Anaphylaxis and Mast Cell Disorders

MAST CELLS AS “TUNABLE” EFFECTOR AND IMMUNOREGULATORY CELLS: Recent Advances

Galli, S. J., Kalesnikoff, J., Grimbaldeston, M. A., Piliponsky, A. M., Williams, C. M. M., & Tsai, M. M. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141025 · Cited by 1,231 · see citing works

Anaphylaxis: guidelines from the European Academy of Allergy and Clinical Immunology

Muraro, A. M., Roberts, G. C., Worm, M., Bilò, M. B., Brockow, K., Fernández‐Rivas, M., Santos, A. F., Zolkipli, Z., Bellou, A., Beyer, K., et al. (2014) · Allergy · doi:10.1111/all.12437 · Cited by 1,052 · see citing works

World Allergy Organization Guidelines for the Assessment and Management of Anaphylaxis

Simons, F. E. R., Ardusso, L., Bilò, M. B., El‐Gamal, Y., Ledford, D. K., Ring, J., Sánchez‐Borges, M., Senna, G., Sheikh, A., & Thong, B. Y. (2011) · World Allergy Organization Journal · doi:10.1097/wox.0b013e318211496c · Cited by 985 · see citing works

Second symposium on the definition and management of anaphylaxis: summary report--second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network symposium

Sampson, H. A., Muñoz-Furlong, A., Campbell, R. L., Adkinson, N. F., Allan Bock, S., Branum, A., Brown, S. G. A., Camargo, C. A., Cydulka, R., Galli, S. J., et al. (2006) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2006.01.018 · Cited by 748 · see citing works

Mastocytosis: 2016 updated WHO classification and novel emerging treatment concepts

Valent, P., Akin, C., & Metcalfe, D. D. (2016) · Blood · doi:10.1182/blood-2016-09-731893 · Cited by 680 · see citing works

Definitions, criteria and global classification of mast cell disorders with special reference to mast cell activation syndromes: a consensus proposal

Valent, P., Akin, C., Arock, M., Brockow, K., Butterfield, J. H., Carter, M. C., Castells, M., Escribano, L., Hartmann, K., Lieberman, P., et al. (2012) · International Archives of Allergy and Immunology · doi:10.1159/000328760 · Cited by 654 · see citing works

Fatal Anaphylaxis: Mortality Rate and Risk Factors

Turner, P., Jerschow, E., Umasunthar, T., Lin, R. Y.-W., Campbell, D. E., & Boyle, R. J. (2017) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2017.06.031 · Cited by 546 · see citing works

Anaphylaxis in patients with mastocytosis: a study on history, clinical features and risk factors in 120 patients

Brockow, K., Jofer, C., Behrendt, H., & Ring, J. (2008) · Allergy · doi:10.1111/j.1398-9995.2007.01569.x · Cited by 523 · see citing works

Efficacy and Safety of Midostaurin in Advanced Systemic Mastocytosis

Gotlib, J. R., Kluin‐Nelemans, H. C., George, T. I., Akin, C., Sotlar, K., Hermine, O., Awan, F. T., Hexner, E. O., Mauro, M. J., Sternberg, D., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1513098 · Cited by 486 · see citing works

Epidemiology of anaphylaxis: findings of the American College of Allergy, Asthma and Immunology Epidemiology of Anaphylaxis Working Group

Lieberman, P., Camargo, C. A., Bohlke, K., Jick, H., Miller, R. L., Sheikh, A., & Simons, F. E. R. (2006) · Annals of Allergy Asthma & Immunology · doi:10.1016/s1081-1206(10)61086-1 · Cited by 480 · see citing works

Predictors of severe systemic anaphylactic reactions in patients with Hymenoptera venom allergy: Importance of baseline serum tryptase—a study of the European Academy of Allergology and Clinical Immunology Interest Group on Insect Venom Hypersensitivity

Ruëff, F., Bernhard Przybilla, A., Bilò, M. B., Müller, U., Scheipl, F., Aberer, W., Birnbaum, J., Bodzenta­‐Łukaszyk, A., Bonifazi, F., Bucher, C., et al. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.08.027 · Cited by 429 · see citing works

The epidemiology of anaphylaxis in Europe: a systematic review

Panesar, S. S., Javad, S., de Silva, D., Nwaru, B. I., Hickstein, L., Muraro, A. M., Roberts, G. C., Worm, M., Bilò, M. B., Cardona, V., et al. (2013) · Allergy · doi:10.1111/all.12272 · Cited by 416 · see citing works

The etiology and incidence of anaphylaxis in Rochester, Minnesota: A report from the Rochester Epidemiology Project

