Therapeutic Potential of Phenolic Compounds in Medicinal Plants—Natural Health Products for Human Health
Open accessAbstract
Phenolic compounds and flavonoids are potential substitutes for bioactive agents in pharmaceutical and medicinal sections to promote human health and prevent and cure different diseases. The most common flavonoids found in nature are anthocyanins, flavones, flavanones, flavonols, flavanonols, isoflavones, and other sub-classes. The impacts of plant flavonoids and other phenolics on human health promoting and diseases curing and preventing are antioxidant effects, antibacterial impacts, cardioprotective effects, anticancer impacts, immune system promoting, anti-inflammatory effects, and skin protective effects from UV radiation. This work aims to provide an overview of phenolic compounds and flavonoids as potential and important sources of pharmaceutical and medical application according to recently published studies, as well as some interesting directions for future research. The keyword searches for flavonoids, phenolics, isoflavones, tannins, coumarins, lignans, quinones, xanthones, curcuminoids, stilbenes, cucurmin, phenylethanoids, and secoiridoids medicinal plant were performed by using Web of Science, Scopus, Google scholar, and PubMed. Phenolic acids contain a carboxylic acid group in addition to the basic phenolic structure and are mainly divided into hydroxybenzoic and hydroxycinnamic acids. Hydroxybenzoic acids are based on a C6-C1 skeleton and are often found bound to small organic acids, glycosyl moieties, or cell structural components. Common hydroxybenzoic acids include gallic, syringic, protocatechuic, p-hydroxybenzoic, vanillic, gentistic, and salicylic acids. Hydroxycinnamic acids are based on a C6-C3 skeleton and are also often bound to other molecules such as quinic acid and glucose. The main hydroxycinnamic acids are caffeic, p-coumaric, ferulic, and sinapic acids.
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Phytochemicals like alkaloids, flavonoids, and terpenoids have demonstrated potential in addressing neurodegenerative diseases including Alzheimer's disease by combating oxidative stress, minimizing inflammation, and protecting neurons.
“Phytochemicals like alkaloids, flavonoids, and terpenoids have demonstrated potential in addressing neurodegenerative diseases (NNDs), including AD, by combating oxidative stress, minimizing inflammation, and protecting neurons [13,14].”
From Cholinesterase Inhibitors from Plants and Their Potential in Alzheimer’s Treatment: Systematic Review (2025) · cites this paper as [14]
The Resveratrol section (no page supplied) reports neuroprotective effects through antioxidant and anti-inflammatory pathways and potential application to Alzheimer’s disease; the Conclusions also identify neuroprotective potential among the benefits of phenolic compounds. But the paper does not extend that neurodegenerative-disease claim to all three named groups: its Introduction mentions alkaloids and terpenoids in connection with diabetes, not neuronal protection. (LLM, conf=0.88)
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Teshome, E., Teka, T. A., Nandasiri, R., Rout, J. R., Harouna, D. V., Astatkie, T., & Urugo, M. M. (2023) · Sustainability · doi:10.3390/su15107840 · Cited by 76 · see citing works
ALNasser, M. N., Alboraiy, G. M., Alsowig, E. M., & Alqattan, F. M. (2025) · Brain Sciences · doi:10.3390/brainsci15020215 · Cited by 35 · see citing works
“Phytochemicals like alkaloids, flavonoids, and terpenoids have demonstrated potential in addressing neurodegenerative diseases (NNDs), including AD, by combating oxidative stress, minimizing inflammation, and protecting neurons [13,14].”
Microbiome-generated antifolates.
London, R. E. (2026) · FEBS Letters · doi:10.1002/1873-3468.70252 · Cited by 1 · see citing works
- Authors
- Sun, W., & Shahrajabian, M. H.
- Affiliations
- Chinese Academy of Agricultural Sciences (CN)
- Corresponding author
- Sun, Wenli
- Venue
- Molecules
- Publisher
- MDPI AG
- Published
- 2023-02-15
- Volume
- 28
- Issue
- 4
- Pages
- 1845
- ISSN
- 1420-3049 (ISSN-L)
- PMC
- PMC9960276
- OpenAlex
- W4321100837
- Cited by
- 806
- References
- 521
- Citations by year
- 2026: 240 · 2025: 316 · 2024: 188 · 2023: 60 · 2022: 1
- FWCI
- 15.97
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Molecules (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- the Natural Science Foundation of Beijing, China (M21026, 2019YFA0904700)
- the National Key R&D Program of China (M21026, 2019YFA0904700)
- Topics
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioactive natural compounds
- Keywords
- phenolic compounds, flavonoids, medicinal plants, natural health products, antioxidant activity, antibacterial activity, cardioprotection, anticancer activity, anti-inflammatory activity, UV protection, isoflavones, tannins, coumarins, hydroxybenzoic acids, hydroxycinnamic acids, gallic acid, caffeic acid, curcuminoids, stilbenes, phenylethanoids, secoiridoids, disease prevention
- MeSH terms
- Anthocyanins, Antioxidants, Coumaric Acids, Pharmaceutical Preparations, Flavonoids, Humans, Isoflavones, Phenols, Plants, Medicinal, Hydroxybenzoates
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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