Second symposium on the definition and management of anaphylaxis: summary report--second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network symposium
Abstract
There is no universal agreement on the definition of anaphylaxis or the criteria for diagnosis. In July 2005, the National Institute of Allergy and Infectious Disease and Food Allergy and Anaphylaxis Network convened a second meeting on anaphylaxis, which included representatives from 16 different organizations or government bodies, including representatives from North America, Europe, and Australia, to continue working toward a universally accepted definition of anaphylaxis, establish clinical criteria that would accurately identify cases of anaphylaxis with high precision, further review the evidence on the most appropriate management of anaphylaxis, and outline the research needs in this area.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Severe MCA (anaphylaxis) often involves two or more organ systems, although it may present primarily as hypotension leading to anaphylactic shock.
“Independent of the clinical diagnosis, severe MCA (anaphylaxis) often involves two or more organ systems, although it may present primarily as hypotension leading to anaphylactic shock.”
From Selecting the Right Criteria and Proper Classification to Diagnose Mast Cell Activation Syndromes: A Critical Review (2021) · cites this paper as [20]
Cites
Pavlovian conditioning of rat mucosal mast cells to secrete rat mast cell protease II
MacQueen, G., Marshall, J., Perdue, M., Siegel, S., & Bienenstock, J. (1989) · Science · doi:10.1126/science.2911721 · Cited by 318 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Valent, P., Akin, C., Arock, M., Brockow, K., Butterfield, J. H., Carter, M. C., Castells, M., Escribano, L., Hartmann, K., Lieberman, P., et al. (2012) · International Archives of Allergy and Immunology · doi:10.1159/000328760 · Cited by 654 · see citing works
Self-citationRisk of anaphylaxis after vaccination in children and adults.
McNeil, M. M., Weintraub, E. S., Duffy, J., Sukumaran, L., Jacobsen, S. J., Klein, N. P., Hambidge, S. J., Lee, G. M., Jackson, L. A., Irving, S. A., et al. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.07.048 · Cited by 381 · see citing works
Mechanisms of mast cell signaling in anaphylaxis
Metcalfe, D. D., Peavy, R. D., & Gilfillan, A. M. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.08.035 · Cited by 283 · see citing works
Self-citationUnderstanding the mechanisms of anaphylaxis
Peavy, R. D., & Metcalfe, D. D. (2008) · Current Opinion in Allergy & Clinical Immunology · doi:10.1097/aci.0b013e3283036a90 · Cited by 211 · see citing works
Self-citationTryptase levels in children presenting with anaphylaxis: Temporal trends and associated factors
De Schryver, S., Halbrich, M., Clarke, A., La Vieille, S., Eisman, H., Alizadehfar, R., Joseph, L., Morris, J., & Ben-Shoshan, M. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.09.001 · Cited by 96 · see citing works
Carter, M. C., Desai, A., Komarow, H. D., Bai, Y., Clayton, S. T., Clark, A. S., Ruiz-Esteves, K. N., Long, L. M., Cantave, D., Wilson, T. M., et al. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.05.036 · Cited by 97 · see citing works
Self-citationvan Anrooij, B., van der Veer, E., de Monchy, J. G. R., van der Heide, S., Kluin-Nelemans, J. C., van Voorst Vader, P. C., van Doormaal, J. J., & Oude Elberink, J. N. G. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.12.1578 · Cited by 89 · see citing works
Risk Factor Analysis of Anaphylactic Reactions in Patients With Systemic Mastocytosis
Gülen, T., Ljung, C., Nilsson, G., & Akin, C. (2017) · The Journal of Allergy and Clinical Immunology: In Practice · doi:10.1016/j.jaip.2017.02.008 · Cited by 83 · see citing works
Gülen, T., Akin, C., Bonadonna, P., Siebenhaar, F., Broesby-Olsen, S., Brockow, K., Niedoszytko, M., Nedoszytko, B., Oude Elberink, H. N. G., Butterfield, J. H., et al. (2021) · The Journal of Allergy and Clinical Immunology: In Practice · doi:10.1016/j.jaip.2021.06.011 · Cited by 83 · see citing works
Self-citationThe presence of mast cell clonality in patients with unexplained anaphylaxis
Gülen, T., Hägglund, H., Sander, B., Dahlén, B., & Nilsson, G. (2014) · Clinical & Experimental Allergy · doi:10.1111/cea.12369 · Cited by 82 · see citing works
Mast cell activation syndromes: Collegium Internationale Allergologicum update 2022
Valent, P., Hartmann, K., Bonadonna, P., Niedoszytko, M., Triggiani, M., Arock, M., & Brockow, K. (2022) · International Archives of Allergy and Immunology · doi:10.1159/000524532 · Cited by 55 · see citing works
Acetylcysteine in paracetamol poisoning: a perspective of 45 years of use
Bateman, D. N., & Dear, J. W. (2019) · Toxicology Research · doi:10.1039/c9tx00002j · Cited by 53 · see citing works
Anaphylaxis as a clinical manifestation of clonal mast cell disorders
Matito, A., Alvarez-Twose, I., Morgado, J. M., Sánchez-Muñoz, L., Orfao, A., & Escribano, L. (2014) · Current Allergy and Asthma Reports · doi:10.1007/s11882-014-0450-8 · Cited by 51 · see citing works
Anaphylaxis and Mast Cell Disorders
Gülen, T., & Akin, C. (2022) · Immunology and Allergy Clinics of North America · doi:10.1016/j.iac.2021.09.007 · Cited by 51 · see citing works
The Utility of Serum Tryptase in the Diagnosis of Food-Induced Anaphylaxis
Wongkaewpothong, P., Pacharn, P., Sripramong, C., Boonchoo, S., Piboonpocanun, S., Visitsunthorn, N., Vichyanond, P., & Jirapongsananuruk, O. (2014) · Allergy, Asthma & Immunology Research · doi:10.4168/aair.2014.6.4.304 · Cited by 50 · see citing works
Low frequency of IgE-mediated food hypersensitivity in mastocytosis
Jarkvist, J., Brockow, K., & Gülen, T. (2020) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2020.05.044 · Cited by 41 · see citing works
Hereditary alpha-tryptasemia: a commonly inherited modifier of anaphylaxis
Wu, R., & Lyons, J. J. (2021) · Current Allergy and Asthma Reports · doi:10.1007/s11882-021-01010-1 · Cited by 43 · see citing works
Cutaneous and systemic mastocytosis in children: a risk factor for anaphylaxis?
