Cited by 18Nanoparticle-Based Drug DeliveryDrug Solubulity and Delivery SystemsAdvanced Drug Delivery Systems

An overview on nanoplatforms for statins delivery: Perspectives for safe and effective therapy

Etemad, Leila, Salmasi, Zahra, Moosavian Kalat, Seyedeh Alia, Moshiri, Mohammad, Zamanian, Javad, Kesharwani, Prashant, Sahebkar, Amirhossein·2023·Environmental Research

Abstract

Statins are the most widely used pharmacological agents for reducing blood cholesterol levels and treating atherosclerotic cardiovascular diseases. Most of the statins' derivatives have been limited by water solubility, bioavailability, and oral absorption, which has led to adverse effects on several organs, especially at high doses. As an approach to reducing statin intolerance, achieving a stable formulation with improved efficacy and bioavailability at low doses has been suggested. Nanotechnology-based formulations may provide a therapeutic benefit over traditional formulations in terms of potency and biosafety. Nanocarriers can provide tailored delivery platforms for statins, thereby enhancing the localized biological effects and lowering the risk of undesired side effects while boosting statin's therapeutic index. Furthermore, tailored nanoparticles can deliver the active cargo to the desired site, which culminates in reducing off-targeting and toxicity. Nanomedicine could also provide opportunities for therapeutic methods by personalized medicine. This review delves into the existing data on the potential improvement of statin therapy using nano-formulations.

Integrity signals

Registry

Crossref · 10.1016/j.envres.2023.116572

Cites

173 of 173 references verified0 citation errors · 0 not checkable

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  • Encapsulation protects statins from chemical and enzymatic degradation and facilitates sustained and targeted delivery, optimizing drug concentration at the intended site of action.

    “Encapsulation not only protects statins from chemical and enzymatic degradation but also facilitates sustained and targeted delivery, thereby optimizing drug concentration at the intended site of action.”

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Authors
Etemad, L., Salmasi, Z., Moosavian Kalat, S. A., Moshiri, M., Zamanian, J., Kesharwani, P., & Sahebkar, A.
Affiliations
  • Mashhad University of Medical Sciences (IR)
  • Jamia Hamdard (IN)
Corresponding author
  • Kesharwani, Prashant
  • Sahebkar, Amirhossein
Venue
Environmental Research
Publisher
Elsevier BV
Published
2023-10
Volume
234
Pages
116572
ISSN
0013-9351 (ISSN-L)
OpenAlex
W4383617274
Cited by
18
References
173
Citations by year
2026: 4 · 2025: 9 · 2024: 4 · 2023: 1
FWCI
0.32
Type
journal article
Language
en
Open access
closed
Locations
  • Environmental Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Keywords
statins, nanoplatforms, nanocarriers, drug delivery, bioavailability, statin intolerance, cholesterol lowering, atherosclerotic cardiovascular disease, nanoparticle drug delivery, targeted delivery, personalized medicine, nanomedicine
MeSH terms
Hydroxymethylglutaryl-CoA Reductase Inhibitors, Nanotechnology, Nanomedicine

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