Cited by 1,410Drug Solubulity and Delivery SystemsAdvanced Drug Delivery SystemsInhalation and Respiratory Drug Delivery

The DOI matches its Crossref record; 68 of the 86 references it cites were found in a registry or an index.

Insoluble drug delivery strategies: review of recent advances and business prospects

Open access

Kalepu, Sandeep, Nekkanti, Vijaykumar·2015·Acta Pharmaceutica Sinica B

DOI 10.1016/j.apsb.2015.07.003PMC PMC4629443

Open this paper in CoChat — free account Open PDF

Abstract

The emerging trends in the combinatorial chemistry and drug design have led to the development of drug candidates with greater lipophilicity, high molecular weight and poor water solubility. Majority of the failures in new drug development have been attributed to poor water solubility of the drug. Issues associated with poor solubility can lead to low bioavailability resulting in suboptimal drug delivery. About 40% of drugs with market approval and nearly 90% of molecules in the discovery pipeline are poorly water-soluble. With the advent of various insoluble drug delivery technologies, the challenge to formulate poorly water soluble drugs could be achieved. Numerous drugs associated with poor solubility and low bioavailabilities have been formulated into successful drug products. Several marketed drugs were reformulated to improve efficacy, safety and patient compliance. In order to gain marketing exclusivity and patent protection for such products, revitalization of poorly soluble drugs using insoluble drug delivery technologies have been successfully adopted by many pharmaceutical companies. This review covers the recent advances in the field of insoluble drug delivery and business prospects.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.apsb.2015.07.003

Cites

68 of 68 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Improving drug solubility for oral delivery using solid dispersions
Leuner, C. (2000) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/s0939-6411(00)00076-x · Cited by 2,581
Pharmaceutical Applications of Cyclodextrins. 1. Drug Solubilization and Stabilization
Loftsson, Þ., & Brewster, M. E. (1996) · Journal of Pharmaceutical Sciences · doi:10.1021/js950534b · Cited by 2,179
Negative staining of phospholipids and their structural modification by surface-active agents as observed in the electron microscope
Bangham, A. D., & Horne, R. W. (1964) · Journal of Molecular Biology · doi:10.1016/s0022-2836(64)80115-7 · Cited by 1,810
Cyclodextrins and their pharmaceutical applications
Loftsson, Þ., & Duchêne, D. (2006) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2006.10.044 · Cited by 1,766
Salt formation to improve drug solubility
Serajuddin, A. T. M. (2007) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.05.010 · Cited by 1,443
Amorphous pharmaceutical solids: preparation, characterization and stabilization
Yu, L. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(01)00098-9 · Cited by 1,408
Nanosuspensions as particulate drug formulations in therapy
Müller, R. H., Jacobs, C., & Kayser, O. (2001) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(00)00118-6 · Cited by 1,370
Nanostructured lipid matrices for improved microencapsulation of drugs
Müller, R. H., Radtke, M., & Wissing, S. A. (2002) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(02)00180-1 · Cited by 1,256
Pharmaceutical applications of cyclodextrins: basic science and product development
Loftsson, Þ., & Brewster, M. E. (2010) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.2010.01030.x · Cited by 1,088
Polymeric Micelles in Anticancer Therapy: Targeting, Imaging and Triggered Release
Oerlemans, C., Bult, W., Bos, M. A., Storm, G., Nijsen, J. F. W., & Hennink, W. E. (2010) · Pharmaceutical Research · doi:10.1007/s11095-010-0233-4 · Cited by 969

Flagged first, then by citations

Show all 86 references

18 of the 86 references couldn’t be matched to a known paper.

Research works printed but not linked: 3

Durate, 2011, Overcoming poor bioavailability through amorphous solid dispersions, Ind Pharm, 30, 4
Miller DA. Improved oral absorption of poorly water-soluble drugs by advanced solid dispersion systems [dissertation]. Austin: University of Texas; 2007
Kaparissides, 2006, Recent advances in novel drug delivery systems, J Nanotechnol, 2, 1

