/j.anai.2009.11.007 · DOI
- Gupta, 2019, Prevalence and severity of food allergies among US adults, JAMA Netw Open, 2, e185630, 10.1001/jamanetworkopen.2018.5630 · DOI
- Kamdar, 2015, Prevalence and characteristics of adult-onset food allergy, J Allergy Clin Immunol Pract, 3, 114, 10.1016/j.jaip.2014.07.007 · DOI
- Bedolla-Barajas, 2017, Prevalence of oral allergy syndrome in children with atopic diseases, Allergol Immunopathol (Madr), 45, 127, 10.1016/j.aller.2016.04.017 · DOI
- Chang, 2018, Oral allergy syndrome in birch pollen sensitized patients in Korea: results of a retrospectice chart review, J Allergy Clin Immunol, 141, AB63, 10.1016/j.jaci.2017.12.202 · DOI
- Cascone, 2016, Seasonal allergies, how they relate to oral allergy syndrome (OAS), J Allergy Clin Immunol, 137, AB83, 10.1016/j.jaci.2015.12.400 · DOI
- Letner, 2018, Pollen-food allergy syndrome is a common allergic comorbidity in adults with eosinophilic esophagitis, Dis Esophagus, 31, dox122, 10.1093/dote/dox122 · DOI
- Leigh, 2019, An in-depth characterization of a large cohort of adult patients with eosinophilic esophagitis, Ann Allergy Asthma Immunol, 122, 65, 10.1016/j.anai.2018.09.452 · DOI
- Azamar-Jácome, 2016, P281 Pollen-food syndrome in a pediatric population attending an allergy clinic in Mexico City, Ann Allergy Asthma Immunol, 117, S105, 10.1016/j.anai.2016.09.294 · DOI
- Dondi, 2013, Pollen-induced allergic rhinitis in 1360 Italian children: comorbidities and determinants of severity, Pediatr Allergy Immunol, 24, 742, 10.1111/pai.12136 · DOI
- Ivković-Jureković, 2015, Oral allergy syndrome in children, Int Dent J, 65, 164, 10.1111/idj.12164 · DOI
- Bedolla-Barajas, 2013, Frequency and clinical features of the oral allergy syndrome in Mexican adults with nasal pollinosis, Rev Alerg Mex, 60, 17
- Morfín-Maciel, 2009, Sensitization to pollens of the Oleaceae family in a group of patients in Mexico City, Rev Alerg Mex, 56, 198
- Skypala, 2013, The prevalence of PFS and prevalence and characteristics of reported food allergy: a survey of UK adults aged 18-75 incorporating a validated PFS diagnostic questionnaire, Clin Exp Allergy, 43, 928, 10.1111/cea.12104 · DOI
- Movsisyan, 2019, Pollen food allergy syndrome (PFAS) among young Armenian adults, J Allergy Clin Immunol, 143, AB433, 10.1016/j.jaci.2018.12.981 · DOI
- Mogensen, 2002, The major birch allergen, Bet v 1, shows affinity for a broad spectrum of physiological ligands, J Biol Chem, 277, 23684, 10.1074/jbc.M202065200 · DOI
- Hoffmann-Sommergruber, 1999, Molecular characterization of Dau c 1, the Bet v 1 homologous protein from carrot and its cross-reactivity with Bet v 1 and Api g 1, Clin Exp Allergy, 29, 840, 10.1046/j.1365-2222.1999.00529.x · DOI
- Katelaris, 2010, Food allergy and oral allergy or pollen-food syndrome, Curr Opin Allergy Clin Immunol, 10, 246, 10.1097/ACI.0b013e32833973fb · DOI
- Bousquet, 1991, Clinical and immunologic reactivity of patients allergic to grass pollens and to multiple pollen species. I. Clinical and immunological characteristics, J Allergy Clin Immunol, 87, 737, 10.1016/0091-6749(91)90397-7 · DOI
- Ma, 2003, A survey on the management of pollen-food allergy syndrome in allergy practices, J Allergy Clin Immunol, 112, 784, 10.1016/S0091-6749(03)02008-6 · DOI