Matito, A., & Carter, M. (2015) · Current Allergy and Asthma Reports · doi:10.1007/s11882-015-0525-1 · Cited by 39 · see citing works
Egner, W., Sargur, R., Shrimpton, A., York, M., & Green, K. (2016) · Clinical & Experimental Allergy · doi:10.1111/cea.12785 · Cited by 31 · see citing works
Zaghmout, T., Maclachlan, L., Bedi, N., & Gülen, T. (2024) · The Journal of Allergy and Clinical Immunology: In Practice · doi:10.1016/j.jaip.2023.11.041 · Cited by 23 · see citing works
Assessment of in vivo mast cell reactivity in patients with systemic mastocytosis
Gülen, T., Möller Westerberg, C., Lyberg, K., Ekoff, M., Kolmert, J., Bood, J., Öhd, J., James, A., Dahlén, S. ‐., Nilsson, G., et al. (2017) · Clinical & Experimental Allergy · doi:10.1111/cea.12914 · Cited by 20 · see citing works
Defining hereditary alpha-tryptasemia as a risk/modifying factor for anaphylaxis: Are we there yet?
Couto, M. L., Silva, M., Barbosa, M. J., Ferreira, F., Fragoso, A. S., & Azenha Rama, T. (2023) · European Annals of Allergy and Clinical Immunology · doi:10.23822/eurannaci.1764-1489.288 · Cited by 10 · see citing works
- Authors
- Sampson, H. A., Muñoz-Furlong, A., Campbell, R. L., Adkinson, N. F., Allan Bock, S., Branum, A., Brown, S. G. A., Camargo, C. A., Cydulka, R., Galli, S. J., Gidudu, J., Gruchalla, R. S., Harlor, A. D., Hepner, D. L., Lewis, L. M., Lieberman, P. L., Metcalfe, D. D., O’Connor, R., Muraro, A., Rudman, A., Schmitt, C., Scherrer, D., Simons, F. E., Thomas, S., Wood, J. P., & Decker, W. W.
- Affiliations
- Icahn School of Medicine at Mount Sinai (US)
- Mayo Clinic (US)
- Johns Hopkins University (US)
- Centers for Disease Control and Prevention (US)
- Fremantle Hospital (AU)
- Harvard University (US)
- Case Western Reserve University (US)
- Stanford University (US)
- The University of Texas at Dallas (US)
- American Academy of Pediatrics (US)
- American Society of Anesthesiologists (US)
- Society for Academic Emergency Medicine (US)
- National Institutes of Health (US)
- University of Padua (IT)
- American College of Emergency Physicians (US)
- ORCID
- Venue
- Annals of Emergency Medicine
- Publisher
- Elsevier BV
- Published
- 2006-04
- Volume
- 47
- Issue
- 4
- Pages
- 373-380
- ISSN
- 0196-0644 (ISSN-L)
- OpenAlex
- W2140341488
- Cited by
- 748
- References
- 1
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 16 · 2023: 31 · 2022: 28 · 2021: 63 · 2020: 54 · 2019: 63 · 2018: 66 · 2017: 60 · 2016: 54 · 2015: 51 · 2014: 49 · 2013: 57 · 2012: 35
- FWCI
- 10.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Emergency Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Immunology and Allergy › Food Allergy and Anaphylaxis Research
- Health Sciences › Medicine › Pharmacology › Drug-Induced Adverse Reactions
- Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
- Keywords
- anaphylaxis, anaphylaxis diagnosis, clinical criteria, anaphylaxis management, food allergy, research needs
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review