Decker, W. W., Campbell, R. L., Manivannan, V., Luke, A., Sauver, J. L. S., Weaver, A. L., Bellolio, F., Bergstralh, E. J., Ganti, L., & Li, J. T. C. (2008) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.09.043 · Cited by 410 · see citing works

Mast cells in allergy and infection: versatile effector and regulatory cells in innate and adaptive immunity

Galli, S. J., & Tsai, M. (2010) · European Journal of Immunology · doi:10.1002/eji.201040559 · Cited by 403 · see citing works

Anaphylaxis in America: The prevalence and characteristics of anaphylaxis in the United States

Wood, R. A., Camargo, C. A., Lieberman, P. L., Sampson, H. A., Schwartz, L. B., Zitt, M. J., Collins, C., Tringale, M., Wilkinson, M., Boyle, J. M., et al. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.08.016 · Cited by 395 · see citing works

Elevated basal serum tryptase identifies a multisystem disorder associated with increased TPSAB1 copy number

Lyons, J. J., Yu, X., Hughes, J. D., Le, Q. T., Jamil, A., Bai, Y., Ho, N., Zhao, M., Liu, Y., O'Connell, M. P., et al. (2016) · Nature Genetics · doi:10.1038/ng.3696 · Cited by 394 · see citing works

Clonal mast cell disorders in patients with systemic reactions to Hymenoptera stings and increased serum tryptase levels

Bonadonna, P., Perbellini, O., Passalacqua, G., Caruso, B., Colarossi, S., Dal Fior, D., Castellani, L., Bonetto, C., Frattini, F., Dama, A., et al. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.11.018 · Cited by 392 · see citing works

Epidemiology of life-threatening and lethal anaphylaxis: a review

Moneret‐Vautrin, D. A., Morisset, M., Flabbee, J., Beaudouin, E., & Kanny, G. (2005) · Allergy · doi:10.1111/j.1398-9995.2005.00785.x · Cited by 386 · see citing works

Mast cell activation syndrome: Proposed diagnostic criteria

Akin, C., Valent, P., & Metcalfe, D. D. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.08.035 · Cited by 327 · see citing works

Basophils and allergic inflammation

Siracusa, M. C., Kim, B., Spergel, J. M., & Artis, D. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.07.046 · Cited by 320 · see citing works

Clinical, biological, and molecular characteristics of clonal mast cell disorders presenting with systemic mast cell activation symptoms

Álvarez-Twose, I., González de Olano, D., Sánchez-Muñoz, L., Matito, A., Esteban-López, M. I., Vega, A., Mateo, M. B., Alonso Díaz de Durana, M. D., de la Hoz, B., del Pozo Gil, M. D., et al. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.02.019 · Cited by 294 · see citing works

Mechanisms of mast cell signaling in anaphylaxis

Metcalfe, D. D., Peavy, R. D., & Gilfillan, A. M. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.08.035 · Cited by 283 · see citing works

Paediatric emergency department anaphylaxis: different patterns from adults

Braganza, S. (2005) · Archives of Disease in Childhood · doi:10.1136/adc.2004.069914 · Cited by 265 · see citing works

Mast cells: Versatile regulators of inflammation, tissue remodeling, host defense and homeostasis

Galli, S. J., & Tsai, M. M. (2007) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2007.09.009 · Cited by 260 · see citing works

Regulation of Mast Cell Responses in Health and Disease

Gilfillan, A. M., & Beaven, M. A. (2011) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.v31.i6.30 · Cited by 258 · see citing works

Prevalence of allergy and anaphylactic symptoms in 210 adult and pediatric patients with mastocytosis in Spain: a study of the Spanish network on mastocytosis (REMA)

González de Olano, D., De La Hoz Caballer, B., Núñez López, R., Sánchez Muñoz, L., Cuevas Agustín, M., Diéguez, M. C., Álvarez Twose, I., Castells, M. C., & Escribano Mora, L. (2007) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2007.02804.x · Cited by 245 · see citing works

Demonstration of an aberrant mast-cell population with clonal markers in a subset of patients with “idiopathic” anaphylaxis

Akin, C., Scott, L. M., Kocabas, C. N., Kushnir-Sukhov, N., Brittain, E., Noel, P., & Metcalfe, D. D. (2007) · Blood · doi:10.1182/blood-2006-06-028100 · Cited by 240 · see citing works

