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Cited by 121Long-Term Effects of COVID-19Intensive Care Unit Cognitive DisordersCOVID-19 Clinical Research Studies

The DOI matches its Crossref record; 16 of the 18 references it cites were found in a registry or an index.

Neuropsychological Features of Severe Hospitalized Coronavirus Disease 2019 Patients at Clinical Stability and Clues for Postacute Rehabilitation

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Negrini, Francesco, Ferrario, Irene, Mazziotti, Daniele, Berchicci, Marzia, Bonazzi, Maurizio, de Sire, Alessandro, Negrini, Stefano, Zapparoli, Laura·2021·Archives of Physical Medicine and Rehabilitation
DOI 10.1016/j.apmr.2020.09.376PMC PMC7521874
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Abstract

Objectives To report the cognitive features of patients with severe coronavirus disease 2019 (COVID-19) entering the postacute phase, to understand whether COVID-19 acute respiratory distress syndrome itself could result in long-term cognitive deficits, and to determine whether neuropsychological treatment after the acute stage might represent a specific rehabilitation need.Design Case series.Setting Rehabilitation hospital.Participants We assessed the general cognitive functioning through tablet-supported video calls in 9 of 12 consecutive patients (N=9) admitted to the hospital at least 30 days earlier for acute respiratory distress syndrome due to COVID-19. Three patients were excluded based on the exclusion criteria. None of the patients presented cognitive symptoms before hospitalization.Main outcome measure General cognitive functioning, measured using the Mini-Mental State Examination (MMSE) test.Results A general cognitive decay was observed in 3 patients (33.3%) who had a pathologic score on the MMSE, with a specific decline in attention, memory, language, and praxis abilities. The cognitive malfunctioning appears to be linearly associated with the length of stay (in d) in the intensive care unit (ICU). The longer the amount of time spent in the ICU, the lower the MMSE score, indicating a lower global cognitive functioning.Conclusions Our results indicate that some patients with COVID-19 might also benefit from neuropsychological rehabilitation, given their possible global cognitive decay. The link between neuropsychological functioning and the length of stay in the ICU suggests that neurocognitive rehabilitative treatments should be directed explicitly toward patients who treated in the ICU, rather than toward every patient who experienced acute respiratory distress syndrome owing to COVID-19. However, given the limitation of a case series study, those hypotheses should be tested with future studies with larger samples and a longer follow-up period.

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Authors
Negrini, F., Ferrario, I., Mazziotti, D., Berchicci, M., Bonazzi, M., de Sire, A., Negrini, S., & Zapparoli, L.
Affiliations
  • IRCCS Ospedale Galeazzi - Sant'Ambrogio (IT)
  • Istituto Scientifico Italiano Colonna Vertebrale (IT)
ORCID
Venue
Archives of Physical Medicine and Rehabilitation
Publisher
Elsevier BV
Published
2021-01
Volume
102
Issue
1
Pages
155-158
ISSN
0003-9993 (ISSN-L)
DOI
10.1016/j.apmr.2020.09.376
PMC
PMC7521874
OpenAlex
W3088369215
Cited by
121
References
18
Citations by year
2026: 5 · 2025: 10 · 2024: 14 · 2023: 27 · 2022: 31 · 2021: 34
FWCI
9.96
Type
journal article
Language
en
Open access
Licence
Locations
  • Archives of Physical Medicine and Rehabilitation (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
  • BOA (University of Milano-Bicocca) (submittedVersion)
  • IrInSubria (University of Insubria) (submittedVersion)
  • Lirias (submittedVersion)
Topics
  • Health Sciences › Medicine › Clinical Neurology › Long-Term Effects of COVID-19
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Intensive Care Unit Cognitive Disorders
  • Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
Keywords
COVID-19 pandemic, neuropsychological rehabilitation, acute respiratory distress syndrome, ICU length of stay, cognitive impairment, attention and memory deficits, Mini-Mental State Examination, hospitalized patients
MeSH terms
Mental Status and Dementia Tests, COVID-19, SARS-CoV-2, Adult, Aged, Cognition Disorders, Female, Hospitalization, Humans, Intensive Care Units, Length of Stay, Male, Middle Aged, Pneumonia, Viral, Risk Factors, Subacute Care

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