Sorted by citations

Items 501–600 of 1,000

Thermodynamic Stability Is a Poor Indicator of Cocrystallization in Models of Organic Molecules
Pimonova, Y. A., Carpenter, J. E., & Gruenwald, M. (2024) · Journal of the American Chemical Society · doi:10.1021/jacs.3c13030 · Cited by 20
Quality-by-design approach for the development of telmisartan potassium tablets
Oh, G.-H., Park, J., Shin, H., Kim, J.-E., & Park, Y.-J. (2017) · Drug Development and Industrial Pharmacy · doi:10.1080/03639045.2017.1414233 · Cited by 20
From formulation to in vivo model: A comprehensive study of a synergistic relationship between vancomycin, carvacrol, and cuminaldehyde against Enterococcus faecium
Owen, L., Webb, J. P., Green, J. D., Smith, L. J., & Laird, K. (2020) · Phytotherapy Research · doi:10.1002/ptr.6631 · Cited by 20
Comparative studies of the effects of novel excipients amino acids with cyclodextrins on enhancement of dissolution and oral bioavailability of the non-ionizable drug carbamazepine
Abou‐Taleb, H. A., Fathalla, Z. M. A., & Abdelkader, H. (2020) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2020.105562 · Cited by 20
Matrix assisted antibacterial activity of polymer conjugates with pendant antibiotics, and bioactive and biopassive moieties
Mukherjee, I., Ghosh, A., Bhadury, P., & De, P. (2019) · Journal of Materials Chemistry B · doi:10.1039/c9tb00328b · Cited by 20
Refined tamoxifen administration in mice by encouraging voluntary consumption of palatable formulations
Vanhecke, D., Bugada, V., Steiner, R., Polić, B., & Buch, T. (2024) · Lab Animal · doi:10.1038/s41684-024-01409-z · Cited by 19
β-Cyclodextrin-based materials for 3D printing, cancer therapy, tissue engineering, and wound healing
Sathuvan, M., Min, S., Narayanan, K., Gaur, A., Hong, H., Vivek, R., Ganapathy, A., Cheong, K., Kang, H., & Thangam, R. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.157272 · Cited by 19
Polymorphism and Particle Formation Pathway of Carbamazepine during Sonoprecipitation from Ionic Liquid Solutions
Prasad, R., Panwar, K., Katla, J., & Dalvi, S. V. (2020) · Crystal Growth & Design · doi:10.1021/acs.cgd.0c00382 · Cited by 19
Neuroprotection by resveratrol: A review on brain delivery strategies for Alzheimer's and Parkinson's disease
Chinraj, V., & Sureshkumar, R. (2022) · Journal of Applied Pharmaceutical Science · doi:10.7324/japs.2022.120701 · Cited by 24
Roles of effective stabilizers in improving oral bioavailability of naringenin nanocrystals: Maintenance of supersaturation generated upon dissolution by inhibition of drug dimerization
Zhang, G., Guan, H., Li, J., Li, M., Sui, X., Tian, B., Dong, H., Liu, B., He, Z., Li, N., et al. (2022) · Asian Journal of Pharmaceutical Sciences · doi:10.1016/j.ajps.2022.09.001 · Cited by 19
Equilibrium solubility investigation and thermodynamic aspects of paracetamol, salicylic acid and 5-aminosalicylic acid in polyethylene glycol dimethyl ether 250 + water mixtures
Barzegar-Jalali, M., Jafari, P., Hemmati, S., & Jouyban, A. (2023) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2022.121185 · Cited by 19
A Compendium of Bioavailability Enhancement via Niosome Technology
Sharma, S., Kumari, N., Garg, D., & Chauhan, S. (2023) · Pharmaceutical Nanotechnology · doi:10.2174/2211738511666230309104323 · Cited by 19
Amphiphilic Dendritic Hydrogels with Carbosilane Nanodomains: Preparation and Characterization as Drug Delivery Systems
Recio-Ruiz, J., Carloni, R., Ranganathan, S., Muñoz‐Moreno, L., Carmena, M. J., Ottaviani, M. F., de la Mata, F. J., & García‐Gallego, S. (2023) · Chemistry of Materials · doi:10.1021/acs.chemmater.2c03436 · Cited by 19
Surfactant-free solubilization and systemic delivery of anti-cancer drug using low molecular weight methylcellulose
Chung, J. Y., Ko, J. H., Lee, Y. J., Choi, H. S., & Kim, Y. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.02.028 · Cited by 19
Studying the effect of solubilizing agents on drug diffusion through the unstirred water layer (UWL) by localized spectroscopy