Epidemiology of systemic mastocytosis in Denmark

Cohen, S. S., Skovbo, S., Vestergaard, H., Kristensen, T. K., Møller, M. B., Bindslev‐Jensen, C., Fryzek, J. P., & Broesby‐Olsen, S. (2014) · British Journal of Haematology · doi:10.1111/bjh.12916 · Cited by 235 · see citing works

Response to Interferon Alfa-2b in a Patient with Systemic Mastocytosis

Kluin‐Nelemans, H. C., Jansen, J. H., Breukelman, H., Wolthers, B. G., Kluin, P. M., Kroon, H. M. J. A., & Willemze, R. (1992) · New England Journal of Medicine · doi:10.1056/nejm199202273260907 · Cited by 231 · see citing works

Heritable risk for severe anaphylaxis associated with increased α-tryptase–encoding germline copy number at TPSAB1

Lyons, J. J., Chovanec, J., O’Connell, M. P., Liu, Y., Šelb, J., Zanotti, R., Bai, Y., Kim, J., Le, Q. T., DiMaggio, T., et al. (2021) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.06.035 · Cited by 230 · see citing works

Proposed Diagnostic Algorithm for Patients with Suspected Mast Cell Activation Syndrome

Valent, P., Akin, C., Bonadonna, P., Hartmann, K., Brockow, K., Niedoszytko, M., Nedoszytko, B., Siebenhaar, F., Sperr, W. R., Oude Elberink, J. N. G., et al. (2019) · The Journal of Allergy and Clinical Immunology: In Practice · doi:10.1016/j.jaip.2019.01.006 · Cited by 220 · see citing works

Hereditary α tryptasemia is a valid genetic biomarker for severe mediator-related symptoms in mastocytosis

Greiner, G., Sprinzl, B., Górska, A., Ratzinger, F., Gurbisz, M., Witzeneder, N., Schmetterer, K. G., Gisslinger, B., Uyanik, G., Hadzijusufovic, E., et al. (2021) · Blood · doi:10.1182/blood.2020006157 · Cited by 189 · see citing works

Triggers and Treatment of Anaphylaxis

Worm, M., Eckermann, O., Dölle-Bierke, S., Aberer, W., Beyer, K., Hawranek, T., Hompes, S., Koehli, A., Mahler, V., Nemat, K., et al. (2014) · Deutsches Ärzteblatt international · doi:10.3238/arztebl.2014.0367 · Cited by 184 · see citing works

Mast cells as a unique hematopoietic lineage and cell system: From Paul Ehrlich's visions to precision medicine concepts

Valent, P., Akin, C., Hartmann, K., Nilsson, G. P., Reiter, A., Hermine, O., Sotlar, K., Sperr, W. R., Escribano, L., George, T. I., et al. (2020) · Theranostics · doi:10.7150/thno.46719 · Cited by 183 · see citing works

Omalizumab for the treatment of unprovoked anaphylaxis in patients with systemic mastocytosis

Carter, M. C., Robyn, J. A., Bressler, P. B., Walker, J. C., Shapiro, G. G., & Metcalfe, D. D. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.03.032 · Cited by 172 · see citing works

Trends in national incidence, lifetime prevalence and adrenaline prescribing for anaphylaxis in England

Sheikh, A., Hippisley‐Cox, J., Newton, J. N., & Fenty, J. (2008) · Journal of the Royal Society of Medicine · doi:10.1258/jrsm.2008.070306 · Cited by 170 · see citing works

Anaphylaxis and reactions to foods in children – a population‐based case study of emergency department visits

Vetander, M., Helander, D., Flodström, C., Östblom, E., Alfvén, T., Ly, D. H., Hedlin, G., Lilja, G., Nilsson, C. A., & Wickman, M. C. (2011) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2011.03954.x · Cited by 161 · see citing works

High prevalence of anaphylaxis in patients with systemic mastocytosis - a single-centre experience

Gülen, T., Hägglund, H., Dahlén, B., & Nilsson, G. (2014) · Clinical & Experimental Allergy · doi:10.1111/cea.12225 · Cited by 156 · see citing works

Mendelian inheritance of elevated serum tryptase associated with atopy and connective tissue abnormalities

Lyons, J. J., Sun, G., Stone, K. D., Nelson, C., Wisch, L., O'Brien, M., Jones, N., Lindsley, A., Komarow, H. D., Bai, Y., et al. (2014) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.11.039 · Cited by 136 · see citing works

Diagnostic and subdiagnostic accumulation of mast cells in the bone marrow of patients with anaphylaxis: monoclonal mast cell activation syndrome

Sonneck, K., Florian, S., Müllauer, L., Wimazal, F., Födinger, M., Sperr, W. R., & Valent, P. (2007) · International Archives of Allergy and Immunology · doi:10.1159/000096442 · Cited by 129 · see citing works

