EMT and Cancer: More Than Meets the Eye

Molecular mechanisms of epithelial–mesenchymal transition

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EMT: 2016

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New insights into the mechanisms of epithelial–mesenchymal transition and implications for cancer

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EMT Transition States during Tumor Progression and Metastasis

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EMT, CSCs, and drug resistance: the mechanistic link and clinical implications

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Slug and Sox9 Cooperatively Determine the Mammary Stem Cell State

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EMT Subtype Influences Epithelial Plasticity and Mode of Cell Migration

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Regulation of the Immune Response by TGF-β: From Conception to Autoimmunity and InfectionPreprint

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Non-redundant functions of EMT transcription factors

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New insights into the role of <scp>EMT</scp> in tumor immune escape

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Epithelial-to-Mesenchymal Transition Contributes to Immunosuppression in Breast Carcinomas

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Therapy resistance mediated by cancer stem cells

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Chronic TGF-β exposure drives stabilized EMT, tumor stemness, and cancer drug resistance with vulnerability to bitopic mTOR inhibition

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A common framework for EMT and collective cell migration

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Epithelial-mesenchymal transition and senescence: two cancer-related processes are crossing paths

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TGF-β reduces DNA ds-break repair mechanisms to heighten genetic diversity and adaptability of CD44+/CD24− cancer cells

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The molecular mechanisms and therapeutic strategies of EMT in tumor progression and metastasis

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EMT, MET, Plasticity, and Tumor Metastasis

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TGFβ biology in cancer progression and immunotherapy

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Fluids and their mechanics in tumour transit: shaping metastasis

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Tumour budding in solid cancers

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Interleukin-8: A chemokine at the intersection of cancer plasticity, angiogenesis, and immune suppression

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EMT Factors and Metabolic Pathways in Cancer

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Inflammation-Induced Tumorigenesis and Metastasis

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TGFβ-induced metabolic reprogramming during epithelial-to-mesenchymal transition in cancer

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Context specificity of the EMT transcriptional response

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Epithelial to Mesenchymal Transition: A Mechanism that Fuels Cancer Radio/Chemoresistance

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Beyond just a tight fortress: contribution of stroma to epithelial-mesenchymal transition in pancreatic cancer

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In primary airway epithelial cells, the unjamming transition is distinct from the epithelial-to-mesenchymal transition

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Epithelial plasticity, epithelial-mesenchymal transition, and the TGF-β family

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Cytoskeletal dynamics in epithelial-mesenchymal transition: insights into therapeutic targets for cancer metastasis

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Progress of exosomes in the diagnosis and treatment of lung cancer

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TGF-β, EMT, and resistance to anti-cancer treatment

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A Perspective on the Development of TGF-β Inhibitors for Cancer Treatment

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Regulation of breast cancer metastasis signaling by miRNAs

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Tumor Plasticity and Resistance to Immunotherapy

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Role of Epithelial to Mesenchymal Transition in Colorectal Cancer

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Epithelial‐to‐mesenchymal‐like transition events in melanoma

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Low-Dose Vertical Inhibition of the RAF-MEK-ERK Cascade Causes Apoptotic Death of KRAS Mutant Cancers

Ozkan‐Dagliyan, I., Diehl, J. N., George, S. D., Schaefer, A., Papke, B., Klotz‐Noack, K., Waters, A. M., Goodwin, C. M., Gautam, P., Pierobon, M., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107764 · Cited by 102 · see citing works

Role of glycosylation in TGF-β signaling and epithelial-to-mesenchymal transition in cancer

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CircRNA: A novel potential strategy to treat thyroid cancer (Review)

Zhu, G., Chang, X., Kang, Y., Zhao, X., Tang, X., Ma, C., & Fu, S. (2021) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2021.5034 · Cited by 93 · see citing works

Unveiling the link between chronic inflammation and cancer

Tripathi, S., Sharma, Y., & Kumar, D. (2025) · Metabolism Open · doi:10.1016/j.metop.2025.100347 · Cited by 91 · see citing works

Regulation of Collective Metastasis by Nanolumenal Signaling

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The Inflammatory Profile of the Tumor Microenvironment, Orchestrated by Cyclooxygenase-2, Promotes Epithelial-Mesenchymal Transition

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Epigenetic regulation in lung cancer

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Cofilin: A Promising Protein Implicated in Cancer Metastasis and Apoptosis

Xu, J., Huang, Y., Zhao, J., Wu, L., Qi, Q., Liu, Y., Li, G., Li, J., Liu, H., & Wu, H. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.599065 · Cited by 68 · see citing works

HGF/c-Met pathway facilitates the perineural invasion of pancreatic cancer by activating the mTOR/NGF axis

