RETRACTED: Substance P-modified human serum albumin nanoparticles loaded with paclitaxel for targeted therapy of glioma
Open accessAbstract
The blood–brain barrier (BBB) and the poor ability of many drugs to cross that barrier greatly limits the efficacy of chemotherapies for glioblastoma multiforme (GBM). The present study exploits albumin as drug delivery vehicle to promote the chemotherapeutic efficacy of paclitaxel (PTX) by improving the stability and targeting efficiency of PTX/albumin nanoparticles (NPs). Here we characterize PTX-loaded human serum albumin (HSA) NPs stabilized with intramolecular disulfide bonds and modified with substance P (SP) peptide as the targeting ligand. The fabricated SP-HSA-PTX NPs exhibited satisfactory drug-loading content (7.89%) and entrapment efficiency (85.7%) with a spherical structure (about 150 nm) and zeta potential of −12.0 mV. The in vitro drug release from SP-HSA-PTX NPs occurred in a redox-responsive manner. Due to the targeting effect of the SP peptide, cellular uptake of SP-HSA-PTX NPs into brain capillary endothelial cells (BCECs) and U87 cells was greatly improved. The low IC 50 , prolonged survival period and the obvious pro-apoptotic effect shown by TUNEL analysis all demonstrated that the fabricated SP-HSA-PTX NPs showed a satisfactory anti-tumor effect and could serve as a novel strategy for GBM treatment.
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Glioblastoma involves deregulation of P53 and cell cycle signalling pathways.
“The disease involves deregulation of P53 and cell cycle signalling pathways1, 2, 3, 4.”
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Self-citation
- Authors
- Ruan, C., Liu, L., Lu, Y., Zhang, Y., He, X., Chen, X., Zhang, Y., Chen, Q., Guo, Q., Sun, T., & Jiang, C.
- Affiliations
- Fudan University (CN)
- Corresponding author
- Sun, Tao
- Venue
- Acta Pharmaceutica Sinica B
- Publisher
- Elsevier BV
- Published
- 2018-01
- Volume
- 8
- Issue
- 1
- Pages
- 85-96
- ISSN
- 2211-3835 (ISSN-L)
- PMC
- PMC5985627
- OpenAlex
- W2765938728
- Cited by
- 138
- References
- 34
- Citations by year
- 2026: 11 · 2025: 13 · 2024: 19 · 2023: 22 · 2022: 13 · 2021: 18 · 2020: 21 · 2019: 16 · 2018: 5
- FWCI
- 4.14
- Type
- journal article
- Language
- en
- Status
- Retracted
- Update notices
- retraction (2018-01-01)
- Open access
- gold
- doi.org
- Licence
- Locations
- Acta Pharmaceutica Sinica B (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (21602030, 81172993)
- National Key Research and Development Program of China (2013CB932500)
- National Science Fund for Distinguished Young Scholars (81425023)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Health Sciences › Medicine › Genetics › Glioma Diagnosis and Treatment
- Keywords
- substance P, human serum albumin nanoparticles, paclitaxel, glioblastoma, blood-brain barrier, targeted drug delivery, intramolecular disulfide bond, redox-responsive drug release, brain microvascular endothelial cells, U87 cells, apoptosis, nanoparticle drug delivery
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