di Cagno, M. P., & Stein, P. C. (2019) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2019.04.005 · Cited by 19
Enhancing the physical stability and supersaturation generation of amorphous drug-polyelectrolyte nanoparticle complex via incorporation of crystallization inhibitor at the nanoparticle formation step: A case of HPMC versus PVP
Dong, B., Lim, L. M., & Hadinoto, K. (2019) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2019.105035 · Cited by 19
Hyaluronidase Coated Molecular Envelope Technology Nanoparticles Enhance Drug Absorption via the Subcutaneous Route
Soundararajan, R., Wang, G., Petkova, A., Uchegbu, I. F., & Schätzlein, A. G. (2020) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.0c00294 · Cited by 20
Impact of drying on dissolution behavior of carvedilol-loaded sustained release solid dispersion: development and characterization
Halder, S., Ahmed, F., Shuma, M. L., Azad, M. A. K., & Kabir, E. R. (2020) · Heliyon · doi:10.1016/j.heliyon.2020.e05026 · Cited by 19
Micelle-in-Liposomes for Sustained Delivery of Anticancer Agents That Promote Potent TRAIL-Induced Cancer Cell Apoptosis
Zhang, Z., Patel, S. B., & King, M. R. (2020) · Molecules · doi:10.3390/molecules26010157 · Cited by 20
Covalent and non-covalent albumin binding of Au(i) bis-NHCs via post-synthetic amide modification†
Sen, S., Perrin, M. W., Sedgwick, A. C., Lynch, V., Sessler, J., & Arambula, J. (2021) · Chemical Science · doi:10.1039/d1sc01055g · Cited by 12
An overview on nanoplatforms for statins delivery: Perspectives for safe and effective therapy
Etemad, L., Salmasi, Z., Moosavian Kalat, S. A., Moshiri, M., Zamanian, J., Kesharwani, P., & Sahebkar, A. (2023) · Environmental Research · doi:10.1016/j.envres.2023.116572 · Cited by 18
Effects of Dendrimer-Like Biopolymers on Physical Stability of Amorphous Solid Dispersions and Drug Permeability Across Caco-2 Cell Monolayers
Lavan, M., & Knipp, G. T. (2018) · AAPS PharmSciTech · doi:10.1208/s12249-018-1080-6 · Cited by 18
Insight into the in vivo translocation of oral liposomes by fluorescence resonance energy transfer effect
Liu, W., Li, D., Dong, Z., Liu, K., He, H., Lü, Y., Wu, W., Li, Q., Gan, L., & Qi, J. (2020) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2020.119682 · Cited by 18
Phase Behavior of Non‐Ionic Surfactant‐Medium Chain Triglyceride‐Water Microemulsion Systems
Callender, S. P., & Wettig, S. D. (2021) · Journal of Surfactants and Detergents · doi:10.1002/jsde.12510 · Cited by 18
Pharmaceutical cocrystals of Efavirenz: Towards the improvement of solubility, dissolution rate and stability
Gowda, B. H. J., Nechipadappu, S. K., Shankar, S. J., Chavali, M. S., Paul, K., Ahmed, M. G., Sanjana, A., & Shanthala, H. K. (2021) · Materials Today Proceedings · doi:10.1016/j.matpr.2021.05.535 · Cited by 18
Oral delivery of polyester nanoparticles for brain-targeting: Challenges and opportunities
Wang, P., Wang, Y., Li, P., Chen, C., Ma, S., Zhao, L., He, H., Yin, T., Zhang, Y. X., Tang, X., et al. (2022) · Chinese Chemical Letters · doi:10.1016/j.cclet.2022.07.034 · Cited by 18
Development of a new class of sulforaphane-enabled self-emulsifying drug delivery systems (SFN-SEDDS) by high throughput screening: A case study with curcumin
Kamal, M. M., & Nazzal, S. (2018) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2018.01.045 · Cited by 18
Improved Activity of Rifampicin Against Biofilms of Staphylococcus aureus by Multicomponent Complexation
Córdoba, A. V. D., Aiassa, V., Longhi, M. R., Quevedo, M. A., & Zoppi, A. (2020) · AAPS PharmSciTech · doi:10.1208/s12249-020-01706-z · Cited by 18
A synthetically lethal nanomedicine delivering novel inhibitors of polynucleotide kinase 3′-phosphatase (PNKP) for targeted therapy of PTEN-deficient colorectal cancer
Sadat, S. M. A., de Paiva, I. M., Shire, Z., Sanaee, F., Morgan, T. D. R., Paladino, M., Karimi‐Busheri, F., Mani, R. S., Martin, G. R., Jirik, F. R., et al. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.04.034 · Cited by 18
Usnic Acid: Potential Role in Management of Wound Infections
