Exercise significantly increases plasma adrenaline and oxidized low-density lipoprotein in normal healthy subjects but not in persons with spinal cord injury
Abstract
Objectives To compare plasma concentrations of oxidized low-density lipoprotein (oxLDL) and adrenaline during exercise between persons with spinal cord injury (SCI) and able-bodied (AB) individuals.Design Randomized controlled study.Setting Human laboratory at a medical university.Participants Persons with SCI (n=7) and AB individuals (n=9).Intervention Two-hour arm crank ergometer exercise at 60% maximum oxygen consumption.Main outcome measures Plasma oxLDL and adrenaline levels.Results Exercise significantly increased plasma adrenaline levels in AB persons (mean ± SD: rest, 45.4±32.2 pg/mL; exercise, 200.9±113.7 pg/mL; P<.05) and persons with SCI; however; the magnitude of the increase in those with SCI was attenuated (mean ± SD: rest, 45.4±14.0 pg/mL; exercise, 83.0±55.8 pg/mL; P<.05). Exercise also significantly increased plasma oxLDL levels in AB persons (mean ± SD: rest, 102.2±30.2 U/L; exercise, 179.7±60.0 U/L; P<.05), but not in persons with SCI (mean ± SD: rest, 124.3±66.0 U/L; exercise, 138.9±59.5 U/L).Conclusions The results suggest that increases in plasma adrenaline levels during exercise contribute to the increase in plasma oxLDL levels.
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“, 2013; Smith, 2018); (2) improved lipoprotein protein profiles, through reduced triglyceride and low-density lipoproteins [LDL] levels, and increased high density lipoprotein [HDL] levels (Warburton et al., 2006; Mitsui et al., 2012); (3) greater efficiency in glucose homeostasis and insulin sensitivity (Tan et al.”
BackgroundCirculating progenitor cell response to exercise in wheelchair racing athletes
NIEMIRO, G. M., EDWARDS, T., BARFIELD, J. P., BEALS, J. W., BROAD, E. M., MOTL, R. W., BURD, N. A., PILUTTI, L. A., & DE LISIO, M. (2018) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001402 · Cited by 10 · see citing works
- Authors
- Mitsui, T., Nakamura, T., Ito, T., Umemoto, Y., Sakamoto, K., Kinoshita, T., Nakagawa, M., & Tajima, F.
- Affiliations
- Wakayama Medical University (JP)
- Corresponding author
- Tajima, Fumihiro
- ORCID
- Venue
- Archives of Physical Medicine and Rehabilitation
- Publisher
- Elsevier BV
- Published
- 2012-04
- Volume
- 93
- Issue
- 4
- Pages
- 725-727
- ISSN
- 0003-9993 (ISSN-L)
- OpenAlex
- W2073319596
- Cited by
- 12
- References
- 8
- Citations by year
- 2023: 1 · 2022: 1 · 2021: 1 · 2019: 1 · 2018: 1 · 2017: 3 · 2014: 2 · 2013: 2
- FWCI
- 3.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Physical Medicine and Rehabilitation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Health Sciences › Medicine › Pathology and Forensic Medicine › Spinal Cord Injury Research
- Keywords
- spinal cord injury, physical activity, epinephrine, plasma adrenaline, oxidized LDL, oxidative stress, healthy volunteers
- MeSH terms
- Adult, Analysis of Variance, Epinephrine, Exercise Test, Humans, Lipoproteins, LDL, Male, Oxygen Consumption, Paraplegia, Spinal Cord Injuries, Exercise
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