Sensitive KIT D816V mutation analysis of blood as a diagnostic test in mastocytosis

Kristensen, T. K., Vestergaard, H., Bindslev‐Jensen, C., Møller, M. B., & Broesby‐Olsen, S. (2014) · American Journal of Hematology · doi:10.1002/ajh.23672 · Cited by 126 · see citing works

Hereditary alpha-tryptasemia: UK prevalence and variability in disease expression

Robey, R. C., Wilcock, A., Bonin, H., Beaman, G., Myers, B., Grattan, C., Briggs, T. A., & Arkwright, P. D. (2020) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2020.05.057 · Cited by 119 · see citing works

Mast cell mediators in allergic inflammation and mastocytosis

Castells, M. (2006) · Immunology and Allergy Clinics of North America · doi:10.1016/j.iac.2006.05.005 · Cited by 112 · see citing works

Omalizumab prevents anaphylaxis and improves symptoms in systemic mastocytosis: efficacy and safety observations

Broesby‐Olsen, S., Vestergaard, H., Mortz, C. G., Jensen, B., Havelund, T., Hermann, A. P., Siebenhaar, F., Møller, M. B., Kristensen, T. K., Bindslev‐Jensen, C., et al. (2018) · Allergy · doi:10.1111/all.13237 · Cited by 112 · see citing works

Drug hypersensitivity in clonal mast cell disorders: ENDA / EAACI position paper

Bonadonna, P., Pagani, M., Aberer, W., Bilò, M. B., Brockow, K., Elberink, H. O., Garvey, L. H., Mosbech, H., Romano, A. G., Zanotti, R., et al. (2015) · Allergy · doi:10.1111/all.12617 · Cited by 102 · see citing works

Prevalence of indolent systemic mastocytosis in a Dutch region

van Doormaal, J. J., Arends, S., Brunekreeft, K. L., van der Wal, V. B., Sietsma, J., Vader, P. C. V. V., Elberink, J. N. G. O., Kluin‐Nelemans, H. C., van der Veer, E., & de Monchy, J. G. R. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.10.015 · Cited by 100 · see citing works

A distinct biomolecular profile identifies monoclonal mast cell disorders in patients with idiopathic anaphylaxis

Carter, M. C., Desai, A., Komarow, H. D., Bai, Y., Clayton, S. T., Clark, A. S., Ruiz-Esteves, K. N., Long, L. M., Cantave, D., Wilson, T. M., et al. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.05.036 · Cited by 97 · see citing works

Recognition and First-Line Treatment of Anaphylaxis

Lieberman, P. L. (2013) · The American Journal of Medicine · doi:10.1016/j.amjmed.2013.09.008 · Cited by 94 · see citing works

Hereditary alpha tryptasemia is not associated with specific clinical phenotypes

Chollet, M. B., & Akin, C. (2022) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2021.06.017 · Cited by 90 · see citing works

Risk Factor Analysis of Anaphylactic Reactions in Patients With Systemic Mastocytosis

Gülen, T., Ljung, C., Nilsson, G., & Akin, C. (2017) · The Journal of Allergy and Clinical Immunology: In Practice · doi:10.1016/j.jaip.2017.02.008 · Cited by 83 · see citing works

Selecting the Right Criteria and Proper Classification to Diagnose Mast Cell Activation Syndromes: A Critical Review

Gülen, T., Akin, C., Bonadonna, P., Siebenhaar, F., Broesby-Olsen, S., Brockow, K., Niedoszytko, M., Nedoszytko, B., Oude Elberink, H. N. G., Butterfield, J. H., et al. (2021) · The Journal of Allergy and Clinical Immunology: In Practice · doi:10.1016/j.jaip.2021.06.011 · Cited by 83 · see citing works

The presence of mast cell clonality in patients with unexplained anaphylaxis

Gülen, T., Hägglund, H., Sander, B., Dahlén, B., & Nilsson, G. (2014) · Clinical & Experimental Allergy · doi:10.1111/cea.12369 · Cited by 82 · see citing works

Intervention with epinephrine in hypotension associated with mastocytosis

TURK, J. W., Oates, J. A., & Roberts, L. J. (1983) · Journal of Allergy and Clinical Immunology · doi:10.1016/0091-6749(83)90098-2 · Cited by 81 · see citing works

Midostaurin: a magic bullet that blocks mast cell expansion and activation

Valent, P., Akin, C., Hartmann, K., George, T. I., Sotlar, K., Peter, B., Gleixner, K. V., Blatt, K., Sperr, W. R., Manley, P. W., et al. (2017) · Annals of Oncology · doi:10.1093/annonc/mdx290 · Cited by 79 · see citing works