Francolini, I., Piozzi, A., & Donelli, G. (2018) · Advances in experimental medicine and biology · doi:10.1007/5584_2018_260 · Cited by 18
Nanotherapeutics for the Treatment of Cancer and Arthritis
Patel, P., Meghani, N., Kansara, K., & Kumar, A. (2018) · Current Drug Metabolism · doi:10.2174/1389200220666181127102720 · Cited by 19
Therapeutic nanofibrous scaffolds in precision drug delivery: formulation design, challenges and regulatory frameworks
Shokoya, M. M., Szabó, E., Nagy, Z. K., Sebe, I., & Zelkó, R. (2026) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2026.2619643 · Cited by 17
Cell-penetrating peptide-conjugated copper complexes for redox-mediated anticancer therapy
Peña, Q., Rodríguez-Calado, S., Simaan, A. J., Capdevila, M., Bayón, P., Palacios, Ò., Lorenzo, J., & Iranzo, O. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1060827 · Cited by 18
Drug-device systems based on biodegradable metals for bone applications: Potential, development and challenges
Yusop, A. H. M., Sarian, M. N., Januddi, F., & Nur, H. (2022) · Journal of Applied Biomedicine · doi:10.1016/j.bbe.2022.11.002 · Cited by 16
A Comparison of Spray-Drying and Co-Precipitation for the Generation of Amorphous Solid Dispersions (ASDs) of Hydrochlorothiazide and Simvastatin
Myślińska, M., Stocker, M. W., Ferguson, S., & Healy, A. M. (2023) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2023.02.012 · Cited by 17
Thermal and redox responsive polyamidoamine dendrimer–poly(N‐isopropylacrylamide) bridged by disulfide linkages for targeted and controlled drug delivery system
Luu, C. H., Nguyen, D. T. D., Chee, C. Y., Thi, T. C. N., Nguyen, D. Y. P., Nguyen, D. H., & Nguyen, C. K. (2023) · Journal of Applied Polymer Science · doi:10.1002/app.54108 · Cited by 17
Production of pharmaceutical micro and nano particles by subcritical water based technologies: A review
Mohammadi, H. S., Asl, A. H., & Khajenoori, M. (2023) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2023.104621 · Cited by 17
Combining machine learning and molecular simulations to predict the stability of amorphous drugs
Barnard, T., & Sosso, G. C. (2023) · The Journal of Chemical Physics · doi:10.1063/5.0156222 · Cited by 17
Solubility and Stability of Carvedilol in Deep Eutectic Solvents: A Step Towards a Sustainable Pharmaceutical Formulation in the Liquid State
Lomba, L., Polo, A., Martínez, N., Alejandre, J., & Giner, B. (2024) · ChemistrySelect · doi:10.1002/slct.202305218 · Cited by 17
Impact of colloidal drug-rich droplet size and amorphous solubility on drug membrane permeability: A comprehensive analysis
Ueda, K., Takemoto, S., Higashi, K., & Moribe, K. (2024) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2024.06.017 · Cited by 17
ROS‐Responsive Microneedle Patches Enable Peri‐Lacrimal Gland Therapeutic Administration for Long‐Acting Therapy of Sjögren's Syndrome‐Related Dry Eye
Mu, J., Ding, X., Song, Y., Mi, B., Fang, X., Chen, B., Yao, B., Sun, X., Yuan, X., Guo, S., et al. (2025) · Advanced Science · doi:10.1002/advs.202409562 · Cited by 17
Preparation of redox-sensitive β-CD-based nanoparticles with controlled release of curcumin for improved therapeutic effect on liver cancer in vitro
Yang, D. H., Kim, H. J., Kim, J., Chun, H. J., & Park, K. (2016) · Journal of Industrial and Engineering Chemistry · doi:10.1016/j.jiec.2016.09.018 · Cited by 17
Spectroscopic imaging studies of nanoscale polarity and mass transport phenomena in self-assembled organic nanotubes
Xu, H., Nagasaka, S., Kameta, N., Masuda, M., Ito, T., & Higgins, D. A. (2017) · Physical Chemistry Chemical Physics · doi:10.1039/c7cp03672h · Cited by 17
Linking the concentrations of itraconazole and 2-hydroxypropyl-β-cyclodextrin in human intestinal fluids after oral intake of Sporanox®
Berben, P., Stappaerts, J., Vink, M. J. A., Domínguez‐Vega, E., Somsen, G. W., Brouwers, J., & Augustijns, P. (2018) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2018.06.025 · Cited by 17
Influence of Mixing on the Precipitation of Organic Nanoparticles: A Lagrangian Perspective on Scale‐up Based on Self‐Similar Distributions
