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Anti-SARS coronavirus 3C-like protease effects of Isatis indigotica root and plant-derived phenolic compounds
Open accessAbstract
The 3C-like protease (3CLpro) of SARS-coronavirus mediates the proteolytic processing of replicase polypeptides 1a and 1ab into functional proteins, becoming an important target for the drug development. In this study, Isatis indigotica root extract, five major compounds of I. indigotica root, and seven plant-derived phenolic compounds were tested for anti-SARS-CoV 3CLpro effects using cell-free and cell-based cleavage assays. Cleavage assays with the 3CLpro demonstrated that IC50 values were in micromolar ranges for I. indigotica root extract, indigo, sinigrin, aloe emodin and hesperetin. Sinigrin (IC50: 217 μM) was more efficient in blocking the cleavage processing of the 3CLpro than indigo (IC50: 752 μM) and beta-sitosterol (IC50: 1210 μM) in the cell-based assay. Only two phenolic compounds aloe emodin and hesperetin dose-dependently inhibited cleavage activity of the 3CLpro, in which the IC50 was 366 μM for aloe emodin and 8.3 μM for hesperetin in the cell-based assay.
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Identification of a novel coronavirus in patients with severe acute respiratory syndrome
Drosten, C., Günther, S., Preiser, W., van der Werf, S., Brodt, H.-R., Becker, S., Rabenau, H., Panning, M., Kolesnikova, L., Fouchier, R. A. M., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa030747 · Cited by 4,574
Holmes, K. V. (2003) · New England Journal of Medicine · doi:10.1056/nejmp030078 · Cited by 330
McGovern, S. L., & Shoichet, B. K. (2003) · Journal of Medicinal Chemistry · doi:10.1021/jm0300330 · Cited by 276
Kao, R. Y., Tsui, W. H. W., Lee, T. S. W., Tanner, J. A., Watt, R. M., Huang, J.-D., Hu, L., Chen, G., Chen, Z., Zhang, L., et al. (2004) · Chemistry & Biology · doi:10.1016/j.chembiol.2004.07.013 · Cited by 156
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Coronavirus disease 2019 (COVID-19): current status and future perspectives
Li, H., Liu, S.-M., Yu, X.-H., Tang, S.-L., & Tang, C.-K. (2020) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2020.105951 · Cited by 1,156
Yang, Y., Islam, M. S., Wang, J., Li, Y., & Chen, X. (2020) · International Journal of Biological Sciences · doi:10.7150/ijbs.45538 · Cited by 960
Sun, W., & Shahrajabian, M. H. (2023) · Molecules · doi:10.3390/molecules28041845 · Cited by 806
Saini, R. K., Ranjit, A., Sharma, K., Prasad, P., Shang, X., Gowda, K. G. M., & Keum, Y.-S. (2022) · Antioxidants · doi:10.3390/antiox11020239 · Cited by 584
Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 interaction
HO, T., WU, S., CHEN, J., LI, C., & HSIANG, C. (2007) · Antiviral Research · doi:10.1016/j.antiviral.2006.04.014 · Cited by 516
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Metadata
- Authors
- Lin, C.-W., Tsai, F.-J., Tsai, C.-H., Lai, C.-C., Wan, L., Ho, T.-Y., Hsieh, C.-C., & Chao, P.-D. L.
- Venue
- Antiviral Research
- Publisher
- Elsevier BV
- Published
- 2005-10
- Volume
- 68
- Issue
- 1
- Pages
- 36-42
- ISSN
- 0166-3542 (ISSN-L)
- OpenAlex
- W1978897742
- Cited by
- 545
- References
- 4
- FWCI
- 2.20
- Type
- journal article
- Language
- en
- Open access
- green
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- Lin, C.-W., Tsai, F.-J., Tsai, C.-H., Lai, C.-C., Wan, L., Ho, T.-Y., Hsieh, C.-C., & Chao, P.-D. L. (2005). Anti-SARS coronavirus 3C-like protease effects of Isatis indigotica root and plant-derived phenolic compounds. Antiviral Research. https://doi.org/10.1016/j.antiviral.2005.07.002
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