Severe Life-Threatening or Disabling Anaphylaxis in Patients with Systemic Mastocytosis: A Single-Center Experience

Wimazal, F., Geißler, P., Shnawa, P., Sperr, W. R., & Valent, P. (2011) · International Archives of Allergy and Immunology · doi:10.1159/000329218 · Cited by 76 · see citing works

Mastocytosis: The puzzling clinical spectrum and challenging diagnostic aspects of an enigmatic disease

Gülen, T., Hägglund, H., Dahlén, B., & Nilsson, G. (2016) · Journal of Internal Medicine · doi:10.1111/joim.12410 · Cited by 75 · see citing works

Anaphylaxis: Mechanisms of Mast Cell Activation

Kalesnikoff, J., & Galli, S. J. (2010) · Chemical Immunology and Allergy · doi:10.1159/000315937 · Cited by 67 · see citing works

Midostaurin improves quality of life and mediator-related symptoms in advanced systemic mastocytosis

Hartmann, K., Gotlib, J. R., Akin, C., Hermine, O., Awan, F. T., Hexner, E. O., Mauro, M. J., Menssen, H. D., Redhu, S., Knoll, S., et al. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.03.044 · Cited by 60 · see citing works

Mast cell activation disorders

Akin, C. (2014) · The Journal of Allergy and Clinical Immunology: In Practice · doi:10.1016/j.jaip.2014.03.007 · Cited by 56 · see citing works

Amplification mechanisms for the enhancement of antigen-mediated mast cell activation

Gilfillan, A. M., Peavy, R. D., & Metcalfe, D. D. (2008) · Immunologic Research · doi:10.1007/s12026-008-8046-9 · Cited by 53 · see citing works

Patterns of anaphylaxis after diagnostic workup: A follow‐up study of 226 patients with suspected anaphylaxis

Oropeza, A. R., Bindslev‐Jensen, C., Broesby‐Olsen, S., Kristensen, T. K., Møller, M. B., Vestergaard, H., Kjær, H. F., Halken, S., Lassen, A. T., & Mortz, C. G. (2017) · Allergy · doi:10.1111/all.13207 · Cited by 53 · see citing works

Venom immunotherapy in patients with clonal mast cell disorders: IgG4 correlates with protection

Jarkvist, J., Salehi, C., Akin, C., & Gülen, T. (2019) · Allergy · doi:10.1111/all.13980 · Cited by 53 · see citing works

Hymenoptera venom-induced anaphylaxis and hereditary alpha-tryptasemia

O’Connell, M. P., & Lyons, J. J. (2020) · Current Opinion in Allergy & Clinical Immunology · doi:10.1097/aci.0000000000000678 · Cited by 53 · see citing works

Novel approaches to treating advanced systemic mastocytosis

Gilreath, J., Tchertanov, L., & Deininger, M. W. (2019) · Clinical Pharmacology Advances and Applications · doi:10.2147/cpaa.s206615 · Cited by 48 · see citing works

Important and specific role for basophils in acute allergic reactions

Korošec, P., Gibbs, B. F., Rijavec, M., Čustović, A., & Turner, P. (2018) · Clinical & Experimental Allergy · doi:10.1111/cea.13117 · Cited by 45 · see citing works

Low frequency of IgE-mediated food hypersensitivity in mastocytosis

Jarkvist, J., Brockow, K., & Gülen, T. (2020) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2020.05.044 · Cited by 41 · see citing works

Mast Cells: Fascinating but Still Elusive after 140 Years from Their Discovery

Varricchi, G., & Marone, G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21020464 · Cited by 40 · see citing works

Epidemiology of Anaphylaxis

Worm, M. (2010) · Chemical immunology/Fortschritte der Allergielehre/Progress in allergy/Chemical immunology and allergy · doi:10.1159/000315935 · Cited by 37 · see citing works

Shock syndrome associated with mastocytosis: pharmacologic reversal of the acute episode and therapeutic prevention of recurrent attacks.

Roberts, L. J., Jw, T., & Oates, J. A. (1982) · PubMed · Cited by 36 · see citing works

Anaphylactoid Reaction to Intravenous Contrast in Patient with Systemic Mastocytosis

Weingarten, T. N., Volcheck, G. W., & Šprung, J. (2009) · Anaesthesia and Intensive Care · doi:10.1177/0310057x0903700415 · Cited by 33 · see citing works

Anaphylaxis Management: Time to Re-Evaluate the Role of Corticosteroids

Campbell, D. E. (2019) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2019.07.005 · Cited by 33 · see citing works

Emergency treatment and prevention of insect-sting anaphylaxis

Clark, S., & Camargo, C. A. (2006) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/01.all.0000235902.02924.e9 · Cited by 32 · see citing works

Non-steroidal anti-inflammatory drug hypersensitivity: association with elevated basal serum tryptase?