Schikarski, T., Trzenschiok, H., Avila, M., & Peukert, W. (2019) · Chemical Engineering & Technology · doi:10.1002/ceat.201900095 · Cited by 17
Plastically bendable pregabalin multi-component systems with improved tabletability and compressibility
Khandavilli, U. B. R., Yousuf, M., Schaller, B. E., Steendam, R. R. E., Keshavarz, L., McArdle, P., & Frawley, P. J. (2019) · CrystEngComm · doi:10.1039/c9ce01625b · Cited by 17
Self-assembled hydrophobic Ala-Aib peptide encapsulating curcumin: a convenient system for water insoluble drugs
Locarno, S. A., Argentiere, S., Ruffoni, A., Maggioni, D., Soave, R., Bucci, R., Erba, E., Lenardi, C., Gelmi, M. L., & Clerici, F. (2020) · RSC Advances · doi:10.1039/c9ra10981a · Cited by 17
Efficacy of Combination Therapy with Linalool and Doxorubicin Encapsulated by Liposomes as a Two-in-One Hybrid Carrier System for Epithelial Ovarian Carcinoma
Wi, T. I., Won, J. E., Lee, C. M., Lee, J., Kang, T. H., Shin, B. C., Han, H. D., & Park, Y. (2020) · International Journal of Nanomedicine · doi:10.2147/ijn.s272319 · Cited by 18
Noyes‐Whitney Dissolution Model‐Based pH‐Sensitive Slow Release of Paclitaxel (Taxol) from Human Hair‐Derived Keratin Microparticle Carriers
Wimalasiri, V. W., Dunuweera, S. P., Dunuweera, A. N., & Rajapakse, R. M. G. (2021) · BioMed Research International · doi:10.1155/2021/6657482 · Cited by 17
Surface modification of paper-based microfluidic devices via initiated chemical vapor deposition
Bacheller, S., & Gupta, M. (2024) · Lab on a Chip · doi:10.1039/d4lc00414k · Cited by 16
Crystal engineering for poorly water-soluble drugs: From design to applications
Chen, A., Peng, Y., Chen, Z., Lu, Y., Guo, M., & Cai, T. (2025) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2025.12.003 · Cited by 16
Process Intensification in Continuous Crystallization
Stelzer, T., Lakerveld, R., & Myerson, A. S. (2020) · Royal Society of Chemistry eBooks · doi:10.1039/9781788013581-00266 · Cited by 16
Solubility Advantage of Amorphous Ketoprofen. Thermodynamic and Kinetic Aspects by Molecular Dynamics and Free Energy Approaches
Gobbo, D., Ballone, P., Decherchi, S., & Cavalli, A. (2020) · Journal of Chemical Theory and Computation · doi:10.1021/acs.jctc.0c00166 · Cited by 16
Physicochemical Study of Albumin Nanoparticles with Chlorambucil
Kulig, K., Ziąbka, M., Pilarczyk, K., Owczarzy, A., Rogóż, W., & Maciążek-Jurczyk, M. (2022) · Processes · doi:10.3390/pr10061170 · Cited by 16
Impact of solvent properties on the precipitation of active pharmaceutical ingredients
Schikarski, T., Trzenschiok, H., Avila, M., & Peukert, W. (2022) · Powder Technology · doi:10.1016/j.powtec.2022.118032 · Cited by 20
Deep Eutectic Solvents: Fundamental Aspect, Characterizations and Applications
Dangre, P. V., Borase, H. P., Gunde, M. C., Pethe, A. M., & Borkar, M. R. (2022) · Recent Advances in Drug Delivery and Formulation · doi:10.2174/2667387817666221228141746 · Cited by 16
Nanoemulsion Composed of α-Tocopherol Succinate and Dequalinium Shows Mitochondria-Targeting and Anticancer Effects
Thủy, L. T. T., Lee, S., Dongquoc, V., & Choi, J. S. (2023) · Antioxidants · doi:10.3390/antiox12020437 · Cited by 16
Advances in solvent based cocrystallization: Bridging the gap between theory and practice
Sarangi, S., Remya, P. N., & Damodharan, N. (2024) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2024.105619 · Cited by 16
Solid Dispersions Obtained by Ball Milling as Delivery Platform of Etodolac, a Model Poorly Soluble Drug
Czajkowska-Kośnik, A., Misztalewska‐Turkowicz, I., Wilczewska, A. Z., Basa, A., & Winnicka, K. (2024) · Materials · doi:10.3390/ma17163923 · Cited by 16
Ascorbyl palmitate nanofiber-reinforced hydrogels for drug delivery in soft tissues
Shamiya, Y., Chakraborty, A., Zahid, A. A., Bainbridge, N. A., Guan, J., Feng, B., Pjontek, D., Chakrabarti, S., & Paul, A. (2024) · Communications Materials · doi:10.1038/s43246-024-00641-x · Cited by 16
Kinetic and theoretical studies of novel biodegradable thermo-sensitive xerogels based on PEG/PVP/silica for sustained release of enrofloxacin