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NOX4‐Derived ROS Mediates TGF‐β1‐Induced Metabolic Reprogramming during Epithelial‐Mesenchymal Transition through the PI3K/AKT/HIF‐1α Pathway in Glioblastoma

Su, X., Yang, Y., Guo, C., Zhang, R., Sun, S., Wang, Y., Qiao, Q., Fu, Y., & Pang, Q. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/5549047 · Cited by 66 · see citing works

Roles of Notch Signaling in the Tumor Microenvironment

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Long non‐coding RNAs and TGF‐β signaling in cancer

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Epithelial–mesenchymal plasticity: emerging parallels between tissue morphogenesis and cancer metastasis

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Sophflarine A, a novel matrine-derived alkaloid from Sophora flavescens with therapeutic potential for non-small cell lung cancer through ROS-mediated pyroptosis and autophagy

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KRT7 promotes epithelial‑mesenchymal transition in ovarian cancer via the TGF‑β/Smad2/3 signaling pathway

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Conversion from epithelial to partial-EMT phenotype by Fusobacterium nucleatum infection promotes invasion of oral cancer cells

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Extracellular Vesicles and Transforming Growth Factor β Signaling in Cancer

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Factors Determining Epithelial-Mesenchymal Transition in Cancer Progression

Tomecka, P., Kunachowicz, D., Górczyńska, J., Gebuza, M., Kuźnicki, J., Skinderowicz, K., & Choromańska, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25168972 · Cited by 57 · see citing works

ILT3 promotes tumor cell motility and angiogenesis in non-small cell lung cancer

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IL-37 protects against airway remodeling by reversing bronchial epithelial–mesenchymal transition via IL-24 signaling pathway in chronic asthma

Feng, K.-N., Meng, P., Zou, X., Zhang, M., Li, H., Yang, H., Li, H., & Zhang, T. (2022) · Respiratory Research · doi:10.1186/s12931-022-02167-7 · Cited by 55 · see citing works

Cellular senescence or stemness: hypoxia flips the coin

Otero-Albiol, D., & Carnero, A. (2021) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-021-02035-0 · Cited by 53 · see citing works

Fibroblasts as Turned Agents in Cancer Progression

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Changes in Wnt and TGF-β Signaling Mediate the Development of Regorafenib Resistance in Hepatocellular Carcinoma Cell Line HuH7

Karabicici, M., Azbazdar, Y., Özhan, G., Şentürk, Ş., Karagonlar, Z. F., & Erdal, E. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.639779 · Cited by 53 · see citing works

AXL Receptor in Cancer Metastasis and Drug Resistance: When Normal Functions Go Askew

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Advances and Challenges in Targeting TGF-β Isoforms for Therapeutic Intervention of Cancer: A Mechanism-Based Perspective

Danielpour, D. (2024) · Pharmaceuticals · doi:10.3390/ph17040533 · Cited by 52 · see citing works

EMT and cancer stem cells: Drivers of therapy resistance and promising therapeutic targets

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Mechanical Forces as Determinants of Disseminated Metastatic Cell Fate

Montagner, M., & Dupont, S. (2020) · Cells · doi:10.3390/cells9010250 · Cited by 51 · see citing works

Epithelial to Mesenchymal Transition History: From Embryonic Development to Cancers

Lachat, C., Peixoto, P., & Hervouet, É. (2021) · Biomolecules · doi:10.3390/biom11060782 · Cited by 49 · see citing works

Measuring and Modelling the Epithelial- Mesenchymal Hybrid State in Cancer: Clinical Implications

Jolly, M. K., Murphy, R. J., Bhatia, S., Whitfield, H. J., Redfern, A. D., Davis, M. J., & Thompson, E. W. (2021) · Cells Tissues Organs · doi:10.1159/000515289 · Cited by 48 · see citing works

Tumor budding is an independent prognostic factor in stage III colon cancer patients: a post-hoc analysis of the IDEA-France phase III trial (PRODIGE-GERCOR)

Basile, D., Broudin, C., Emile, J. F., Falcoz, A., Pagès, F., Mineur, L., Bennouna, J., Louvet, C., Artru, P., Fratte, S., et al. (2022) · Annals of Oncology · doi:10.1016/j.annonc.2022.03.002 · Cited by 47 · see citing works

Targeted therapy for pancreatic ductal adenocarcinoma: Mechanisms and clinical study

Kung, H., & Yu, J. (2023) · MedComm · doi:10.1002/mco2.216 · Cited by 43 · see citing works

MicroRNA‑199a‑5p suppresses cell proliferation, migration and invasion by targeting ITGA3 in colorectal cancer

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Autophagy-mediating microRNAs in cancer chemoresistance

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The high-grade serous ovarian cancer metastasis and chemoresistance in 3D models

Tadić, V., Zhang, W., & Brozović, A. (2023) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2023.189052 · Cited by 42 · see citing works

