Drug hypersensitivity in the fast lane
Open accessAbstract
Objective To review novel concepts in drug hypersensitivity and the management of immediate hypersensitivity reactions.Data sources English language literature on MEDLINE and Embase surrounding drug hypersensitivity and desensitization.Study selections References were selected based on relevance, date of publication, and originality.Results There are numerous citations looking at categorizing drug reactions, pathogenesis, biomarkers, and desensitization. Current understanding supports the use of a phenotype-endotype-biomarker model for categorizing immediate hypersensitivity reactions. Drug desensitization is a powerful therapeutic strategy that enables temporary induction of tolerance to medications that triggered immediate reactions.Conclusion Immediate hypersensitivity reactions are diverse in presentation and pathogenesis. Drug desensitization is an effective intervention with sufficient evidence to support its more widespread availability.
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Atypical mast cell activation symptoms may be associated with serum elevation of IL-6 and are observed in patients with acute reactions to monoclonal antibodies and chemotherapy.
“These atypical symptoms may be associated with serum elevation of IL-6 and are observed in patients with acute reactions to monoclonal antibodies and chemotherapy.15”
From Mast cell activation syndrome: Current understanding and research needs (2024) · cites this paper as [15]
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- Authors
- Jakubovic, B. D., Vecillas, L. D. L., Jimenez-Rodriguez, T. W., Sanchez-Sanchez, S., & Castells, M.
- Affiliations
- Sunnybrook Health Science Centre (CA)
- Marqués de Valdecilla University Hospital (ES)
- Brigham and Women's Hospital (US)
- Corresponding author
- Jakubovic, Baruch D.
- Venue
- Annals of Allergy, Asthma & Immunology
- Publisher
- Elsevier BV
- Published
- 2020-06
- Volume
- 124
- Issue
- 6
- Pages
- 566-572
- ISSN
- 1081-1206 (ISSN-L)
- OpenAlex
- W3016670854
- Cited by
- 33
- References
- 51
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 3 · 2023: 6 · 2022: 9 · 2021: 1 · 2020: 4
- FWCI
- 0.65
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annals of Allergy Asthma & Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Drug-Induced Adverse Reactions
- Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
- Keywords
- drug hypersensitivity, immediate hypersensitivity, drug desensitization, drug tolerance, biomarkers, pathogenesis
- MeSH terms
- Basophils, Desensitization, Immunologic, Disease Susceptibility, Drug Hypersensitivity, Humans, Hypersensitivity, Immediate, Immunoglobulin E, Phenotype, Severity of Illness Index, Skin Tests, Biomarkers, Health Care Costs, Disease Management, Genetic Predisposition to Disease
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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