Ebadi, A., Rafati, A. A., Bavafa, S., & Mohammadi, M. (2017) · Applied Surface Science · doi:10.1016/j.apsusc.2017.07.046 · Cited by 16
Layer-by-Layer coated drug-core nanoparticles as versatile delivery platforms
Paiva‐Santos, A. C., Caldas, M., Pattekari, P. P., Ribeiro, C., Ribeiro, A. J., LVOV, Y. M., & Veiga, F. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-813627-0.00016-8 · Cited by 16
Development of Self-Associating SN-38-Conjugated Poly(ethylene oxide)-Poly(ester) Micelles for Colorectal Cancer Therapy
Sadat, S. M. A., Vakili, M. R., de Paiva, I. M., Weinfeld, M., & Lavasanifar, A. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12111033 · Cited by 16
Insights into the ameliorating ability of mesoporous silica in modulating drug release in ternary amorphous solid dispersion prepared by hot melt extrusion
Solomon, S., Iqbal, J., & Albadarin, A. B. (2021) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2021.04.017 · Cited by 16
Formulation of ternary genistein β-cyclodextrin inclusion complex: In vitro characterization and cytotoxicity assessment using breast cancer cell line
Zafar, A., Alruwaili, N. K., Imam, S. S., Alsaidan, O. A., Alharbi, K. S., Mostafa, E. M., Musa, A., Gilani, S. J., Ghoneim, M. M., Alshehri, S., et al. (2021) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2021.102932 · Cited by 16
Pulmonary Drug Delivery System: Newer Patents
Kaur, S. S. (2017) · Pharmaceutical Patent Analyst · doi:10.4155/ppa-2017-0019 · Cited by 16
Preparation and Characterization of Simvastatin Nanocapsules: Encapsulation of Hydrophobic Drugs in Calcium Alginate
Ahmadi, M., Madrakian, T., & Ghavami, S. (2018) · Methods in molecular biology · doi:10.1007/7651_2018_191 · Cited by 16
Insight into the Structure and Properties of Novel Imidazole-Based Salts of Salicylic Acid
Martins, I. C. B., Al‐Sabbagh, D., Meyer, K., Maiwald, M., Scholz, G., & Emmerling, F. (2019) · Molecules · doi:10.3390/molecules24224144 · Cited by 16
Preparation and characterization of micellar nanoparticles using crude saponins from five Congolese plant species
Lokole, P. B., Ngombe, N. K., Motomba, D. I., Safari, J. B., Mpuza, M. K., Krause, R. W. M., Mutwale, P. K., & Nkanga, C. I. (2024) · Pharmaceutical Science Advances · doi:10.1016/j.pscia.2024.100055 · Cited by 17
Andrographolide Sulfonates and Xiyanping: A Review of Chemical Composition, Pharmacological Activities, Clinical Applications, and Adverse Reactions
Li, Z., Yao, L., Liu, Z., Wang, L., Ruan, H., Shen, Y., Zhang, P., Li, K., Wang, H., Fan, L., et al. (2025) · Pharmaceuticals · doi:10.3390/ph18020183 · Cited by 15
Dry Gels: Concept, Current Trends, and New Avenues in Drug Delivery and Biomedical Application
Boruah, M., & Sarma, A. (2025) · Advanced Healthcare Materials · doi:10.1002/adhm.202500863 · Cited by 18
Role of Salt Selection in Drug Discovery and Development
Acharya, P. C., Marwein, S., Mishra, B., Ghosh, R., Vora, A., & Tekade, R. K. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-814423-7.00013-7 · Cited by 15
Amalgamation of Solid Dispersion and Melt Adsorption Technique: Improved In Vitro and In Vivo Performance of Ticagrelor Tablets
Yadav, M., Sarolia, J., Vyas, B., Lalan, M. S., Mangrulkar, S. V., & Shah, P. (2021) · AAPS PharmSciTech · doi:10.1208/s12249-021-02138-z · Cited by 15
Glucose-Sensitive Delivery of Vitamin K by Using Surface-Functionalized, Dextran-Capped Mesoporous Silica Nanoparticles To Alleviate Hyperglycemia
Sarkar, S., Sadhukhan, P., Das, D., Basyach, P., Das, J., Das, M. R., Saikia, L., Wann, S. B., Kalita, J., Sil, P. C., et al. (2022) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c05974 · Cited by 15
Neural Network Prediction Model of Cocrystal Melting Temperature Based on Molecular Descriptors and Graphs
Yue, H., Wang, J., & Lu, M. (2023) · Crystal Growth & Design · doi:10.1021/acs.cgd.2c01441 · Cited by 15
G-Quadruplex Hydrogel-Based Stimuli-Responsive High-Internal-Phase Emulsion Scaffold for Biocatalytic Cascades and Synergistic Antimicrobial Activity
Das, S., Solra, M., Sahoo, J., Srivastava, A., Fathima, S., De, M., & Rana, S. (2023) · Chemistry of Materials · doi:10.1021/acs.chemmater.3c02173 · Cited by 15