Stem-Like Cancer Cells in a Dynamic 3D Culture System: A Model to Study Metastatic Cell Adhesion and Anti-Cancer Drugs

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Microfluidic Control of Tumor and Stromal Cell Spheroids Pairing and Merging for Three-Dimensional Metastasis Study

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Collective metastasis: coordinating the multicellular voyage

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The Cell Cycle-Associated Protein CDKN2A May Promotes Colorectal Cancer Cell Metastasis by Inducing Epithelial-Mesenchymal Transition

Shi, W., Li, Y., Bai, X., & Lin, G. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.834235 · Cited by 41 · see citing works

SUMO E3 ligase CBX4 regulates hTERT-mediated transcription of CDH1 and promotes breast cancer cell migration and invasion

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ST3GAL5‐catalyzed gangliosides inhibit TGF‐β‐induced epithelial‐mesenchymal transition via TβRI degradation

Zhang, J., van der Zon, G., Ma, J., Mei, H., Cabukusta, B., Agaser, C., Madunić, K., Wuhrer, M., Zhang, T., & ten Dijke, P. (2022) · The EMBO Journal · doi:10.15252/embj.2021110553 · Cited by 39 · see citing works

Mechanistic Insights Delineating the Role of Cholesterol in Epithelial Mesenchymal Transition and Drug Resistance in Cancer

Abdulla, N., Vincent, C. T., & Kaur, M. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.728325 · Cited by 38 · see citing works

Role of Exosomes in Epithelial–Mesenchymal Transition

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Vitamin D Regulates CXCL12/CXCR4 and Epithelial-to-Mesenchymal Transition in a Model of Breast Cancer Metastasis to Lung

Li, J., Luco, A.-L., Camirand, A., St‐Arnaud, R., & Kremer, R. B. (2021) · Endocrinology · doi:10.1210/endocr/bqab049 · Cited by 36 · see citing works

Emerging roles for HMGA2 in colorectal cancer

Wang, X., Wang, J., & Wu, J. (2020) · Translational Oncology · doi:10.1016/j.tranon.2020.100894 · Cited by 36 · see citing works

FBXO32 links ubiquitination to epigenetic reprograming of melanoma cells

Habel, N., Hachem, N. E., Soysouvanh, F., Bzioueche, H., Giuliano, S., Nguyen, S., Horák, P., Gay, A.-S., Debayle, D., Nottet, N., et al. (2021) · Cell Death and Differentiation · doi:10.1038/s41418-020-00710-x · Cited by 34 · see citing works

Crosstalk of Long Non-coding RNAs and EMT: Searching the Missing Pieces of an Incomplete Puzzle for Lung Cancer Therapy

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Breast cancer circulating tumor cells with mesenchymal features—an unreachable target?

Topa, J., Grešner, P., Zaczek, A. J., & Markiewicz, A. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-04064-6 · Cited by 31 · see citing works

Revisiting the Tenascins: Exploitable as Cancer Targets?

Tucker, R. P., & Degen, M. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.908247 · Cited by 31 · see citing works

Autophagy orchestrates resistance in hepatocellular carcinoma cells

Seydi, H., Nouri, K., Rezaei, N., Tamimi, A., Hassan, M., Mirzaei, H., & Vosough, M. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114487 · Cited by 31 · see citing works

Transcription Factors and Markers Related to Epithelial–Mesenchymal Transition and Their Role in Resistance to Therapies in Head and Neck Cancers

Pawlicka, M., Gumbarewicz, E., Błaszczak, E., & Stepulak, A. (2024) · Cancers · doi:10.3390/cancers16071354 · Cited by 30 · see citing works

Beyond single biomarkers: multi-omics strategies to predict immunotherapy outcomes in blood cancers

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Ionising Radiation Promotes Invasive Potential of Breast Cancer Cells: The Role of Exosomes in the Process

AL-Abedi, R., Cagatay, S. T., Mayah, A., Brooks, S. A., & Kadhim, M. A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111570 · Cited by 30 · see citing works

YBX1 Enhances Metastasis and Stemness by Transcriptionally Regulating MUC1 in Lung Adenocarcinoma

Xie, Q., Zhao, S., Liu, W., Cui, Y., Li, F., Li, Z., Guo, T., Yu, W., Guo, W., Deng, W., et al. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.702491 · Cited by 30 · see citing works

Potential Therapeutic Applications of N-Cadherin Antagonists and Agonists

Blaschuk, O. W. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.866200 · Cited by 30 · see citing works

The microRNA-183/96/182 cluster inhibits lung cancer progression and metastasis by inducing an interleukin-2-mediated antitumor CD8+ cytotoxic T-cell responsePreprint

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The interactions of Bcl9/Bcl9L with β-catenin and Pygopus promote breast cancer growth, invasion, and metastasis

