A prospective analysis of prolonged sitting time and risk of renal cell carcinoma among 300,000 older adults
Open accessAbstract
Purpose Accumulating evidence suggests an etiologic role in renal cell carcinoma (RCC) for physical activity. However, it is unknown if prolonged sitting, which is thought to be distinct from too little moderate-vigorous physical activity, is an independent risk factor for RCC. The authors prospectively examined the relationship of prolonged sitting and risk of RCC among 289,512 women and men in the National Institutes of Health-AARP Diet and Health Study.Methods From 1996 through 2006, 1206 invasive RCC cancer cases were identified. Cox proportional hazards regression was used to estimate multivariate hazard ratios (HR) and 95% confidence intervals.Results After controlling for known risk factors for RCC, we did not find evidence of associations between RCC risk and time spent per day sitting while watching television or videos (HR(7 + hrs: < 1 hr) = 0.96 (0.66, 1.38); p trend = 0.707) or total sitting time (HR(9 + hrs: < 3 hrs) = 1.11 (0.87, 1.41); p trend = 0.765).Conclusions Prolonged sitting time was not associated with RCC risk among men and women in this large cohort.
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Significant independent association between sitting time and invasive breast cancer risk and risk of renal cell carcinoma was not shown, although a weak correlation could not be ruled out.
“However, association between sitting time and invasive breast cancer risk and risk of renal cell carcinoma has been specifically examined and significant independent association was not shown, although a weak correlation could not be ruled out [31,32].”
From Prevalence of Sedentary Behavior in Older Adults: A Systematic Review (2013) · cites this paper as [32]
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- Authors
- George, S. M., Moore, S. C., Chow, W.-H., Schatzkin, A., Hollenbeck, A. R., & Matthews, C. E.
- Affiliations
- National Cancer Institute (US)
- AARP (US)
- Corresponding author
- George, Stephanie M.
- Venue
- Annals of Epidemiology
- Publisher
- Elsevier BV
- Published
- 2011-10
- Volume
- 21
- Issue
- 10
- Pages
- 787-790
- ISSN
- 1047-2797 (ISSN-L)
- PMC
- PMC3413322
- OpenAlex
- W2112589200
- Cited by
- 28
- References
- 20
- Citations by year
- 2025: 1 · 2023: 2 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 4 · 2016: 2 · 2014: 5 · 2013: 5 · 2012: 2
- FWCI
- 3.27
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annals of Epidemiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (Z99 CA999999)
- National Cancer Institute (Y99 CA999999)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Renal cell carcinoma treatment
- Health Sciences › Medicine › Oncology › Cancer Risks and Factors
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Keywords
- prolonged sitting, sedentary behavior, renal cell carcinoma, cancer risk, television viewing, older adults, physical activity, AARP Diet and Health Study
- MeSH terms
- Carcinoma, Renal Cell, Female, Humans, Kidney Neoplasms, Male, Prospective Studies, Risk Factors, Exercise
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