Seitz, C. S., Brockow, K., Hain, J., & Trautmann, A. (2014) · Allergy Asthma and Clinical Immunology · doi:10.1186/1710-1492-10-19 · Cited by 28 · see citing works

Case Report: Perioperative immediate hypersensitivity involves not only allergy but also mastocytosis

Renauld, V., Goudet, V., Mouton‐Faivre, C., Debaene, B., & Dewachter, P. (2011) · Canadian Journal of Anesthesia/Journal canadien d anesthésie · doi:10.1007/s12630-011-9472-z · Cited by 27 · see citing works

Flushing, fatigue, and recurrent anaphylaxis: a delayed diagnosis of mastocytosis

Gülen, T., Hägglund, H., Dahlén, S.-E., Sander, B., Dahlén, B., & Nilsson, G. (2014) · The Lancet · doi:10.1016/s0140-6736(14)60585-7 · Cited by 27 · see citing works

Roles of Adaptor Molecules in Mast Cell Activation

Tkaczyk, C., Iwaki, S., Metcalfe, D. D., & Gilfillan, A. M. (2005) · KARGER eBooks · doi:10.1159/000087570 · Cited by 25 · see citing works

α-Gal—a new clue for anaphylaxis in mastocytosis

Roenneberg, S., Böhner, A., Brockow, K., Arnold, A. J., Darsow, U. G., Eberlein, B., & Biedermann, T. (2016) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2015.11.027 · Cited by 24 · see citing works

Pharmacotherapy of mast cell disorders

Gülen, T., & Akin, C. (2017) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0000000000000377 · Cited by 21 · see citing works

MRGPRX2 signaling and skin test results

Kelso, J. M. (2020) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2019.09.038 · Cited by 21 · see citing works

Distinct plasma biomarkers confirm the diagnosis of mastocytosis and identify increased risk of anaphylaxis

Gülen, T., Teufelberger, A. R., Ekoff, M., Westerberg, C. M., Lyberg, K., Dahlén, S., Dahlén, B., & Nilsson, G. P. (2021) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2021.02.023 · Cited by 21 · see citing works

Assessment of in vivo mast cell reactivity in patients with systemic mastocytosis

Gülen, T., Möller Westerberg, C., Lyberg, K., Ekoff, M., Kolmert, J., Bood, J., Öhd, J., James, A., Dahlén, S. ‐., Nilsson, G., et al. (2017) · Clinical & Experimental Allergy · doi:10.1111/cea.12914 · Cited by 20 · see citing works

PIONEER: A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study of Avapritinib in Patients with Indolent or Smoldering Systemic Mastocytosis (SM) With Symptoms Inadequately Controlled by Standard Therapy

Akin, C., Elberink, H. O., Gotlib, J. R., Sabato, V., Hartmann, K., Broesby‐Olsen, S., Castells, M., Deininger, M. W., Heaney, M. L., George, T. I., et al. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2019.12.062 · Cited by 17 · see citing works

Clonal Mast Cell Activation Syndrome with Anaphylaxis to Sulfites

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Systemic mastocytosis with an associated hematologic neoplasm complicated by recurrent anaphylaxis: Prompt resolution of anaphylaxis with the addition of avapritinib

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Diagnosis and Treatment of Anaphylaxis in Patients with Mastocytosis

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Global classification of mast cell activation disorders: an ICD-10-CM–adjusted proposal of the ECNM-AIM Consortium

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New Insights into the Pathogenesis of Mastocytosis: Emerging Concepts in Diagnosis and Therapy

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Mast cell activation syndromes: Collegium Internationale Allergologicum update 2022

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Focus on mast cells in the tumor microenvironment: Current knowledge and future directions

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Pathophysiologic implications of elevated prevalence of hereditary alpha-tryptasemia in all mastocytosis subtypes

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Fatal and Near-Fatal Anaphylaxis: Data From the European Anaphylaxis Registry and National Health Statistics

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Epidemiology of mastocytosis: a population-based study (Sweden)

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Biological Effects of Animal Venoms on the Human Immune System

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Refined Treatment Response Criteria for Indolent Systemic Mastocytosis Proposed by the ECNM-AIM Consortium

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Drug-induced mast cell eradication: A novel approach to treat mast cell activation disorders?

