An overview on nanoplatforms for statins delivery: Perspectives for safe and effective therapy
Abstract
Statins are the most widely used pharmacological agents for reducing blood cholesterol levels and treating atherosclerotic cardiovascular diseases. Most of the statins' derivatives have been limited by water solubility, bioavailability, and oral absorption, which has led to adverse effects on several organs, especially at high doses. As an approach to reducing statin intolerance, achieving a stable formulation with improved efficacy and bioavailability at low doses has been suggested. Nanotechnology-based formulations may provide a therapeutic benefit over traditional formulations in terms of potency and biosafety. Nanocarriers can provide tailored delivery platforms for statins, thereby enhancing the localized biological effects and lowering the risk of undesired side effects while boosting statin's therapeutic index. Furthermore, tailored nanoparticles can deliver the active cargo to the desired site, which culminates in reducing off-targeting and toxicity. Nanomedicine could also provide opportunities for therapeutic methods by personalized medicine. This review delves into the existing data on the potential improvement of statin therapy using nano-formulations.
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Encapsulation protects statins from chemical and enzymatic degradation and facilitates sustained and targeted delivery, optimizing drug concentration at the intended site of action.
“Encapsulation not only protects statins from chemical and enzymatic degradation but also facilitates sustained and targeted delivery, thereby optimizing drug concentration at the intended site of action.”
From Statins as Antifungal Agents: A Review on Drug Repurposing and Nanotechnology-Driven Delivery Strategies (2025) · cites this paper as [132]
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Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
e Silva, D. M., de Souza Lacerda, L., de Souza Andrioli, A., Braz, W. R., Campos, L. M., de Paiva, M. R. B., Pittella, F., Fabri, R. L., & Tavares, G. D. (2025) · Fundamental & Clinical Pharmacology · doi:10.1111/fcp.70046 · Cited by 7 · see citing works
“Such delivery strategies have been associated with increased bioavailability and reduced adverse effects compared with conventional statin formulations [27, 132].”
- Authors
- Etemad, L., Salmasi, Z., Moosavian Kalat, S. A., Moshiri, M., Zamanian, J., Kesharwani, P., & Sahebkar, A.
- Affiliations
- Mashhad University of Medical Sciences (IR)
- Jamia Hamdard (IN)
- Corresponding author
- Kesharwani, Prashant
- Sahebkar, Amirhossein
- ORCID
- Venue
- Environmental Research
- Publisher
- Elsevier BV
- Published
- 2023-10
- Volume
- 234
- Pages
- 116572
- ISSN
- 0013-9351 (ISSN-L)
- OpenAlex
- W4383617274
- Cited by
- 18
- References
- 173
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 4 · 2023: 1
- FWCI
- 0.32
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Environmental Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Drug Solubulity and Delivery Systems
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- statins, nanoplatforms, nanocarriers, drug delivery, bioavailability, statin intolerance, cholesterol lowering, atherosclerotic cardiovascular disease, nanoparticle drug delivery, targeted delivery, personalized medicine, nanomedicine
- MeSH terms
- Hydroxymethylglutaryl-CoA Reductase Inhibitors, Nanotechnology, Nanomedicine
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