- Purohit-Sheth, 2005, Oral allergy syndrome (pollen-food allergy syndrome), Allergy Asthma Proc, 26, 229
- Sussman, 2010, Oral allergy syndrome, CMAJ, 182, 1210, 10.1503/cmaj.090314 · DOI
- Mari, 2005, The oral allergy syndrome: improved diagnostic and treatment methods, Curr Opin Allergy Clin Immunol, 5, 267, 10.1097/01.all.0000168793.27948.b0 · DOI
- Sloane, 2001, Oral allergy syndrome, Allergy Asthma Proc, 22, 321
- Chang, 2005, Oral allergy syndrome and contact urticaria to apples, J Am Acad Dermatol, 53, 736, 10.1016/j.jaad.2004.09.041 · DOI
- Ausucua, 2009, Oral allergy syndrome (OAS): general and stomatological aspects, Med Oral Patol Oral Cir Bucal, 14, e568, 10.4317/medoral.14.e568 · DOI
- Mancuso, 2001, Oral allergy syndrome from kiwi fruit after a lover's kiss, Contact Dermatitis, 45, 41, 10.1034/j.1600-0536.2001.045001041.x · DOI
- Konstantinou, 2008, Food contact hypersensitivity syndrome: the mucosal contact urticaria paradigm, Clin Exp Dermatol, 33, 383, 10.1111/j.1365-2230.2008.02893.x · DOI
- Sanchez, 1997, Oral allergy syndrome induced by spinach, Allergy, 52, 1245, 10.1111/j.1398-9995.1997.tb02533.x · DOI
- Kleine-Tebbe, 2002, Severe oral allergy syndrome and anaphylactic reactions caused by a Bet v 1-related PR-10 protein in soybean, SAM22, J Allergy Clin Immunol, 110, 797, 10.1067/mai.2002.128946 · DOI
- Egger, 2006, Pollen-food syndromes associated with weed pollinosis: an update from the molecular point of view, Allergy, 61, 461, 10.1111/j.1398-9995.2006.00994.x · DOI
- Luttkopf, 2000, Celery allergens in patients with positive double blind placebo-controlled food challenge, J Allergy Clin Immunol, 106, 390, 10.1067/mai.2000.108711 · DOI
- Pastorello, 1994, Allergenic cross-reactivity among peach, apricot, plum, and cherry in patients with oral allergy syndrome: an in vivo and in vitro study, J Allergy Clin Immunol, 94, 699, 10.1016/0091-6749(94)90177-5 · DOI
- Asakura, 2009, Evaluation of relationships between foods and pollen antigens in peach oral allergy patients-serous specific IgE levels of peach recombinant Antigen [in Japanese], Arerugi, 58, 133
- Rohrer, 1998, Anaphylaxis: clinical aspects, etiology and course in 118 patients, Schweiz Med Wochenschr, 128, 53
- Mills, 2003, Food allergens of plant origin: their molecular and evolutionary relationships, Trends in Food Science and Technology, 14, 145, 10.1016/S0924-2244(03)00026-8 · DOI
- Jenkins, 2007, Evolutionary distance from human homologs reflects allergenicity of animal food proteins, J Allergy Clin Immunol, 120, 1399, 10.1016/j.jaci.2007.08.019 · DOI
- Sancho, 2005, The effect of thermal processing on the IgE reactivity of the non-specific lipid transfer protein from apple, Mal d 3, Allergy, 60, 1262, 10.1111/j.1398-9995.2005.00876.x · DOI
- Asero, 2009, Causes of food-induced anaphylaxis in Italian adults: a multi-centre study, Int Arch Allergy Immunol, 150, 271, 10.1159/000222679 · DOI
- Palacin, 2012, Graph based study of allergen cross-reactivity of plant lipid transfer proteins (LTPs) using a microarray in a multicenter study, PLoS One, 7, e50799, 10.1371/journal.pone.0050799 · DOI
- Schulten, 2011, Pru p 3, the non-specific lipid transfer protein from peach, dominates the immune response to its homolog in hazelnut, Allergy, 66, 1005, 10.1111/j.1398-9995.2011.02567.x · DOI
- Garcia-Moral, 2019, Molecular IgE reactivity pattern in lipid transfer protein (LTP) allergy using a new multiplex array, J Allergy Clin Immunol, 143, AB278, 10.1016/j.jaci.2018.12.849 · DOI
- Mills, 2004, Structural, biological, and evolutionary relationships of plant food allergens sensitizing via the gastrointestinal tract, Crit Rev Food Sci Nutr, 44, 379, 10.1080/10408690490489224 · DOI
- Wilson, 2001, Analysis of Asn-linked glycans from vegetable foodstuffs: widespread occurrence of Lewis a, core alpha 1,3-linked fucose and xylose substitutions, Glycobiology, 11, 261, 10.1093/glycob/11.4.261 · DOI · Paper page
- Midoro-Horiuti, 2001, Pathogenesis-related proteins of plants as allergens, Ann Allergy Asthma Immunol, 87, 261, 10.1016/S1081-1206(10)62238-7 · DOI
- Mothes, 2004, Transition from a botanical to a molecular classification in tree pollen allergy: implications for diagnosis and therapy, Int Arch Allergy Immunol, 135, 357, 10.1159/000082332 · DOI
- Vieths, 2002, Current understanding of cross-reactivity of food allergens and pollen, Ann N Y Acad Sci, 964, 47, 10.1111/j.1749-6632.2002.tb04132.x · DOI
- Kazemi-Shirazi, 2000, Quantitative IgE inhibition experiments with purified recombinant allergens indicate pollen-derived allergens as the sensitizing agents responsible for many forms of plant food allergy, J Allergy Clin Immunol, 105, 116, 10.1016/S0091-6749(00)90186-6 · DOI
- Wensing, 2002, IgE to Bet v 1 and profilin: cross-reactivity patterns and clinical relevance, J Allergy Clin Immunol, 110, 435, 10.1067/mai.2002.126380 · DOI
- Lucas, 2008, The effect of digestion and pH on the allergenicity of kiwifruit proteins, Pediatr Allergy Immunol, 19, 392, 10.1111/j.1399-3038.2007.00678.x · DOI
- Ballmer-Weber, 2005, Component-resolved in vitro diagnosis in carrot allergy: does the use of recombinant carrot allergens improve the reliability of the diagnostic procedure?, Clin Exp Allergy, 35, 970, 10.1111/j.1365-2222.2005.02294.x · DOI
- Hoffmann-Sommergruber, 2009, Food allergen protein families and their structural characteristics and application in component-resolved diagnosis: new data from EuroPrevall project, Anal Bioanal Chem, 395, 25, 10.1007/s00216-009-2953-z · DOI
- Witke, 2004, The role of profilin complexes in cell motility and other cellular processes, Trends Cell Biol, 14, 461, 10.1016/j.tcb.2004.07.003 · DOI
- Ramesh, 2017, Adult-onset food allergies, Ann Allergy Asthma Immunol, 119, 111, 10.1016/j.anai.2017.05.014 · DOI
- Flores, 2012, Plant food allergy in patients with pollinosis from the Mediterranean area, Int Arch Allergy Immunol, 159, 346, 10.1159/000338282 · DOI
- Price, 2015, Oral allergy syndrome (pollen-fool allergy syndrome), Dermatitis, 26, 78, 10.1097/DER.0000000000000087 · DOI
- Asero, 2013, Anaphylaxis to plant-foods and pollen allergens in patients with lipid transfer protein syndrome, Curr Opin Allergy Clin Immunol, 13, 379, 10.1097/ACI.0b013e32835f5b07 · DOI
- Van Ree, 1995, Pollen-related allergy to peach and apple: an important role for profilin, J Allergy Clin Immunol, 95, 726, 10.1016/S0091-6749(95)70178-8 · DOI
- Turner, 2015, Management of pollen food and oral allergy syndrome by health care professionals in the United Kingdom, Ann Allergy Asthma Immunol, 114, 427, 10.1016/j.anai.2015.02.011 · DOI
- Sampson, 2014, Food allergy: a practice parameter update-2014, J Allergy Clin Immunol, 134, 1016, 10.1016/j.jaci.2014.05.013 · DOI · Paper page
- Hunter, 2018, Eosinophilic esophagitis linked to pollen food syndrome, J Allergy Clin Immunol Pract, 6, 667, 10.1016/j.jaip.2017.06.040 · DOI
- Barbi, 2008, Food allergy: from the loss of tolerance induced by exclusion diets to specific oral tolerance induction, Recent Pat Inflamm Allergy Drug Discov, 2, 212, 10.2174/187221308786241875 · DOI
- Clark, 2010, British Society for Allergy and Clinical Immunology guidelines for the management of egg allergy, Clin Exp Allergy, 40, 1116, 10.1111/j.1365-2222.2010.03557.x · DOI
- Pastorello, 1989, Role of elimination diet in adults with food allergy, J Allergy Clin Immunol, 84, 475, 10.1016/0091-6749(89)90360-6 · DOI
- Ramesh, 2016, Carrot Immunotherapy for Pollen Food Syndrome, Ann Allergy Asthma Immunol, 117, S105, 10.1016/j.anai.2016.09.293 · DOI
- Kopac, 2012, Continuous apple consumption induces oral tolerance in birch-pollen-associated apple allergy, Allergy, 67, 280, 10.1111/j.1398-9995.2011.02744.x · DOI
- Hansen, 2004, Food allergy to apple and specific immunotherapy with birch pollen, Mol Nutr Food Res, 48, 441, 10.1002/mnfr.200400037 · DOI
- Asero, 2004, Effects of birch pollen SIT on apple allergy; a matter of dosage?, Allergy, 59, 1269, 10.1111/j.1398-9995.2004.00561.x · DOI
- Moller, 1989, Effect of pollen immunotherapy on food hypersensitivity in children with birch pollinosis, Ann Allergy, 62, 343
- Kinaciyan, 2007, Successful sublingual immunotherapy with birch pollen has little effects on concomitant food allergy to apple and the immune response to the Bet v 1 homolog Mal d 1, J Allergy Clin Immunol, 119, 937, 10.1016/j.jaci.2006.11.010 · DOI
- Bolhaar, 2004, Efficacy of birch-pollen immunotherapy on cross-reactive food allergy confirmed by skin tests and double-blind food challenges, Clin Exp Allergy, 34, 761, 10.1111/j.1365-2222.2004.1939.x · DOI · Paper page
- Akenroye, 2017, Does omalizumab help improve symptoms in patients with pollen food syndrome?, J Allergy Clin Immunol, 139, AB136, 10.1016/j.jaci.2016.12.445 · DOI
- Dunn, 2017, The allergenicity of genetically modified foods from genetically engineered crops, Ann Allergy Asthma Immunol, 119, 214, 10.1016/j.anai.2017.07.010 · DOI
- Dubois, 2015, First successful reduction of clinical allergenicity of food by genetic modification: Mal d 1-silenced apples cause fewer allergy symptoms then wild type cultivars, Allergy, 70, 1406, 10.1111/all.12684 · DOI
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Metadata
- Authors
- Carlson, G., & Coop, C.
- Venue
- Annals of Allergy, Asthma & Immunology
- Publisher
- Elsevier BV
- Published
- 2019-10
- Volume
- 123
- Issue
- 4
- Pages
- 359-365
- ISSN
- 1081-1206
- Cited by
- 171
- References
- 4
- Language
- en
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- Carlson, G., & Coop, C. (2019). Pollen food allergy syndrome (PFAS): A review of current available literature. Annals of Allergy, Asthma & Immunology. https://doi.org/10.1016/j.anai.2019.07.022