The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Inhibition of Hepatitis B Virus Replication by Drug-Induced Depletion of Nucleocapsids
Abstract
Chronic hepatitis B virus (HBV) infection is a major cause of liver disease. Only interferon-α and the nucleosidic inhibitors of the viral polymerase, 3TC and adefovir, are approved for therapy. However, these therapies are limited by the side effects of interferon and the substantial resistance of the virus to nucleosidic inhibitors. Potent new antiviral compounds suitable for monotherapy or combination therapy are highly desired. We describe non-nucleosidic inhibitors of HBV nucleocapsid maturation that possess in vitro and in vivo antiviral activity. These inhibitors have potential for future therapeutic regimens to combat chronic HBV infection.
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Cites
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Nassal, M. (1992) · Journal of Virology · doi:10.1128/jvi.66.7.4107-4116.1992 · Cited by 449
Characterization of binding interactions by isothermal titration calorimetry
Doyle, M. L. (1997) · Current Opinion in Biotechnology · doi:10.1016/s0958-1669(97)80154-1 · Cited by 207
Weber, O., Schlemmer, K.-H., Hartmann, E., Hagelschuer, I., Paessens, A., Graef, E., Deres, K., Goldmann, S., Niewoehner, U., Stoltefuss, J., et al. (2002) · Antiviral Research · doi:10.1016/s0166-3542(01)00216-9 · Cited by 163
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Hepatitis B Virus Morphogenesis
Nassal, M. (1996) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-80145-7_10 · Cited by 75
Lamivudine resistance in hepatitis B: mechanisms and clinical implications
Fischer, K. P., Gutfreund, K. S., & Tyrrell, D. L. (2001) · Drug Resistance Updates · doi:10.1054/drup.2001.0190 · Cited by 61
Cited by
Core protein: A pleiotropic keystone in the HBV lifecycle
Zlotnick, A., Venkatakrishnan, B., Tan, Z., Lewellyn, E., Turner, W., & Francis, S. (2015) · Antiviral Research · doi:10.1016/j.antiviral.2015.06.020 · Cited by 268
Zeisel, M. B., Lucifora, J., Mason, W. S., Sureau, C., Beck, J., Levrero, M., Kann, M., Knolle, P. A., Benkirane, M., Durantel, D., et al. (2015) · Gut · doi:10.1136/gutjnl-2014-308943 · Cited by 256
Alexander, C. G., Jürgens, M. C., Shepherd, D. A., Freund, S. M. V., Ashcroft, A. E., & Ferguson, N. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1308846110 · Cited by 85
Metadata
- Authors
- Deres, K., Schröder, C. H., Paessens, A., Goldmann, S., Hacker, H. J., Weber, O., Krämer, T., Niewöhner, U., Pleiss, U., Stoltefuss, J., Graef, E., Koletzki, D., Masantschek, R. N. A., Reimann, A., Jaeger, R., Groß, R., Beckermann, B., Schlemmer, K.-H., Haebich, D., & Rübsamen-Waigmann, H.
- Venue
- Science
- Published
- 2003-02-07
- Volume
- 299
- Issue
- 5608
- Pages
- 893-896
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2136744556
- Cited by
- 508
- References
- 8
- FWCI
- 14.35
- Type
- journal article
- Language
- en
- Open access
- closed
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- Deres, K., Schröder, C. H., Paessens, A., Goldmann, S., Hacker, H. J., Weber, O., Krämer, T., Niewöhner, U., Pleiss, U., Stoltefuss, J., Graef, E., Koletzki, D., Masantschek, R. N. A., Reimann, A., Jaeger, R., Groß, R., Beckermann, B., Schlemmer, K.-H., Haebich, D., & Rübsamen-Waigmann, H. (2003). Inhibition of Hepatitis B Virus Replication by Drug-Induced Depletion of Nucleocapsids. Science. https://doi.org/10.1126/science.1077215
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