Drugs in Cyclodextrin in Liposomes: How a Suitable Formulation of an Active Substance Can Improve Its Efficiency?
Levet, G., Krykun, S., Cornelio, B., Pilato, S., Moffa, S., Fontana, A., Gouhier, G., & Estour, F. (2024) · Processes · doi:10.3390/pr12030478 · Cited by 15
Nanocarriers' repartitioning of drugs between blood subcompartments as a mechanism of improving pharmacokinetics, safety, and efficacy
Zaleski, M. H., Omo‐Lamai, S., Nong, J., Chase, L. S., Myerson, J. W., Glassman, P. M., Lee, F. T., Reyes‐Esteves, S., Wang, Z., Patel, M. N., et al. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.07.070 · Cited by 18
Development of a novel progesterone analog in the treatment of traumatic brain injury
Sayeed, I., Wali, B., Guthrie, D. B., Saindane, M., Natchus, M. G., Liotta, D. C., & Stein, D. G. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.09.013 · Cited by 15
Sodium deoxycholate as a versatile dispersing and coating-forming agent: A new facet of electrophoretic deposition technology
Zhao, Q., Liu, X., Veldhuis, S. C., & Zhitomirsky, I. (2019) · Colloids and Surfaces A Physicochemical and Engineering Aspects · doi:10.1016/j.colsurfa.2019.124382 · Cited by 15
In-Silico Screening of Lipid-Based Drug Delivery Systems
Brinkmann, J., Exner, L., Luebbert, C., & Sadowski, G. (2020) · Pharmaceutical Research · doi:10.1007/s11095-020-02955-0 · Cited by 15
Clinical translation status of nanoformulations
Shukla, R., Thok, K., Kakade, S., Handa, M., & Beg, S. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-821095-6.00012-4 · Cited by 15
Investigation on Formulation Strategies to Mitigate Compression-Induced Destabilization in Supersaturated Celecoxib Amorphous Solid Dispersions
Bērziņš, K., Fraser‐Miller, S. J., Walker, G. F., Rades, T., & Gordon, K. C. (2021) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.1c00540 · Cited by 15
Active Targeted Nanoemulsions for Repurposing of Tegaserod in Alzheimer’s Disease Treatment
Séguy, L., Guyon, L., Maurel, M., Verdié, P., Davis, A., Corvaisier, S., Lisowski, V., Dallemagne, P., Groo, A., & Malzert‐Fréon, A. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13101626 · Cited by 16
Identification and validation of LGR5-binding peptide for molecular imaging of gastric cancer
Kwak, M. H., Yang, S. M., Yun, S. K., Kim, S., Choi, M., & Park, J. M. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2021.09.073 · Cited by 15
Multi-material 3D printing of programmable and stretchable oromucosal patches for delivery of saquinavir
He, S., Radeke, C., Jacobsen, J. B., Lind, J. U., & Mu, H. (2021) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2021.121236 · Cited by 15
Comparative Interaction Studies of Quercetin with 2-Hydroxyl-propyl-β-cyclodextrin and 2,6-Methylated-β-cyclodextrin
Vakali, V., Papadourakis, M., Georgiou, N., Zoupanou, N., Diamantis, D. A., Javornik, U., Papakyriakopoulou, P., Plavec, J., Valsami, G. N., Tzakos, A. G., et al. (2022) · Molecules · doi:10.3390/molecules27175490 · Cited by 15
Supercritical Fluids and Nanoparticles in Cancer Therapy
Marco, I. D. (2022) · Micromachines · doi:10.3390/mi13091449 · Cited by 15
Magnetic sustentation as an adsorption characterization technique for paramagnetic metal-organic frameworks
Barroso, N., Andreo, J., Beobide, G., Castillo, Ó., Luque, A., Pérez‐Yáñez, S., & Wuttke, S. (2023) · Communications Chemistry · doi:10.1038/s42004-022-00799-w · Cited by 16
Fabrication of hesperetin/hydroxypropyl-β-cyclodextrin complex nanoparticles for enhancement of bioactivity using supercritical antisolvent technology
Wang, C., Yan, T., Yan, T., & Wang, Z. (2023) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2023.134947 · Cited by 15
The effect of different polymers on the solubility, permeability and distribution of poor soluble 1,2,4-thiadiazole derivative
Volkova, Т. V., Domanina, E. N., Kumeev, R. S., Proshin, A. N., & Terekhova, I. V. (2018) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2018.08.062 · Cited by 15