Valent, P., Akin, C., Hartmann, K., Reiter, A., Gotlib, J. R., Sotlar, K., Sperr, W. R., Degenfeld‐Schonburg, L., Smiljkovic, D., Triggiani, M., et al. (2022) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2022.04.003 · Cited by 26 · see citing works

Acute Urticaria and Anaphylaxis: Differences and Similarities in Clinical Management

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Non-steroidal anti-inflammatory drug-induced anaphylaxis infrequent in 388 patients with mastocytosis: A two-center retrospective cohort study

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Low Prevalence of Idiopathic Mast Cell Activation Syndrome Among 703 Patients With Suspected Mast Cell Disorders

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A Puzzling Mast Cell Trilogy: Anaphylaxis, MCAS, and Mastocytosis

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Diagnostic Significance of Tryptase for Suspected Mast Cell Disorders

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Using the Right Criteria for MCAS

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Disease Spectrum of Anaphylaxis Disorders

González de Olano, D., Cain, W. V., Bernstein, J. A., & Akin, C. (2023) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2023.05.012 · Cited by 19 · see citing works

Current and future therapeutics targeting mast cells in disease

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Detecting Changes in Mast Cell Numbers Versus Activation in Human Disease: A Roadblock for Current Biomarkers?

Akin, C., Siebenhaar, F., Wechsler, J. B., Youngblood, B. A., & Maurer, M. (2024) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2024.03.010 · Cited by 15 · see citing works

Drug-Induced Anaphylaxis Uncommon in Mastocytosis: Findings From Two Large Cohorts

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Perioperative anaphylaxis to fibrin sealants in children with Noonan Syndrome

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Management of Mediator Symptoms, Allergy, and Anaphylaxis in Mastocytosis

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Mast Cell Diseases in Practice and Research: Issues and Perspectives Raised by Patients and Their Recommendations to the Scientific Community and Beyond

Jennings, S. V., Finnerty, C. C., Hobart, J. S., Martín‐Martinez, M., Sinclair, K. A., Slee, V. M., Agopian, J., Akin, C., Álvarez‐Twöse, I., Bonadonna, P., et al. (2022) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2022.06.018 · Cited by 12 · see citing works

Diagnosis and Management of Patients With Mast Cell Activation Syndromes: Status 2026

Akin, C., Gülen, T., Castells, M., Elberink, H. O., & Valent, P. (2025) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2025.10.046 · Cited by 11 · see citing works

Diagnostic Evaluation of Hypersensitivity Reactions to Antibiotics in a Large Cohort of Mastocytosis Patients

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Anaphylaxis: Advances in the Past 10 Years

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Defining hereditary alpha-tryptasemia as a risk/modifying factor for anaphylaxis: Are we there yet?

Couto, M. L., Silva, M., Barbosa, M. J., Ferreira, F., Fragoso, A. S., & Azenha Rama, T. (2023) · European Annals of Allergy and Clinical Immunology · doi:10.23822/eurannaci.1764-1489.288 · Cited by 10 · see citing works

Cold-induced anaphylaxis: new insights into clinical and genetic characteristics

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Anaphylaxis in Pregnancy

Kuder, M. M., Baird, R. C., Hopkins, M. K., & Lang, D. M. (2022) · Immunology and Allergy Clinics of North America · doi:10.1016/j.iac.2022.07.004 · Cited by 7 · see citing works

Mast cell activators as adjuvants for intranasal mucosal vaccines

Murphy, C. T., Bachelder, E. M., & Ainslie, K. M. (2025) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2025.125300 · Cited by 4 · see citing works

FosB/ΔFosB activation in mast cells regulates gene expression to modulate allergic inflammation in male micePreprint

Duque‐Wilckens, N., Joseph, D., Syed, M., Smith, B., Maradiaga, N. C., Yeh, S.-Y., Srinivasan, V., Sotomayor, F., Durga, K., Nestler, E. J., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.06.592755 · Cited by 4 · see citing works

Fatal anaphylactic shock due to hymenoptera venom in a farmer suffering from indolent systemic mastocytosis. The comparative diagnostic relevance of perimortem serum tryptase levels

Broi, U. D., Simonit, F., Perogio, M., Visentini, D., Reccardini, F., Tse, R. D., Garland, J., Ondruschka, B., & Desinan, L. (2025) · International Journal of Legal Medicine · doi:10.1007/s00414-025-03487-1 · Cited by 3 · see citing works

Idiopathic mast cell activation syndrome in real-life practice: clinical features and management