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Combinatorial Therapy of Cancer: Possible Advantages of Involving Modulators of Ionic Mechanisms

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Long noncoding RNA Smyca coactivates TGF-β/Smad and Myc pathways to drive tumor progression

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From shape-shifting embryonic cells to oncology: The fascinating history of epithelial mesenchymal transition

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Scutellarin Alleviates Ovalbumin-Induced Airway Remodeling in Mice and TGF-β-Induced Pro-fibrotic Phenotype in Human Bronchial Epithelial Cells via MAPK and Smad2/3 Signaling Pathways

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Targeting the ILK/YAP axis by LFG-500 blocks epithelial–mesenchymal transition and metastasis

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Formation, contents, functions of exosomes and their potential in lung cancer diagnostics and therapeutics

Xia, Z., Qing, B., Wang, W., Gu, L., Chen, H., & Yuan, Y. (2021) · Thoracic Cancer · doi:10.1111/1759-7714.14217 · Cited by 28 · see citing works

Matricellular protein tenascin C: Implications in glioma progression, gliomagenesis, and treatment

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Neuropilin-1 Interacts with Fibronectin-1 to Promote Epithelial–Mesenchymal Transition Progress in Gastric Cancer

Wu, C., Zeng, M., Liao, G., Qian, K., & Li, H. (2020) · OncoTargets and Therapy · doi:10.2147/ott.s275327 · Cited by 27 · see citing works

FAM126A interacted with ENO1 mediates proliferation and metastasis in pancreatic cancer via PI3K/AKT signaling pathway

Li, Y., Li, Y., Luo, J., Fu, X., Liu, P., Liu, S., & Pan, Y. (2022) · Cell Death Discovery · doi:10.1038/s41420-022-01047-9 · Cited by 27 · see citing works

Resistance to mesenchymal reprogramming sustains clonal propagation in metastatic breast cancer

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HOXB5 promotes malignant progression in pancreatic cancer via the miR-6732 pathway

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How germline genes promote malignancy in cancer cells

Bruggeman, J. W., Köster, J., van Pelt, A. M. M., Speijer, D., & Hamer, G. (2022) · BioEssays · doi:10.1002/bies.202200112 · Cited by 25 · see citing works

Mesenchymal–epithelial transition in lymph node metastases of oral squamous cell carcinoma is accompanied by ZEB1 expression

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PIEZO1 acts as a cancer suppressor by regulating the ROS / Wnt /β‐catenin axis

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KLF4, Slug and EMT in Head and Neck Squamous Cell Carcinoma

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Crosstalk between lipid metabolism and EMT: emerging mechanisms and cancer therapy

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Role of SPARC in the epithelial-mesenchymal transition induced by PTHrP in human colon cancer cells

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P2X7 receptor promotes migration and invasion of non-small cell lung cancer A549 cells through the PI3K/Akt pathways

Bai, X., Li, Q., Peng, X., Li, X., Qiao, C., Tang, Y., & Zhao, R. (2023) · Purinergic Signalling · doi:10.1007/s11302-023-09928-z · Cited by 24 · see citing works

Epithelial to mesenchymal transition (EMT) in metaplastic breast cancer and phyllodes breast tumors

Ακρίδα, Ι., Mulita, F., Plachouri, K., Benetatos, N., Maroulis, I. C., & Papadaki, H. H. (2023) · Medical Oncology · doi:10.1007/s12032-023-02259-4 · Cited by 23 · see citing works

EMT-related transcription factors and protein stabilization mechanisms involvement in cadherin switch of head and neck squamous cell carcinoma

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EMT, Stemness, and Drug Resistance in Biological Context: A 3D Tumor Tissue/In Silico Platform for Analysis of Combinatorial Treatment in NSCLC with Aggressive KRAS-Biomarker Signatures

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The Hallmarks of Cancer as Eco-Evolutionary Processes

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Epithelial-to-Mesenchymal Transition

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Lack of basic rationale in epithelial-mesenchymal transition and its related concepts

Cao, Y. (2024) · Cell & Bioscience · doi:10.1186/s13578-024-01282-w · Cited by 14 · see citing works

The epithelial mesenchymal transition and the progression of carcinoma

Lu, Y. (2007) · Weiliang yuansu yu jiankang yanjiu

The epithelial-mesenchymal transition (EMT) phenomenon Pierre P. Savagner * IRCM, Institut de recherche en cancérologie de Montpellier

Val, D., Lamarque, A. P., Inserm, U., & I, U. É. M. (2014)

Epithelial–Mesenchymal Transition in Development and Cancer

Micalizzi, D. S., & Ford, H. L. (2009) · Future Oncology · doi:10.2217/fon.09.94 · Cited by 144 · see citing works