Cited by 225Colorectal Cancer Treatments and StudiesLung Cancer Treatments and MutationsColorectal Cancer Surgical Treatments

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Implementing anti-epidermal growth factor receptor (EGFR) therapy in metastatic colorectal cancer: challenges and future perspectives

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Martinelli, E., Ciardiello, D., Martini, G., Troiani, T., Cardone, C., Vitiello, P.P., Normanno, N., Rachiglio, A.M., Maiello, E., Latiano, T., De Vita, F., Ciardiello, F.·2020·Annals of Oncology

DOI 10.1016/j.annonc.2019.10.007

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Abstract

Epidermal growth factor receptor (EGFR) inhibitors are valuable therapeutics in metastatic colorectal cancer (mCRC). Anti-EGFR monoclonal antibodies (MoAbs), such as cetuximab or panitumumab, in combination with chemotherapy are effective treatment options for patients with RAS and BRAF wild-type mCRC. Nevertheless, several issues are still open concerning the optimal use of anti-EGFR drugs in the continuum of care of mCRC. Novel approaches for increasing the efficacy of anti-EGFR therapies include better molecular selection of EGFR-dependent mCRC, intensification of chemotherapy, combination of anti-EGFR MoAbs and immune checkpoint inhibitors, and reintroduction of EGFR blockade or 'rechallenge' in selected patients who have previously responded to anti-EGFR MoAb therapy. An extensive translational research program was conducted in the Cetuximab After Progression in KRAS wIld-type colorectal cancer patients-Gruppo Oncologico dell' Italia Meridionale (CAPRI-GOIM) study with the aims of determining which subgroups of patients could benefit from the continuous inhibition of EGFR, from evaluating the role of liquid biopsy-based and its concordance with tissue-based molecular testing, and from investigating novel potential mechanisms of resistance to anti-EGFR therapies. In this review, we summarize the translational and clinical findings of the CAPRI-GOIM program in the context of the current knowledge of therapeutic strategies and of ongoing research on more appropriate uses of anti-EGFR therapies in RAS and BRAF wild-type mCRC patients.

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Authors: Martinelli, E., Ciardiello, D., Martini, G., Troiani, T., Cardone, C., Vitiello, P. P., Normanno, N., Rachiglio, A. M., Maiello, E., Latiano, T., De Vita, F., & Ciardiello, F.
Affiliations: University of Campania "Luigi Vanvitelli" (IT)
Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale" (IT)
Casa Sollievo della Sofferenza (IT)
Corresponding author: Ciardiello, F.
ORCID: Ciardiello, D.
Martini, G.
Troiani, T.
Cardone, C.
Vitiello, P.P.
Normanno, N.
Rachiglio, A.M.
Maiello, E.
Ciardiello, F.
Venue: Annals of Oncology
Publisher: Elsevier BV
Published: 2020-01
Volume: 31
Issue: 1
Pages: 30-40
ISSN: 0923-7534 (ISSN-L)
DOI: 10.1016/j.annonc.2019.10.007
OpenAlex: W2999771324
Cited by: 225
References: 91
Citations by year: 2026: 11 · 2025: 25 · 2024: 32 · 2023: 42 · 2022: 66 · 2021: 32 · 2020: 16
FWCI: 4.19
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor, 85 d)
Locations: Annals of Oncology (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli" (submittedVersion)
INFM-OAR (INFN Catania) (submittedVersion, cc-by-nc-nd)
Funders: Associazione Italiana per la Ricerca sul Cancro
Regione Campania
Sanofi
Amgen
Merck KgA
Roche
Servier
Bayer
Array
MSD
BMS
Topics: Health Sciences › Medicine › Oncology › Colorectal Cancer Treatments and Studies
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Lung Cancer Treatments and Mutations
Health Sciences › Medicine › Oncology › Colorectal Cancer Surgical Treatments
Keywords: EGFR inhibitors, metastatic colorectal cancer, cetuximab, panitumumab, RAS wild-type, BRAF wild-type, drug rechallenge, immune checkpoint inhibitors, liquid biopsy, resistance mechanisms, molecular selection, chemotherapy intensification
MeSH terms: Cetuximab, Panitumumab, Antineoplastic Agents, Humans, Mutation, Colorectal Neoplasms, Proto-Oncogene Proteins p21(ras), ErbB Receptors

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