İğde, M. H., Korkmaz, P., Toprak, İ. D., Karabacak, D. E., Demir, S., Ünal, D., & Gelincik, A. A. (2025) · Allergy and Asthma Proceedings · doi:10.2500/aap.2025.46.250025 · Cited by 3 · see citing works

Beyond the appearances: exploring complexities in anaphylaxis differential diagnosis

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Markedly Increased Diamine Oxidase During Acute Anaphylaxis Is Associated With an Underlying Clonal Mast Cell Disorder

Rijavec, M., Kogovšek, Ž., Inkret, J., Kopač, P., Košnik, M., & Korošec, P. (2026) · Clinical & Experimental Allergy · doi:10.1111/cea.70227 · Cited by 2 · see citing works

Hymenoptera anaphylaxis and mast cell activation disorders

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Central Role of Mast Cells in Mastocytosis, Hereditary α-Tryptasemia, Mast Cell Activation Syndrome, Urticaria, and Angioedema

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Mast cell activation syndrome: The overdiagnosis problems

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Immunological and Non-Immunological Risk Factors in Anaphylaxis

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Immunology of Septic Shock and Traumatic Injury: A Review

Heuser, W., Frieri, M., Kumar, K., & Boutin, A. (2015) · American Journal of Immunology · doi:10.3844/ajisp.2015.116.124

Mast cell disorders and food allergy

Khokhar, D. S., & Akin, C. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-96018-2.00007-9

Diagnostics différentiels de l’anaphylaxie

Pouessel, G. (2023) · Revue française d'allergologie · doi:10.1016/j.reval.2023.103670

Developmental PBDE exposure impairs histamine release from mast cells by altering granule maturation and calcium signaling in adult male and female micePreprint

Franges, J., Malinowski, L., Alwis, C. D., Doolittle, T., Dixon, H., Tang, Y., Watson, H., Peace, J., Jima, D. D., Sombers, L. A., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.28.661534

Lactate in Anaphylaxis: 100 Years On

Borzova, E. Y., & Gibbs, B. F. (2025) · Sports Medicine · doi:10.1007/s40279-025-02273-8

Evaluating Melanoma Risk in Adult Mastocytosis: Potential Impact of Detection Bias – A Registry-based Study (Sweden)

Bergström, A., Hägglund, H., Berglund, A., Nilsson, G. P., & Lambe, M. P. (2025) · Acta Dermato Venereologica · doi:10.2340/actadv.v105.43052

The role of tryptase in the human body: From normal to pathology

Lisiecka, M. Z. (2025) · Medicinski casopis · doi:10.5937/mckg59-55869

Hereditary Alpha-Tryptasemia and Mastocytosis: What We Know and What We Need To Learn

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Hereditary alpha-tryptasemia demonstrates relative basophil enrichment without signs of cellular hyperreactivity

Johnsson, A., Atanasoai, I., Nilsson, G. P., & Gülen, T. (2026) · Journal of Allergy and Clinical Immunology Global · doi:10.1016/j.jacig.2026.100699

Advances in the Management of Mediator-Related Symptoms in Non-Advanced Systemic Mastocytosis

Gülen, T., & Sabato, V. (2026) · ImmunoTargets and Therapy · doi:10.2147/itt.s609692

Successful allo‐hematopoietic stem cell transplantation using washed hematopoietic stem cells in a pediatric patient complicated by acute myeloid leukemia and severe anaphylaxis to blood product

Tian, J., Zhu, G., Qin, M., Jia, C., Ma, S., Wang, B., & Luo, Y. (2026) · Pediatric Investigation · doi:10.1002/ped4.70065

Neutrophil extracellular trap-associated responses are associated with tissue factor expression and coagulation abnormalities during anaphylaxis

Huang, Y., Xu, S., Rong, P., Wang, D., & Lu, J. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1905112

Mastocytosis and Mast Cell Activation Syndromes Presenting as Anaphylaxis

Akin, C., & Metcalfe, D. D. (2010) · Humana Press eBooks · doi:10.1007/978-1-60327-951-2_15 · Cited by 4 · see citing works

Mast cell activation syndromes and anaphylaxis

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Anaphylaxis and Mast Cell Disease: What Is the Risk?

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Clonal mast cell disorders and hereditary α-tryptasemia as risk factors for anaphylaxis

Kačar, M., Rijavec, M., Šelb, J., & Korošec, P. (2023) · Clinical & Experimental Allergy · doi:10.1111/cea.14264 · Cited by 37 · see citing works

The Role of KIT Mutations in Anaphylaxis

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