Tumor budding is an independent prognostic factor in stage III colon cancer patients: a post-hoc analysis of the IDEA-France phase III trial (PRODIGE-GERCOR)
Open accessAbstract
BACKGROUND: Histological characteristics at the invasive front may reflect tumor aggressiveness; specifically, tumor budding (Bd) is an emerging prognostic biomarker in colon cancer (CC). We explored further the significance of Bd for risk stratification by evaluating survival of stage III CC patients included in the IDEA-France phase III trial. PATIENTS AND METHODS: ), Bd2 (5-9 buds), and Bd3 (≥10 buds) categories. Disease-free survival (DFS) and overall survival (OS) were analyzed by the log-rank test. Clinicopathological features and Immunoscore® were correlated with Bd. RESULTS: Overall, Bd1, Bd2, and Bd3 were observed in 39%, 28%, and 33% of CC, respectively. Bd2 and Bd3 were associated with vascular (P = 0.002) and perineural invasions (P = 0.0009). The 3-year DFS and the 5-year OS rates for Bd (1 versus 2-3) were 79.4% versus 67.2% (P = 0.001) and 89.2% versus 80.8% (P = 0.001), respectively. This was confirmed after adjustment for relevant clinicopathological features for DFS [hazard ratio (HR) 1.41, 95% confidence interval (CI) 1.12-1.77, P = 0.003] and OS (HR 1.65, 95% CI 1.22-2.22, P = 0.001). When combined with pTN stage and Immunoscore® subgroups, Bd significantly improved disease prognostication. CONCLUSIONS: Bd demonstrated its independent prognostic value for DFS and OS. Given these findings, Bd as per the ITBCC 2016 should be mandatory in every pathology report in stage III CC patients. Bd and Immunoscore® could play a complementary role in personalized health care in this setting.
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Tumor budding is associated with poor prognosis.
“a trait that is associated with poor prognosis (32).”
From Clinical Challenges of Consensus Molecular Subtype CMS4 Colon Cancer in the Era of Precision Medicine (2024) · cites this paper as [32]
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- Authors
- Basile, D., Broudin, C., Emile, J. F., Falcoz, A., Pagès, F., Mineur, L., Bennouna, J., Louvet, C., Artru, P., Fratte, S., Ghiringhelli, F., André, T., Derangère, V., Vernerey, D., Taieb, J., & Svrcek, M.
- Affiliations
- University of Udine (IT)
- Assistance Publique – Hôpitaux de Paris (FR)
- Université de Versailles Saint-Quentin-en-Yvelines (FR)
- Inserm (FR)
- Université Paris Cité (FR)
- Institut Sainte Catherine (FR)
- Centre Hospitalier Universitaire de Nantes (FR)
- Institute Mutualiste Montsouris (FR)
- Hôpital Privé Jean Mermo (FR)
- Sorbonne Université (FR)
- Corresponding author
- Svrcek, M.
- ORCID
- Venue
- Annals of Oncology
- Publisher
- Elsevier BV
- Published
- 2022-06
- Volume
- 33
- Issue
- 6
- Pages
- 628-637
- ISSN
- 0923-7534 (ISSN-L)
- OpenAlex
- W4220689866
- Cited by
- 47
- References
- 32
- Citations by year
- 2026: 9 · 2025: 11 · 2024: 15 · 2023: 8 · 2022: 4
- FWCI
- 3.99
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Annals of Oncology (publishedVersion, other-oa)
- PubMed (publishedVersion)
- HAL (submittedVersion, cc-by-nc)
- Funders
- Roche
- Sirtex Medical
- Bristol-Myers Squibb
- GlaxoSmithKline
- National Cancer Institute
- Cilag
- Eli Lilly and Company
- Amgen
- Merck
- Merck KGaA
- Celgene
- Genentech
- Institut National Du Cancer (2012-218, AOM09 202)
- Astellas Pharma
- Servier
- Sanofi
- Meso Scale Diagnostics
- Topics
- Health Sciences › Medicine › Oncology › Colorectal Cancer Surgical Treatments
- Health Sciences › Medicine › Oncology › Colorectal Cancer Treatments and Studies
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Keywords
- tumor budding, stage III colon cancer, prognostic factors, disease-free survival, overall survival, immune score, perineural invasion, vascular invasion, risk stratification, adjuvant chemotherapy
- MeSH terms
- Colonic Neoplasms, France, Humans, Neoplasm Staging, Prognosis, Proportional Hazards Models, Disease-Free Survival
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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