Nanoliposomal Encapsulation Enhances In Vivo Anti-Tumor Activity of Niclosamide against Melanoma
Hatamipour, M., Jaafari, M. R., Momtazi‐Borojeni, A. A., Ramezani, M., & Sahebkar, A. (2019) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1871520619666190705120011 · Cited by 15
Insights about the interaction of methotrexate loaded hydrophilic gold nanoparticles: Spectroscopic, morphological and structural characterizations
Cerra, S., Matassa, R., Beltrán, A. M., Familiari, G., Battocchio, C., Píš, I., Sciubba, F., Scaramuzzo, F. A., Giudice, A. D., & Fratoddi, I. (2020) · Materials Science and Engineering C · doi:10.1016/j.msec.2020.111337 · Cited by 15
ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF ACETYLSALICYLIC ACID VIA CO-CRYSTALLIZATION TECHNIQUE: A NOVEL ASA-VALINE COCRYSTAL
Shanthala, H. K., Jayaprakash, H. V., Muniganti, R. K., Gowda, B. H. J., Paul, K., Shankar, S. J., Ahmed, M. G., & Sanjana, A. (2021) · International Journal of Applied Pharmaceutics · doi:10.22159/ijap.2021v13i1.40054 · Cited by 15
Nanoparticles as Drug Delivery Systems
Carissimi, G., Montalbán, M. G., Fuster, M. G., & Víllora, G. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.100253 · Cited by 15
Nasal Bioadhesive Drug Delivery Systems and Their Applications
Badhe, R. V., & Nipate, S. S. (2020) · Wiley eBooks · doi:10.1002/9781119640240.ch10 · Cited by 16
Crystal Engineering to Design of Solids: From Single to Multicomponent Organic Materials
Araya‐Sibaja, A. M., Fandaruff, C., Wilhelm-Romero, K., Vega‐Baudrit, J. R., Guillén-Girón, T., & Navarro-Hoyos, M. (2019) · Mini-Reviews in Organic Chemistry · doi:10.2174/1570193x16666190430153231 · Cited by 14
SARS-CoV-2 main protease (3CLpro) interaction with acyclovir antiviral drug/methyl-β-cyclodextrin complex: Physiochemical characterization and molecular docking
Mohandoss, S., Sukanya, R., Ganesan, S., Alkallas, F. H., Trabelsi, A. B. G., Kusmartsev, F. V., Velu, K. S., Thambusamy, S., Lo, H., & Lee, Y. R. (2022) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2022.120292 · Cited by 14
High amount of lecithin facilitates oral delivery of a poorly soluble pyrazoloquinolinone ligand formulated in lipid nanoparticles: Physicochemical, structural and pharmacokinetic performances
Mitrović, J. R., Divović, B., Knutson, D. E., Petković, M., Djorovic, D. J., Randjelovic, D. V., Dobričić, V., Đoković, J. B., Lunter, D. J., Cook, J. M., et al. (2023) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2023.122613 · Cited by 14
Synthesis, computational docking and molecular dynamics studies of a new class of spiroquinoxalinopyrrolidine embedded chromanone hybrids as potent anti-cholinesterase agents
Arumugam, N., M., D. D. V., Venketesh, V., Pradhan, S. S., Garg, A., Sivaramakrishnan, V., Kanchi, S., & Mahalingam, S. M. (2024) · RSC Advances · doi:10.1039/d4ra02432j · Cited by 14

Authors: Kalepu, S., & Nekkanti, V.
Affiliations: Western University of Health Sciences (US)
Corresponding author: Kalepu, Sandeep
Venue: Acta Pharmaceutica Sinica B
Publisher: Elsevier BV
Published: 2015-09
Volume: 5
Issue: 5
Pages: 442-453
ISSN: 2211-3835 (ISSN-L)
DOI: 10.1016/j.apsb.2015.07.003
PMC: PMC4629443
OpenAlex: W1195955210
Cited by: 1,410
References: 86
Citations by year: 2026: 111 · 2025: 140 · 2024: 148 · 2023: 166 · 2022: 155 · 2021: 179 · 2020: 191 · 2019: 139 · 2018: 95 · 2017: 62 · 2016: 20 · 2015: 2
FWCI: 6.68
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor)
Locations: Acta Pharmaceutica Sinica B (publishedVersion, cc-by-nc-nd)
Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
PubMed Central (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Inhalation and Respiratory Drug Delivery
Keywords: poorly water-soluble drugs, drug solubility, bioavailability, drug formulation, drug reformulation, pharmaceutical patents, marketing exclusivity, lipophilic drugs, high molecular weight drugs

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Insoluble drug delivery strategies: review of recent advances and business prospects

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks