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Reaction phenotypes in IgE-mediated food allergy and anaphylaxis

Chong, Kok Wee, Ruiz-Garcia, Monica, Patel, Nandinee, Boyle, Robert J., Turner, Paul J.·2020·Annals of Allergy, Asthma & Immunology
DOI 10.1016/j.anai.2019.12.023PMC PMC7251627
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Figure 1 Heat map of symptom severity by organ involvement (skin, gut, or lower respiratory tract) in 19 children and 28 adults undergoing a peanut double-blind, placebo-controlled food challenge on 2 separate occasions (labeled 1 and 2).
Figure 1 Heat map of symptom severity by organ involvement (skin, gut, or lower respiratory tract) in 19 children and 28 adults undergoing a peanut double-blind, placebo-controlled food challenge on 2 separate occasions (labeled 1 and 2).CC BY · PubMed Central
Figure 2 Different patterns of clinical reactivity are seen at food challenge. Many individuals will initially experience subjective symptoms, with objective symptoms appearing with further doses (A). Anaphylaxis will only develop if the food challenge continues. Others will experience anaphylaxis as their first objective symptom: at a dose of allergen exposure with no preceding subjective symptoms (B) or with prior subjective symptoms (C). Note that anaphylaxis can occur at all levels of exposure (both at low levels of allergen exposure, represented by the solid bars, and higher doses, indicated by dotted lines). Reproduced with permission from Turner and Wainstein23
Figure 2 Different patterns of clinical reactivity are seen at food challenge. Many individuals will initially experience subjective symptoms, with objective symptoms appearing with further doses (A). Anaphylaxis will only develop if the food challenge continues. Others will experience anaphylaxis as their first objective symptom: at a dose of allergen exposure with no preceding subjective symptoms (B) or with prior subjective symptoms (C). Note that anaphylaxis can occur at all levels of exposure (both at low levels of allergen exposure, represented by the solid bars, and higher doses, indicated by dotted lines). Reproduced with permission from Turner and Wainstein23CC BY · PubMed Central
Figure 3 Proposed mechanism for severe IgE-mediated food allergy. Food is initially absorbed in the mouth and across the gastrointestinal tract. The absorbed allergen passes into the bloodstream, where it quickly reaches the respiratory system; those participants who have a higher mast cell density in the lungs have more severe respiratory compromise. Mediators released in the lungs rapidly reach the heart through pulmonary venous circulation and responsible for the cardiac response during IgE-mediated food allergy.
Figure 3 Proposed mechanism for severe IgE-mediated food allergy. Food is initially absorbed in the mouth and across the gastrointestinal tract. The absorbed allergen passes into the bloodstream, where it quickly reaches the respiratory system; those participants who have a higher mast cell density in the lungs have more severe respiratory compromise. Mediators released in the lungs rapidly reach the heart through pulmonary venous circulation and responsible for the cardiac response during IgE-mediated food allergy.CC BY · PubMed Central

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Research works printed but not linked: 38

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Metadata

Authors
Chong, K. W., Ruiz-Garcia, M., Patel, N., Boyle, R. J., & Turner, P. J.
Venue
Annals of Allergy, Asthma & Immunology
Publisher
Elsevier BV
Published
2020-05
Volume
124
Issue
5
Pages
473-478
ISSN
1081-1206
DOI
10.1016/j.anai.2019.12.023
PMC
PMC7251627
Cited by
44
References
0
Language
en
Licence
Funders
  • National Institute for Health Research
  • Medical Research Council

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